Amino acid dipepetide frequency for Aspergillus cristatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.538AlaAla: 8.538 ± 0.053	1.005AlaCys: 1.005 ± 0.016	4.055AlaAsp: 4.055 ± 0.029	5.106AlaGlu: 5.106 ± 0.04	3.004AlaPhe: 3.004 ± 0.026	5.547AlaGly: 5.547 ± 0.043	1.781AlaHis: 1.781 ± 0.02	4.138AlaIle: 4.138 ± 0.032	3.94AlaLys: 3.94 ± 0.029	7.437AlaLeu: 7.437 ± 0.05	1.91AlaMet: 1.91 ± 0.022	3.076AlaAsn: 3.076 ± 0.027	4.853AlaPro: 4.853 ± 0.05	3.527AlaGln: 3.527 ± 0.032	4.936AlaArg: 4.936 ± 0.037	6.969AlaSer: 6.969 ± 0.047	5.0AlaThr: 5.0 ± 0.04	5.167AlaVal: 5.167 ± 0.04	1.106AlaTrp: 1.106 ± 0.017	2.139AlaTyr: 2.139 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.878CysAla: 0.878 ± 0.016	0.235CysCys: 0.235 ± 0.01	0.63CysAsp: 0.63 ± 0.013	0.613CysGlu: 0.613 ± 0.012	0.524CysPhe: 0.524 ± 0.01	0.899CysGly: 0.899 ± 0.016	0.335CysHis: 0.335 ± 0.008	0.654CysIle: 0.654 ± 0.011	0.49CysLys: 0.49 ± 0.011	1.253CysLeu: 1.253 ± 0.019	0.272CysMet: 0.272 ± 0.009	0.424CysAsn: 0.424 ± 0.01	0.645CysPro: 0.645 ± 0.013	0.475CysGln: 0.475 ± 0.011	0.769CysArg: 0.769 ± 0.014	0.887CysSer: 0.887 ± 0.013	0.671CysThr: 0.671 ± 0.012	0.758CysVal: 0.758 ± 0.013	0.221CysTrp: 0.221 ± 0.007	0.35CysTyr: 0.35 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.542AspAla: 4.542 ± 0.035	0.616AspCys: 0.616 ± 0.011	4.26AspAsp: 4.26 ± 0.045	4.658AspGlu: 4.658 ± 0.044	2.153AspPhe: 2.153 ± 0.022	3.941AspGly: 3.941 ± 0.032	1.296AspHis: 1.296 ± 0.017	3.156AspIle: 3.156 ± 0.023	2.394AspLys: 2.394 ± 0.021	5.019AspLeu: 5.019 ± 0.036	1.253AspMet: 1.253 ± 0.016	2.09AspAsn: 2.09 ± 0.023	3.402AspPro: 3.402 ± 0.025	2.032AspGln: 2.032 ± 0.018	3.056AspArg: 3.056 ± 0.032	4.156AspSer: 4.156 ± 0.034	3.015AspThr: 3.015 ± 0.03	3.657AspVal: 3.657 ± 0.028	0.873AspTrp: 0.873 ± 0.014	1.684AspTyr: 1.684 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.345GluAla: 5.345 ± 0.035	0.64GluCys: 0.64 ± 0.012	4.383GluAsp: 4.383 ± 0.043	6.014GluGlu: 6.014 ± 0.072	2.02GluPhe: 2.02 ± 0.022	3.922GluGly: 3.922 ± 0.031	1.469GluHis: 1.469 ± 0.018	3.097GluIle: 3.097 ± 0.028	3.902GluLys: 3.902 ± 0.036	5.216GluLeu: 5.216 ± 0.037	1.505GluMet: 1.505 ± 0.02	2.532GluAsn: 2.532 ± 0.021	3.032GluPro: 3.032 ± 0.065	2.894GluGln: 2.894 ± 0.034	4.141GluArg: 4.141 ± 0.036	4.535GluSer: 4.535 ± 0.035	3.599GluThr: 3.599 ± 0.027	3.586GluVal: 3.586 ± 0.028	0.932GluTrp: 0.932 ± 0.013	1.77GluTyr: 1.77 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.926PheAla: 2.926 ± 0.026	0.551PheCys: 0.551 ± 0.01	2.326PheAsp: 2.326 ± 0.024	2.114PheGlu: 2.114 ± 0.021	1.555PhePhe: 1.555 ± 0.021	2.728PheGly: 2.728 ± 0.031	0.933PheHis: 0.933 ± 0.015	1.781PheIle: 1.781 ± 0.023	1.458PheLys: 1.458 ± 0.019	3.511PheLeu: 3.511 ± 0.032	0.792PheMet: 0.792 ± 0.012	1.469PheAsn: 1.469 ± 0.017	2.009PhePro: 2.009 ± 0.02	1.442PheGln: 1.442 ± 0.018	1.993PheArg: 1.993 ± 0.021	2.956PheSer: 2.956 ± 0.025	2.065PheThr: 2.065 ± 0.022	2.291PheVal: 2.291 ± 0.027	0.609PheTrp: 0.609 ± 0.011	1.109PheTyr: 1.109 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.129GlyAla: 5.129 ± 0.046	0.846GlyCys: 0.846 ± 0.015	3.606GlyAsp: 3.606 ± 0.032	3.715GlyGlu: 3.715 ± 0.032	2.748GlyPhe: 2.748 ± 0.028	5.375GlyGly: 5.375 ± 0.049	1.764GlyHis: 1.764 ± 0.022	3.525GlyIle: 3.525 ± 0.031	3.473GlyLys: 3.473 ± 0.03	6.035GlyLeu: 6.035 ± 0.042	1.571GlyMet: 1.571 ± 0.022	2.601GlyAsn: 2.601 ± 0.024	3.293GlyPro: 3.293 ± 0.033	2.68GlyGln: 2.68 ± 0.028	4.041GlyArg: 4.041 ± 0.033	5.589GlySer: 5.589 ± 0.038	3.773GlyThr: 3.773 ± 0.033	4.324GlyVal: 4.324 ± 0.035	1.144GlyTrp: 1.144 ± 0.019	2.142GlyTyr: 2.142 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.887HisAla: 1.887 ± 0.02	0.33HisCys: 0.33 ± 0.009	1.362HisAsp: 1.362 ± 0.019	1.397HisGlu: 1.397 ± 0.019	0.912HisPhe: 0.912 ± 0.015	1.729HisGly: 1.729 ± 0.021	0.897HisHis: 0.897 ± 0.017	1.227HisIle: 1.227 ± 0.018	0.896HisLys: 0.896 ± 0.013	2.296HisLeu: 2.296 ± 0.022	0.504HisMet: 0.504 ± 0.011	0.886HisAsn: 0.886 ± 0.013	1.798HisPro: 1.798 ± 0.024	1.025HisGln: 1.025 ± 0.014	1.576HisArg: 1.576 ± 0.022	1.815HisSer: 1.815 ± 0.022	1.298HisThr: 1.298 ± 0.018	1.428HisVal: 1.428 ± 0.02	0.353HisTrp: 0.353 ± 0.009	0.72HisTyr: 0.72 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.997IleAla: 3.997 ± 0.033	0.762IleCys: 0.762 ± 0.013	2.828IleAsp: 2.828 ± 0.025	2.954IleGlu: 2.954 ± 0.03	1.961IlePhe: 1.961 ± 0.027	3.039IleGly: 3.039 ± 0.03	1.243IleHis: 1.243 ± 0.018	2.368IleIle: 2.368 ± 0.025	2.146IleLys: 2.146 ± 0.025	4.59IleLeu: 4.59 ± 0.034	0.955IleMet: 0.955 ± 0.015	1.837IleAsn: 1.837 ± 0.02	3.146IlePro: 3.146 ± 0.022	2.036IleGln: 2.036 ± 0.025	2.835IleArg: 2.835 ± 0.025	3.733IleSer: 3.733 ± 0.027	2.739IleThr: 2.739 ± 0.027	2.991IleVal: 2.991 ± 0.028	0.715IleTrp: 0.715 ± 0.012	1.451IleTyr: 1.451 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.062LysAla: 4.062 ± 0.033	0.493LysCys: 0.493 ± 0.01	2.812LysAsp: 2.812 ± 0.027	3.569LysGlu: 3.569 ± 0.036	1.358LysPhe: 1.358 ± 0.018	3.0LysGly: 3.0 ± 0.026	1.134LysHis: 1.134 ± 0.016	2.206LysIle: 2.206 ± 0.023	3.476LysLys: 3.476 ± 0.075	3.966LysLeu: 3.966 ± 0.036	0.988LysMet: 0.988 ± 0.014	1.827LysAsn: 1.827 ± 0.021	2.87LysPro: 2.87 ± 0.034	2.059LysGln: 2.059 ± 0.02	3.48LysArg: 3.48 ± 0.03	3.418LysSer: 3.418 ± 0.036	2.805LysThr: 2.805 ± 0.025	2.724LysVal: 2.724 ± 0.021	0.667LysTrp: 0.667 ± 0.012	1.37LysTyr: 1.37 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.392LeuAla: 7.392 ± 0.044	1.173LeuCys: 1.173 ± 0.017	5.215LeuAsp: 5.215 ± 0.04	5.713LeuGlu: 5.713 ± 0.046	3.321LeuPhe: 3.321 ± 0.034	5.801LeuGly: 5.801 ± 0.038	2.232LeuHis: 2.232 ± 0.025	3.831LeuIle: 3.831 ± 0.036	4.099LeuLys: 4.099 ± 0.031	8.325LeuLeu: 8.325 ± 0.061	1.78LeuMet: 1.78 ± 0.019	3.254LeuAsn: 3.254 ± 0.032	5.417LeuPro: 5.417 ± 0.034	3.991LeuGln: 3.991 ± 0.039	5.849LeuArg: 5.849 ± 0.04	7.374LeuSer: 7.374 ± 0.04	4.653LeuThr: 4.653 ± 0.034	5.332LeuVal: 5.332 ± 0.036	1.161LeuTrp: 1.161 ± 0.017	2.387LeuTyr: 2.387 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.162MetAla: 2.162 ± 0.023	0.225MetCys: 0.225 ± 0.007	1.322MetAsp: 1.322 ± 0.019	1.379MetGlu: 1.379 ± 0.016	0.724MetPhe: 0.724 ± 0.011	1.509MetGly: 1.509 ± 0.02	0.461MetHis: 0.461 ± 0.01	0.969MetIle: 0.969 ± 0.017	1.009MetLys: 1.009 ± 0.017	1.815MetLeu: 1.815 ± 0.022	0.543MetMet: 0.543 ± 0.01	0.851MetAsn: 0.851 ± 0.014	1.261MetPro: 1.261 ± 0.017	0.907MetGln: 0.907 ± 0.014	1.255MetArg: 1.255 ± 0.014	1.82MetSer: 1.82 ± 0.02	1.255MetThr: 1.255 ± 0.017	1.322MetVal: 1.322 ± 0.02	0.237MetTrp: 0.237 ± 0.008	0.505MetTyr: 0.505 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.276AsnAla: 3.276 ± 0.026	0.485AsnCys: 0.485 ± 0.01	2.083AsnAsp: 2.083 ± 0.021	2.284AsnGlu: 2.284 ± 0.02	1.364AsnPhe: 1.364 ± 0.019	3.061AsnGly: 3.061 ± 0.029	0.927AsnHis: 0.927 ± 0.014	2.028AsnIle: 2.028 ± 0.019	1.619AsnLys: 1.619 ± 0.02	3.255AsnLeu: 3.255 ± 0.026	0.848AsnMet: 0.848 ± 0.013	1.673AsnAsn: 1.673 ± 0.023	2.598AsnPro: 2.598 ± 0.028	1.525AsnGln: 1.525 ± 0.022	2.181AsnArg: 2.181 ± 0.019	2.701AsnSer: 2.701 ± 0.029	2.331AsnThr: 2.331 ± 0.023	2.362AsnVal: 2.362 ± 0.021	0.59AsnTrp: 0.59 ± 0.012	1.079AsnTyr: 1.079 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.32ProAla: 5.32 ± 0.053	0.516ProCys: 0.516 ± 0.013	3.309ProAsp: 3.309 ± 0.034	4.311ProGlu: 4.311 ± 0.061	2.112ProPhe: 2.112 ± 0.024	4.044ProGly: 4.044 ± 0.037	1.304ProHis: 1.304 ± 0.017	2.528ProIle: 2.528 ± 0.026	2.702ProLys: 2.702 ± 0.032	4.672ProLeu: 4.672 ± 0.036	1.105ProMet: 1.105 ± 0.015	2.272ProAsn: 2.272 ± 0.023	5.256ProPro: 5.256 ± 0.081	2.722ProGln: 2.722 ± 0.032	3.534ProArg: 3.534 ± 0.036	6.232ProSer: 6.232 ± 0.053	3.964ProThr: 3.964 ± 0.032	3.752ProVal: 3.752 ± 0.036	0.728ProTrp: 0.728 ± 0.013	1.539ProTyr: 1.539 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.582GlnAla: 3.582 ± 0.031	0.459GlnCys: 0.459 ± 0.011	2.211GlnAsp: 2.211 ± 0.023	2.781GlnGlu: 2.781 ± 0.028	1.347GlnPhe: 1.347 ± 0.017	2.591GlnGly: 2.591 ± 0.026	1.143GlnHis: 1.143 ± 0.016	1.914GlnIle: 1.914 ± 0.022	2.196GlnLys: 2.196 ± 0.024	3.571GlnLeu: 3.571 ± 0.03	0.912GlnMet: 0.912 ± 0.014	1.721GlnAsn: 1.721 ± 0.022	2.862GlnPro: 2.862 ± 0.04	2.828GlnGln: 2.828 ± 0.05	2.862GlnArg: 2.862 ± 0.028	3.396GlnSer: 3.396 ± 0.029	2.45GlnThr: 2.45 ± 0.022	2.255GlnVal: 2.255 ± 0.024	0.576GlnTrp: 0.576 ± 0.012	1.223GlnTyr: 1.223 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.702ArgAla: 4.702 ± 0.035	0.723ArgCys: 0.723 ± 0.012	3.419ArgAsp: 3.419 ± 0.032	4.137ArgGlu: 4.137 ± 0.04	2.213ArgPhe: 2.213 ± 0.021	3.749ArgGly: 3.749 ± 0.031	1.592ArgHis: 1.592 ± 0.02	2.921ArgIle: 2.921 ± 0.027	3.499ArgLys: 3.499 ± 0.032	5.563ArgLeu: 5.563 ± 0.043	1.377ArgMet: 1.377 ± 0.019	2.35ArgAsn: 2.35 ± 0.024	3.627ArgPro: 3.627 ± 0.039	2.782ArgGln: 2.782 ± 0.029	5.18ArgArg: 5.18 ± 0.046	4.741ArgSer: 4.741 ± 0.042	3.368ArgThr: 3.368 ± 0.03	3.479ArgVal: 3.479 ± 0.027	0.936ArgTrp: 0.936 ± 0.013	1.705ArgTyr: 1.705 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.378SerAla: 6.378 ± 0.036	0.829SerCys: 0.829 ± 0.013	4.246SerAsp: 4.246 ± 0.037	4.253SerGlu: 4.253 ± 0.032	3.017SerPhe: 3.017 ± 0.026	5.432SerGly: 5.432 ± 0.033	1.978SerHis: 1.978 ± 0.022	3.863SerIle: 3.863 ± 0.032	3.672SerLys: 3.672 ± 0.028	7.203SerLeu: 7.203 ± 0.047	1.753SerMet: 1.753 ± 0.023	3.104SerAsn: 3.104 ± 0.029	5.575SerPro: 5.575 ± 0.048	3.512SerGln: 3.512 ± 0.032	5.078SerArg: 5.078 ± 0.046	8.805SerSer: 8.805 ± 0.086	5.524SerThr: 5.524 ± 0.047	4.533SerVal: 4.533 ± 0.031	1.077SerTrp: 1.077 ± 0.014	2.06SerTyr: 2.06 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.061ThrAla: 5.061 ± 0.036	0.728ThrCys: 0.728 ± 0.014	2.88ThrAsp: 2.88 ± 0.027	3.244ThrGlu: 3.244 ± 0.028	2.117ThrPhe: 2.117 ± 0.021	4.179ThrGly: 4.179 ± 0.036	1.246ThrHis: 1.246 ± 0.015	2.994ThrIle: 2.994 ± 0.026	2.546ThrLys: 2.546 ± 0.025	5.101ThrLeu: 5.101 ± 0.037	1.159ThrMet: 1.159 ± 0.016	2.161ThrAsn: 2.161 ± 0.024	4.536ThrPro: 4.536 ± 0.043	2.186ThrGln: 2.186 ± 0.023	3.162ThrArg: 3.162 ± 0.027	5.119ThrSer: 5.119 ± 0.043	4.376ThrThr: 4.376 ± 0.051	3.684ThrVal: 3.684 ± 0.032	0.789ThrTrp: 0.789 ± 0.014	1.529ThrTyr: 1.529 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.83ValAla: 4.83 ± 0.034	0.789ValCys: 0.789 ± 0.015	3.751ValAsp: 3.751 ± 0.028	3.835ValGlu: 3.835 ± 0.03	2.464ValPhe: 2.464 ± 0.025	3.846ValGly: 3.846 ± 0.038	1.454ValHis: 1.454 ± 0.016	2.938ValIle: 2.938 ± 0.029	2.867ValLys: 2.867 ± 0.021	5.502ValLeu: 5.502 ± 0.037	1.307ValMet: 1.307 ± 0.016	2.363ValAsn: 2.363 ± 0.023	3.623ValPro: 3.623 ± 0.028	2.497ValGln: 2.497 ± 0.024	3.473ValArg: 3.473 ± 0.027	4.64ValSer: 4.64 ± 0.034	3.42ValThr: 3.42 ± 0.029	4.132ValVal: 4.132 ± 0.041	0.815ValTrp: 0.815 ± 0.015	1.733ValTyr: 1.733 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.066TrpAla: 1.066 ± 0.014	0.172TrpCys: 0.172 ± 0.006	0.876TrpAsp: 0.876 ± 0.014	0.863TrpGlu: 0.863 ± 0.013	0.524TrpPhe: 0.524 ± 0.01	0.916TrpGly: 0.916 ± 0.016	0.36TrpHis: 0.36 ± 0.01	0.756TrpIle: 0.756 ± 0.014	0.828TrpLys: 0.828 ± 0.013	1.303TrpLeu: 1.303 ± 0.017	0.375TrpMet: 0.375 ± 0.008	0.622TrpAsn: 0.622 ± 0.011	0.574TrpPro: 0.574 ± 0.011	0.59TrpGln: 0.59 ± 0.011	0.958TrpArg: 0.958 ± 0.017	0.994TrpSer: 0.994 ± 0.015	0.866TrpThr: 0.866 ± 0.016	0.899TrpVal: 0.899 ± 0.015	0.275TrpTrp: 0.275 ± 0.007	0.425TrpTyr: 0.425 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.163TyrAla: 2.163 ± 0.026	0.403TyrCys: 0.403 ± 0.01	1.678TyrAsp: 1.678 ± 0.022	1.592TyrGlu: 1.592 ± 0.02	1.181TyrPhe: 1.181 ± 0.017	2.067TyrGly: 2.067 ± 0.022	0.788TyrHis: 0.788 ± 0.012	1.432TyrIle: 1.432 ± 0.019	1.074TyrLys: 1.074 ± 0.016	2.671TyrLeu: 2.671 ± 0.025	0.62TyrMet: 0.62 ± 0.011	1.155TyrAsn: 1.155 ± 0.015	1.546TyrPro: 1.546 ± 0.022	1.168TyrGln: 1.168 ± 0.015	1.702TyrArg: 1.702 ± 0.016	2.011TyrSer: 2.011 ± 0.023	1.626TyrThr: 1.626 ± 0.018	1.599TyrVal: 1.599 ± 0.02	0.443TyrTrp: 0.443 ± 0.01	0.975TyrTyr: 0.975 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10115 proteins (4808824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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