Amino acid dipepetide frequency for Plasticicumulans acidivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.698AlaAla: 20.698 ± 0.259	1.67AlaCys: 1.67 ± 0.041	7.36AlaAsp: 7.36 ± 0.094	8.187AlaGlu: 8.187 ± 0.102	3.863AlaPhe: 3.863 ± 0.055	11.49AlaGly: 11.49 ± 0.114	2.726AlaHis: 2.726 ± 0.05	5.377AlaIle: 5.377 ± 0.068	2.607AlaLys: 2.607 ± 0.064	17.131AlaLeu: 17.131 ± 0.185	2.734AlaMet: 2.734 ± 0.051	2.466AlaAsn: 2.466 ± 0.05	5.942AlaPro: 5.942 ± 0.096	5.337AlaGln: 5.337 ± 0.068	10.473AlaArg: 10.473 ± 0.129	6.359AlaSer: 6.359 ± 0.073	5.706AlaThr: 5.706 ± 0.077	9.079AlaVal: 9.079 ± 0.084	1.837AlaTrp: 1.837 ± 0.04	2.501AlaTyr: 2.501 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.565CysAla: 1.565 ± 0.039	0.204CysCys: 0.204 ± 0.013	0.581CysAsp: 0.581 ± 0.023	0.632CysGlu: 0.632 ± 0.021	0.399CysPhe: 0.399 ± 0.017	1.314CysGly: 1.314 ± 0.035	0.307CysHis: 0.307 ± 0.018	0.448CysIle: 0.448 ± 0.021	0.202CysLys: 0.202 ± 0.014	1.132CysLeu: 1.132 ± 0.029	0.188CysMet: 0.188 ± 0.012	0.248CysAsn: 0.248 ± 0.014	0.582CysPro: 0.582 ± 0.026	0.289CysGln: 0.289 ± 0.013	0.873CysArg: 0.873 ± 0.031	0.632CysSer: 0.632 ± 0.023	0.535CysThr: 0.535 ± 0.022	0.862CysVal: 0.862 ± 0.028	0.163CysTrp: 0.163 ± 0.011	0.258CysTyr: 0.258 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.723AspAla: 7.723 ± 0.087	0.632AspCys: 0.632 ± 0.024	3.107AspAsp: 3.107 ± 0.054	3.424AspGlu: 3.424 ± 0.054	2.133AspPhe: 2.133 ± 0.04	5.349AspGly: 5.349 ± 0.078	1.077AspHis: 1.077 ± 0.029	2.549AspIle: 2.549 ± 0.049	1.262AspLys: 1.262 ± 0.036	5.425AspLeu: 5.425 ± 0.078	1.051AspMet: 1.051 ± 0.034	1.167AspAsn: 1.167 ± 0.038	3.046AspPro: 3.046 ± 0.054	1.353AspGln: 1.353 ± 0.034	3.43AspArg: 3.43 ± 0.057	2.623AspSer: 2.623 ± 0.053	2.8AspThr: 2.8 ± 0.047	3.821AspVal: 3.821 ± 0.056	1.182AspTrp: 1.182 ± 0.032	1.603AspTyr: 1.603 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.325GluAla: 7.325 ± 0.086	0.512GluCys: 0.512 ± 0.022	2.466GluAsp: 2.466 ± 0.051	2.575GluGlu: 2.575 ± 0.061	1.894GluPhe: 1.894 ± 0.041	3.346GluGly: 3.346 ± 0.051	1.7GluHis: 1.7 ± 0.039	2.651GluIle: 2.651 ± 0.051	1.4GluLys: 1.4 ± 0.044	7.605GluLeu: 7.605 ± 0.078	1.126GluMet: 1.126 ± 0.031	1.165GluAsn: 1.165 ± 0.032	2.841GluPro: 2.841 ± 0.055	2.869GluGln: 2.869 ± 0.052	6.089GluArg: 6.089 ± 0.083	2.41GluSer: 2.41 ± 0.049	2.661GluThr: 2.661 ± 0.045	4.026GluVal: 4.026 ± 0.062	0.734GluTrp: 0.734 ± 0.021	1.22GluTyr: 1.22 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.55PheAla: 4.55 ± 0.072	0.446PheCys: 0.446 ± 0.019	2.363PheAsp: 2.363 ± 0.051	2.095PheGlu: 2.095 ± 0.04	1.261PhePhe: 1.261 ± 0.034	3.398PheGly: 3.398 ± 0.052	0.757PheHis: 0.757 ± 0.024	1.533PheIle: 1.533 ± 0.045	0.739PheLys: 0.739 ± 0.029	3.1PheLeu: 3.1 ± 0.051	0.67PheMet: 0.67 ± 0.023	0.964PheAsn: 0.964 ± 0.035	1.389PhePro: 1.389 ± 0.032	0.865PheGln: 0.865 ± 0.029	2.093PheArg: 2.093 ± 0.041	2.06PheSer: 2.06 ± 0.049	1.782PheThr: 1.782 ± 0.041	2.634PheVal: 2.634 ± 0.047	0.486PheTrp: 0.486 ± 0.021	0.827PheTyr: 0.827 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.026GlyAla: 9.026 ± 0.11	1.175GlyCys: 1.175 ± 0.034	4.26GlyAsp: 4.26 ± 0.053	5.251GlyGlu: 5.251 ± 0.071	3.216GlyPhe: 3.216 ± 0.051	7.065GlyGly: 7.065 ± 0.12	2.037GlyHis: 2.037 ± 0.04	4.045GlyIle: 4.045 ± 0.065	2.387GlyLys: 2.387 ± 0.049	9.414GlyLeu: 9.414 ± 0.106	2.033GlyMet: 2.033 ± 0.044	1.967GlyAsn: 1.967 ± 0.041	2.944GlyPro: 2.944 ± 0.049	2.926GlyGln: 2.926 ± 0.048	6.504GlyArg: 6.504 ± 0.073	4.715GlySer: 4.715 ± 0.079	4.071GlyThr: 4.071 ± 0.077	6.501GlyVal: 6.501 ± 0.088	1.497GlyTrp: 1.497 ± 0.037	2.271GlyTyr: 2.271 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	3.109HisAla: 3.109 ± 0.056	0.32HisCys: 0.32 ± 0.019	1.351HisAsp: 1.351 ± 0.033	1.274HisGlu: 1.274 ± 0.033	0.981HisPhe: 0.981 ± 0.028	2.322HisGly: 2.322 ± 0.045	0.665HisHis: 0.665 ± 0.025	0.989HisIle: 0.989 ± 0.031	0.462HisLys: 0.462 ± 0.018	2.336HisLeu: 2.336 ± 0.045	0.445HisMet: 0.445 ± 0.023	0.476HisAsn: 0.476 ± 0.019	1.472HisPro: 1.472 ± 0.038	0.694HisGln: 0.694 ± 0.025	1.547HisArg: 1.547 ± 0.037	1.091HisSer: 1.091 ± 0.029	1.084HisThr: 1.084 ± 0.033	1.54HisVal: 1.54 ± 0.036	0.488HisTrp: 0.488 ± 0.02	0.704HisTyr: 0.704 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.395IleAla: 6.395 ± 0.072	0.447IleCys: 0.447 ± 0.02	3.348IleAsp: 3.348 ± 0.051	3.528IleGlu: 3.528 ± 0.06	1.181IlePhe: 1.181 ± 0.041	4.474IleGly: 4.474 ± 0.066	0.939IleHis: 0.939 ± 0.023	1.644IleIle: 1.644 ± 0.045	1.081IleLys: 1.081 ± 0.032	3.254IleLeu: 3.254 ± 0.054	0.65IleMet: 0.65 ± 0.022	1.298IleAsn: 1.298 ± 0.037	1.954IlePro: 1.954 ± 0.039	0.978IleGln: 0.978 ± 0.028	2.9IleArg: 2.9 ± 0.041	2.329IleSer: 2.329 ± 0.052	2.132IleThr: 2.132 ± 0.042	3.557IleVal: 3.557 ± 0.056	0.439IleTrp: 0.439 ± 0.02	0.932IleTyr: 0.932 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.753LysAla: 2.753 ± 0.066	0.158LysCys: 0.158 ± 0.011	1.086LysAsp: 1.086 ± 0.035	1.044LysGlu: 1.044 ± 0.034	0.631LysPhe: 0.631 ± 0.026	1.678LysGly: 1.678 ± 0.047	0.485LysHis: 0.485 ± 0.021	1.129LysIle: 1.129 ± 0.032	0.838LysLys: 0.838 ± 0.03	2.668LysLeu: 2.668 ± 0.058	0.455LysMet: 0.455 ± 0.02	0.652LysAsn: 0.652 ± 0.027	1.539LysPro: 1.539 ± 0.044	0.823LysGln: 0.823 ± 0.028	1.759LysArg: 1.759 ± 0.045	1.214LysSer: 1.214 ± 0.035	1.308LysThr: 1.308 ± 0.037	1.731LysVal: 1.731 ± 0.045	0.237LysTrp: 0.237 ± 0.012	0.525LysTyr: 0.525 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	17.208LeuAla: 17.208 ± 0.182	1.428LeuCys: 1.428 ± 0.04	7.475LeuAsp: 7.475 ± 0.096	6.044LeuGlu: 6.044 ± 0.074	3.789LeuPhe: 3.789 ± 0.066	10.044LeuGly: 10.044 ± 0.112	2.749LeuHis: 2.749 ± 0.053	4.943LeuIle: 4.943 ± 0.067	2.678LeuLys: 2.678 ± 0.056	14.751LeuLeu: 14.751 ± 0.187	2.101LeuMet: 2.101 ± 0.049	2.579LeuAsn: 2.579 ± 0.048	6.996LeuPro: 6.996 ± 0.089	4.28LeuGln: 4.28 ± 0.065	9.59LeuArg: 9.59 ± 0.1	6.551LeuSer: 6.551 ± 0.075	5.29LeuThr: 5.29 ± 0.081	7.413LeuVal: 7.413 ± 0.094	1.518LeuTrp: 1.518 ± 0.04	2.452LeuTyr: 2.452 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.34MetAla: 2.34 ± 0.044	0.161MetCys: 0.161 ± 0.011	0.924MetAsp: 0.924 ± 0.029	0.864MetGlu: 0.864 ± 0.028	0.56MetPhe: 0.56 ± 0.025	1.295MetGly: 1.295 ± 0.037	0.508MetHis: 0.508 ± 0.021	0.881MetIle: 0.881 ± 0.031	0.725MetLys: 0.725 ± 0.023	2.385MetLeu: 2.385 ± 0.046	0.406MetMet: 0.406 ± 0.017	0.781MetAsn: 0.781 ± 0.027	1.264MetPro: 1.264 ± 0.036	0.836MetGln: 0.836 ± 0.026	1.46MetArg: 1.46 ± 0.034	1.6MetSer: 1.6 ± 0.033	1.15MetThr: 1.15 ± 0.031	1.241MetVal: 1.241 ± 0.029	0.167MetTrp: 0.167 ± 0.012	0.332MetTyr: 0.332 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.884AsnAla: 2.884 ± 0.055	0.258AsnCys: 0.258 ± 0.013	1.243AsnAsp: 1.243 ± 0.032	1.03AsnGlu: 1.03 ± 0.026	0.837AsnPhe: 0.837 ± 0.03	2.013AsnGly: 2.013 ± 0.045	0.483AsnHis: 0.483 ± 0.019	1.068AsnIle: 1.068 ± 0.038	0.521AsnLys: 0.521 ± 0.022	2.476AsnLeu: 2.476 ± 0.046	0.421AsnMet: 0.421 ± 0.02	0.571AsnAsn: 0.571 ± 0.026	1.597AsnPro: 1.597 ± 0.035	0.643AsnGln: 0.643 ± 0.023	1.673AsnArg: 1.673 ± 0.04	1.04AsnSer: 1.04 ± 0.033	1.181AsnThr: 1.181 ± 0.039	1.704AsnVal: 1.704 ± 0.035	0.333AsnTrp: 0.333 ± 0.018	0.59AsnTyr: 0.59 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.701ProAla: 7.701 ± 0.117	0.448ProCys: 0.448 ± 0.02	2.937ProAsp: 2.937 ± 0.045	3.047ProGlu: 3.047 ± 0.049	1.687ProPhe: 1.687 ± 0.037	4.286ProGly: 4.286 ± 0.061	1.09ProHis: 1.09 ± 0.028	1.781ProIle: 1.781 ± 0.042	1.061ProLys: 1.061 ± 0.031	6.539ProLeu: 6.539 ± 0.085	1.008ProMet: 1.008 ± 0.028	1.109ProAsn: 1.109 ± 0.031	2.934ProPro: 2.934 ± 0.072	2.513ProGln: 2.513 ± 0.047	3.365ProArg: 3.365 ± 0.059	2.374ProSer: 2.374 ± 0.044	2.249ProThr: 2.249 ± 0.043	3.93ProVal: 3.93 ± 0.065	0.827ProTrp: 0.827 ± 0.029	1.178ProTyr: 1.178 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.349GlnAla: 5.349 ± 0.082	0.329GlnCys: 0.329 ± 0.016	1.336GlnAsp: 1.336 ± 0.031	1.529GlnGlu: 1.529 ± 0.038	1.104GlnPhe: 1.104 ± 0.029	2.412GlnGly: 2.412 ± 0.046	0.978GlnHis: 0.978 ± 0.026	1.644GlnIle: 1.644 ± 0.039	0.753GlnLys: 0.753 ± 0.026	4.576GlnLeu: 4.576 ± 0.061	0.77GlnMet: 0.77 ± 0.025	0.674GlnAsn: 0.674 ± 0.024	2.394GlnPro: 2.394 ± 0.046	1.92GlnGln: 1.92 ± 0.048	3.584GlnArg: 3.584 ± 0.058	1.662GlnSer: 1.662 ± 0.037	1.815GlnThr: 1.815 ± 0.043	2.576GlnVal: 2.576 ± 0.043	0.578GlnTrp: 0.578 ± 0.019	0.722GlnTyr: 0.722 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.076ArgAla: 9.076 ± 0.102	0.84ArgCys: 0.84 ± 0.023	4.024ArgAsp: 4.024 ± 0.05	5.137ArgGlu: 5.137 ± 0.068	2.993ArgPhe: 2.993 ± 0.052	5.247ArgGly: 5.247 ± 0.067	2.041ArgHis: 2.041 ± 0.044	3.811ArgIle: 3.811 ± 0.056	1.634ArgLys: 1.634 ± 0.04	10.43ArgLeu: 10.43 ± 0.127	1.702ArgMet: 1.702 ± 0.037	1.646ArgAsn: 1.646 ± 0.034	3.698ArgPro: 3.698 ± 0.057	3.084ArgGln: 3.084 ± 0.054	6.569ArgArg: 6.569 ± 0.081	3.716ArgSer: 3.716 ± 0.047	3.194ArgThr: 3.194 ± 0.049	5.452ArgVal: 5.452 ± 0.062	1.29ArgTrp: 1.29 ± 0.032	2.083ArgTyr: 2.083 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.984SerAla: 6.984 ± 0.079	0.561SerCys: 0.561 ± 0.02	2.596SerAsp: 2.596 ± 0.059	2.702SerGlu: 2.702 ± 0.042	1.897SerPhe: 1.897 ± 0.045	5.524SerGly: 5.524 ± 0.086	1.071SerHis: 1.071 ± 0.03	2.156SerIle: 2.156 ± 0.046	1.089SerLys: 1.089 ± 0.037	5.542SerLeu: 5.542 ± 0.079	1.032SerMet: 1.032 ± 0.033	1.192SerAsn: 1.192 ± 0.034	2.484SerPro: 2.484 ± 0.043	1.517SerGln: 1.517 ± 0.032	3.537SerArg: 3.537 ± 0.047	2.884SerSer: 2.884 ± 0.076	2.722SerThr: 2.722 ± 0.059	3.949SerVal: 3.949 ± 0.062	0.752SerTrp: 0.752 ± 0.026	1.19SerTyr: 1.19 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.934ThrAla: 5.934 ± 0.08	0.405ThrCys: 0.405 ± 0.017	2.319ThrAsp: 2.319 ± 0.047	2.2ThrGlu: 2.2 ± 0.04	1.467ThrPhe: 1.467 ± 0.038	3.86ThrGly: 3.86 ± 0.064	1.155ThrHis: 1.155 ± 0.031	1.983ThrIle: 1.983 ± 0.047	0.797ThrLys: 0.797 ± 0.027	7.171ThrLeu: 7.171 ± 0.088	0.838ThrMet: 0.838 ± 0.026	0.886ThrAsn: 0.886 ± 0.031	3.415ThrPro: 3.415 ± 0.057	1.722ThrGln: 1.722 ± 0.037	3.314ThrArg: 3.314 ± 0.052	2.143ThrSer: 2.143 ± 0.041	2.403ThrThr: 2.403 ± 0.06	3.804ThrVal: 3.804 ± 0.074	0.504ThrTrp: 0.504 ± 0.021	0.959ThrTyr: 0.959 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.744ValAla: 8.744 ± 0.093	0.911ValCys: 0.911 ± 0.028	4.193ValAsp: 4.193 ± 0.058	4.411ValGlu: 4.411 ± 0.069	2.672ValPhe: 2.672 ± 0.052	5.178ValGly: 5.178 ± 0.065	1.688ValHis: 1.688 ± 0.037	3.407ValIle: 3.407 ± 0.054	1.616ValLys: 1.616 ± 0.047	8.64ValLeu: 8.64 ± 0.11	1.562ValMet: 1.562 ± 0.04	1.841ValAsn: 1.841 ± 0.041	3.632ValPro: 3.632 ± 0.052	2.405ValGln: 2.405 ± 0.05	5.401ValArg: 5.401 ± 0.058	4.051ValSer: 4.051 ± 0.064	3.431ValThr: 3.431 ± 0.059	5.593ValVal: 5.593 ± 0.095	0.929ValTrp: 0.929 ± 0.028	1.619ValTyr: 1.619 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.319TrpAla: 1.319 ± 0.035	0.184TrpCys: 0.184 ± 0.012	0.616TrpAsp: 0.616 ± 0.023	0.588TrpGlu: 0.588 ± 0.024	0.545TrpPhe: 0.545 ± 0.02	0.943TrpGly: 0.943 ± 0.029	0.381TrpHis: 0.381 ± 0.017	0.613TrpIle: 0.613 ± 0.023	0.374TrpLys: 0.374 ± 0.018	2.516TrpLeu: 2.516 ± 0.052	0.287TrpMet: 0.287 ± 0.014	0.384TrpAsn: 0.384 ± 0.017	0.768TrpPro: 0.768 ± 0.025	0.837TrpGln: 0.837 ± 0.027	1.328TrpArg: 1.328 ± 0.036	0.803TrpSer: 0.803 ± 0.027	0.62TrpThr: 0.62 ± 0.023	0.885TrpVal: 0.885 ± 0.028	0.264TrpTrp: 0.264 ± 0.015	0.332TrpTyr: 0.332 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.858TyrAla: 2.858 ± 0.044	0.323TyrCys: 0.323 ± 0.015	1.173TyrAsp: 1.173 ± 0.032	1.051TyrGlu: 1.051 ± 0.031	0.903TyrPhe: 0.903 ± 0.03	2.066TyrGly: 2.066 ± 0.042	0.514TyrHis: 0.514 ± 0.023	0.809TyrIle: 0.809 ± 0.028	0.488TyrLys: 0.488 ± 0.019	2.79TyrLeu: 2.79 ± 0.045	0.401TyrMet: 0.401 ± 0.019	0.498TyrAsn: 0.498 ± 0.022	1.174TyrPro: 1.174 ± 0.029	0.815TyrGln: 0.815 ± 0.027	2.178TyrArg: 2.178 ± 0.045	1.121TyrSer: 1.121 ± 0.034	1.143TyrThr: 1.143 ± 0.033	1.627TyrVal: 1.627 ± 0.038	0.363TyrTrp: 0.363 ± 0.016	0.613TyrTyr: 0.613 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3852 proteins (1284836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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