Amino acid dipepetide frequency for Microvirga guangxiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.687AlaAla: 14.687 ± 0.174	0.979AlaCys: 0.979 ± 0.029	5.95AlaAsp: 5.95 ± 0.069	7.173AlaGlu: 7.173 ± 0.091	4.551AlaPhe: 4.551 ± 0.065	9.482AlaGly: 9.482 ± 0.088	2.149AlaHis: 2.149 ± 0.043	6.388AlaIle: 6.388 ± 0.073	4.324AlaLys: 4.324 ± 0.066	12.917AlaLeu: 12.917 ± 0.138	3.341AlaMet: 3.341 ± 0.054	2.788AlaAsn: 2.788 ± 0.044	5.176AlaPro: 5.176 ± 0.065	4.128AlaGln: 4.128 ± 0.064	7.662AlaArg: 7.662 ± 0.092	6.748AlaSer: 6.748 ± 0.083	5.603AlaThr: 5.603 ± 0.067	8.392AlaVal: 8.392 ± 0.079	1.395AlaTrp: 1.395 ± 0.036	2.709AlaTyr: 2.709 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.837CysAla: 0.837 ± 0.028	0.108CysCys: 0.108 ± 0.01	0.427CysAsp: 0.427 ± 0.019	0.41CysGlu: 0.41 ± 0.016	0.293CysPhe: 0.293 ± 0.015	0.814CysGly: 0.814 ± 0.023	0.246CysHis: 0.246 ± 0.016	0.418CysIle: 0.418 ± 0.017	0.166CysLys: 0.166 ± 0.01	0.79CysLeu: 0.79 ± 0.024	0.142CysMet: 0.142 ± 0.01	0.204CysAsn: 0.204 ± 0.013	0.435CysPro: 0.435 ± 0.02	0.197CysGln: 0.197 ± 0.012	0.603CysArg: 0.603 ± 0.021	0.503CysSer: 0.503 ± 0.022	0.414CysThr: 0.414 ± 0.019	0.542CysVal: 0.542 ± 0.023	0.096CysTrp: 0.096 ± 0.008	0.166CysTyr: 0.166 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.069AspAla: 6.069 ± 0.077	0.396AspCys: 0.396 ± 0.017	2.787AspAsp: 2.787 ± 0.055	3.644AspGlu: 3.644 ± 0.055	1.978AspPhe: 1.978 ± 0.041	4.679AspGly: 4.679 ± 0.084	1.181AspHis: 1.181 ± 0.033	2.944AspIle: 2.944 ± 0.054	1.798AspLys: 1.798 ± 0.043	6.056AspLeu: 6.056 ± 0.077	1.267AspMet: 1.267 ± 0.034	1.256AspAsn: 1.256 ± 0.033	3.315AspPro: 3.315 ± 0.053	1.747AspGln: 1.747 ± 0.039	4.054AspArg: 4.054 ± 0.056	2.032AspSer: 2.032 ± 0.036	2.565AspThr: 2.565 ± 0.05	4.171AspVal: 4.171 ± 0.063	0.82AspTrp: 0.82 ± 0.026	1.324AspTyr: 1.324 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.962GluAla: 7.962 ± 0.096	0.363GluCys: 0.363 ± 0.017	2.809GluAsp: 2.809 ± 0.052	3.717GluGlu: 3.717 ± 0.067	1.802GluPhe: 1.802 ± 0.035	4.69GluGly: 4.69 ± 0.066	1.235GluHis: 1.235 ± 0.03	3.616GluIle: 3.616 ± 0.058	2.515GluLys: 2.515 ± 0.06	5.35GluLeu: 5.35 ± 0.062	1.521GluMet: 1.521 ± 0.035	1.733GluAsn: 1.733 ± 0.039	2.895GluPro: 2.895 ± 0.053	2.189GluGln: 2.189 ± 0.043	5.518GluArg: 5.518 ± 0.077	2.551GluSer: 2.551 ± 0.041	3.587GluThr: 3.587 ± 0.052	3.971GluVal: 3.971 ± 0.067	0.735GluTrp: 0.735 ± 0.022	1.019GluTyr: 1.019 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.12PheAla: 4.12 ± 0.063	0.361PheCys: 0.361 ± 0.016	2.381PheAsp: 2.381 ± 0.049	2.233PheGlu: 2.233 ± 0.042	1.486PhePhe: 1.486 ± 0.044	3.665PheGly: 3.665 ± 0.058	0.707PheHis: 0.707 ± 0.023	1.912PheIle: 1.912 ± 0.042	1.202PheLys: 1.202 ± 0.032	3.542PheLeu: 3.542 ± 0.061	0.894PheMet: 0.894 ± 0.024	1.087PheAsn: 1.087 ± 0.028	1.585PhePro: 1.585 ± 0.035	1.116PheGln: 1.116 ± 0.03	2.253PheArg: 2.253 ± 0.037	2.389PheSer: 2.389 ± 0.04	1.982PheThr: 1.982 ± 0.041	2.867PheVal: 2.867 ± 0.047	0.56PheTrp: 0.56 ± 0.021	0.895PheTyr: 0.895 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.59GlyAla: 8.59 ± 0.087	0.778GlyCys: 0.778 ± 0.028	4.118GlyAsp: 4.118 ± 0.073	4.708GlyGlu: 4.708 ± 0.063	3.687GlyPhe: 3.687 ± 0.06	7.143GlyGly: 7.143 ± 0.117	1.862GlyHis: 1.862 ± 0.04	4.822GlyIle: 4.822 ± 0.057	3.181GlyLys: 3.181 ± 0.057	8.975GlyLeu: 8.975 ± 0.096	2.215GlyMet: 2.215 ± 0.046	2.388GlyAsn: 2.388 ± 0.073	3.349GlyPro: 3.349 ± 0.05	2.98GlyGln: 2.98 ± 0.056	6.004GlyArg: 6.004 ± 0.067	5.148GlySer: 5.148 ± 0.075	4.644GlyThr: 4.644 ± 0.069	5.894GlyVal: 5.894 ± 0.074	1.298GlyTrp: 1.298 ± 0.033	2.273GlyTyr: 2.273 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.222HisAla: 2.222 ± 0.047	0.212HisCys: 0.212 ± 0.014	1.177HisAsp: 1.177 ± 0.031	1.186HisGlu: 1.186 ± 0.024	0.769HisPhe: 0.769 ± 0.025	1.861HisGly: 1.861 ± 0.04	0.584HisHis: 0.584 ± 0.024	0.932HisIle: 0.932 ± 0.03	0.557HisLys: 0.557 ± 0.02	2.086HisLeu: 2.086 ± 0.038	0.49HisMet: 0.49 ± 0.022	0.497HisAsn: 0.497 ± 0.018	1.381HisPro: 1.381 ± 0.036	0.591HisGln: 0.591 ± 0.02	1.479HisArg: 1.479 ± 0.034	0.984HisSer: 0.984 ± 0.029	0.838HisThr: 0.838 ± 0.027	1.527HisVal: 1.527 ± 0.035	0.298HisTrp: 0.298 ± 0.016	0.508HisTyr: 0.508 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.262IleAla: 7.262 ± 0.089	0.485IleCys: 0.485 ± 0.021	3.474IleAsp: 3.474 ± 0.056	3.796IleGlu: 3.796 ± 0.057	1.7IlePhe: 1.7 ± 0.04	5.242IleGly: 5.242 ± 0.081	0.989IleHis: 0.989 ± 0.026	2.544IleIle: 2.544 ± 0.049	1.659IleLys: 1.659 ± 0.038	5.188IleLeu: 5.188 ± 0.071	1.172IleMet: 1.172 ± 0.032	1.409IleAsn: 1.409 ± 0.036	2.572IlePro: 2.572 ± 0.046	1.452IleGln: 1.452 ± 0.032	3.479IleArg: 3.479 ± 0.05	2.953IleSer: 2.953 ± 0.053	2.801IleThr: 2.801 ± 0.047	4.777IleVal: 4.777 ± 0.072	0.615IleTrp: 0.615 ± 0.023	1.167IleTyr: 1.167 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.684LysAla: 4.684 ± 0.072	0.163LysCys: 0.163 ± 0.011	2.03LysAsp: 2.03 ± 0.042	1.924LysGlu: 1.924 ± 0.043	0.854LysPhe: 0.854 ± 0.023	3.045LysGly: 3.045 ± 0.059	0.652LysHis: 0.652 ± 0.022	1.837LysIle: 1.837 ± 0.043	1.418LysLys: 1.418 ± 0.044	3.436LysLeu: 3.436 ± 0.059	0.727LysMet: 0.727 ± 0.027	1.029LysAsn: 1.029 ± 0.032	2.403LysPro: 2.403 ± 0.044	1.08LysGln: 1.08 ± 0.031	2.614LysArg: 2.614 ± 0.05	1.952LysSer: 1.952 ± 0.042	2.07LysThr: 2.07 ± 0.043	2.7LysVal: 2.7 ± 0.051	0.336LysTrp: 0.336 ± 0.016	0.564LysTyr: 0.564 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.609LeuAla: 12.609 ± 0.136	0.839LeuCys: 0.839 ± 0.023	5.796LeuAsp: 5.796 ± 0.07	5.504LeuGlu: 5.504 ± 0.071	3.691LeuPhe: 3.691 ± 0.053	8.2LeuGly: 8.2 ± 0.087	1.897LeuHis: 1.897 ± 0.042	5.496LeuIle: 5.496 ± 0.075	4.181LeuLys: 4.181 ± 0.061	9.58LeuLeu: 9.58 ± 0.112	2.478LeuMet: 2.478 ± 0.051	2.814LeuAsn: 2.814 ± 0.051	5.53LeuPro: 5.53 ± 0.065	3.057LeuGln: 3.057 ± 0.047	6.694LeuArg: 6.694 ± 0.085	7.1LeuSer: 7.1 ± 0.086	5.693LeuThr: 5.693 ± 0.067	7.749LeuVal: 7.749 ± 0.074	1.169LeuTrp: 1.169 ± 0.039	2.113LeuTyr: 2.113 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.038MetAla: 3.038 ± 0.049	0.134MetCys: 0.134 ± 0.01	1.092MetAsp: 1.092 ± 0.028	1.179MetGlu: 1.179 ± 0.032	0.69MetPhe: 0.69 ± 0.021	1.866MetGly: 1.866 ± 0.038	0.441MetHis: 0.441 ± 0.017	1.419MetIle: 1.419 ± 0.033	1.09MetLys: 1.09 ± 0.029	2.398MetLeu: 2.398 ± 0.047	0.707MetMet: 0.707 ± 0.028	0.844MetAsn: 0.844 ± 0.025	1.47MetPro: 1.47 ± 0.033	0.845MetGln: 0.845 ± 0.028	1.913MetArg: 1.913 ± 0.04	1.71MetSer: 1.71 ± 0.033	1.855MetThr: 1.855 ± 0.038	1.637MetVal: 1.637 ± 0.038	0.207MetTrp: 0.207 ± 0.013	0.303MetTyr: 0.303 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.168AsnAla: 3.168 ± 0.053	0.204AsnCys: 0.204 ± 0.012	1.645AsnAsp: 1.645 ± 0.059	1.49AsnGlu: 1.49 ± 0.035	0.948AsnPhe: 0.948 ± 0.025	2.562AsnGly: 2.562 ± 0.061	0.487AsnHis: 0.487 ± 0.02	1.416AsnIle: 1.416 ± 0.03	0.819AsnLys: 0.819 ± 0.032	2.8AsnLeu: 2.8 ± 0.054	0.587AsnMet: 0.587 ± 0.022	0.751AsnAsn: 0.751 ± 0.027	1.967AsnPro: 1.967 ± 0.042	0.799AsnGln: 0.799 ± 0.027	1.903AsnArg: 1.903 ± 0.037	1.272AsnSer: 1.272 ± 0.034	1.364AsnThr: 1.364 ± 0.034	2.111AsnVal: 2.111 ± 0.045	0.383AsnTrp: 0.383 ± 0.016	0.646AsnTyr: 0.646 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.629ProAla: 5.629 ± 0.078	0.302ProCys: 0.302 ± 0.016	3.4ProAsp: 3.4 ± 0.046	3.771ProGlu: 3.771 ± 0.063	1.985ProPhe: 1.985 ± 0.04	4.308ProGly: 4.308 ± 0.06	1.185ProHis: 1.185 ± 0.033	2.546ProIle: 2.546 ± 0.048	1.916ProLys: 1.916 ± 0.039	4.757ProLeu: 4.757 ± 0.068	1.198ProMet: 1.198 ± 0.028	1.521ProAsn: 1.521 ± 0.036	2.484ProPro: 2.484 ± 0.057	1.833ProGln: 1.833 ± 0.042	2.923ProArg: 2.923 ± 0.051	3.271ProSer: 3.271 ± 0.053	2.459ProThr: 2.459 ± 0.046	4.22ProVal: 4.22 ± 0.053	0.715ProTrp: 0.715 ± 0.023	1.197ProTyr: 1.197 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.358GlnAla: 4.358 ± 0.066	0.184GlnCys: 0.184 ± 0.012	1.697GlnAsp: 1.697 ± 0.036	1.921GlnGlu: 1.921 ± 0.035	0.992GlnPhe: 0.992 ± 0.025	2.651GlnGly: 2.651 ± 0.054	0.648GlnHis: 0.648 ± 0.023	1.863GlnIle: 1.863 ± 0.046	1.141GlnLys: 1.141 ± 0.028	2.722GlnLeu: 2.722 ± 0.045	0.864GlnMet: 0.864 ± 0.026	0.975GlnAsn: 0.975 ± 0.029	1.797GlnPro: 1.797 ± 0.04	1.332GlnGln: 1.332 ± 0.04	2.498GlnArg: 2.498 ± 0.052	1.902GlnSer: 1.902 ± 0.032	1.729GlnThr: 1.729 ± 0.043	2.44GlnVal: 2.44 ± 0.047	0.384GlnTrp: 0.384 ± 0.018	0.589GlnTyr: 0.589 ± 0.02	0.001GlnXaa: 0.001 ± 0.001
Arg	7.025ArgAla: 7.025 ± 0.086	0.477ArgCys: 0.477 ± 0.02	3.732ArgAsp: 3.732 ± 0.045	4.482ArgGlu: 4.482 ± 0.067	3.004ArgPhe: 3.004 ± 0.044	4.652ArgGly: 4.652 ± 0.067	1.578ArgHis: 1.578 ± 0.038	4.322ArgIle: 4.322 ± 0.06	2.4ArgLys: 2.4 ± 0.042	7.851ArgLeu: 7.851 ± 0.095	1.965ArgMet: 1.965 ± 0.037	2.002ArgAsn: 2.002 ± 0.042	3.419ArgPro: 3.419 ± 0.071	2.546ArgGln: 2.546 ± 0.045	5.593ArgArg: 5.593 ± 0.083	4.153ArgSer: 4.153 ± 0.066	3.504ArgThr: 3.504 ± 0.057	4.881ArgVal: 4.881 ± 0.073	0.993ArgTrp: 0.993 ± 0.028	1.72ArgTyr: 1.72 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.176SerAla: 6.176 ± 0.077	0.483SerCys: 0.483 ± 0.017	2.998SerAsp: 2.998 ± 0.05	3.204SerGlu: 3.204 ± 0.053	2.469SerPhe: 2.469 ± 0.047	5.606SerGly: 5.606 ± 0.08	1.131SerHis: 1.131 ± 0.029	3.157SerIle: 3.157 ± 0.048	1.788SerLys: 1.788 ± 0.038	6.207SerLeu: 6.207 ± 0.078	1.421SerMet: 1.421 ± 0.032	1.54SerAsn: 1.54 ± 0.032	3.019SerPro: 3.019 ± 0.046	1.792SerGln: 1.792 ± 0.043	3.92SerArg: 3.92 ± 0.062	3.637SerSer: 3.637 ± 0.059	2.962SerThr: 2.962 ± 0.052	4.158SerVal: 4.158 ± 0.058	0.788SerTrp: 0.788 ± 0.022	1.426SerTyr: 1.426 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.766ThrAla: 5.766 ± 0.065	0.409ThrCys: 0.409 ± 0.019	2.669ThrAsp: 2.669 ± 0.045	2.732ThrGlu: 2.732 ± 0.043	2.17ThrPhe: 2.17 ± 0.041	4.983ThrGly: 4.983 ± 0.073	1.028ThrHis: 1.028 ± 0.031	3.252ThrIle: 3.252 ± 0.056	1.745ThrLys: 1.745 ± 0.042	5.957ThrLeu: 5.957 ± 0.057	1.225ThrMet: 1.225 ± 0.032	1.39ThrAsn: 1.39 ± 0.032	3.152ThrPro: 3.152 ± 0.049	1.521ThrGln: 1.521 ± 0.035	3.273ThrArg: 3.273 ± 0.057	3.003ThrSer: 3.003 ± 0.049	2.79ThrThr: 2.79 ± 0.058	4.181ThrVal: 4.181 ± 0.061	0.704ThrTrp: 0.704 ± 0.022	1.295ThrTyr: 1.295 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.699ValAla: 8.699 ± 0.087	0.608ValCys: 0.608 ± 0.025	3.909ValAsp: 3.909 ± 0.052	4.796ValGlu: 4.796 ± 0.06	2.812ValPhe: 2.812 ± 0.046	5.553ValGly: 5.553 ± 0.067	1.389ValHis: 1.389 ± 0.036	4.174ValIle: 4.174 ± 0.067	2.53ValLys: 2.53 ± 0.058	7.696ValLeu: 7.696 ± 0.097	1.853ValMet: 1.853 ± 0.036	1.999ValAsn: 1.999 ± 0.038	3.803ValPro: 3.803 ± 0.054	2.273ValGln: 2.273 ± 0.046	5.055ValArg: 5.055 ± 0.071	4.585ValSer: 4.585 ± 0.062	4.463ValThr: 4.463 ± 0.063	5.959ValVal: 5.959 ± 0.083	0.883ValTrp: 0.883 ± 0.024	1.547ValTyr: 1.547 ± 0.035	0.001ValXaa: 0.001 ± 0.001
Trp	1.152TrpAla: 1.152 ± 0.03	0.119TrpCys: 0.119 ± 0.01	0.611TrpAsp: 0.611 ± 0.02	0.578TrpGlu: 0.578 ± 0.019	0.498TrpPhe: 0.498 ± 0.022	0.914TrpGly: 0.914 ± 0.029	0.325TrpHis: 0.325 ± 0.016	0.725TrpIle: 0.725 ± 0.022	0.448TrpLys: 0.448 ± 0.02	1.605TrpLeu: 1.605 ± 0.035	0.348TrpMet: 0.348 ± 0.017	0.439TrpAsn: 0.439 ± 0.019	0.693TrpPro: 0.693 ± 0.021	0.515TrpGln: 0.515 ± 0.019	1.065TrpArg: 1.065 ± 0.031	0.842TrpSer: 0.842 ± 0.024	0.782TrpThr: 0.782 ± 0.026	0.798TrpVal: 0.798 ± 0.027	0.242TrpTrp: 0.242 ± 0.014	0.277TrpTyr: 0.277 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.49TyrAla: 2.49 ± 0.04	0.21TyrCys: 0.21 ± 0.013	1.379TyrAsp: 1.379 ± 0.035	1.326TyrGlu: 1.326 ± 0.032	0.86TyrPhe: 0.86 ± 0.027	2.141TyrGly: 2.141 ± 0.05	0.465TyrHis: 0.465 ± 0.02	0.953TyrIle: 0.953 ± 0.028	0.641TyrLys: 0.641 ± 0.021	2.276TyrLeu: 2.276 ± 0.046	0.425TyrMet: 0.425 ± 0.018	0.655TyrAsn: 0.655 ± 0.022	1.175TyrPro: 1.175 ± 0.033	0.694TyrGln: 0.694 ± 0.022	1.796TyrArg: 1.796 ± 0.038	1.148TyrSer: 1.148 ± 0.029	1.14TyrThr: 1.14 ± 0.03	1.612TyrVal: 1.612 ± 0.039	0.354TyrTrp: 0.354 ± 0.016	0.669TyrTyr: 0.669 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 4496 proteins (1369810 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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