Amino acid dipepetide frequency for Paracoccus phage vB_PbeS_Pben1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.565AlaAla: 18.565 ± 1.665
0.892AlaCys: 0.892 ± 0.283
7.458AlaAsp: 7.458 ± 0.821
8.269AlaGlu: 8.269 ± 0.812
3.486AlaPhe: 3.486 ± 0.557
10.134AlaGly: 10.134 ± 0.999
2.108AlaHis: 2.108 ± 0.371
4.864AlaIle: 4.864 ± 0.659
3.324AlaLys: 3.324 ± 0.602
9.891AlaLeu: 9.891 ± 0.771
3.81AlaMet: 3.81 ± 0.478
3.243AlaAsn: 3.243 ± 0.531
6.648AlaPro: 6.648 ± 0.772
3.972AlaGln: 3.972 ± 0.565
9.891AlaArg: 9.891 ± 0.629
5.594AlaSer: 5.594 ± 0.744
6.161AlaThr: 6.161 ± 0.768
7.296AlaVal: 7.296 ± 0.669
2.756AlaTrp: 2.756 ± 0.478
3.0AlaTyr: 3.0 ± 0.493
0.0AlaXaa: 0.0 ± 0.0
Cys
0.73CysAla: 0.73 ± 0.26
0.162CysCys: 0.162 ± 0.107
0.486CysAsp: 0.486 ± 0.197
0.567CysGlu: 0.567 ± 0.197
0.73CysPhe: 0.73 ± 0.172
1.297CysGly: 1.297 ± 0.346
0.243CysHis: 0.243 ± 0.147
0.162CysIle: 0.162 ± 0.109
0.243CysLys: 0.243 ± 0.168
0.567CysLeu: 0.567 ± 0.24
0.324CysMet: 0.324 ± 0.176
0.243CysAsn: 0.243 ± 0.154
1.216CysPro: 1.216 ± 0.333
0.162CysGln: 0.162 ± 0.104
0.486CysArg: 0.486 ± 0.177
0.567CysSer: 0.567 ± 0.269
0.486CysThr: 0.486 ± 0.219
0.162CysVal: 0.162 ± 0.1
0.405CysTrp: 0.405 ± 0.186
0.243CysTyr: 0.243 ± 0.165
0.0CysXaa: 0.0 ± 0.0
Asp
6.81AspAla: 6.81 ± 0.555
0.892AspCys: 0.892 ± 0.23
4.135AspAsp: 4.135 ± 0.76
3.648AspGlu: 3.648 ± 0.518
2.594AspPhe: 2.594 ± 0.562
6.729AspGly: 6.729 ± 0.696
1.459AspHis: 1.459 ± 0.378
2.756AspIle: 2.756 ± 0.389
1.459AspLys: 1.459 ± 0.338
4.621AspLeu: 4.621 ± 0.66
2.513AspMet: 2.513 ± 0.461
0.73AspAsn: 0.73 ± 0.26
4.702AspPro: 4.702 ± 0.671
1.621AspGln: 1.621 ± 0.296
5.432AspArg: 5.432 ± 0.73
3.081AspSer: 3.081 ± 0.584
2.108AspThr: 2.108 ± 0.393
3.648AspVal: 3.648 ± 0.486
1.946AspTrp: 1.946 ± 0.53
1.216AspTyr: 1.216 ± 0.245
0.0AspXaa: 0.0 ± 0.0
Glu
9.485GluAla: 9.485 ± 0.76
0.649GluCys: 0.649 ± 0.202
3.567GluAsp: 3.567 ± 0.911
4.621GluGlu: 4.621 ± 0.896
2.108GluPhe: 2.108 ± 0.296
3.81GluGly: 3.81 ± 0.463
0.649GluHis: 0.649 ± 0.25
3.405GluIle: 3.405 ± 0.509
2.027GluLys: 2.027 ± 0.447
4.945GluLeu: 4.945 ± 0.711
1.946GluMet: 1.946 ± 0.415
1.297GluAsn: 1.297 ± 0.304
3.0GluPro: 3.0 ± 0.454
1.621GluGln: 1.621 ± 0.297
4.378GluArg: 4.378 ± 0.505
2.675GluSer: 2.675 ± 0.585
2.027GluThr: 2.027 ± 0.509
4.945GluVal: 4.945 ± 0.675
1.216GluTrp: 1.216 ± 0.339
1.297GluTyr: 1.297 ± 0.271
0.0GluXaa: 0.0 ± 0.0
Phe
3.243PheAla: 3.243 ± 0.341
0.567PheCys: 0.567 ± 0.22
2.27PheAsp: 2.27 ± 0.369
1.946PheGlu: 1.946 ± 0.428
1.378PhePhe: 1.378 ± 0.385
2.675PheGly: 2.675 ± 0.454
0.567PheHis: 0.567 ± 0.223
1.135PheIle: 1.135 ± 0.277
0.73PheLys: 0.73 ± 0.279
2.27PheLeu: 2.27 ± 0.392
0.486PheMet: 0.486 ± 0.149
0.73PheAsn: 0.73 ± 0.236
1.865PhePro: 1.865 ± 0.382
1.378PheGln: 1.378 ± 0.296
3.0PheArg: 3.0 ± 0.479
2.837PheSer: 2.837 ± 0.438
2.108PheThr: 2.108 ± 0.34
2.189PheVal: 2.189 ± 0.369
0.486PheTrp: 0.486 ± 0.231
0.973PheTyr: 0.973 ± 0.256
0.0PheXaa: 0.0 ± 0.0
Gly
9.972GlyAla: 9.972 ± 0.936
1.135GlyCys: 1.135 ± 0.372
5.432GlyAsp: 5.432 ± 0.548
5.026GlyGlu: 5.026 ± 0.598
2.513GlyPhe: 2.513 ± 0.541
8.593GlyGly: 8.593 ± 0.869
1.946GlyHis: 1.946 ± 0.331
3.972GlyIle: 3.972 ± 0.62
3.0GlyLys: 3.0 ± 0.523
7.702GlyLeu: 7.702 ± 1.016
2.837GlyMet: 2.837 ± 0.53
1.865GlyAsn: 1.865 ± 0.487
4.054GlyPro: 4.054 ± 0.606
3.729GlyGln: 3.729 ± 0.478
6.81GlyArg: 6.81 ± 0.894
5.107GlySer: 5.107 ± 0.763
5.107GlyThr: 5.107 ± 0.579
6.323GlyVal: 6.323 ± 0.828
2.27GlyTrp: 2.27 ± 0.582
1.135GlyTyr: 1.135 ± 0.374
0.0GlyXaa: 0.0 ± 0.0
His
1.784HisAla: 1.784 ± 0.476
0.324HisCys: 0.324 ± 0.14
1.54HisAsp: 1.54 ± 0.293
0.486HisGlu: 0.486 ± 0.188
0.811HisPhe: 0.811 ± 0.21
1.54HisGly: 1.54 ± 0.363
0.567HisHis: 0.567 ± 0.217
0.811HisIle: 0.811 ± 0.271
0.567HisLys: 0.567 ± 0.174
2.027HisLeu: 2.027 ± 0.375
0.649HisMet: 0.649 ± 0.226
0.649HisAsn: 0.649 ± 0.246
1.459HisPro: 1.459 ± 0.442
0.324HisGln: 0.324 ± 0.173
1.459HisArg: 1.459 ± 0.42
0.811HisSer: 0.811 ± 0.27
0.973HisThr: 0.973 ± 0.243
1.216HisVal: 1.216 ± 0.38
0.324HisTrp: 0.324 ± 0.217
0.649HisTyr: 0.649 ± 0.242
0.0HisXaa: 0.0 ± 0.0
Ile
6.81IleAla: 6.81 ± 0.817
0.649IleCys: 0.649 ± 0.308
3.162IleAsp: 3.162 ± 0.492
3.243IleGlu: 3.243 ± 0.503
1.216IlePhe: 1.216 ± 0.362
3.891IleGly: 3.891 ± 0.59
0.73IleHis: 0.73 ± 0.212
2.756IleIle: 2.756 ± 0.452
1.459IleLys: 1.459 ± 0.322
3.648IleLeu: 3.648 ± 0.509
1.054IleMet: 1.054 ± 0.271
1.702IleAsn: 1.702 ± 0.38
3.0IlePro: 3.0 ± 0.479
1.54IleGln: 1.54 ± 0.287
4.054IleArg: 4.054 ± 0.544
4.135IleSer: 4.135 ± 0.545
2.432IleThr: 2.432 ± 0.445
2.108IleVal: 2.108 ± 0.351
1.216IleTrp: 1.216 ± 0.338
1.702IleTyr: 1.702 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
3.729LysAla: 3.729 ± 0.735
0.243LysCys: 0.243 ± 0.147
1.54LysAsp: 1.54 ± 0.366
1.054LysGlu: 1.054 ± 0.268
0.567LysPhe: 0.567 ± 0.197
2.351LysGly: 2.351 ± 0.444
0.567LysHis: 0.567 ± 0.215
2.189LysIle: 2.189 ± 0.416
0.567LysLys: 0.567 ± 0.27
2.837LysLeu: 2.837 ± 0.427
0.811LysMet: 0.811 ± 0.252
1.135LysAsn: 1.135 ± 0.3
1.784LysPro: 1.784 ± 0.357
1.378LysGln: 1.378 ± 0.362
2.756LysArg: 2.756 ± 0.527
1.865LysSer: 1.865 ± 0.343
1.621LysThr: 1.621 ± 0.353
2.351LysVal: 2.351 ± 0.42
0.73LysTrp: 0.73 ± 0.212
0.324LysTyr: 0.324 ± 0.2
0.0LysXaa: 0.0 ± 0.0
Leu
10.377LeuAla: 10.377 ± 1.139
0.567LeuCys: 0.567 ± 0.218
4.945LeuAsp: 4.945 ± 0.798
3.729LeuGlu: 3.729 ± 0.579
2.189LeuPhe: 2.189 ± 0.37
6.323LeuGly: 6.323 ± 0.738
1.865LeuHis: 1.865 ± 0.424
3.729LeuIle: 3.729 ± 0.558
3.729LeuLys: 3.729 ± 0.731
6.729LeuLeu: 6.729 ± 0.849
1.946LeuMet: 1.946 ± 0.408
2.189LeuAsn: 2.189 ± 0.401
4.702LeuPro: 4.702 ± 0.684
3.567LeuGln: 3.567 ± 0.637
6.567LeuArg: 6.567 ± 0.58
7.377LeuSer: 7.377 ± 0.78
4.783LeuThr: 4.783 ± 0.539
4.621LeuVal: 4.621 ± 0.546
0.892LeuTrp: 0.892 ± 0.301
1.135LeuTyr: 1.135 ± 0.35
0.0LeuXaa: 0.0 ± 0.0
Met
3.324MetAla: 3.324 ± 0.472
0.243MetCys: 0.243 ± 0.138
1.378MetAsp: 1.378 ± 0.347
1.459MetGlu: 1.459 ± 0.29
0.567MetPhe: 0.567 ± 0.319
1.378MetGly: 1.378 ± 0.273
0.405MetHis: 0.405 ± 0.196
2.027MetIle: 2.027 ± 0.348
1.378MetLys: 1.378 ± 0.449
2.27MetLeu: 2.27 ± 0.341
0.73MetMet: 0.73 ± 0.288
1.54MetAsn: 1.54 ± 0.254
2.27MetPro: 2.27 ± 0.409
0.405MetGln: 0.405 ± 0.194
2.351MetArg: 2.351 ± 0.359
2.108MetSer: 2.108 ± 0.415
2.108MetThr: 2.108 ± 0.378
1.54MetVal: 1.54 ± 0.346
0.405MetTrp: 0.405 ± 0.176
0.162MetTyr: 0.162 ± 0.116
0.0MetXaa: 0.0 ± 0.0
Asn
3.405AsnAla: 3.405 ± 0.446
0.162AsnCys: 0.162 ± 0.123
1.702AsnAsp: 1.702 ± 0.365
1.216AsnGlu: 1.216 ± 0.32
1.135AsnPhe: 1.135 ± 0.284
2.513AsnGly: 2.513 ± 0.392
0.243AsnHis: 0.243 ± 0.136
1.135AsnIle: 1.135 ± 0.357
0.486AsnLys: 0.486 ± 0.198
1.459AsnLeu: 1.459 ± 0.367
0.486AsnMet: 0.486 ± 0.181
0.73AsnAsn: 0.73 ± 0.252
1.946AsnPro: 1.946 ± 0.319
1.054AsnGln: 1.054 ± 0.29
2.675AsnArg: 2.675 ± 0.551
2.27AsnSer: 2.27 ± 0.354
1.297AsnThr: 1.297 ± 0.252
1.135AsnVal: 1.135 ± 0.252
0.324AsnTrp: 0.324 ± 0.159
0.649AsnTyr: 0.649 ± 0.231
0.0AsnXaa: 0.0 ± 0.0
Pro
6.648ProAla: 6.648 ± 0.808
0.892ProCys: 0.892 ± 0.259
4.135ProAsp: 4.135 ± 0.587
5.026ProGlu: 5.026 ± 0.671
2.108ProPhe: 2.108 ± 0.367
6.729ProGly: 6.729 ± 0.733
1.216ProHis: 1.216 ± 0.357
2.675ProIle: 2.675 ± 0.47
2.108ProLys: 2.108 ± 0.541
4.135ProLeu: 4.135 ± 0.539
1.297ProMet: 1.297 ± 0.293
1.378ProAsn: 1.378 ± 0.336
3.0ProPro: 3.0 ± 0.595
1.297ProGln: 1.297 ± 0.381
3.567ProArg: 3.567 ± 0.534
3.81ProSer: 3.81 ± 0.652
2.675ProThr: 2.675 ± 0.419
3.729ProVal: 3.729 ± 0.669
0.811ProTrp: 0.811 ± 0.296
1.459ProTyr: 1.459 ± 0.288
0.0ProXaa: 0.0 ± 0.0
Gln
3.81GlnAla: 3.81 ± 0.479
0.0GlnCys: 0.0 ± 0.0
2.351GlnAsp: 2.351 ± 0.436
2.108GlnGlu: 2.108 ± 0.506
0.486GlnPhe: 0.486 ± 0.236
3.243GlnGly: 3.243 ± 0.491
0.892GlnHis: 0.892 ± 0.24
1.702GlnIle: 1.702 ± 0.329
1.459GlnLys: 1.459 ± 0.325
2.594GlnLeu: 2.594 ± 0.519
1.297GlnMet: 1.297 ± 0.299
0.405GlnAsn: 0.405 ± 0.141
1.54GlnPro: 1.54 ± 0.296
1.54GlnGln: 1.54 ± 0.384
3.081GlnArg: 3.081 ± 0.534
1.702GlnSer: 1.702 ± 0.388
1.135GlnThr: 1.135 ± 0.252
1.946GlnVal: 1.946 ± 0.488
0.73GlnTrp: 0.73 ± 0.222
0.243GlnTyr: 0.243 ± 0.144
0.0GlnXaa: 0.0 ± 0.0
Arg
9.485ArgAla: 9.485 ± 0.899
0.811ArgCys: 0.811 ± 0.311
4.783ArgAsp: 4.783 ± 0.647
4.783ArgGlu: 4.783 ± 0.645
2.919ArgPhe: 2.919 ± 0.465
6.729ArgGly: 6.729 ± 0.832
1.946ArgHis: 1.946 ± 0.399
4.216ArgIle: 4.216 ± 0.535
2.756ArgLys: 2.756 ± 0.43
7.54ArgLeu: 7.54 ± 0.876
1.865ArgMet: 1.865 ± 0.441
3.162ArgAsn: 3.162 ± 0.608
5.27ArgPro: 5.27 ± 0.852
2.351ArgGln: 2.351 ± 0.452
7.377ArgArg: 7.377 ± 1.171
4.783ArgSer: 4.783 ± 0.558
3.324ArgThr: 3.324 ± 0.411
4.783ArgVal: 4.783 ± 0.656
2.513ArgTrp: 2.513 ± 0.478
1.459ArgTyr: 1.459 ± 0.335
0.0ArgXaa: 0.0 ± 0.0
Ser
6.972SerAla: 6.972 ± 0.649
0.324SerCys: 0.324 ± 0.172
3.324SerAsp: 3.324 ± 0.494
4.135SerGlu: 4.135 ± 0.506
2.189SerPhe: 2.189 ± 0.486
6.648SerGly: 6.648 ± 0.739
0.892SerHis: 0.892 ± 0.232
3.324SerIle: 3.324 ± 0.481
1.378SerLys: 1.378 ± 0.356
5.351SerLeu: 5.351 ± 0.707
2.351SerMet: 2.351 ± 0.378
1.135SerAsn: 1.135 ± 0.331
3.405SerPro: 3.405 ± 0.468
1.135SerGln: 1.135 ± 0.302
4.864SerArg: 4.864 ± 0.591
4.135SerSer: 4.135 ± 0.613
3.0SerThr: 3.0 ± 0.5
3.324SerVal: 3.324 ± 0.576
1.946SerTrp: 1.946 ± 0.349
1.702SerTyr: 1.702 ± 0.389
0.0SerXaa: 0.0 ± 0.0
Thr
4.783ThrAla: 4.783 ± 0.645
0.243ThrCys: 0.243 ± 0.117
3.243ThrAsp: 3.243 ± 0.499
2.351ThrGlu: 2.351 ± 0.482
2.189ThrPhe: 2.189 ± 0.409
6.08ThrGly: 6.08 ± 0.629
0.811ThrHis: 0.811 ± 0.268
3.486ThrIle: 3.486 ± 0.468
1.459ThrLys: 1.459 ± 0.366
4.216ThrLeu: 4.216 ± 0.576
0.892ThrMet: 0.892 ± 0.277
1.216ThrAsn: 1.216 ± 0.381
2.756ThrPro: 2.756 ± 0.421
1.459ThrGln: 1.459 ± 0.318
3.243ThrArg: 3.243 ± 0.504
2.513ThrSer: 2.513 ± 0.406
2.189ThrThr: 2.189 ± 0.352
4.297ThrVal: 4.297 ± 0.742
1.054ThrTrp: 1.054 ± 0.248
1.135ThrTyr: 1.135 ± 0.333
0.0ThrXaa: 0.0 ± 0.0
Val
6.729ValAla: 6.729 ± 0.689
0.243ValCys: 0.243 ± 0.154
3.972ValAsp: 3.972 ± 0.478
4.135ValGlu: 4.135 ± 0.405
2.189ValPhe: 2.189 ± 0.445
4.702ValGly: 4.702 ± 0.687
0.973ValHis: 0.973 ± 0.264
3.648ValIle: 3.648 ± 0.633
1.135ValLys: 1.135 ± 0.372
5.756ValLeu: 5.756 ± 0.759
1.621ValMet: 1.621 ± 0.359
1.702ValAsn: 1.702 ± 0.352
3.081ValPro: 3.081 ± 0.434
2.189ValGln: 2.189 ± 0.465
6.242ValArg: 6.242 ± 0.68
4.135ValSer: 4.135 ± 0.627
4.216ValThr: 4.216 ± 0.705
3.891ValVal: 3.891 ± 0.765
1.216ValTrp: 1.216 ± 0.346
0.892ValTyr: 0.892 ± 0.303
0.0ValXaa: 0.0 ± 0.0
Trp
2.919TrpAla: 2.919 ± 0.458
0.243TrpCys: 0.243 ± 0.125
1.054TrpAsp: 1.054 ± 0.355
0.892TrpGlu: 0.892 ± 0.268
0.811TrpPhe: 0.811 ± 0.27
1.459TrpGly: 1.459 ± 0.401
0.324TrpHis: 0.324 ± 0.223
1.621TrpIle: 1.621 ± 0.297
0.649TrpLys: 0.649 ± 0.2
1.865TrpLeu: 1.865 ± 0.459
0.324TrpMet: 0.324 ± 0.139
0.649TrpAsn: 0.649 ± 0.223
1.621TrpPro: 1.621 ± 0.415
1.054TrpGln: 1.054 ± 0.31
2.594TrpArg: 2.594 ± 0.521
1.054TrpSer: 1.054 ± 0.273
0.811TrpThr: 0.811 ± 0.286
1.378TrpVal: 1.378 ± 0.324
0.243TrpTrp: 0.243 ± 0.128
0.567TrpTyr: 0.567 ± 0.226
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.784TyrAla: 1.784 ± 0.454
0.243TyrCys: 0.243 ± 0.143
1.621TyrAsp: 1.621 ± 0.314
0.973TyrGlu: 0.973 ± 0.281
0.649TyrPhe: 0.649 ± 0.165
1.702TyrGly: 1.702 ± 0.418
0.567TyrHis: 0.567 ± 0.188
0.892TyrIle: 0.892 ± 0.308
0.567TyrLys: 0.567 ± 0.223
1.54TyrLeu: 1.54 ± 0.34
0.73TyrMet: 0.73 ± 0.197
0.324TyrAsn: 0.324 ± 0.153
1.378TyrPro: 1.378 ± 0.339
0.486TyrGln: 0.486 ± 0.191
2.027TyrArg: 2.027 ± 0.416
0.973TyrSer: 0.973 ± 0.391
1.054TyrThr: 1.054 ± 0.252
1.784TyrVal: 1.784 ± 0.386
0.649TyrTrp: 0.649 ± 0.219
0.405TyrTyr: 0.405 ± 0.204
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (12336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski