Amino acid dipepetide frequency for Microbacterium foliorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.101AlaAla: 20.101 ± 0.244
0.622AlaCys: 0.622 ± 0.027
8.844AlaAsp: 8.844 ± 0.128
8.02AlaGlu: 8.02 ± 0.105
3.934AlaPhe: 3.934 ± 0.06
11.666AlaGly: 11.666 ± 0.118
2.508AlaHis: 2.508 ± 0.053
6.019AlaIle: 6.019 ± 0.092
2.576AlaLys: 2.576 ± 0.067
14.144AlaLeu: 14.144 ± 0.142
2.61AlaMet: 2.61 ± 0.052
2.175AlaAsn: 2.175 ± 0.048
6.538AlaPro: 6.538 ± 0.098
3.918AlaGln: 3.918 ± 0.069
8.905AlaArg: 8.905 ± 0.12
7.811AlaSer: 7.811 ± 0.114
7.579AlaThr: 7.579 ± 0.101
11.757AlaVal: 11.757 ± 0.126
1.863AlaTrp: 1.863 ± 0.044
2.377AlaTyr: 2.377 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.653CysAla: 0.653 ± 0.022
0.036CysCys: 0.036 ± 0.006
0.319CysAsp: 0.319 ± 0.02
0.238CysGlu: 0.238 ± 0.017
0.17CysPhe: 0.17 ± 0.01
0.484CysGly: 0.484 ± 0.02
0.097CysHis: 0.097 ± 0.011
0.188CysIle: 0.188 ± 0.015
0.046CysLys: 0.046 ± 0.008
0.411CysLeu: 0.411 ± 0.018
0.083CysMet: 0.083 ± 0.011
0.082CysAsn: 0.082 ± 0.009
0.253CysPro: 0.253 ± 0.016
0.108CysGln: 0.108 ± 0.01
0.281CysArg: 0.281 ± 0.016
0.304CysSer: 0.304 ± 0.02
0.31CysThr: 0.31 ± 0.018
0.437CysVal: 0.437 ± 0.023
0.057CysTrp: 0.057 ± 0.008
0.085CysTyr: 0.085 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
9.851AspAla: 9.851 ± 0.12
0.224AspCys: 0.224 ± 0.016
4.928AspAsp: 4.928 ± 0.096
4.537AspGlu: 4.537 ± 0.081
1.745AspPhe: 1.745 ± 0.041
6.473AspGly: 6.473 ± 0.093
1.125AspHis: 1.125 ± 0.034
2.626AspIle: 2.626 ± 0.061
0.95AspLys: 0.95 ± 0.033
6.485AspLeu: 6.485 ± 0.088
0.831AspMet: 0.831 ± 0.03
0.968AspAsn: 0.968 ± 0.032
4.15AspPro: 4.15 ± 0.069
1.54AspGln: 1.54 ± 0.038
4.576AspArg: 4.576 ± 0.071
2.809AspSer: 2.809 ± 0.054
3.003AspThr: 3.003 ± 0.053
5.576AspVal: 5.576 ± 0.073
0.969AspTrp: 0.969 ± 0.034
1.231AspTyr: 1.231 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.829GluAla: 6.829 ± 0.093
0.232GluCys: 0.232 ± 0.014
2.732GluAsp: 2.732 ± 0.064
2.959GluGlu: 2.959 ± 0.071
1.741GluPhe: 1.741 ± 0.043
4.299GluGly: 4.299 ± 0.074
1.383GluHis: 1.383 ± 0.04
2.946GluIle: 2.946 ± 0.054
1.467GluLys: 1.467 ± 0.049
6.062GluLeu: 6.062 ± 0.079
0.995GluMet: 0.995 ± 0.029
1.339GluAsn: 1.339 ± 0.038
2.887GluPro: 2.887 ± 0.068
2.089GluGln: 2.089 ± 0.049
4.999GluArg: 4.999 ± 0.084
3.154GluSer: 3.154 ± 0.061
3.222GluThr: 3.222 ± 0.061
4.642GluVal: 4.642 ± 0.081
0.895GluTrp: 0.895 ± 0.032
1.213GluTyr: 1.213 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
4.38PheAla: 4.38 ± 0.074
0.151PheCys: 0.151 ± 0.011
2.432PheAsp: 2.432 ± 0.044
1.662PheGlu: 1.662 ± 0.042
1.103PhePhe: 1.103 ± 0.037
3.37PheGly: 3.37 ± 0.07
0.541PheHis: 0.541 ± 0.022
1.243PheIle: 1.243 ± 0.041
0.406PheLys: 0.406 ± 0.019
2.945PheLeu: 2.945 ± 0.067
0.453PheMet: 0.453 ± 0.022
0.622PheAsn: 0.622 ± 0.028
1.389PhePro: 1.389 ± 0.033
0.773PheGln: 0.773 ± 0.029
1.855PheArg: 1.855 ± 0.047
1.853PheSer: 1.853 ± 0.044
2.206PheThr: 2.206 ± 0.047
2.867PheVal: 2.867 ± 0.054
0.513PheTrp: 0.513 ± 0.021
0.651PheTyr: 0.651 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
11.045GlyAla: 11.045 ± 0.131
0.538GlyCys: 0.538 ± 0.021
5.267GlyAsp: 5.267 ± 0.086
5.024GlyGlu: 5.024 ± 0.074
3.236GlyPhe: 3.236 ± 0.055
7.602GlyGly: 7.602 ± 0.133
1.803GlyHis: 1.803 ± 0.044
5.051GlyIle: 5.051 ± 0.072
1.88GlyLys: 1.88 ± 0.048
8.621GlyLeu: 8.621 ± 0.102
1.997GlyMet: 1.997 ± 0.043
1.577GlyAsn: 1.577 ± 0.049
3.615GlyPro: 3.615 ± 0.057
2.287GlyGln: 2.287 ± 0.051
6.108GlyArg: 6.108 ± 0.073
5.586GlySer: 5.586 ± 0.081
5.653GlyThr: 5.653 ± 0.116
7.989GlyVal: 7.989 ± 0.098
1.613GlyTrp: 1.613 ± 0.04
2.248GlyTyr: 2.248 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.346HisAla: 2.346 ± 0.052
0.089HisCys: 0.089 ± 0.009
1.365HisAsp: 1.365 ± 0.037
1.158HisGlu: 1.158 ± 0.032
0.55HisPhe: 0.55 ± 0.023
1.94HisGly: 1.94 ± 0.044
0.514HisHis: 0.514 ± 0.022
0.758HisIle: 0.758 ± 0.029
0.255HisLys: 0.255 ± 0.016
1.955HisLeu: 1.955 ± 0.05
0.288HisMet: 0.288 ± 0.017
0.36HisAsn: 0.36 ± 0.019
1.5HisPro: 1.5 ± 0.043
0.477HisGln: 0.477 ± 0.023
1.645HisArg: 1.645 ± 0.047
0.97HisSer: 0.97 ± 0.028
0.934HisThr: 0.934 ± 0.035
1.582HisVal: 1.582 ± 0.042
0.297HisTrp: 0.297 ± 0.017
0.4HisTyr: 0.4 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.409IleAla: 7.409 ± 0.081
0.248IleCys: 0.248 ± 0.016
3.767IleAsp: 3.767 ± 0.06
2.957IleGlu: 2.957 ± 0.053
1.201IlePhe: 1.201 ± 0.042
4.835IleGly: 4.835 ± 0.078
0.684IleHis: 0.684 ± 0.028
2.023IleIle: 2.023 ± 0.052
0.719IleLys: 0.719 ± 0.03
4.139IleLeu: 4.139 ± 0.076
0.643IleMet: 0.643 ± 0.029
0.847IleAsn: 0.847 ± 0.029
2.54IlePro: 2.54 ± 0.053
0.995IleGln: 0.995 ± 0.034
3.0IleArg: 3.0 ± 0.061
2.512IleSer: 2.512 ± 0.042
2.978IleThr: 2.978 ± 0.061
4.842IleVal: 4.842 ± 0.07
0.572IleTrp: 0.572 ± 0.023
0.75IleTyr: 0.75 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
2.268LysAla: 2.268 ± 0.054
0.056LysCys: 0.056 ± 0.008
1.134LysAsp: 1.134 ± 0.035
0.935LysGlu: 0.935 ± 0.035
0.449LysPhe: 0.449 ± 0.02
1.488LysGly: 1.488 ± 0.045
0.365LysHis: 0.365 ± 0.021
0.914LysIle: 0.914 ± 0.032
0.78LysLys: 0.78 ± 0.034
1.654LysLeu: 1.654 ± 0.049
0.38LysMet: 0.38 ± 0.021
0.518LysAsn: 0.518 ± 0.025
1.036LysPro: 1.036 ± 0.035
0.628LysGln: 0.628 ± 0.027
1.33LysArg: 1.33 ± 0.041
1.148LysSer: 1.148 ± 0.033
1.292LysThr: 1.292 ± 0.04
1.54LysVal: 1.54 ± 0.048
0.244LysTrp: 0.244 ± 0.016
0.41LysTyr: 0.41 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
14.184LeuAla: 14.184 ± 0.149
0.48LeuCys: 0.48 ± 0.02
6.855LeuAsp: 6.855 ± 0.098
4.952LeuGlu: 4.952 ± 0.077
3.021LeuPhe: 3.021 ± 0.056
9.059LeuGly: 9.059 ± 0.109
1.88LeuHis: 1.88 ± 0.047
4.715LeuIle: 4.715 ± 0.083
1.564LeuLys: 1.564 ± 0.042
10.271LeuLeu: 10.271 ± 0.137
1.646LeuMet: 1.646 ± 0.046
1.702LeuAsn: 1.702 ± 0.042
5.378LeuPro: 5.378 ± 0.072
2.595LeuGln: 2.595 ± 0.05
7.651LeuArg: 7.651 ± 0.089
6.224LeuSer: 6.224 ± 0.08
6.363LeuThr: 6.363 ± 0.075
9.095LeuVal: 9.095 ± 0.115
1.345LeuTrp: 1.345 ± 0.035
1.606LeuTyr: 1.606 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.001MetAla: 2.001 ± 0.048
0.089MetCys: 0.089 ± 0.009
0.788MetAsp: 0.788 ± 0.03
0.607MetGlu: 0.607 ± 0.026
0.524MetPhe: 0.524 ± 0.022
1.226MetGly: 1.226 ± 0.036
0.366MetHis: 0.366 ± 0.02
0.96MetIle: 0.96 ± 0.033
0.401MetLys: 0.401 ± 0.021
2.069MetLeu: 2.069 ± 0.051
0.341MetMet: 0.341 ± 0.021
0.505MetAsn: 0.505 ± 0.025
1.21MetPro: 1.21 ± 0.029
0.558MetGln: 0.558 ± 0.021
1.416MetArg: 1.416 ± 0.034
1.568MetSer: 1.568 ± 0.036
1.758MetThr: 1.758 ± 0.046
1.351MetVal: 1.351 ± 0.033
0.218MetTrp: 0.218 ± 0.014
0.265MetTyr: 0.265 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.403AsnAla: 2.403 ± 0.05
0.107AsnCys: 0.107 ± 0.011
1.222AsnAsp: 1.222 ± 0.04
0.96AsnGlu: 0.96 ± 0.029
0.626AsnPhe: 0.626 ± 0.026
1.829AsnGly: 1.829 ± 0.053
0.331AsnHis: 0.331 ± 0.017
0.823AsnIle: 0.823 ± 0.025
0.368AsnLys: 0.368 ± 0.019
1.831AsnLeu: 1.831 ± 0.049
0.312AsnMet: 0.312 ± 0.019
0.431AsnAsn: 0.431 ± 0.019
1.52AsnPro: 1.52 ± 0.039
0.5AsnGln: 0.5 ± 0.022
1.209AsnArg: 1.209 ± 0.037
0.976AsnSer: 0.976 ± 0.034
1.201AsnThr: 1.201 ± 0.044
1.587AsnVal: 1.587 ± 0.041
0.302AsnTrp: 0.302 ± 0.02
0.438AsnTyr: 0.438 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
6.873ProAla: 6.873 ± 0.114
0.162ProCys: 0.162 ± 0.013
3.764ProAsp: 3.764 ± 0.067
3.809ProGlu: 3.809 ± 0.076
1.76ProPhe: 1.76 ± 0.041
4.852ProGly: 4.852 ± 0.084
1.137ProHis: 1.137 ± 0.036
2.1ProIle: 2.1 ± 0.042
0.947ProLys: 0.947 ± 0.034
5.008ProLeu: 5.008 ± 0.078
0.848ProMet: 0.848 ± 0.025
0.962ProAsn: 0.962 ± 0.03
2.177ProPro: 2.177 ± 0.066
1.589ProGln: 1.589 ± 0.046
3.391ProArg: 3.391 ± 0.057
3.334ProSer: 3.334 ± 0.061
3.389ProThr: 3.389 ± 0.056
4.69ProVal: 4.69 ± 0.073
0.87ProTrp: 0.87 ± 0.031
0.988ProTyr: 0.988 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.323GlnAla: 3.323 ± 0.06
0.103GlnCys: 0.103 ± 0.01
1.329GlnAsp: 1.329 ± 0.037
1.293GlnGlu: 1.293 ± 0.039
0.887GlnPhe: 0.887 ± 0.029
2.181GlnGly: 2.181 ± 0.049
0.622GlnHis: 0.622 ± 0.026
1.424GlnIle: 1.424 ± 0.038
0.677GlnLys: 0.677 ± 0.026
3.016GlnLeu: 3.016 ± 0.055
0.513GlnMet: 0.513 ± 0.021
0.696GlnAsn: 0.696 ± 0.028
1.411GlnPro: 1.411 ± 0.033
1.151GlnGln: 1.151 ± 0.04
2.408GlnArg: 2.408 ± 0.05
1.593GlnSer: 1.593 ± 0.039
1.652GlnThr: 1.652 ± 0.039
2.304GlnVal: 2.304 ± 0.043
0.449GlnTrp: 0.449 ± 0.018
0.561GlnTyr: 0.561 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
8.834ArgAla: 8.834 ± 0.122
0.297ArgCys: 0.297 ± 0.018
4.366ArgAsp: 4.366 ± 0.076
4.269ArgGlu: 4.269 ± 0.078
2.328ArgPhe: 2.328 ± 0.049
5.475ArgGly: 5.475 ± 0.082
1.52ArgHis: 1.52 ± 0.039
3.864ArgIle: 3.864 ± 0.075
1.219ArgLys: 1.219 ± 0.04
7.246ArgLeu: 7.246 ± 0.1
1.88ArgMet: 1.88 ± 0.045
1.317ArgAsn: 1.317 ± 0.036
3.54ArgPro: 3.54 ± 0.06
1.997ArgGln: 1.997 ± 0.054
6.708ArgArg: 6.708 ± 0.103
4.356ArgSer: 4.356 ± 0.062
4.389ArgThr: 4.389 ± 0.068
6.024ArgVal: 6.024 ± 0.081
1.245ArgTrp: 1.245 ± 0.038
1.446ArgTyr: 1.446 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.762SerAla: 7.762 ± 0.115
0.263SerCys: 0.263 ± 0.018
3.61SerAsp: 3.61 ± 0.06
3.006SerGlu: 3.006 ± 0.051
2.013SerPhe: 2.013 ± 0.041
6.026SerGly: 6.026 ± 0.095
1.032SerHis: 1.032 ± 0.032
2.84SerIle: 2.84 ± 0.05
1.059SerLys: 1.059 ± 0.034
5.538SerLeu: 5.538 ± 0.07
1.244SerMet: 1.244 ± 0.036
1.059SerAsn: 1.059 ± 0.035
3.141SerPro: 3.141 ± 0.058
1.423SerGln: 1.423 ± 0.036
4.096SerArg: 4.096 ± 0.066
3.806SerSer: 3.806 ± 0.068
3.964SerThr: 3.964 ± 0.076
5.066SerVal: 5.066 ± 0.08
1.024SerTrp: 1.024 ± 0.032
1.145SerTyr: 1.145 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
8.135ThrAla: 8.135 ± 0.102
0.276ThrCys: 0.276 ± 0.019
3.834ThrAsp: 3.834 ± 0.076
3.128ThrGlu: 3.128 ± 0.065
1.911ThrPhe: 1.911 ± 0.042
5.807ThrGly: 5.807 ± 0.097
1.179ThrHis: 1.179 ± 0.034
2.997ThrIle: 2.997 ± 0.051
1.172ThrLys: 1.172 ± 0.034
6.175ThrLeu: 6.175 ± 0.078
1.033ThrMet: 1.033 ± 0.034
1.195ThrAsn: 1.195 ± 0.04
4.018ThrPro: 4.018 ± 0.072
1.516ThrGln: 1.516 ± 0.038
3.884ThrArg: 3.884 ± 0.056
3.581ThrSer: 3.581 ± 0.069
4.099ThrThr: 4.099 ± 0.086
6.013ThrVal: 6.013 ± 0.12
0.892ThrTrp: 0.892 ± 0.026
1.238ThrTyr: 1.238 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
11.574ValAla: 11.574 ± 0.127
0.474ValCys: 0.474 ± 0.023
5.87ValAsp: 5.87 ± 0.077
4.828ValGlu: 4.828 ± 0.078
2.939ValPhe: 2.939 ± 0.053
7.175ValGly: 7.175 ± 0.092
1.703ValHis: 1.703 ± 0.045
4.637ValIle: 4.637 ± 0.077
1.482ValLys: 1.482 ± 0.044
9.321ValLeu: 9.321 ± 0.097
1.5ValMet: 1.5 ± 0.043
1.711ValAsn: 1.711 ± 0.041
4.627ValPro: 4.627 ± 0.065
2.373ValGln: 2.373 ± 0.054
6.091ValArg: 6.091 ± 0.079
5.316ValSer: 5.316 ± 0.082
5.846ValThr: 5.846 ± 0.119
8.701ValVal: 8.701 ± 0.106
1.192ValTrp: 1.192 ± 0.032
1.484ValTyr: 1.484 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.63TrpAla: 1.63 ± 0.038
0.094TrpCys: 0.094 ± 0.01
0.836TrpAsp: 0.836 ± 0.031
0.683TrpGlu: 0.683 ± 0.029
0.586TrpPhe: 0.586 ± 0.023
1.146TrpGly: 1.146 ± 0.031
0.333TrpHis: 0.333 ± 0.016
0.808TrpIle: 0.808 ± 0.03
0.292TrpLys: 0.292 ± 0.017
1.622TrpLeu: 1.622 ± 0.041
0.357TrpMet: 0.357 ± 0.018
0.456TrpAsn: 0.456 ± 0.022
0.712TrpPro: 0.712 ± 0.023
0.56TrpGln: 0.56 ± 0.024
1.224TrpArg: 1.224 ± 0.034
1.015TrpSer: 1.015 ± 0.03
0.982TrpThr: 0.982 ± 0.032
1.249TrpVal: 1.249 ± 0.038
0.392TrpTrp: 0.392 ± 0.022
0.286TrpTyr: 0.286 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.367TyrAla: 2.367 ± 0.044
0.102TyrCys: 0.102 ± 0.01
1.333TyrAsp: 1.333 ± 0.037
1.062TyrGlu: 1.062 ± 0.035
0.69TyrPhe: 0.69 ± 0.022
1.809TyrGly: 1.809 ± 0.044
0.261TyrHis: 0.261 ± 0.016
0.728TyrIle: 0.728 ± 0.027
0.31TyrLys: 0.31 ± 0.018
2.077TyrLeu: 2.077 ± 0.048
0.266TyrMet: 0.266 ± 0.016
0.456TyrAsn: 0.456 ± 0.026
1.006TyrPro: 1.006 ± 0.031
0.513TyrGln: 0.513 ± 0.025
1.542TyrArg: 1.542 ± 0.043
1.199TyrSer: 1.199 ± 0.043
1.261TyrThr: 1.261 ± 0.05
1.527TyrVal: 1.527 ± 0.038
0.313TyrTrp: 0.313 ± 0.02
0.465TyrTyr: 0.465 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3324 proteins (1078997 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski