Amino acid dipepetide frequency for Sphingosinithalassobacter sp. zrk23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.479AlaAla: 18.479 ± 0.199	1.034AlaCys: 1.034 ± 0.033	7.729AlaAsp: 7.729 ± 0.077	8.598AlaGlu: 8.598 ± 0.098	4.266AlaPhe: 4.266 ± 0.068	11.05AlaGly: 11.05 ± 0.108	2.285AlaHis: 2.285 ± 0.052	6.802AlaIle: 6.802 ± 0.083	3.689AlaLys: 3.689 ± 0.07	13.731AlaLeu: 13.731 ± 0.146	4.071AlaMet: 4.071 ± 0.062	2.998AlaAsn: 2.998 ± 0.049	6.547AlaPro: 6.547 ± 0.107	4.613AlaGln: 4.613 ± 0.066	9.809AlaArg: 9.809 ± 0.119	6.401AlaSer: 6.401 ± 0.086	6.278AlaThr: 6.278 ± 0.069	8.652AlaVal: 8.652 ± 0.099	1.656AlaTrp: 1.656 ± 0.04	2.518AlaTyr: 2.518 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.998CysAla: 0.998 ± 0.031	0.076CysCys: 0.076 ± 0.009	0.575CysAsp: 0.575 ± 0.023	0.458CysGlu: 0.458 ± 0.02	0.299CysPhe: 0.299 ± 0.016	0.877CysGly: 0.877 ± 0.026	0.204CysHis: 0.204 ± 0.014	0.345CysIle: 0.345 ± 0.018	0.158CysLys: 0.158 ± 0.01	0.636CysLeu: 0.636 ± 0.023	0.149CysMet: 0.149 ± 0.012	0.196CysAsn: 0.196 ± 0.014	0.432CysPro: 0.432 ± 0.024	0.186CysGln: 0.186 ± 0.014	0.579CysArg: 0.579 ± 0.023	0.436CysSer: 0.436 ± 0.021	0.412CysThr: 0.412 ± 0.02	0.544CysVal: 0.544 ± 0.024	0.117CysTrp: 0.117 ± 0.011	0.176CysTyr: 0.176 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.325AspAla: 8.325 ± 0.094	0.532AspCys: 0.532 ± 0.023	3.543AspAsp: 3.543 ± 0.053	3.541AspGlu: 3.541 ± 0.064	2.286AspPhe: 2.286 ± 0.052	5.717AspGly: 5.717 ± 0.07	1.277AspHis: 1.277 ± 0.039	3.025AspIle: 3.025 ± 0.053	1.59AspLys: 1.59 ± 0.041	5.572AspLeu: 5.572 ± 0.072	1.609AspMet: 1.609 ± 0.041	1.362AspAsn: 1.362 ± 0.039	3.933AspPro: 3.933 ± 0.058	1.767AspGln: 1.767 ± 0.043	5.038AspArg: 5.038 ± 0.074	2.829AspSer: 2.829 ± 0.042	2.897AspThr: 2.897 ± 0.056	4.127AspVal: 4.127 ± 0.058	1.208AspTrp: 1.208 ± 0.034	1.619AspTyr: 1.619 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.617GluAla: 8.617 ± 0.098	0.36GluCys: 0.36 ± 0.019	3.158GluAsp: 3.158 ± 0.059	3.631GluGlu: 3.631 ± 0.076	1.663GluPhe: 1.663 ± 0.036	5.058GluGly: 5.058 ± 0.064	1.25GluHis: 1.25 ± 0.03	3.258GluIle: 3.258 ± 0.057	2.029GluLys: 2.029 ± 0.045	5.25GluLeu: 5.25 ± 0.065	1.653GluMet: 1.653 ± 0.036	1.52GluAsn: 1.52 ± 0.04	2.886GluPro: 2.886 ± 0.058	2.15GluGln: 2.15 ± 0.046	5.349GluArg: 5.349 ± 0.08	2.918GluSer: 2.918 ± 0.053	3.802GluThr: 3.802 ± 0.062	3.764GluVal: 3.764 ± 0.061	0.859GluTrp: 0.859 ± 0.03	1.241GluTyr: 1.241 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.843PheAla: 4.843 ± 0.067	0.295PheCys: 0.295 ± 0.016	2.735PheAsp: 2.735 ± 0.048	2.233PheGlu: 2.233 ± 0.045	1.323PhePhe: 1.323 ± 0.04	3.614PheGly: 3.614 ± 0.058	0.723PheHis: 0.723 ± 0.024	1.313PheIle: 1.313 ± 0.033	0.748PheLys: 0.748 ± 0.029	3.28PheLeu: 3.28 ± 0.061	0.704PheMet: 0.704 ± 0.025	0.865PheAsn: 0.865 ± 0.028	1.541PhePro: 1.541 ± 0.031	0.924PheGln: 0.924 ± 0.031	2.256PheArg: 2.256 ± 0.047	2.049PheSer: 2.049 ± 0.042	1.932PheThr: 1.932 ± 0.042	2.763PheVal: 2.763 ± 0.054	0.543PheTrp: 0.543 ± 0.022	0.891PheTyr: 0.891 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.967GlyAla: 9.967 ± 0.114	0.848GlyCys: 0.848 ± 0.031	5.394GlyAsp: 5.394 ± 0.071	5.623GlyGlu: 5.623 ± 0.07	3.698GlyPhe: 3.698 ± 0.056	8.25GlyGly: 8.25 ± 0.117	1.775GlyHis: 1.775 ± 0.044	4.443GlyIle: 4.443 ± 0.065	3.057GlyLys: 3.057 ± 0.051	8.288GlyLeu: 8.288 ± 0.1	2.586GlyMet: 2.586 ± 0.056	2.364GlyAsn: 2.364 ± 0.049	3.735GlyPro: 3.735 ± 0.062	2.713GlyGln: 2.713 ± 0.054	6.246GlyArg: 6.246 ± 0.075	4.994GlySer: 4.994 ± 0.073	4.815GlyThr: 4.815 ± 0.077	6.195GlyVal: 6.195 ± 0.083	1.693GlyTrp: 1.693 ± 0.04	2.44GlyTyr: 2.44 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.382HisAla: 2.382 ± 0.051	0.233HisCys: 0.233 ± 0.015	1.244HisAsp: 1.244 ± 0.034	1.061HisGlu: 1.061 ± 0.035	0.8HisPhe: 0.8 ± 0.032	1.96HisGly: 1.96 ± 0.042	0.552HisHis: 0.552 ± 0.025	0.942HisIle: 0.942 ± 0.026	0.404HisLys: 0.404 ± 0.018	1.8HisLeu: 1.8 ± 0.05	0.438HisMet: 0.438 ± 0.021	0.432HisAsn: 0.432 ± 0.017	1.302HisPro: 1.302 ± 0.033	0.54HisGln: 0.54 ± 0.022	1.537HisArg: 1.537 ± 0.039	0.887HisSer: 0.887 ± 0.03	0.654HisThr: 0.654 ± 0.023	1.507HisVal: 1.507 ± 0.039	0.416HisTrp: 0.416 ± 0.02	0.547HisTyr: 0.547 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	8.113IleAla: 8.113 ± 0.092	0.384IleCys: 0.384 ± 0.017	3.906IleAsp: 3.906 ± 0.061	3.641IleGlu: 3.641 ± 0.054	1.552IlePhe: 1.552 ± 0.035	5.133IleGly: 5.133 ± 0.076	0.84IleHis: 0.84 ± 0.027	1.777IleIle: 1.777 ± 0.042	1.032IleLys: 1.032 ± 0.031	4.055IleLeu: 4.055 ± 0.059	0.742IleMet: 0.742 ± 0.029	1.143IleAsn: 1.143 ± 0.035	2.291IlePro: 2.291 ± 0.047	1.097IleGln: 1.097 ± 0.032	3.192IleArg: 3.192 ± 0.055	2.56IleSer: 2.56 ± 0.048	2.494IleThr: 2.494 ± 0.059	4.076IleVal: 4.076 ± 0.068	0.593IleTrp: 0.593 ± 0.024	1.013IleTyr: 1.013 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.443LysAla: 3.443 ± 0.065	0.154LysCys: 0.154 ± 0.013	1.374LysAsp: 1.374 ± 0.037	1.224LysGlu: 1.224 ± 0.037	0.773LysPhe: 0.773 ± 0.029	2.314LysGly: 2.314 ± 0.057	0.525LysHis: 0.525 ± 0.022	1.28LysIle: 1.28 ± 0.039	1.02LysLys: 1.02 ± 0.041	3.113LysLeu: 3.113 ± 0.06	0.727LysMet: 0.727 ± 0.028	0.637LysAsn: 0.637 ± 0.026	1.75LysPro: 1.75 ± 0.047	0.807LysGln: 0.807 ± 0.026	2.223LysArg: 2.223 ± 0.052	1.494LysSer: 1.494 ± 0.038	1.467LysThr: 1.467 ± 0.039	1.86LysVal: 1.86 ± 0.049	0.369LysTrp: 0.369 ± 0.018	0.552LysTyr: 0.552 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.678LeuAla: 13.678 ± 0.133	0.764LeuCys: 0.764 ± 0.023	6.17LeuAsp: 6.17 ± 0.086	5.096LeuGlu: 5.096 ± 0.068	3.541LeuPhe: 3.541 ± 0.062	8.152LeuGly: 8.152 ± 0.095	1.798LeuHis: 1.798 ± 0.041	4.928LeuIle: 4.928 ± 0.073	2.651LeuLys: 2.651 ± 0.058	9.65LeuLeu: 9.65 ± 0.128	2.143LeuMet: 2.143 ± 0.044	2.119LeuAsn: 2.119 ± 0.048	5.617LeuPro: 5.617 ± 0.071	2.414LeuGln: 2.414 ± 0.044	7.097LeuArg: 7.097 ± 0.079	5.853LeuSer: 5.853 ± 0.075	5.369LeuThr: 5.369 ± 0.07	6.928LeuVal: 6.928 ± 0.084	1.264LeuTrp: 1.264 ± 0.036	1.908LeuTyr: 1.908 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.263MetAla: 3.263 ± 0.055	0.167MetCys: 0.167 ± 0.011	1.121MetAsp: 1.121 ± 0.032	1.127MetGlu: 1.127 ± 0.031	0.75MetPhe: 0.75 ± 0.025	1.907MetGly: 1.907 ± 0.041	0.459MetHis: 0.459 ± 0.021	1.39MetIle: 1.39 ± 0.039	0.798MetLys: 0.798 ± 0.029	2.848MetLeu: 2.848 ± 0.053	0.687MetMet: 0.687 ± 0.026	0.694MetAsn: 0.694 ± 0.025	1.552MetPro: 1.552 ± 0.032	0.823MetGln: 0.823 ± 0.027	2.009MetArg: 2.009 ± 0.044	1.419MetSer: 1.419 ± 0.037	1.816MetThr: 1.816 ± 0.046	1.748MetVal: 1.748 ± 0.042	0.25MetTrp: 0.25 ± 0.015	0.295MetTyr: 0.295 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.099AsnAla: 3.099 ± 0.048	0.216AsnCys: 0.216 ± 0.015	1.38AsnAsp: 1.38 ± 0.034	1.199AsnGlu: 1.199 ± 0.036	0.929AsnPhe: 0.929 ± 0.033	2.372AsnGly: 2.372 ± 0.05	0.487AsnHis: 0.487 ± 0.022	1.193AsnIle: 1.193 ± 0.034	0.534AsnLys: 0.534 ± 0.023	2.266AsnLeu: 2.266 ± 0.048	0.571AsnMet: 0.571 ± 0.024	0.605AsnAsn: 0.605 ± 0.026	1.622AsnPro: 1.622 ± 0.038	0.702AsnGln: 0.702 ± 0.028	1.833AsnArg: 1.833 ± 0.037	1.192AsnSer: 1.192 ± 0.036	1.041AsnThr: 1.041 ± 0.032	1.769AsnVal: 1.769 ± 0.04	0.426AsnTrp: 0.426 ± 0.019	0.665AsnTyr: 0.665 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.69ProAla: 6.69 ± 0.113	0.343ProCys: 0.343 ± 0.017	4.029ProAsp: 4.029 ± 0.057	4.384ProGlu: 4.384 ± 0.064	1.881ProPhe: 1.881 ± 0.044	5.143ProGly: 5.143 ± 0.077	1.054ProHis: 1.054 ± 0.031	2.357ProIle: 2.357 ± 0.05	1.3ProLys: 1.3 ± 0.038	4.743ProLeu: 4.743 ± 0.074	1.314ProMet: 1.314 ± 0.032	1.203ProAsn: 1.203 ± 0.033	2.903ProPro: 2.903 ± 0.073	1.81ProGln: 1.81 ± 0.044	3.223ProArg: 3.223 ± 0.064	2.515ProSer: 2.515 ± 0.049	2.409ProThr: 2.409 ± 0.047	4.388ProVal: 4.388 ± 0.073	0.699ProTrp: 0.699 ± 0.025	1.151ProTyr: 1.151 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.058GlnAla: 4.058 ± 0.066	0.236GlnCys: 0.236 ± 0.015	1.529GlnAsp: 1.529 ± 0.041	1.496GlnGlu: 1.496 ± 0.038	0.997GlnPhe: 0.997 ± 0.029	2.519GlnGly: 2.519 ± 0.051	0.589GlnHis: 0.589 ± 0.025	1.581GlnIle: 1.581 ± 0.045	0.798GlnLys: 0.798 ± 0.027	3.069GlnLeu: 3.069 ± 0.048	0.823GlnMet: 0.823 ± 0.027	0.711GlnAsn: 0.711 ± 0.028	1.794GlnPro: 1.794 ± 0.042	1.195GlnGln: 1.195 ± 0.035	2.562GlnArg: 2.562 ± 0.05	1.7GlnSer: 1.7 ± 0.039	1.618GlnThr: 1.618 ± 0.038	2.145GlnVal: 2.145 ± 0.04	0.489GlnTrp: 0.489 ± 0.021	0.641GlnTyr: 0.641 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.84ArgAla: 8.84 ± 0.114	0.516ArgCys: 0.516 ± 0.022	4.699ArgAsp: 4.699 ± 0.067	4.778ArgGlu: 4.778 ± 0.072	3.203ArgPhe: 3.203 ± 0.052	5.389ArgGly: 5.389 ± 0.078	1.692ArgHis: 1.692 ± 0.036	4.158ArgIle: 4.158 ± 0.069	2.166ArgLys: 2.166 ± 0.041	7.906ArgLeu: 7.906 ± 0.093	2.069ArgMet: 2.069 ± 0.042	1.876ArgAsn: 1.876 ± 0.044	3.645ArgPro: 3.645 ± 0.061	2.401ArgGln: 2.401 ± 0.044	5.87ArgArg: 5.87 ± 0.093	3.742ArgSer: 3.742 ± 0.065	3.46ArgThr: 3.46 ± 0.061	4.977ArgVal: 4.977 ± 0.069	1.313ArgTrp: 1.313 ± 0.033	1.929ArgTyr: 1.929 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.5SerAla: 6.5 ± 0.086	0.427SerCys: 0.427 ± 0.019	3.375SerAsp: 3.375 ± 0.05	3.17SerGlu: 3.17 ± 0.055	2.083SerPhe: 2.083 ± 0.045	5.816SerGly: 5.816 ± 0.076	0.968SerHis: 0.968 ± 0.031	2.56SerIle: 2.56 ± 0.048	1.248SerLys: 1.248 ± 0.036	4.965SerLeu: 4.965 ± 0.063	1.178SerMet: 1.178 ± 0.03	1.397SerAsn: 1.397 ± 0.034	2.759SerPro: 2.759 ± 0.052	1.569SerGln: 1.569 ± 0.036	3.605SerArg: 3.605 ± 0.055	2.632SerSer: 2.632 ± 0.062	2.446SerThr: 2.446 ± 0.052	3.8SerVal: 3.8 ± 0.057	0.792SerTrp: 0.792 ± 0.028	1.356SerTyr: 1.356 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.192ThrAla: 6.192 ± 0.072	0.346ThrCys: 0.346 ± 0.016	3.015ThrAsp: 3.015 ± 0.055	2.708ThrGlu: 2.708 ± 0.048	1.691ThrPhe: 1.691 ± 0.04	5.379ThrGly: 5.379 ± 0.081	0.927ThrHis: 0.927 ± 0.027	2.965ThrIle: 2.965 ± 0.061	1.104ThrLys: 1.104 ± 0.035	5.776ThrLeu: 5.776 ± 0.079	1.234ThrMet: 1.234 ± 0.034	1.175ThrAsn: 1.175 ± 0.033	3.444ThrPro: 3.444 ± 0.065	1.55ThrGln: 1.55 ± 0.037	3.56ThrArg: 3.56 ± 0.05	2.587ThrSer: 2.587 ± 0.053	2.564ThrThr: 2.564 ± 0.056	4.102ThrVal: 4.102 ± 0.065	0.546ThrTrp: 0.546 ± 0.024	1.12ThrTyr: 1.12 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.624ValAla: 9.624 ± 0.099	0.543ValCys: 0.543 ± 0.022	4.45ValAsp: 4.45 ± 0.067	4.563ValGlu: 4.563 ± 0.064	2.296ValPhe: 2.296 ± 0.043	5.252ValGly: 5.252 ± 0.09	1.366ValHis: 1.366 ± 0.034	3.682ValIle: 3.682 ± 0.061	1.835ValLys: 1.835 ± 0.05	6.331ValLeu: 6.331 ± 0.074	1.611ValMet: 1.611 ± 0.036	1.821ValAsn: 1.821 ± 0.042	3.987ValPro: 3.987 ± 0.065	2.005ValGln: 2.005 ± 0.044	5.235ValArg: 5.235 ± 0.071	4.268ValSer: 4.268 ± 0.066	4.694ValThr: 4.694 ± 0.063	4.998ValVal: 4.998 ± 0.076	0.836ValTrp: 0.836 ± 0.026	1.394ValTyr: 1.394 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.361TrpAla: 1.361 ± 0.034	0.133TrpCys: 0.133 ± 0.011	0.724TrpAsp: 0.724 ± 0.026	0.723TrpGlu: 0.723 ± 0.025	0.618TrpPhe: 0.618 ± 0.026	1.015TrpGly: 1.015 ± 0.033	0.366TrpHis: 0.366 ± 0.018	0.834TrpIle: 0.834 ± 0.025	0.459TrpLys: 0.459 ± 0.022	1.776TrpLeu: 1.776 ± 0.042	0.372TrpMet: 0.372 ± 0.016	0.455TrpAsn: 0.455 ± 0.016	0.714TrpPro: 0.714 ± 0.026	0.613TrpGln: 0.613 ± 0.021	1.383TrpArg: 1.383 ± 0.033	0.909TrpSer: 0.909 ± 0.029	0.786TrpThr: 0.786 ± 0.027	0.879TrpVal: 0.879 ± 0.032	0.267TrpTrp: 0.267 ± 0.015	0.312TrpTyr: 0.312 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.733TyrAla: 2.733 ± 0.05	0.245TyrCys: 0.245 ± 0.016	1.647TyrAsp: 1.647 ± 0.045	1.161TyrGlu: 1.161 ± 0.034	0.924TyrPhe: 0.924 ± 0.029	2.207TyrGly: 2.207 ± 0.042	0.503TyrHis: 0.503 ± 0.022	0.804TyrIle: 0.804 ± 0.027	0.485TyrLys: 0.485 ± 0.02	2.084TyrLeu: 2.084 ± 0.048	0.441TyrMet: 0.441 ± 0.021	0.53TyrAsn: 0.53 ± 0.022	1.086TyrPro: 1.086 ± 0.032	0.667TyrGln: 0.667 ± 0.027	2.027TyrArg: 2.027 ± 0.045	1.264TyrSer: 1.264 ± 0.036	1.033TyrThr: 1.033 ± 0.038	1.568TyrVal: 1.568 ± 0.038	0.359TyrTrp: 0.359 ± 0.017	0.685TyrTyr: 0.685 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3726 proteins (1161024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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