Amino acid dipepetide frequency for Halorubrum pleomorphic virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.68AlaAla: 10.68 ± 2.608
1.294AlaCys: 1.294 ± 0.714
6.796AlaAsp: 6.796 ± 1.253
4.531AlaGlu: 4.531 ± 1.357
3.236AlaPhe: 3.236 ± 1.516
10.356AlaGly: 10.356 ± 1.274
0.324AlaHis: 0.324 ± 0.287
2.913AlaIle: 2.913 ± 0.967
3.236AlaLys: 3.236 ± 1.143
6.472AlaLeu: 6.472 ± 1.373
1.942AlaMet: 1.942 ± 0.507
1.942AlaAsn: 1.942 ± 0.673
3.236AlaPro: 3.236 ± 0.788
3.56AlaGln: 3.56 ± 0.959
6.796AlaArg: 6.796 ± 1.391
8.091AlaSer: 8.091 ± 2.806
7.12AlaThr: 7.12 ± 1.492
9.385AlaVal: 9.385 ± 2.327
1.618AlaTrp: 1.618 ± 0.923
1.618AlaTyr: 1.618 ± 0.59
0.0AlaXaa: 0.0 ± 0.0
Cys
1.942CysAla: 1.942 ± 1.296
0.324CysCys: 0.324 ± 0.401
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.324CysPhe: 0.324 ± 0.401
0.971CysGly: 0.971 ± 0.545
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.324CysLeu: 0.324 ± 0.333
0.324CysMet: 0.324 ± 0.387
0.324CysAsn: 0.324 ± 0.274
0.324CysPro: 0.324 ± 0.333
0.324CysGln: 0.324 ± 0.274
1.942CysArg: 1.942 ± 1.373
0.971CysSer: 0.971 ± 0.844
0.971CysThr: 0.971 ± 0.822
0.647CysVal: 0.647 ± 0.581
0.324CysTrp: 0.324 ± 0.274
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.738AspAla: 8.738 ± 1.736
0.0AspCys: 0.0 ± 0.0
8.091AspAsp: 8.091 ± 2.647
5.178AspGlu: 5.178 ± 1.272
2.265AspPhe: 2.265 ± 1.124
9.385AspGly: 9.385 ± 2.008
0.971AspHis: 0.971 ± 0.822
2.265AspIle: 2.265 ± 1.144
1.618AspLys: 1.618 ± 0.774
10.68AspLeu: 10.68 ± 1.549
2.589AspMet: 2.589 ± 0.77
1.294AspAsn: 1.294 ± 0.491
4.854AspPro: 4.854 ± 1.384
0.971AspGln: 0.971 ± 0.471
5.178AspArg: 5.178 ± 1.611
5.825AspSer: 5.825 ± 1.107
4.207AspThr: 4.207 ± 0.935
7.767AspVal: 7.767 ± 2.132
1.294AspTrp: 1.294 ± 0.496
2.265AspTyr: 2.265 ± 0.759
0.0AspXaa: 0.0 ± 0.0
Glu
3.56GluAla: 3.56 ± 1.247
0.647GluCys: 0.647 ± 0.454
3.56GluAsp: 3.56 ± 1.135
5.825GluGlu: 5.825 ± 1.907
2.265GluPhe: 2.265 ± 0.606
4.531GluGly: 4.531 ± 1.135
1.618GluHis: 1.618 ± 0.717
3.883GluIle: 3.883 ± 0.717
2.913GluLys: 2.913 ± 1.158
5.825GluLeu: 5.825 ± 1.352
1.942GluMet: 1.942 ± 0.871
1.618GluAsn: 1.618 ± 0.655
2.589GluPro: 2.589 ± 0.558
4.207GluGln: 4.207 ± 1.404
3.883GluArg: 3.883 ± 0.968
3.883GluSer: 3.883 ± 1.139
6.796GluThr: 6.796 ± 1.049
5.825GluVal: 5.825 ± 1.676
0.647GluTrp: 0.647 ± 0.3
0.324GluTyr: 0.324 ± 0.287
0.0GluXaa: 0.0 ± 0.0
Phe
3.236PheAla: 3.236 ± 0.76
0.324PheCys: 0.324 ± 0.274
3.56PheAsp: 3.56 ± 1.003
1.618PheGlu: 1.618 ± 0.74
0.971PhePhe: 0.971 ± 0.465
3.56PheGly: 3.56 ± 0.855
0.647PheHis: 0.647 ± 0.386
0.971PheIle: 0.971 ± 0.698
0.324PheLys: 0.324 ± 0.422
2.913PheLeu: 2.913 ± 0.997
0.647PheMet: 0.647 ± 0.647
0.324PheAsn: 0.324 ± 0.39
0.971PhePro: 0.971 ± 0.551
0.647PheGln: 0.647 ± 0.514
2.589PheArg: 2.589 ± 1.341
1.294PheSer: 1.294 ± 0.775
1.618PheThr: 1.618 ± 0.745
2.913PheVal: 2.913 ± 0.845
0.647PheTrp: 0.647 ± 0.386
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.531GlyAla: 4.531 ± 1.164
0.0GlyCys: 0.0 ± 0.0
8.091GlyAsp: 8.091 ± 2.224
4.207GlyGlu: 4.207 ± 1.088
3.56GlyPhe: 3.56 ± 1.025
7.12GlyGly: 7.12 ± 1.802
1.942GlyHis: 1.942 ± 0.627
3.236GlyIle: 3.236 ± 0.64
2.913GlyLys: 2.913 ± 0.671
8.091GlyLeu: 8.091 ± 1.758
1.618GlyMet: 1.618 ± 0.5
2.589GlyAsn: 2.589 ± 1.177
4.207GlyPro: 4.207 ± 1.565
2.265GlyGln: 2.265 ± 0.786
5.178GlyArg: 5.178 ± 1.704
6.149GlySer: 6.149 ± 1.283
6.149GlyThr: 6.149 ± 1.345
5.178GlyVal: 5.178 ± 1.536
2.913GlyTrp: 2.913 ± 0.662
2.589GlyTyr: 2.589 ± 0.994
0.0GlyXaa: 0.0 ± 0.0
His
1.618HisAla: 1.618 ± 0.566
0.0HisCys: 0.0 ± 0.0
4.207HisAsp: 4.207 ± 1.816
0.971HisGlu: 0.971 ± 0.51
0.647HisPhe: 0.647 ± 0.356
1.618HisGly: 1.618 ± 0.864
0.0HisHis: 0.0 ± 0.0
0.324HisIle: 0.324 ± 0.39
1.618HisLys: 1.618 ± 0.694
0.647HisLeu: 0.647 ± 0.386
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.971HisPro: 0.971 ± 0.408
0.647HisGln: 0.647 ± 0.503
0.971HisArg: 0.971 ± 0.601
0.647HisSer: 0.647 ± 0.514
0.971HisThr: 0.971 ± 0.537
0.971HisVal: 0.971 ± 0.708
0.0HisTrp: 0.0 ± 0.0
0.324HisTyr: 0.324 ± 0.274
0.0HisXaa: 0.0 ± 0.0
Ile
4.854IleAla: 4.854 ± 1.162
0.0IleCys: 0.0 ± 0.0
2.589IleAsp: 2.589 ± 0.727
4.531IleGlu: 4.531 ± 1.123
0.647IlePhe: 0.647 ± 0.433
2.913IleGly: 2.913 ± 0.945
0.324IleHis: 0.324 ± 0.287
0.324IleIle: 0.324 ± 0.332
0.647IleLys: 0.647 ± 0.437
1.294IleLeu: 1.294 ± 0.483
0.0IleMet: 0.0 ± 0.0
0.647IleAsn: 0.647 ± 0.386
1.294IlePro: 1.294 ± 0.548
0.971IleGln: 0.971 ± 0.534
2.589IleArg: 2.589 ± 1.309
3.236IleSer: 3.236 ± 0.975
2.913IleThr: 2.913 ± 1.005
2.913IleVal: 2.913 ± 1.065
0.324IleTrp: 0.324 ± 0.422
0.647IleTyr: 0.647 ± 0.353
0.0IleXaa: 0.0 ± 0.0
Lys
1.942LysAla: 1.942 ± 0.843
0.647LysCys: 0.647 ± 0.671
2.265LysAsp: 2.265 ± 1.013
0.971LysGlu: 0.971 ± 0.513
0.647LysPhe: 0.647 ± 0.386
1.294LysGly: 1.294 ± 0.512
0.324LysHis: 0.324 ± 0.246
0.324LysIle: 0.324 ± 0.246
1.618LysLys: 1.618 ± 1.08
2.589LysLeu: 2.589 ± 0.94
0.647LysMet: 0.647 ± 0.548
0.971LysAsn: 0.971 ± 0.408
1.618LysPro: 1.618 ± 0.706
1.294LysGln: 1.294 ± 0.454
2.265LysArg: 2.265 ± 0.886
1.618LysSer: 1.618 ± 0.777
3.56LysThr: 3.56 ± 0.619
1.618LysVal: 1.618 ± 0.957
0.647LysTrp: 0.647 ± 0.386
0.971LysTyr: 0.971 ± 0.41
0.0LysXaa: 0.0 ± 0.0
Leu
10.356LeuAla: 10.356 ± 2.491
0.647LeuCys: 0.647 ± 0.572
9.709LeuAsp: 9.709 ± 2.531
5.825LeuGlu: 5.825 ± 1.982
1.294LeuPhe: 1.294 ± 0.72
6.472LeuGly: 6.472 ± 1.271
0.971LeuHis: 0.971 ± 0.822
4.207LeuIle: 4.207 ± 1.078
2.589LeuLys: 2.589 ± 1.022
7.12LeuLeu: 7.12 ± 2.326
1.294LeuMet: 1.294 ± 0.47
3.883LeuAsn: 3.883 ± 1.157
4.207LeuPro: 4.207 ± 2.012
1.942LeuGln: 1.942 ± 0.722
7.12LeuArg: 7.12 ± 1.978
4.854LeuSer: 4.854 ± 0.896
4.854LeuThr: 4.854 ± 1.465
9.385LeuVal: 9.385 ± 1.629
0.324LeuTrp: 0.324 ± 0.333
3.56LeuTyr: 3.56 ± 1.336
0.0LeuXaa: 0.0 ± 0.0
Met
2.265MetAla: 2.265 ± 0.582
0.0MetCys: 0.0 ± 0.0
0.971MetAsp: 0.971 ± 0.549
0.971MetGlu: 0.971 ± 0.508
0.971MetPhe: 0.971 ± 0.569
0.971MetGly: 0.971 ± 0.476
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.589MetLeu: 2.589 ± 1.023
0.324MetMet: 0.324 ± 0.246
0.0MetAsn: 0.0 ± 0.0
0.647MetPro: 0.647 ± 0.548
0.0MetGln: 0.0 ± 0.0
1.294MetArg: 1.294 ± 0.777
5.502MetSer: 5.502 ± 0.868
0.971MetThr: 0.971 ± 0.411
0.324MetVal: 0.324 ± 0.39
0.324MetTrp: 0.324 ± 0.39
0.324MetTyr: 0.324 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
2.265AsnAla: 2.265 ± 0.734
0.324AsnCys: 0.324 ± 0.274
0.971AsnAsp: 0.971 ± 0.517
0.971AsnGlu: 0.971 ± 0.475
1.618AsnPhe: 1.618 ± 0.756
2.913AsnGly: 2.913 ± 0.713
0.324AsnHis: 0.324 ± 0.246
0.324AsnIle: 0.324 ± 0.246
1.294AsnLys: 1.294 ± 0.828
1.942AsnLeu: 1.942 ± 0.893
0.647AsnMet: 0.647 ± 0.338
0.647AsnAsn: 0.647 ± 0.3
0.647AsnPro: 0.647 ± 0.371
1.294AsnGln: 1.294 ± 0.562
0.647AsnArg: 0.647 ± 0.355
1.942AsnSer: 1.942 ± 0.594
3.883AsnThr: 3.883 ± 0.991
1.942AsnVal: 1.942 ± 0.987
1.294AsnTrp: 1.294 ± 0.491
0.647AsnTyr: 0.647 ± 0.3
0.0AsnXaa: 0.0 ± 0.0
Pro
4.854ProAla: 4.854 ± 1.898
0.324ProCys: 0.324 ± 0.333
2.913ProAsp: 2.913 ± 0.953
5.178ProGlu: 5.178 ± 1.03
0.647ProPhe: 0.647 ± 0.442
3.236ProGly: 3.236 ± 1.478
1.294ProHis: 1.294 ± 0.523
1.294ProIle: 1.294 ± 0.555
0.971ProLys: 0.971 ± 0.411
4.531ProLeu: 4.531 ± 1.116
0.647ProMet: 0.647 ± 0.353
0.324ProAsn: 0.324 ± 0.287
2.913ProPro: 2.913 ± 1.009
0.647ProGln: 0.647 ± 0.356
3.56ProArg: 3.56 ± 1.065
2.913ProSer: 2.913 ± 0.884
3.236ProThr: 3.236 ± 1.404
1.294ProVal: 1.294 ± 0.879
0.647ProTrp: 0.647 ± 0.356
0.647ProTyr: 0.647 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
1.618GlnAla: 1.618 ± 0.606
0.0GlnCys: 0.0 ± 0.0
1.942GlnAsp: 1.942 ± 0.557
1.942GlnGlu: 1.942 ± 0.533
1.294GlnPhe: 1.294 ± 0.472
1.942GlnGly: 1.942 ± 0.794
1.294GlnHis: 1.294 ± 0.562
0.647GlnIle: 0.647 ± 0.356
0.647GlnLys: 0.647 ± 0.548
3.883GlnLeu: 3.883 ± 0.663
0.647GlnMet: 0.647 ± 0.515
0.971GlnAsn: 0.971 ± 0.738
1.294GlnPro: 1.294 ± 0.784
2.265GlnGln: 2.265 ± 0.621
2.589GlnArg: 2.589 ± 1.386
3.56GlnSer: 3.56 ± 1.056
2.265GlnThr: 2.265 ± 0.741
1.942GlnVal: 1.942 ± 0.821
0.647GlnTrp: 0.647 ± 0.434
0.971GlnTyr: 0.971 ± 0.584
0.0GlnXaa: 0.0 ± 0.0
Arg
9.385ArgAla: 9.385 ± 2.809
1.618ArgCys: 1.618 ± 1.301
4.854ArgAsp: 4.854 ± 2.107
6.149ArgGlu: 6.149 ± 1.658
1.942ArgPhe: 1.942 ± 1.008
5.178ArgGly: 5.178 ± 1.168
2.265ArgHis: 2.265 ± 0.803
2.913ArgIle: 2.913 ± 1.179
0.647ArgLys: 0.647 ± 0.418
5.825ArgLeu: 5.825 ± 1.83
1.618ArgMet: 1.618 ± 0.551
1.942ArgAsn: 1.942 ± 0.9
2.265ArgPro: 2.265 ± 0.671
1.942ArgGln: 1.942 ± 0.867
11.003ArgArg: 11.003 ± 4.341
5.825ArgSer: 5.825 ± 1.908
3.883ArgThr: 3.883 ± 1.242
4.531ArgVal: 4.531 ± 1.933
1.294ArgTrp: 1.294 ± 0.743
0.971ArgTyr: 0.971 ± 0.822
0.0ArgXaa: 0.0 ± 0.0
Ser
5.502SerAla: 5.502 ± 0.571
0.647SerCys: 0.647 ± 0.588
6.472SerAsp: 6.472 ± 1.56
6.796SerGlu: 6.796 ± 1.359
2.913SerPhe: 2.913 ± 0.937
7.443SerGly: 7.443 ± 1.885
0.647SerHis: 0.647 ± 0.548
2.589SerIle: 2.589 ± 0.689
1.942SerLys: 1.942 ± 0.747
8.091SerLeu: 8.091 ± 2.716
1.294SerMet: 1.294 ± 0.852
3.236SerAsn: 3.236 ± 1.01
2.589SerPro: 2.589 ± 0.641
1.618SerGln: 1.618 ± 0.564
4.531SerArg: 4.531 ± 1.6
7.12SerSer: 7.12 ± 3.74
4.854SerThr: 4.854 ± 1.895
3.56SerVal: 3.56 ± 0.972
1.618SerTrp: 1.618 ± 0.758
3.236SerTyr: 3.236 ± 0.835
0.0SerXaa: 0.0 ± 0.0
Thr
7.767ThrAla: 7.767 ± 2.458
0.971ThrCys: 0.971 ± 0.523
6.796ThrAsp: 6.796 ± 1.375
3.56ThrGlu: 3.56 ± 1.338
1.618ThrPhe: 1.618 ± 0.823
4.207ThrGly: 4.207 ± 0.822
0.324ThrHis: 0.324 ± 0.274
3.56ThrIle: 3.56 ± 1.61
1.294ThrLys: 1.294 ± 0.823
7.12ThrLeu: 7.12 ± 0.804
0.647ThrMet: 0.647 ± 0.3
2.913ThrAsn: 2.913 ± 0.951
2.265ThrPro: 2.265 ± 0.69
2.913ThrGln: 2.913 ± 0.84
5.825ThrArg: 5.825 ± 1.671
4.207ThrSer: 4.207 ± 0.931
4.207ThrThr: 4.207 ± 0.827
6.472ThrVal: 6.472 ± 1.8
1.618ThrTrp: 1.618 ± 0.823
0.971ThrTyr: 0.971 ± 0.621
0.0ThrXaa: 0.0 ± 0.0
Val
7.767ValAla: 7.767 ± 2.509
1.294ValCys: 1.294 ± 0.862
7.767ValAsp: 7.767 ± 1.408
3.56ValGlu: 3.56 ± 1.148
2.589ValPhe: 2.589 ± 0.629
6.149ValGly: 6.149 ± 2.136
1.942ValHis: 1.942 ± 0.783
1.294ValIle: 1.294 ± 0.852
1.294ValLys: 1.294 ± 0.707
7.12ValLeu: 7.12 ± 0.919
0.647ValMet: 0.647 ± 0.437
1.294ValAsn: 1.294 ± 0.683
3.883ValPro: 3.883 ± 0.662
2.913ValGln: 2.913 ± 0.966
5.178ValArg: 5.178 ± 1.326
6.796ValSer: 6.796 ± 1.921
3.883ValThr: 3.883 ± 1.365
8.091ValVal: 8.091 ± 2.541
0.971ValTrp: 0.971 ± 0.665
2.913ValTyr: 2.913 ± 0.962
0.0ValXaa: 0.0 ± 0.0
Trp
0.971TrpAla: 0.971 ± 0.513
0.971TrpCys: 0.971 ± 0.597
0.971TrpAsp: 0.971 ± 0.561
0.324TrpGlu: 0.324 ± 0.326
0.0TrpPhe: 0.0 ± 0.0
0.647TrpGly: 0.647 ± 0.455
0.647TrpHis: 0.647 ± 0.437
0.971TrpIle: 0.971 ± 0.704
1.618TrpLys: 1.618 ± 0.495
2.265TrpLeu: 2.265 ± 0.966
0.647TrpMet: 0.647 ± 0.407
0.647TrpAsn: 0.647 ± 0.353
0.324TrpPro: 0.324 ± 0.287
0.0TrpGln: 0.0 ± 0.0
1.294TrpArg: 1.294 ± 0.505
1.618TrpSer: 1.618 ± 0.627
1.294TrpThr: 1.294 ± 0.608
1.294TrpVal: 1.294 ± 0.454
0.324TrpTrp: 0.324 ± 0.274
0.971TrpTyr: 0.971 ± 0.408
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.294TyrAla: 1.294 ± 0.648
0.0TyrCys: 0.0 ± 0.0
2.913TyrAsp: 2.913 ± 0.922
3.236TyrGlu: 3.236 ± 1.019
0.647TyrPhe: 0.647 ± 0.412
1.618TyrGly: 1.618 ± 0.698
1.294TyrHis: 1.294 ± 0.533
1.618TyrIle: 1.618 ± 1.039
0.647TyrLys: 0.647 ± 0.356
1.294TyrLeu: 1.294 ± 0.549
0.0TyrMet: 0.0 ± 0.0
0.971TyrAsn: 0.971 ± 0.581
0.971TyrPro: 0.971 ± 0.574
1.942TyrGln: 1.942 ± 0.742
1.618TyrArg: 1.618 ± 0.676
0.647TyrSer: 0.647 ± 0.353
1.618TyrThr: 1.618 ± 0.703
1.294TyrVal: 1.294 ± 0.673
0.324TyrTrp: 0.324 ± 0.274
0.971TyrTyr: 0.971 ± 0.584
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (3091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski