Amino acid dipepetide frequency for Brevundimonas abyssalis TAR-001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.768AlaAla: 20.768 ± 0.246	1.21AlaCys: 1.21 ± 0.043	8.272AlaAsp: 8.272 ± 0.104	8.887AlaGlu: 8.887 ± 0.132	4.81AlaPhe: 4.81 ± 0.075	11.81AlaGly: 11.81 ± 0.159	2.314AlaHis: 2.314 ± 0.056	5.045AlaIle: 5.045 ± 0.089	2.864AlaLys: 2.864 ± 0.082	14.212AlaLeu: 14.212 ± 0.174	3.805AlaMet: 3.805 ± 0.076	2.603AlaAsn: 2.603 ± 0.052	7.41AlaPro: 7.41 ± 0.116	4.205AlaGln: 4.205 ± 0.092	11.1AlaArg: 11.1 ± 0.134	6.351AlaSer: 6.351 ± 0.085	5.798AlaThr: 5.798 ± 0.095	10.619AlaVal: 10.619 ± 0.144	2.059AlaTrp: 2.059 ± 0.054	2.608AlaTyr: 2.608 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.017CysAla: 1.017 ± 0.037	0.124CysCys: 0.124 ± 0.014	0.478CysAsp: 0.478 ± 0.023	0.418CysGlu: 0.418 ± 0.023	0.212CysPhe: 0.212 ± 0.015	0.842CysGly: 0.842 ± 0.038	0.157CysHis: 0.157 ± 0.014	0.263CysIle: 0.263 ± 0.018	0.126CysLys: 0.126 ± 0.011	0.592CysLeu: 0.592 ± 0.028	0.144CysMet: 0.144 ± 0.014	0.144CysAsn: 0.144 ± 0.014	0.45CysPro: 0.45 ± 0.025	0.164CysGln: 0.164 ± 0.015	0.584CysArg: 0.584 ± 0.028	0.364CysSer: 0.364 ± 0.022	0.319CysThr: 0.319 ± 0.02	0.552CysVal: 0.552 ± 0.027	0.133CysTrp: 0.133 ± 0.01	0.136CysTyr: 0.136 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.029AspAla: 8.029 ± 0.106	0.391AspCys: 0.391 ± 0.026	3.704AspAsp: 3.704 ± 0.079	3.808AspGlu: 3.808 ± 0.074	2.039AspPhe: 2.039 ± 0.059	6.048AspGly: 6.048 ± 0.108	1.528AspHis: 1.528 ± 0.047	2.476AspIle: 2.476 ± 0.052	1.282AspLys: 1.282 ± 0.047	6.427AspLeu: 6.427 ± 0.107	1.467AspMet: 1.467 ± 0.04	1.199AspAsn: 1.199 ± 0.036	4.111AspPro: 4.111 ± 0.075	2.37AspGln: 2.37 ± 0.051	5.21AspArg: 5.21 ± 0.096	2.213AspSer: 2.213 ± 0.047	2.501AspThr: 2.501 ± 0.052	4.219AspVal: 4.219 ± 0.073	1.207AspTrp: 1.207 ± 0.04	1.481AspTyr: 1.481 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	9.561GluAla: 9.561 ± 0.113	0.259GluCys: 0.259 ± 0.021	3.388GluAsp: 3.388 ± 0.071	2.851GluGlu: 2.851 ± 0.062	1.603GluPhe: 1.603 ± 0.044	5.127GluGly: 5.127 ± 0.078	1.137GluHis: 1.137 ± 0.04	3.038GluIle: 3.038 ± 0.069	1.522GluLys: 1.522 ± 0.055	4.799GluLeu: 4.799 ± 0.096	1.421GluMet: 1.421 ± 0.045	1.328GluAsn: 1.328 ± 0.042	3.228GluPro: 3.228 ± 0.069	2.183GluGln: 2.183 ± 0.055	5.49GluArg: 5.49 ± 0.086	2.352GluSer: 2.352 ± 0.057	3.967GluThr: 3.967 ± 0.066	4.057GluVal: 4.057 ± 0.066	0.684GluTrp: 0.684 ± 0.029	0.938GluTyr: 0.938 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.273PheAla: 4.273 ± 0.076	0.288PheCys: 0.288 ± 0.017	2.726PheAsp: 2.726 ± 0.067	2.201PheGlu: 2.201 ± 0.048	1.17PhePhe: 1.17 ± 0.041	3.332PheGly: 3.332 ± 0.067	0.669PheHis: 0.669 ± 0.026	1.575PheIle: 1.575 ± 0.045	0.721PheLys: 0.721 ± 0.029	2.98PheLeu: 2.98 ± 0.06	0.828PheMet: 0.828 ± 0.034	0.968PheAsn: 0.968 ± 0.035	1.424PhePro: 1.424 ± 0.043	1.055PheGln: 1.055 ± 0.035	2.293PheArg: 2.293 ± 0.056	1.882PheSer: 1.882 ± 0.051	2.036PheThr: 2.036 ± 0.05	2.561PheVal: 2.561 ± 0.058	0.564PheTrp: 0.564 ± 0.026	0.783PheTyr: 0.783 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.455GlyAla: 11.455 ± 0.149	0.716GlyCys: 0.716 ± 0.028	5.29GlyAsp: 5.29 ± 0.105	5.528GlyGlu: 5.528 ± 0.076	3.553GlyPhe: 3.553 ± 0.062	8.518GlyGly: 8.518 ± 0.142	1.778GlyHis: 1.778 ± 0.051	3.057GlyIle: 3.057 ± 0.069	2.26GlyLys: 2.26 ± 0.057	9.763GlyLeu: 9.763 ± 0.123	2.261GlyMet: 2.261 ± 0.056	1.52GlyAsn: 1.52 ± 0.047	4.315GlyPro: 4.315 ± 0.084	3.257GlyGln: 3.257 ± 0.072	7.461GlyArg: 7.461 ± 0.097	4.242GlySer: 4.242 ± 0.075	3.45GlyThr: 3.45 ± 0.064	7.821GlyVal: 7.821 ± 0.12	1.731GlyTrp: 1.731 ± 0.048	2.091GlyTyr: 2.091 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.385HisAla: 2.385 ± 0.059	0.151HisCys: 0.151 ± 0.013	1.308HisAsp: 1.308 ± 0.04	1.117HisGlu: 1.117 ± 0.038	0.607HisPhe: 0.607 ± 0.028	2.008HisGly: 2.008 ± 0.053	0.494HisHis: 0.494 ± 0.023	0.703HisIle: 0.703 ± 0.031	0.352HisLys: 0.352 ± 0.022	1.844HisLeu: 1.844 ± 0.051	0.455HisMet: 0.455 ± 0.023	0.36HisAsn: 0.36 ± 0.024	1.289HisPro: 1.289 ± 0.041	0.622HisGln: 0.622 ± 0.028	1.372HisArg: 1.372 ± 0.041	0.739HisSer: 0.739 ± 0.032	0.749HisThr: 0.749 ± 0.032	1.487HisVal: 1.487 ± 0.039	0.31HisTrp: 0.31 ± 0.021	0.449HisTyr: 0.449 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.197IleAla: 6.197 ± 0.09	0.398IleCys: 0.398 ± 0.023	3.262IleAsp: 3.262 ± 0.072	3.248IleGlu: 3.248 ± 0.062	1.251IlePhe: 1.251 ± 0.041	4.262IleGly: 4.262 ± 0.09	0.811IleHis: 0.811 ± 0.033	1.827IleIle: 1.827 ± 0.055	0.993IleLys: 0.993 ± 0.041	4.094IleLeu: 4.094 ± 0.078	0.801IleMet: 0.801 ± 0.037	1.109IleAsn: 1.109 ± 0.037	1.937IlePro: 1.937 ± 0.046	1.376IleGln: 1.376 ± 0.039	3.01IleArg: 3.01 ± 0.061	2.196IleSer: 2.196 ± 0.055	2.55IleThr: 2.55 ± 0.047	3.421IleVal: 3.421 ± 0.061	0.549IleTrp: 0.549 ± 0.026	0.844IleTyr: 0.844 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.74LysAla: 3.74 ± 0.101	0.089LysCys: 0.089 ± 0.012	1.37LysAsp: 1.37 ± 0.051	0.936LysGlu: 0.936 ± 0.04	0.594LysPhe: 0.594 ± 0.026	2.184LysGly: 2.184 ± 0.059	0.412LysHis: 0.412 ± 0.022	1.008LysIle: 1.008 ± 0.039	0.896LysLys: 0.896 ± 0.045	2.113LysLeu: 2.113 ± 0.067	0.477LysMet: 0.477 ± 0.026	0.542LysAsn: 0.542 ± 0.024	1.655LysPro: 1.655 ± 0.05	0.625LysGln: 0.625 ± 0.03	1.939LysArg: 1.939 ± 0.055	1.256LysSer: 1.256 ± 0.046	1.62LysThr: 1.62 ± 0.047	1.758LysVal: 1.758 ± 0.053	0.267LysTrp: 0.267 ± 0.019	0.42LysTyr: 0.42 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.661LeuAla: 13.661 ± 0.171	0.66LeuCys: 0.66 ± 0.025	6.267LeuAsp: 6.267 ± 0.102	5.504LeuGlu: 5.504 ± 0.1	3.546LeuPhe: 3.546 ± 0.074	8.235LeuGly: 8.235 ± 0.117	1.726LeuHis: 1.726 ± 0.047	5.393LeuIle: 5.393 ± 0.088	3.4LeuLys: 3.4 ± 0.078	8.373LeuLeu: 8.373 ± 0.122	2.509LeuMet: 2.509 ± 0.053	2.918LeuAsn: 2.918 ± 0.061	4.921LeuPro: 4.921 ± 0.082	2.383LeuGln: 2.383 ± 0.06	6.559LeuArg: 6.559 ± 0.093	6.1LeuSer: 6.1 ± 0.099	6.502LeuThr: 6.502 ± 0.09	6.451LeuVal: 6.451 ± 0.101	1.28LeuTrp: 1.28 ± 0.043	1.987LeuTyr: 1.987 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.545MetAla: 3.545 ± 0.071	0.102MetCys: 0.102 ± 0.011	1.352MetAsp: 1.352 ± 0.039	1.114MetGlu: 1.114 ± 0.042	0.675MetPhe: 0.675 ± 0.03	2.085MetGly: 2.085 ± 0.053	0.354MetHis: 0.354 ± 0.023	1.34MetIle: 1.34 ± 0.046	0.834MetLys: 0.834 ± 0.032	2.264MetLeu: 2.264 ± 0.058	0.674MetMet: 0.674 ± 0.028	0.749MetAsn: 0.749 ± 0.031	1.219MetPro: 1.219 ± 0.037	0.723MetGln: 0.723 ± 0.03	1.738MetArg: 1.738 ± 0.045	1.49MetSer: 1.49 ± 0.043	2.121MetThr: 2.121 ± 0.045	1.597MetVal: 1.597 ± 0.052	0.229MetTrp: 0.229 ± 0.019	0.228MetTyr: 0.228 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.976AsnAla: 2.976 ± 0.058	0.187AsnCys: 0.187 ± 0.015	1.259AsnAsp: 1.259 ± 0.04	1.082AsnGlu: 1.082 ± 0.036	0.693AsnPhe: 0.693 ± 0.034	2.114AsnGly: 2.114 ± 0.062	0.468AsnHis: 0.468 ± 0.025	1.061AsnIle: 1.061 ± 0.046	0.414AsnLys: 0.414 ± 0.024	2.423AsnLeu: 2.423 ± 0.057	0.482AsnMet: 0.482 ± 0.027	0.539AsnAsn: 0.539 ± 0.026	1.72AsnPro: 1.72 ± 0.043	0.704AsnGln: 0.704 ± 0.03	1.82AsnArg: 1.82 ± 0.045	0.997AsnSer: 0.997 ± 0.033	1.137AsnThr: 1.137 ± 0.038	1.662AsnVal: 1.662 ± 0.045	0.354AsnTrp: 0.354 ± 0.022	0.57AsnTyr: 0.57 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.321ProAla: 7.321 ± 0.109	0.378ProCys: 0.378 ± 0.022	4.399ProAsp: 4.399 ± 0.085	4.228ProGlu: 4.228 ± 0.077	1.985ProPhe: 1.985 ± 0.048	5.232ProGly: 5.232 ± 0.087	1.019ProHis: 1.019 ± 0.033	2.105ProIle: 2.105 ± 0.05	1.137ProLys: 1.137 ± 0.042	4.685ProLeu: 4.685 ± 0.08	1.264ProMet: 1.264 ± 0.04	1.256ProAsn: 1.256 ± 0.042	3.14ProPro: 3.14 ± 0.095	1.521ProGln: 1.521 ± 0.036	3.588ProArg: 3.588 ± 0.067	2.938ProSer: 2.938 ± 0.065	2.715ProThr: 2.715 ± 0.061	4.502ProVal: 4.502 ± 0.077	0.903ProTrp: 0.903 ± 0.035	1.055ProTyr: 1.055 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.97GlnAla: 4.97 ± 0.098	0.177GlnCys: 0.177 ± 0.015	1.512GlnAsp: 1.512 ± 0.046	1.321GlnGlu: 1.321 ± 0.038	0.971GlnPhe: 0.971 ± 0.031	2.757GlnGly: 2.757 ± 0.06	0.546GlnHis: 0.546 ± 0.028	1.595GlnIle: 1.595 ± 0.047	0.752GlnLys: 0.752 ± 0.036	2.597GlnLeu: 2.597 ± 0.062	0.808GlnMet: 0.808 ± 0.03	0.727GlnAsn: 0.727 ± 0.032	1.887GlnPro: 1.887 ± 0.05	0.969GlnGln: 0.969 ± 0.034	2.44GlnArg: 2.44 ± 0.061	1.655GlnSer: 1.655 ± 0.044	2.018GlnThr: 2.018 ± 0.047	2.426GlnVal: 2.426 ± 0.056	0.385GlnTrp: 0.385 ± 0.021	0.474GlnTyr: 0.474 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.871ArgAla: 9.871 ± 0.117	0.47ArgCys: 0.47 ± 0.027	4.536ArgAsp: 4.536 ± 0.081	4.386ArgGlu: 4.386 ± 0.073	3.03ArgPhe: 3.03 ± 0.067	5.577ArgGly: 5.577 ± 0.078	1.599ArgHis: 1.599 ± 0.048	3.943ArgIle: 3.943 ± 0.067	1.865ArgLys: 1.865 ± 0.063	9.184ArgLeu: 9.184 ± 0.139	2.096ArgMet: 2.096 ± 0.055	1.682ArgAsn: 1.682 ± 0.043	4.718ArgPro: 4.718 ± 0.091	2.561ArgGln: 2.561 ± 0.062	7.045ArgArg: 7.045 ± 0.121	3.679ArgSer: 3.679 ± 0.081	3.97ArgThr: 3.97 ± 0.075	5.475ArgVal: 5.475 ± 0.086	1.324ArgTrp: 1.324 ± 0.043	1.705ArgTyr: 1.705 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.334SerAla: 6.334 ± 0.089	0.332SerCys: 0.332 ± 0.021	2.935SerAsp: 2.935 ± 0.058	2.711SerGlu: 2.711 ± 0.058	1.618SerPhe: 1.618 ± 0.045	5.507SerGly: 5.507 ± 0.1	0.903SerHis: 0.903 ± 0.034	2.167SerIle: 2.167 ± 0.05	1.034SerLys: 1.034 ± 0.04	4.93SerLeu: 4.93 ± 0.078	1.219SerMet: 1.219 ± 0.038	1.11SerAsn: 1.11 ± 0.036	3.06SerPro: 3.06 ± 0.063	1.549SerGln: 1.549 ± 0.039	3.893SerArg: 3.893 ± 0.065	2.555SerSer: 2.555 ± 0.067	2.486SerThr: 2.486 ± 0.052	3.59SerVal: 3.59 ± 0.077	0.771SerTrp: 0.771 ± 0.026	1.072SerTyr: 1.072 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.18ThrAla: 7.18 ± 0.101	0.392ThrCys: 0.392 ± 0.023	3.133ThrAsp: 3.133 ± 0.065	2.679ThrGlu: 2.679 ± 0.062	1.793ThrPhe: 1.793 ± 0.05	5.382ThrGly: 5.382 ± 0.087	0.888ThrHis: 0.888 ± 0.033	2.111ThrIle: 2.111 ± 0.054	0.876ThrLys: 0.876 ± 0.035	5.791ThrLeu: 5.791 ± 0.085	0.927ThrMet: 0.927 ± 0.033	1.123ThrAsn: 1.123 ± 0.036	4.186ThrPro: 4.186 ± 0.082	1.318ThrGln: 1.318 ± 0.041	3.864ThrArg: 3.864 ± 0.077	2.467ThrSer: 2.467 ± 0.063	2.725ThrThr: 2.725 ± 0.06	4.443ThrVal: 4.443 ± 0.075	0.73ThrTrp: 0.73 ± 0.031	1.125ThrTyr: 1.125 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.3ValAla: 9.3 ± 0.13	0.58ValCys: 0.58 ± 0.026	4.363ValAsp: 4.363 ± 0.066	4.963ValGlu: 4.963 ± 0.072	2.808ValPhe: 2.808 ± 0.058	5.759ValGly: 5.759 ± 0.105	1.35ValHis: 1.35 ± 0.041	4.03ValIle: 4.03 ± 0.075	1.809ValLys: 1.809 ± 0.051	7.631ValLeu: 7.631 ± 0.1	1.997ValMet: 1.997 ± 0.052	1.901ValAsn: 1.901 ± 0.048	2.969ValPro: 2.969 ± 0.059	2.404ValGln: 2.404 ± 0.053	5.96ValArg: 5.96 ± 0.095	4.237ValSer: 4.237 ± 0.068	4.563ValThr: 4.563 ± 0.08	6.382ValVal: 6.382 ± 0.119	1.109ValTrp: 1.109 ± 0.04	1.377ValTyr: 1.377 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.644TrpAla: 1.644 ± 0.044	0.146TrpCys: 0.146 ± 0.012	0.712TrpAsp: 0.712 ± 0.031	0.645TrpGlu: 0.645 ± 0.03	0.61TrpPhe: 0.61 ± 0.025	1.107TrpGly: 1.107 ± 0.037	0.266TrpHis: 0.266 ± 0.018	0.734TrpIle: 0.734 ± 0.028	0.394TrpLys: 0.394 ± 0.022	1.682TrpLeu: 1.682 ± 0.047	0.421TrpMet: 0.421 ± 0.022	0.408TrpAsn: 0.408 ± 0.024	0.819TrpPro: 0.819 ± 0.028	0.369TrpGln: 0.369 ± 0.021	1.716TrpArg: 1.716 ± 0.047	1.07TrpSer: 1.07 ± 0.032	1.046TrpThr: 1.046 ± 0.041	0.856TrpVal: 0.856 ± 0.026	0.292TrpTrp: 0.292 ± 0.022	0.248TrpTyr: 0.248 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.525TyrAla: 2.525 ± 0.046	0.171TyrCys: 0.171 ± 0.013	1.445TyrAsp: 1.445 ± 0.047	1.308TyrGlu: 1.308 ± 0.039	0.759TyrPhe: 0.759 ± 0.03	2.181TyrGly: 2.181 ± 0.058	0.384TyrHis: 0.384 ± 0.026	0.666TyrIle: 0.666 ± 0.03	0.37TyrLys: 0.37 ± 0.024	1.99TyrLeu: 1.99 ± 0.048	0.374TyrMet: 0.374 ± 0.023	0.477TyrAsn: 0.477 ± 0.026	0.913TyrPro: 0.913 ± 0.034	0.629TyrGln: 0.629 ± 0.029	1.633TyrArg: 1.633 ± 0.052	0.992TyrSer: 0.992 ± 0.035	0.86TyrThr: 0.86 ± 0.036	1.611TyrVal: 1.611 ± 0.043	0.302TyrTrp: 0.302 ± 0.016	0.428TyrTyr: 0.428 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2946 proteins (854767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---