Amino acid dipepetide frequency for Lactate dehydrogenase-elevating virus (LDV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.643AlaAla: 4.643 ± 2.186
2.786AlaCys: 2.786 ± 1.116
0.0AlaAsp: 0.0 ± 0.0
1.857AlaGlu: 1.857 ± 1.014
4.643AlaPhe: 4.643 ± 1.844
9.285AlaGly: 9.285 ± 1.239
1.857AlaHis: 1.857 ± 1.107
10.214AlaIle: 10.214 ± 3.345
0.929AlaLys: 0.929 ± 0.868
10.214AlaLeu: 10.214 ± 0.481
0.929AlaMet: 0.929 ± 1.069
2.786AlaAsn: 2.786 ± 1.955
0.929AlaPro: 0.929 ± 0.995
0.0AlaGln: 0.0 ± 0.0
0.0AlaArg: 0.0 ± 0.0
3.714AlaSer: 3.714 ± 1.105
2.786AlaThr: 2.786 ± 1.229
10.214AlaVal: 10.214 ± 2.749
0.0AlaTrp: 0.0 ± 0.0
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
1.857CysAla: 1.857 ± 1.737
2.786CysCys: 2.786 ± 1.168
0.929CysAsp: 0.929 ± 0.995
1.857CysGlu: 1.857 ± 0.909
2.786CysPhe: 2.786 ± 1.168
0.929CysGly: 0.929 ± 0.739
0.929CysHis: 0.929 ± 0.864
0.929CysIle: 0.929 ± 0.864
0.929CysLys: 0.929 ± 0.739
4.643CysLeu: 4.643 ± 1.815
0.929CysMet: 0.929 ± 0.868
0.929CysAsn: 0.929 ± 0.739
0.0CysPro: 0.0 ± 0.0
0.929CysGln: 0.929 ± 0.763
3.714CysArg: 3.714 ± 1.227
0.929CysSer: 0.929 ± 0.739
2.786CysThr: 2.786 ± 1.181
2.786CysVal: 2.786 ± 1.203
0.929CysTrp: 0.929 ± 0.763
2.786CysTyr: 2.786 ± 1.722
0.0CysXaa: 0.0 ± 0.0
Asp
1.857AspAla: 1.857 ± 1.527
0.929AspCys: 0.929 ± 0.739
2.786AspAsp: 2.786 ± 1.549
0.0AspGlu: 0.0 ± 0.0
3.714AspPhe: 3.714 ± 1.56
2.786AspGly: 2.786 ± 1.168
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
0.0AspLys: 0.0 ± 0.0
0.929AspLeu: 0.929 ± 0.916
0.0AspMet: 0.0 ± 0.0
0.0AspAsn: 0.0 ± 0.0
0.929AspPro: 0.929 ± 0.864
0.929AspGln: 0.929 ± 0.995
0.0AspArg: 0.0 ± 0.0
0.929AspSer: 0.929 ± 0.916
2.786AspThr: 2.786 ± 1.168
2.786AspVal: 2.786 ± 1.549
0.929AspTrp: 0.929 ± 0.763
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
2.786GluAla: 2.786 ± 1.116
0.929GluCys: 0.929 ± 0.864
0.0GluAsp: 0.0 ± 0.0
0.929GluGlu: 0.929 ± 0.739
0.929GluPhe: 0.929 ± 0.995
0.929GluGly: 0.929 ± 0.864
2.786GluHis: 2.786 ± 1.074
0.0GluIle: 0.0 ± 0.0
1.857GluLys: 1.857 ± 0.909
2.786GluLeu: 2.786 ± 1.008
0.0GluMet: 0.0 ± 0.0
2.786GluAsn: 2.786 ± 0.957
0.0GluPro: 0.0 ± 0.0
0.929GluGln: 0.929 ± 0.868
1.857GluArg: 1.857 ± 1.527
0.929GluSer: 0.929 ± 0.739
4.643GluThr: 4.643 ± 1.36
1.857GluVal: 1.857 ± 1.155
0.0GluTrp: 0.0 ± 0.0
1.857GluTyr: 1.857 ± 1.005
0.0GluXaa: 0.0 ± 0.0
Phe
1.857PheAla: 1.857 ± 0.972
4.643PheCys: 4.643 ± 1.841
1.857PheAsp: 1.857 ± 1.479
0.0PheGlu: 0.0 ± 0.0
3.714PhePhe: 3.714 ± 0.922
5.571PheGly: 5.571 ± 2.859
0.929PheHis: 0.929 ± 0.864
5.571PheIle: 5.571 ± 1.987
0.0PheLys: 0.0 ± 0.0
7.428PheLeu: 7.428 ± 1.831
0.929PheMet: 0.929 ± 0.916
3.714PheAsn: 3.714 ± 2.67
4.643PhePro: 4.643 ± 1.464
1.857PheGln: 1.857 ± 1.177
1.857PheArg: 1.857 ± 0.998
7.428PheSer: 7.428 ± 3.582
4.643PheThr: 4.643 ± 1.007
4.643PheVal: 4.643 ± 2.225
0.929PheTrp: 0.929 ± 0.763
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
3.714GlyAla: 3.714 ± 1.957
1.857GlyCys: 1.857 ± 1.036
1.857GlyAsp: 1.857 ± 1.005
0.929GlyGlu: 0.929 ± 0.864
3.714GlyPhe: 3.714 ± 1.558
7.428GlyGly: 7.428 ± 2.9
2.786GlyHis: 2.786 ± 1.786
5.571GlyIle: 5.571 ± 1.694
4.643GlyLys: 4.643 ± 0.922
4.643GlyLeu: 4.643 ± 1.793
0.929GlyMet: 0.929 ± 0.763
2.786GlyAsn: 2.786 ± 1.008
1.857GlyPro: 1.857 ± 1.1
5.571GlyGln: 5.571 ± 3.581
6.5GlyArg: 6.5 ± 2.045
1.857GlySer: 1.857 ± 1.177
2.786GlyThr: 2.786 ± 1.203
4.643GlyVal: 4.643 ± 1.244
0.929GlyTrp: 0.929 ± 0.868
1.857GlyTyr: 1.857 ± 1.737
0.0GlyXaa: 0.0 ± 0.0
His
1.857HisAla: 1.857 ± 1.202
0.929HisCys: 0.929 ± 0.864
0.0HisAsp: 0.0 ± 0.0
2.786HisGlu: 2.786 ± 1.722
2.786HisPhe: 2.786 ± 1.29
0.929HisGly: 0.929 ± 0.868
0.929HisHis: 0.929 ± 0.995
1.857HisIle: 1.857 ± 1.727
1.857HisLys: 1.857 ± 1.107
6.5HisLeu: 6.5 ± 2.145
1.857HisMet: 1.857 ± 1.527
1.857HisAsn: 1.857 ± 1.479
2.786HisPro: 2.786 ± 1.008
1.857HisGln: 1.857 ± 0.972
0.0HisArg: 0.0 ± 0.0
3.714HisSer: 3.714 ± 1.598
0.929HisThr: 0.929 ± 0.864
2.786HisVal: 2.786 ± 1.283
0.0HisTrp: 0.0 ± 0.0
0.929HisTyr: 0.929 ± 0.763
0.0HisXaa: 0.0 ± 0.0
Ile
6.5IleAla: 6.5 ± 2.946
1.857IleCys: 1.857 ± 1.479
0.0IleAsp: 0.0 ± 0.0
0.929IleGlu: 0.929 ± 0.868
6.5IlePhe: 6.5 ± 1.974
1.857IleGly: 1.857 ± 1.036
4.643IleHis: 4.643 ± 1.858
0.0IleIle: 0.0 ± 0.0
1.857IleLys: 1.857 ± 1.527
4.643IleLeu: 4.643 ± 2.145
0.929IleMet: 0.929 ± 0.855
6.5IleAsn: 6.5 ± 2.912
1.857IlePro: 1.857 ± 1.107
1.857IleGln: 1.857 ± 1.036
0.929IleArg: 0.929 ± 0.739
2.786IleSer: 2.786 ± 1.726
1.857IleThr: 1.857 ± 1.727
3.714IleVal: 3.714 ± 1.766
0.0IleTrp: 0.0 ± 0.0
4.643IleTyr: 4.643 ± 2.225
0.0IleXaa: 0.0 ± 0.0
Lys
3.714LysAla: 3.714 ± 0.917
1.857LysCys: 1.857 ± 1.737
0.0LysAsp: 0.0 ± 0.0
0.929LysGlu: 0.929 ± 0.864
0.929LysPhe: 0.929 ± 0.763
6.5LysGly: 6.5 ± 2.358
0.0LysHis: 0.0 ± 0.0
1.857LysIle: 1.857 ± 0.998
7.428LysLys: 7.428 ± 4.328
3.714LysLeu: 3.714 ± 1.212
1.857LysMet: 1.857 ± 1.078
0.929LysAsn: 0.929 ± 0.868
0.929LysPro: 0.929 ± 0.995
1.857LysGln: 1.857 ± 1.155
0.0LysArg: 0.0 ± 0.0
0.929LysSer: 0.929 ± 0.916
3.714LysThr: 3.714 ± 1.591
1.857LysVal: 1.857 ± 1.177
2.786LysTrp: 2.786 ± 1.008
0.929LysTyr: 0.929 ± 0.995
0.0LysXaa: 0.0 ± 0.0
Leu
8.357LeuAla: 8.357 ± 3.125
4.643LeuCys: 4.643 ± 1.328
4.643LeuAsp: 4.643 ± 2.32
5.571LeuGlu: 5.571 ± 1.625
5.571LeuPhe: 5.571 ± 1.898
6.5LeuGly: 6.5 ± 2.565
1.857LeuHis: 1.857 ± 1.202
6.5LeuIle: 6.5 ± 1.763
4.643LeuLys: 4.643 ± 2.145
10.214LeuLeu: 10.214 ± 2.859
4.643LeuMet: 4.643 ± 1.35
4.643LeuAsn: 4.643 ± 1.872
4.643LeuPro: 4.643 ± 2.238
1.857LeuGln: 1.857 ± 1.014
5.571LeuArg: 5.571 ± 1.697
6.5LeuSer: 6.5 ± 1.375
7.428LeuThr: 7.428 ± 2.755
12.999LeuVal: 12.999 ± 3.951
3.714LeuTrp: 3.714 ± 2.289
0.929LeuTyr: 0.929 ± 0.868
0.0LeuXaa: 0.0 ± 0.0
Met
1.857MetAla: 1.857 ± 1.151
1.857MetCys: 1.857 ± 1.151
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.929MetPhe: 0.929 ± 0.739
0.929MetGly: 0.929 ± 0.995
1.857MetHis: 1.857 ± 1.036
0.0MetIle: 0.0 ± 0.0
1.857MetLys: 1.857 ± 1.014
4.643MetLeu: 4.643 ± 2.238
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.929MetGln: 0.929 ± 0.763
0.929MetArg: 0.929 ± 0.763
4.643MetSer: 4.643 ± 2.238
0.929MetThr: 0.929 ± 0.916
1.857MetVal: 1.857 ± 1.131
0.0MetTrp: 0.0 ± 0.0
0.929MetTyr: 0.929 ± 0.995
0.0MetXaa: 0.0 ± 0.0
Asn
5.571AsnAla: 5.571 ± 2.9
1.857AsnCys: 1.857 ± 1.177
0.0AsnAsp: 0.0 ± 0.0
1.857AsnGlu: 1.857 ± 1.1
5.571AsnPhe: 5.571 ± 1.978
1.857AsnGly: 1.857 ± 1.131
0.929AsnHis: 0.929 ± 0.864
2.786AsnIle: 2.786 ± 1.015
3.714AsnLys: 3.714 ± 2.807
3.714AsnLeu: 3.714 ± 1.74
0.0AsnMet: 0.0 ± 0.0
0.0AsnAsn: 0.0 ± 0.0
0.0AsnPro: 0.0 ± 0.0
3.714AsnGln: 3.714 ± 2.815
0.929AsnArg: 0.929 ± 0.868
4.643AsnSer: 4.643 ± 2.156
1.857AsnThr: 1.857 ± 0.998
6.5AsnVal: 6.5 ± 2.495
0.929AsnTrp: 0.929 ± 0.995
0.929AsnTyr: 0.929 ± 0.864
0.0AsnXaa: 0.0 ± 0.0
Pro
4.643ProAla: 4.643 ± 1.949
1.857ProCys: 1.857 ± 1.727
2.786ProAsp: 2.786 ± 1.124
0.0ProGlu: 0.0 ± 0.0
1.857ProPhe: 1.857 ± 0.909
0.929ProGly: 0.929 ± 0.995
0.0ProHis: 0.0 ± 0.0
2.786ProIle: 2.786 ± 1.168
0.929ProLys: 0.929 ± 0.916
1.857ProLeu: 1.857 ± 1.005
0.929ProMet: 0.929 ± 0.916
0.929ProAsn: 0.929 ± 0.916
0.929ProPro: 0.929 ± 0.995
0.929ProGln: 0.929 ± 0.864
1.857ProArg: 1.857 ± 1.527
7.428ProSer: 7.428 ± 1.33
0.929ProThr: 0.929 ± 0.916
1.857ProVal: 1.857 ± 0.909
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
1.857GlnAla: 1.857 ± 1.036
0.929GlnCys: 0.929 ± 0.916
0.0GlnAsp: 0.0 ± 0.0
0.0GlnGlu: 0.0 ± 0.0
0.929GlnPhe: 0.929 ± 0.864
4.643GlnGly: 4.643 ± 1.743
1.857GlnHis: 1.857 ± 1.737
1.857GlnIle: 1.857 ± 0.998
1.857GlnLys: 1.857 ± 1.1
3.714GlnLeu: 3.714 ± 2.005
0.929GlnMet: 0.929 ± 0.916
4.643GlnAsn: 4.643 ± 2.822
1.857GlnPro: 1.857 ± 1.1
2.786GlnGln: 2.786 ± 1.181
0.929GlnArg: 0.929 ± 0.995
1.857GlnSer: 1.857 ± 0.998
0.929GlnThr: 0.929 ± 0.995
2.786GlnVal: 2.786 ± 1.549
0.0GlnTrp: 0.0 ± 0.0
1.857GlnTyr: 1.857 ± 0.909
0.0GlnXaa: 0.0 ± 0.0
Arg
2.786ArgAla: 2.786 ± 1.617
0.929ArgCys: 0.929 ± 0.995
0.929ArgAsp: 0.929 ± 0.763
1.857ArgGlu: 1.857 ± 1.527
0.929ArgPhe: 0.929 ± 0.868
0.929ArgGly: 0.929 ± 0.995
0.929ArgHis: 0.929 ± 0.916
0.0ArgIle: 0.0 ± 0.0
0.929ArgLys: 0.929 ± 0.995
8.357ArgLeu: 8.357 ± 2.37
0.0ArgMet: 0.0 ± 0.0
2.786ArgAsn: 2.786 ± 1.827
2.786ArgPro: 2.786 ± 1.722
0.929ArgGln: 0.929 ± 0.995
4.643ArgArg: 4.643 ± 2.515
4.643ArgSer: 4.643 ± 0.922
1.857ArgThr: 1.857 ± 1.527
4.643ArgVal: 4.643 ± 2.186
0.0ArgTrp: 0.0 ± 0.0
2.786ArgTyr: 2.786 ± 1.57
0.0ArgXaa: 0.0 ± 0.0
Ser
3.714SerAla: 3.714 ± 1.938
0.929SerCys: 0.929 ± 0.868
2.786SerAsp: 2.786 ± 1.137
0.0SerGlu: 0.0 ± 0.0
2.786SerPhe: 2.786 ± 1.137
4.643SerGly: 4.643 ± 1.858
6.5SerHis: 6.5 ± 2.086
1.857SerIle: 1.857 ± 0.909
1.857SerLys: 1.857 ± 1.991
12.071SerLeu: 12.071 ± 3.113
2.786SerMet: 2.786 ± 1.584
2.786SerAsn: 2.786 ± 1.602
3.714SerPro: 3.714 ± 1.558
2.786SerGln: 2.786 ± 1.283
2.786SerArg: 2.786 ± 1.57
11.142SerSer: 11.142 ± 2.683
7.428SerThr: 7.428 ± 2.342
6.5SerVal: 6.5 ± 2.835
3.714SerTrp: 3.714 ± 0.936
2.786SerTyr: 2.786 ± 1.729
0.0SerXaa: 0.0 ± 0.0
Thr
3.714ThrAla: 3.714 ± 1.56
0.929ThrCys: 0.929 ± 0.739
0.929ThrAsp: 0.929 ± 0.739
1.857ThrGlu: 1.857 ± 1.107
0.929ThrPhe: 0.929 ± 0.868
3.714ThrGly: 3.714 ± 1.642
3.714ThrHis: 3.714 ± 1.18
2.786ThrIle: 2.786 ± 1.584
2.786ThrLys: 2.786 ± 1.793
9.285ThrLeu: 9.285 ± 3.03
1.857ThrMet: 1.857 ± 1.389
1.857ThrAsn: 1.857 ± 1.177
2.786ThrPro: 2.786 ± 1.375
3.714ThrGln: 3.714 ± 1.569
1.857ThrArg: 1.857 ± 0.909
5.571ThrSer: 5.571 ± 2.771
4.643ThrThr: 4.643 ± 1.776
6.5ThrVal: 6.5 ± 1.763
2.786ThrTrp: 2.786 ± 1.748
2.786ThrTyr: 2.786 ± 1.472
0.0ThrXaa: 0.0 ± 0.0
Val
4.643ValAla: 4.643 ± 1.203
2.786ValCys: 2.786 ± 1.722
2.786ValAsp: 2.786 ± 1.375
6.5ValGlu: 6.5 ± 1.896
6.5ValPhe: 6.5 ± 2.086
1.857ValGly: 1.857 ± 1.727
0.929ValHis: 0.929 ± 0.864
4.643ValIle: 4.643 ± 1.47
3.714ValLys: 3.714 ± 1.74
7.428ValLeu: 7.428 ± 2.449
2.786ValMet: 2.786 ± 1.181
4.643ValAsn: 4.643 ± 4.003
2.786ValPro: 2.786 ± 1.168
1.857ValGln: 1.857 ± 1.151
6.5ValArg: 6.5 ± 1.37
11.142ValSer: 11.142 ± 2.597
7.428ValThr: 7.428 ± 1.538
4.643ValVal: 4.643 ± 0.593
0.929ValTrp: 0.929 ± 0.995
2.786ValTyr: 2.786 ± 1.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.929TrpAla: 0.929 ± 0.763
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.929TrpGlu: 0.929 ± 0.868
3.714TrpPhe: 3.714 ± 2.289
2.786TrpGly: 2.786 ± 1.015
2.786TrpHis: 2.786 ± 1.116
2.786TrpIle: 2.786 ± 1.116
0.0TrpLys: 0.0 ± 0.0
1.857TrpLeu: 1.857 ± 0.972
0.929TrpMet: 0.929 ± 0.995
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.929TrpArg: 0.929 ± 0.868
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.857TrpTyr: 1.857 ± 1.201
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.857TyrAla: 1.857 ± 1.737
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
2.786TyrPhe: 2.786 ± 0.957
1.857TyrGly: 1.857 ± 0.972
0.929TyrHis: 0.929 ± 0.995
1.857TyrIle: 1.857 ± 1.201
0.929TyrLys: 0.929 ± 0.868
2.786TyrLeu: 2.786 ± 1.124
0.0TyrMet: 0.0 ± 0.0
2.786TyrAsn: 2.786 ± 0.957
0.0TyrPro: 0.0 ± 0.0
0.929TyrGln: 0.929 ± 0.995
1.857TyrArg: 1.857 ± 1.014
2.786TyrSer: 2.786 ± 1.124
4.643TyrThr: 4.643 ± 2.815
3.714TyrVal: 3.714 ± 1.046
0.929TyrTrp: 0.929 ± 0.868
0.929TyrTyr: 0.929 ± 0.739
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski