Amino acid dipepetide frequency for Aeromicrobium terrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.452AlaAla: 17.452 ± 0.221
0.911AlaCys: 0.911 ± 0.032
8.605AlaAsp: 8.605 ± 0.095
8.09AlaGlu: 8.09 ± 0.15
3.733AlaPhe: 3.733 ± 0.074
11.294AlaGly: 11.294 ± 0.119
2.412AlaHis: 2.412 ± 0.055
4.904AlaIle: 4.904 ± 0.069
3.184AlaLys: 3.184 ± 0.078
12.64AlaLeu: 12.64 ± 0.14
2.915AlaMet: 2.915 ± 0.059
2.086AlaAsn: 2.086 ± 0.042
5.296AlaPro: 5.296 ± 0.083
3.493AlaGln: 3.493 ± 0.068
8.417AlaArg: 8.417 ± 0.104
6.413AlaSer: 6.413 ± 0.1
7.243AlaThr: 7.243 ± 0.091
11.476AlaVal: 11.476 ± 0.129
1.895AlaTrp: 1.895 ± 0.043
2.382AlaTyr: 2.382 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.782CysAla: 0.782 ± 0.031
0.068CysCys: 0.068 ± 0.008
0.451CysAsp: 0.451 ± 0.025
0.384CysGlu: 0.384 ± 0.024
0.217CysPhe: 0.217 ± 0.016
0.816CysGly: 0.816 ± 0.034
0.187CysHis: 0.187 ± 0.016
0.225CysIle: 0.225 ± 0.016
0.144CysLys: 0.144 ± 0.012
0.589CysLeu: 0.589 ± 0.026
0.111CysMet: 0.111 ± 0.011
0.121CysAsn: 0.121 ± 0.01
0.409CysPro: 0.409 ± 0.022
0.179CysGln: 0.179 ± 0.013
0.498CysArg: 0.498 ± 0.021
0.413CysSer: 0.413 ± 0.021
0.458CysThr: 0.458 ± 0.024
0.632CysVal: 0.632 ± 0.031
0.098CysTrp: 0.098 ± 0.009
0.116CysTyr: 0.116 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.853AspAla: 8.853 ± 0.115
0.355AspCys: 0.355 ± 0.017
5.577AspAsp: 5.577 ± 0.098
4.797AspGlu: 4.797 ± 0.082
1.714AspPhe: 1.714 ± 0.048
6.678AspGly: 6.678 ± 0.082
1.65AspHis: 1.65 ± 0.042
2.108AspIle: 2.108 ± 0.052
1.292AspLys: 1.292 ± 0.045
7.198AspLeu: 7.198 ± 0.084
0.857AspMet: 0.857 ± 0.03
0.989AspAsn: 0.989 ± 0.045
4.358AspPro: 4.358 ± 0.067
1.864AspGln: 1.864 ± 0.039
4.905AspArg: 4.905 ± 0.075
2.629AspSer: 2.629 ± 0.054
3.158AspThr: 3.158 ± 0.074
7.319AspVal: 7.319 ± 0.093
0.953AspTrp: 0.953 ± 0.038
1.141AspTyr: 1.141 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.371GluAla: 7.371 ± 0.134
0.347GluCys: 0.347 ± 0.022
3.077GluAsp: 3.077 ± 0.062
3.31GluGlu: 3.31 ± 0.082
1.447GluPhe: 1.447 ± 0.042
4.143GluGly: 4.143 ± 0.072
1.788GluHis: 1.788 ± 0.043
2.766GluIle: 2.766 ± 0.056
1.722GluLys: 1.722 ± 0.055
6.588GluLeu: 6.588 ± 0.098
1.073GluMet: 1.073 ± 0.031
1.108GluAsn: 1.108 ± 0.033
3.341GluPro: 3.341 ± 0.075
2.319GluGln: 2.319 ± 0.058
5.291GluArg: 5.291 ± 0.095
2.945GluSer: 2.945 ± 0.061
3.056GluThr: 3.056 ± 0.056
5.152GluVal: 5.152 ± 0.077
0.778GluTrp: 0.778 ± 0.03
1.103GluTyr: 1.103 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.787PheAla: 3.787 ± 0.071
0.278PheCys: 0.278 ± 0.017
2.341PheAsp: 2.341 ± 0.052
1.706PheGlu: 1.706 ± 0.045
0.963PhePhe: 0.963 ± 0.035
3.226PheGly: 3.226 ± 0.063
0.604PheHis: 0.604 ± 0.028
0.931PheIle: 0.931 ± 0.036
0.558PheLys: 0.558 ± 0.027
2.525PheLeu: 2.525 ± 0.053
0.504PheMet: 0.504 ± 0.024
0.623PheAsn: 0.623 ± 0.028
1.294PhePro: 1.294 ± 0.036
0.66PheGln: 0.66 ± 0.026
1.754PheArg: 1.754 ± 0.04
1.679PheSer: 1.679 ± 0.048
2.089PheThr: 2.089 ± 0.049
2.787PheVal: 2.787 ± 0.058
0.446PheTrp: 0.446 ± 0.022
0.658PheTyr: 0.658 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
9.628GlyAla: 9.628 ± 0.098
0.698GlyCys: 0.698 ± 0.03
5.598GlyAsp: 5.598 ± 0.096
4.86GlyGlu: 4.86 ± 0.071
3.175GlyPhe: 3.175 ± 0.061
7.924GlyGly: 7.924 ± 0.148
2.072GlyHis: 2.072 ± 0.048
4.108GlyIle: 4.108 ± 0.074
2.418GlyLys: 2.418 ± 0.051
9.035GlyLeu: 9.035 ± 0.107
1.967GlyMet: 1.967 ± 0.053
1.658GlyAsn: 1.658 ± 0.046
4.345GlyPro: 4.345 ± 0.079
2.484GlyGln: 2.484 ± 0.051
6.532GlyArg: 6.532 ± 0.087
5.539GlySer: 5.539 ± 0.081
5.596GlyThr: 5.596 ± 0.092
7.978GlyVal: 7.978 ± 0.099
1.608GlyTrp: 1.608 ± 0.046
2.059GlyTyr: 2.059 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.497HisAla: 2.497 ± 0.058
0.177HisCys: 0.177 ± 0.014
1.714HisAsp: 1.714 ± 0.043
1.333HisGlu: 1.333 ± 0.038
0.608HisPhe: 0.608 ± 0.029
2.172HisGly: 2.172 ± 0.049
0.711HisHis: 0.711 ± 0.032
0.562HisIle: 0.562 ± 0.024
0.327HisLys: 0.327 ± 0.018
2.31HisLeu: 2.31 ± 0.049
0.333HisMet: 0.333 ± 0.017
0.345HisAsn: 0.345 ± 0.018
1.543HisPro: 1.543 ± 0.04
0.63HisGln: 0.63 ± 0.026
1.767HisArg: 1.767 ± 0.043
0.917HisSer: 0.917 ± 0.032
1.127HisThr: 1.127 ± 0.035
2.201HisVal: 2.201 ± 0.052
0.31HisTrp: 0.31 ± 0.018
0.438HisTyr: 0.438 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.504IleAla: 5.504 ± 0.083
0.334IleCys: 0.334 ± 0.018
3.205IleAsp: 3.205 ± 0.059
2.633IleGlu: 2.633 ± 0.053
0.986IlePhe: 0.986 ± 0.037
4.38IleGly: 4.38 ± 0.076
0.734IleHis: 0.734 ± 0.026
1.342IleIle: 1.342 ± 0.036
0.918IleLys: 0.918 ± 0.039
2.962IleLeu: 2.962 ± 0.058
0.547IleMet: 0.547 ± 0.026
0.872IleAsn: 0.872 ± 0.031
1.938IlePro: 1.938 ± 0.05
0.86IleGln: 0.86 ± 0.03
2.371IleArg: 2.371 ± 0.055
2.111IleSer: 2.111 ± 0.043
2.601IleThr: 2.601 ± 0.049
3.903IleVal: 3.903 ± 0.065
0.426IleTrp: 0.426 ± 0.021
0.689IleTyr: 0.689 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.312LysAla: 3.312 ± 0.097
0.122LysCys: 0.122 ± 0.011
1.522LysAsp: 1.522 ± 0.041
1.222LysGlu: 1.222 ± 0.042
0.516LysPhe: 0.516 ± 0.025
2.028LysGly: 2.028 ± 0.047
0.558LysHis: 0.558 ± 0.025
1.072LysIle: 1.072 ± 0.039
1.074LysLys: 1.074 ± 0.055
2.105LysLeu: 2.105 ± 0.053
0.398LysMet: 0.398 ± 0.024
0.659LysAsn: 0.659 ± 0.029
1.521LysPro: 1.521 ± 0.049
0.85LysGln: 0.85 ± 0.034
1.695LysArg: 1.695 ± 0.045
1.295LysSer: 1.295 ± 0.038
1.54LysThr: 1.54 ± 0.049
2.218LysVal: 2.218 ± 0.058
0.245LysTrp: 0.245 ± 0.016
0.482LysTyr: 0.482 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.83LeuAla: 13.83 ± 0.16
0.645LeuCys: 0.645 ± 0.025
7.401LeuAsp: 7.401 ± 0.103
5.618LeuGlu: 5.618 ± 0.094
2.611LeuPhe: 2.611 ± 0.06
9.274LeuGly: 9.274 ± 0.122
2.011LeuHis: 2.011 ± 0.045
3.341LeuIle: 3.341 ± 0.065
2.292LeuLys: 2.292 ± 0.053
9.896LeuLeu: 9.896 ± 0.139
1.803LeuMet: 1.803 ± 0.041
1.723LeuAsn: 1.723 ± 0.04
5.258LeuPro: 5.258 ± 0.074
2.491LeuGln: 2.491 ± 0.052
7.276LeuArg: 7.276 ± 0.118
5.387LeuSer: 5.387 ± 0.066
6.317LeuThr: 6.317 ± 0.091
10.142LeuVal: 10.142 ± 0.137
1.113LeuTrp: 1.113 ± 0.039
1.542LeuTyr: 1.542 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.44MetAla: 2.44 ± 0.043
0.119MetCys: 0.119 ± 0.011
0.989MetAsp: 0.989 ± 0.029
0.81MetGlu: 0.81 ± 0.033
0.586MetPhe: 0.586 ± 0.026
1.445MetGly: 1.445 ± 0.04
0.415MetHis: 0.415 ± 0.02
0.799MetIle: 0.799 ± 0.025
0.543MetLys: 0.543 ± 0.022
1.893MetLeu: 1.893 ± 0.046
0.358MetMet: 0.358 ± 0.02
0.465MetAsn: 0.465 ± 0.021
1.161MetPro: 1.161 ± 0.038
0.519MetGln: 0.519 ± 0.025
1.591MetArg: 1.591 ± 0.041
1.515MetSer: 1.515 ± 0.036
1.836MetThr: 1.836 ± 0.045
1.54MetVal: 1.54 ± 0.039
0.185MetTrp: 0.185 ± 0.014
0.284MetTyr: 0.284 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.323AsnAla: 2.323 ± 0.05
0.12AsnCys: 0.12 ± 0.01
1.217AsnAsp: 1.217 ± 0.037
0.894AsnGlu: 0.894 ± 0.033
0.466AsnPhe: 0.466 ± 0.022
1.845AsnGly: 1.845 ± 0.055
0.4AsnHis: 0.4 ± 0.019
0.783AsnIle: 0.783 ± 0.03
0.444AsnLys: 0.444 ± 0.026
1.958AsnLeu: 1.958 ± 0.048
0.259AsnMet: 0.259 ± 0.017
0.432AsnAsn: 0.432 ± 0.024
1.391AsnPro: 1.391 ± 0.038
0.574AsnGln: 0.574 ± 0.024
1.337AsnArg: 1.337 ± 0.033
0.807AsnSer: 0.807 ± 0.028
1.08AsnThr: 1.08 ± 0.038
1.749AsnVal: 1.749 ± 0.053
0.24AsnTrp: 0.24 ± 0.016
0.412AsnTyr: 0.412 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.066ProAla: 6.066 ± 0.081
0.279ProCys: 0.279 ± 0.018
4.542ProAsp: 4.542 ± 0.078
3.776ProGlu: 3.776 ± 0.066
1.637ProPhe: 1.637 ± 0.048
4.939ProGly: 4.939 ± 0.077
1.141ProHis: 1.141 ± 0.036
1.926ProIle: 1.926 ± 0.047
1.348ProLys: 1.348 ± 0.041
4.559ProLeu: 4.559 ± 0.079
1.065ProMet: 1.065 ± 0.034
1.004ProAsn: 1.004 ± 0.031
2.553ProPro: 2.553 ± 0.061
1.422ProGln: 1.422 ± 0.036
3.295ProArg: 3.295 ± 0.064
3.15ProSer: 3.15 ± 0.059
3.273ProThr: 3.273 ± 0.062
4.847ProVal: 4.847 ± 0.079
0.859ProTrp: 0.859 ± 0.033
1.166ProTyr: 1.166 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.579GlnAla: 3.579 ± 0.069
0.165GlnCys: 0.165 ± 0.013
1.358GlnAsp: 1.358 ± 0.038
1.4GlnGlu: 1.4 ± 0.045
0.747GlnPhe: 0.747 ± 0.033
2.002GlnGly: 2.002 ± 0.051
0.757GlnHis: 0.757 ± 0.034
1.203GlnIle: 1.203 ± 0.042
0.763GlnLys: 0.763 ± 0.032
3.069GlnLeu: 3.069 ± 0.054
0.587GlnMet: 0.587 ± 0.023
0.536GlnAsn: 0.536 ± 0.026
1.462GlnPro: 1.462 ± 0.041
1.087GlnGln: 1.087 ± 0.035
2.493GlnArg: 2.493 ± 0.056
1.317GlnSer: 1.317 ± 0.036
1.448GlnThr: 1.448 ± 0.04
2.776GlnVal: 2.776 ± 0.049
0.431GlnTrp: 0.431 ± 0.023
0.585GlnTyr: 0.585 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.971ArgAla: 7.971 ± 0.098
0.432ArgCys: 0.432 ± 0.021
4.587ArgAsp: 4.587 ± 0.08
4.566ArgGlu: 4.566 ± 0.093
2.324ArgPhe: 2.324 ± 0.048
5.157ArgGly: 5.157 ± 0.078
1.721ArgHis: 1.721 ± 0.046
3.227ArgIle: 3.227 ± 0.056
1.693ArgLys: 1.693 ± 0.049
7.815ArgLeu: 7.815 ± 0.097
1.776ArgMet: 1.776 ± 0.04
1.274ArgAsn: 1.274 ± 0.036
3.865ArgPro: 3.865 ± 0.075
2.104ArgGln: 2.104 ± 0.052
6.827ArgArg: 6.827 ± 0.118
4.093ArgSer: 4.093 ± 0.074
4.469ArgThr: 4.469 ± 0.066
5.967ArgVal: 5.967 ± 0.091
1.271ArgTrp: 1.271 ± 0.038
1.554ArgTyr: 1.554 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.302SerAla: 6.302 ± 0.095
0.396SerCys: 0.396 ± 0.026
3.365SerAsp: 3.365 ± 0.066
2.658SerGlu: 2.658 ± 0.054
1.82SerPhe: 1.82 ± 0.043
5.518SerGly: 5.518 ± 0.074
1.086SerHis: 1.086 ± 0.039
2.327SerIle: 2.327 ± 0.056
1.303SerLys: 1.303 ± 0.041
5.16SerLeu: 5.16 ± 0.064
1.44SerMet: 1.44 ± 0.036
1.037SerAsn: 1.037 ± 0.032
2.84SerPro: 2.84 ± 0.066
1.355SerGln: 1.355 ± 0.037
3.693SerArg: 3.693 ± 0.068
3.529SerSer: 3.529 ± 0.08
3.708SerThr: 3.708 ± 0.081
4.795SerVal: 4.795 ± 0.081
0.893SerTrp: 0.893 ± 0.03
1.229SerTyr: 1.229 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.016ThrAla: 7.016 ± 0.1
0.458ThrCys: 0.458 ± 0.023
3.83ThrAsp: 3.83 ± 0.061
3.059ThrGlu: 3.059 ± 0.05
2.156ThrPhe: 2.156 ± 0.06
5.678ThrGly: 5.678 ± 0.082
1.13ThrHis: 1.13 ± 0.031
2.79ThrIle: 2.79 ± 0.056
1.504ThrLys: 1.504 ± 0.048
5.954ThrLeu: 5.954 ± 0.085
1.187ThrMet: 1.187 ± 0.036
1.197ThrAsn: 1.197 ± 0.041
3.52ThrPro: 3.52 ± 0.069
1.527ThrGln: 1.527 ± 0.04
3.779ThrArg: 3.779 ± 0.064
3.745ThrSer: 3.745 ± 0.071
4.179ThrThr: 4.179 ± 0.085
6.071ThrVal: 6.071 ± 0.089
1.011ThrTrp: 1.011 ± 0.032
1.548ThrTyr: 1.548 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
12.126ValAla: 12.126 ± 0.126
0.708ValCys: 0.708 ± 0.028
6.725ValAsp: 6.725 ± 0.084
5.838ValGlu: 5.838 ± 0.084
2.496ValPhe: 2.496 ± 0.051
7.78ValGly: 7.78 ± 0.101
1.957ValHis: 1.957 ± 0.046
3.751ValIle: 3.751 ± 0.07
2.176ValLys: 2.176 ± 0.055
9.967ValLeu: 9.967 ± 0.133
1.728ValMet: 1.728 ± 0.042
1.885ValAsn: 1.885 ± 0.043
5.032ValPro: 5.032 ± 0.072
2.312ValGln: 2.312 ± 0.051
6.461ValArg: 6.461 ± 0.088
4.957ValSer: 4.957 ± 0.06
6.05ValThr: 6.05 ± 0.083
10.573ValVal: 10.573 ± 0.127
1.102ValTrp: 1.102 ± 0.038
1.536ValTyr: 1.536 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.515TrpAla: 1.515 ± 0.043
0.133TrpCys: 0.133 ± 0.013
0.819TrpAsp: 0.819 ± 0.033
0.624TrpGlu: 0.624 ± 0.028
0.529TrpPhe: 0.529 ± 0.024
1.055TrpGly: 1.055 ± 0.032
0.334TrpHis: 0.334 ± 0.016
0.617TrpIle: 0.617 ± 0.023
0.353TrpLys: 0.353 ± 0.02
1.672TrpLeu: 1.672 ± 0.045
0.332TrpMet: 0.332 ± 0.021
0.349TrpAsn: 0.349 ± 0.021
0.739TrpPro: 0.739 ± 0.029
0.49TrpGln: 0.49 ± 0.024
1.181TrpArg: 1.181 ± 0.033
0.976TrpSer: 0.976 ± 0.029
0.985TrpThr: 0.985 ± 0.028
1.165TrpVal: 1.165 ± 0.036
0.358TrpTrp: 0.358 ± 0.019
0.311TrpTyr: 0.311 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.487TyrAla: 2.487 ± 0.051
0.153TyrCys: 0.153 ± 0.011
1.473TyrAsp: 1.473 ± 0.048
1.147TyrGlu: 1.147 ± 0.035
0.683TyrPhe: 0.683 ± 0.031
1.93TyrGly: 1.93 ± 0.047
0.351TyrHis: 0.351 ± 0.02
0.535TyrIle: 0.535 ± 0.023
0.379TyrLys: 0.379 ± 0.021
2.076TyrLeu: 2.076 ± 0.048
0.25TyrMet: 0.25 ± 0.017
0.368TyrAsn: 0.368 ± 0.019
0.983TyrPro: 0.983 ± 0.029
0.544TyrGln: 0.544 ± 0.026
1.53TyrArg: 1.53 ± 0.045
1.038TyrSer: 1.038 ± 0.037
1.127TyrThr: 1.127 ± 0.043
1.869TyrVal: 1.869 ± 0.041
0.313TyrTrp: 0.313 ± 0.016
0.445TyrTyr: 0.445 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3087 proteins (983032 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski