Amino acid dipepetide frequency for Cardiobacterium valvarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.393AlaAla: 17.393 ± 0.304
1.36AlaCys: 1.36 ± 0.048
7.295AlaAsp: 7.295 ± 0.118
6.744AlaGlu: 6.744 ± 0.126
3.701AlaPhe: 3.701 ± 0.077
8.067AlaGly: 8.067 ± 0.124
2.861AlaHis: 2.861 ± 0.076
6.026AlaIle: 6.026 ± 0.109
4.165AlaLys: 4.165 ± 0.118
12.895AlaLeu: 12.895 ± 0.21
2.447AlaMet: 2.447 ± 0.058
3.374AlaAsn: 3.374 ± 0.089
4.569AlaPro: 4.569 ± 0.094
5.39AlaGln: 5.39 ± 0.134
7.04AlaArg: 7.04 ± 0.147
4.814AlaSer: 4.814 ± 0.091
5.991AlaThr: 5.991 ± 0.109
7.442AlaVal: 7.442 ± 0.122
1.581AlaTrp: 1.581 ± 0.051
3.471AlaTyr: 3.471 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.115CysAla: 1.115 ± 0.038
0.169CysCys: 0.169 ± 0.015
0.595CysAsp: 0.595 ± 0.027
0.5CysGlu: 0.5 ± 0.026
0.36CysPhe: 0.36 ± 0.024
0.995CysGly: 0.995 ± 0.039
0.309CysHis: 0.309 ± 0.022
0.506CysIle: 0.506 ± 0.025
0.35CysLys: 0.35 ± 0.022
0.995CysLeu: 0.995 ± 0.037
0.17CysMet: 0.17 ± 0.015
0.276CysAsn: 0.276 ± 0.018
0.506CysPro: 0.506 ± 0.029
0.297CysGln: 0.297 ± 0.019
0.67CysArg: 0.67 ± 0.031
0.537CysSer: 0.537 ± 0.027
0.525CysThr: 0.525 ± 0.026
0.52CysVal: 0.52 ± 0.028
0.169CysTrp: 0.169 ± 0.016
0.372CysTyr: 0.372 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
6.409AspAla: 6.409 ± 0.107
0.551AspCys: 0.551 ± 0.029
3.865AspAsp: 3.865 ± 0.096
3.365AspGlu: 3.365 ± 0.086
2.101AspPhe: 2.101 ± 0.056
5.182AspGly: 5.182 ± 0.121
1.221AspHis: 1.221 ± 0.047
4.074AspIle: 4.074 ± 0.074
3.02AspLys: 3.02 ± 0.103
5.029AspLeu: 5.029 ± 0.09
1.194AspMet: 1.194 ± 0.041
2.757AspAsn: 2.757 ± 0.081
2.705AspPro: 2.705 ± 0.062
1.291AspGln: 1.291 ± 0.051
2.814AspArg: 2.814 ± 0.07
3.141AspSer: 3.141 ± 0.084
3.345AspThr: 3.345 ± 0.099
3.157AspVal: 3.157 ± 0.084
1.015AspTrp: 1.015 ± 0.041
2.467AspTyr: 2.467 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
6.27GluAla: 6.27 ± 0.124
0.375GluCys: 0.375 ± 0.021
2.587GluAsp: 2.587 ± 0.066
3.181GluGlu: 3.181 ± 0.08
1.224GluPhe: 1.224 ± 0.048
3.155GluGly: 3.155 ± 0.077
1.655GluHis: 1.655 ± 0.045
3.249GluIle: 3.249 ± 0.069
3.34GluLys: 3.34 ± 0.101
5.044GluLeu: 5.044 ± 0.089
1.27GluMet: 1.27 ± 0.045
2.5GluAsn: 2.5 ± 0.071
2.076GluPro: 2.076 ± 0.075
2.85GluGln: 2.85 ± 0.073
3.95GluArg: 3.95 ± 0.088
2.374GluSer: 2.374 ± 0.061
3.209GluThr: 3.209 ± 0.068
2.766GluVal: 2.766 ± 0.068
0.64GluTrp: 0.64 ± 0.03
1.657GluTyr: 1.657 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
4.451PheAla: 4.451 ± 0.082
0.441PheCys: 0.441 ± 0.021
2.094PheAsp: 2.094 ± 0.057
1.344PheGlu: 1.344 ± 0.044
1.485PhePhe: 1.485 ± 0.056
2.725PheGly: 2.725 ± 0.077
0.809PheHis: 0.809 ± 0.035
2.182PheIle: 2.182 ± 0.054
1.019PheLys: 1.019 ± 0.039
3.126PheLeu: 3.126 ± 0.075
0.676PheMet: 0.676 ± 0.03
1.281PheAsn: 1.281 ± 0.038
1.432PhePro: 1.432 ± 0.042
0.889PheGln: 0.889 ± 0.034
1.755PheArg: 1.755 ± 0.052
2.03PheSer: 2.03 ± 0.059
2.205PheThr: 2.205 ± 0.064
2.04PheVal: 2.04 ± 0.052
0.505PheTrp: 0.505 ± 0.029
1.175PheTyr: 1.175 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
6.611GlyAla: 6.611 ± 0.108
0.75GlyCys: 0.75 ± 0.032
4.37GlyAsp: 4.37 ± 0.081
4.651GlyGlu: 4.651 ± 0.091
2.702GlyPhe: 2.702 ± 0.062
6.234GlyGly: 6.234 ± 0.177
1.825GlyHis: 1.825 ± 0.063
5.312GlyIle: 5.312 ± 0.083
4.707GlyLys: 4.707 ± 0.144
6.472GlyLeu: 6.472 ± 0.103
1.855GlyMet: 1.855 ± 0.045
3.112GlyAsn: 3.112 ± 0.128
1.329GlyPro: 1.329 ± 0.044
2.922GlyGln: 2.922 ± 0.091
3.977GlyArg: 3.977 ± 0.086
4.412GlySer: 4.412 ± 0.086
3.964GlyThr: 3.964 ± 0.131
4.829GlyVal: 4.829 ± 0.085
1.136GlyTrp: 1.136 ± 0.044
2.677GlyTyr: 2.677 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.445HisAla: 2.445 ± 0.06
0.349HisCys: 0.349 ± 0.023
1.766HisAsp: 1.766 ± 0.058
1.221HisGlu: 1.221 ± 0.037
0.961HisPhe: 0.961 ± 0.039
2.266HisGly: 2.266 ± 0.059
0.935HisHis: 0.935 ± 0.039
1.965HisIle: 1.965 ± 0.058
0.932HisLys: 0.932 ± 0.038
2.704HisLeu: 2.704 ± 0.066
0.502HisMet: 0.502 ± 0.023
1.032HisAsn: 1.032 ± 0.038
1.606HisPro: 1.606 ± 0.049
0.822HisGln: 0.822 ± 0.036
1.541HisArg: 1.541 ± 0.048
1.437HisSer: 1.437 ± 0.044
1.46HisThr: 1.46 ± 0.048
1.127HisVal: 1.127 ± 0.04
0.455HisTrp: 0.455 ± 0.024
1.366HisTyr: 1.366 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
7.301IleAla: 7.301 ± 0.119
0.622IleCys: 0.622 ± 0.028
3.58IleAsp: 3.58 ± 0.069
3.355IleGlu: 3.355 ± 0.068
1.907IlePhe: 1.907 ± 0.06
4.575IleGly: 4.575 ± 0.095
1.546IleHis: 1.546 ± 0.049
3.597IleIle: 3.597 ± 0.082
2.264IleLys: 2.264 ± 0.07
5.759IleLeu: 5.759 ± 0.112
1.047IleMet: 1.047 ± 0.038
2.537IleAsn: 2.537 ± 0.068
2.767IlePro: 2.767 ± 0.064
1.625IleGln: 1.625 ± 0.049
3.784IleArg: 3.784 ± 0.076
3.549IleSer: 3.549 ± 0.074
3.85IleThr: 3.85 ± 0.067
3.316IleVal: 3.316 ± 0.076
0.536IleTrp: 0.536 ± 0.026
1.681IleTyr: 1.681 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.566LysAla: 4.566 ± 0.112
0.181LysCys: 0.181 ± 0.016
2.29LysAsp: 2.29 ± 0.075
2.32LysGlu: 2.32 ± 0.081
0.776LysPhe: 0.776 ± 0.034
2.81LysGly: 2.81 ± 0.104
1.027LysHis: 1.027 ± 0.035
2.561LysIle: 2.561 ± 0.063
2.279LysLys: 2.279 ± 0.062
3.494LysLeu: 3.494 ± 0.084
0.955LysMet: 0.955 ± 0.042
2.179LysAsn: 2.179 ± 0.059
2.25LysPro: 2.25 ± 0.081
1.89LysGln: 1.89 ± 0.058
2.621LysArg: 2.621 ± 0.067
2.17LysSer: 2.17 ± 0.046
3.247LysThr: 3.247 ± 0.081
2.19LysVal: 2.19 ± 0.088
0.445LysTrp: 0.445 ± 0.035
1.174LysTyr: 1.174 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
13.247LeuAla: 13.247 ± 0.203
1.157LeuCys: 1.157 ± 0.043
6.124LeuAsp: 6.124 ± 0.102
4.639LeuGlu: 4.639 ± 0.081
3.575LeuPhe: 3.575 ± 0.086
7.153LeuGly: 7.153 ± 0.124
2.966LeuHis: 2.966 ± 0.071
5.724LeuIle: 5.724 ± 0.119
3.656LeuLys: 3.656 ± 0.077
11.207LeuLeu: 11.207 ± 0.204
2.212LeuMet: 2.212 ± 0.061
3.597LeuAsn: 3.597 ± 0.083
6.349LeuPro: 6.349 ± 0.114
4.22LeuGln: 4.22 ± 0.089
6.675LeuArg: 6.675 ± 0.127
5.606LeuSer: 5.606 ± 0.094
6.046LeuThr: 6.046 ± 0.11
5.434LeuVal: 5.434 ± 0.103
1.439LeuTrp: 1.439 ± 0.051
3.195LeuTyr: 3.195 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.076MetAla: 2.076 ± 0.055
0.145MetCys: 0.145 ± 0.012
1.037MetAsp: 1.037 ± 0.04
0.895MetGlu: 0.895 ± 0.032
0.615MetPhe: 0.615 ± 0.031
1.304MetGly: 1.304 ± 0.043
0.555MetHis: 0.555 ± 0.025
0.995MetIle: 0.995 ± 0.039
1.209MetLys: 1.209 ± 0.044
2.319MetLeu: 2.319 ± 0.058
0.555MetMet: 0.555 ± 0.031
0.98MetAsn: 0.98 ± 0.037
1.225MetPro: 1.225 ± 0.044
1.21MetGln: 1.21 ± 0.046
1.406MetArg: 1.406 ± 0.051
1.195MetSer: 1.195 ± 0.052
1.579MetThr: 1.579 ± 0.049
1.145MetVal: 1.145 ± 0.047
0.159MetTrp: 0.159 ± 0.013
0.435MetTyr: 0.435 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.817AsnAla: 3.817 ± 0.075
0.312AsnCys: 0.312 ± 0.02
2.081AsnAsp: 2.081 ± 0.076
1.706AsnGlu: 1.706 ± 0.05
1.107AsnPhe: 1.107 ± 0.046
3.157AsnGly: 3.157 ± 0.095
1.064AsnHis: 1.064 ± 0.053
2.645AsnIle: 2.645 ± 0.067
1.455AsnLys: 1.455 ± 0.045
3.644AsnLeu: 3.644 ± 0.077
0.646AsnMet: 0.646 ± 0.026
1.646AsnAsn: 1.646 ± 0.078
2.719AsnPro: 2.719 ± 0.095
1.196AsnGln: 1.196 ± 0.047
2.439AsnArg: 2.439 ± 0.078
1.931AsnSer: 1.931 ± 0.075
2.161AsnThr: 2.161 ± 0.101
1.895AsnVal: 1.895 ± 0.06
0.487AsnTrp: 0.487 ± 0.028
1.215AsnTyr: 1.215 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
6.279ProAla: 6.279 ± 0.124
0.409ProCys: 0.409 ± 0.026
3.379ProAsp: 3.379 ± 0.069
3.015ProGlu: 3.015 ± 0.075
1.747ProPhe: 1.747 ± 0.052
2.954ProGly: 2.954 ± 0.088
1.286ProHis: 1.286 ± 0.037
2.009ProIle: 2.009 ± 0.05
1.514ProLys: 1.514 ± 0.046
5.261ProLeu: 5.261 ± 0.09
1.021ProMet: 1.021 ± 0.035
1.582ProAsn: 1.582 ± 0.102
3.026ProPro: 3.026 ± 0.137
2.634ProGln: 2.634 ± 0.099
2.281ProArg: 2.281 ± 0.058
2.056ProSer: 2.056 ± 0.059
2.372ProThr: 2.372 ± 0.066
3.345ProVal: 3.345 ± 0.095
0.599ProTrp: 0.599 ± 0.031
1.642ProTyr: 1.642 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
4.795GlnAla: 4.795 ± 0.094
0.287GlnCys: 0.287 ± 0.018
1.864GlnAsp: 1.864 ± 0.064
2.335GlnGlu: 2.335 ± 0.068
1.171GlnPhe: 1.171 ± 0.04
2.684GlnGly: 2.684 ± 0.085
1.345GlnHis: 1.345 ± 0.049
2.23GlnIle: 2.23 ± 0.058
1.779GlnLys: 1.779 ± 0.051
3.899GlnLeu: 3.899 ± 0.083
0.952GlnMet: 0.952 ± 0.032
1.554GlnAsn: 1.554 ± 0.058
2.344GlnPro: 2.344 ± 0.106
2.657GlnGln: 2.657 ± 0.083
2.761GlnArg: 2.761 ± 0.074
2.019GlnSer: 2.019 ± 0.056
2.572GlnThr: 2.572 ± 0.062
2.04GlnVal: 2.04 ± 0.053
0.61GlnTrp: 0.61 ± 0.031
1.417GlnTyr: 1.417 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
6.335ArgAla: 6.335 ± 0.114
0.646ArgCys: 0.646 ± 0.031
3.934ArgAsp: 3.934 ± 0.083
3.905ArgGlu: 3.905 ± 0.076
2.379ArgPhe: 2.379 ± 0.063
3.922ArgGly: 3.922 ± 0.089
2.105ArgHis: 2.105 ± 0.062
3.651ArgIle: 3.651 ± 0.071
2.335ArgLys: 2.335 ± 0.06
7.413ArgLeu: 7.413 ± 0.137
1.269ArgMet: 1.269 ± 0.045
1.906ArgAsn: 1.906 ± 0.051
2.671ArgPro: 2.671 ± 0.06
2.899ArgGln: 2.899 ± 0.076
4.514ArgArg: 4.514 ± 0.103
2.784ArgSer: 2.784 ± 0.055
2.536ArgThr: 2.536 ± 0.071
3.296ArgVal: 3.296 ± 0.069
0.942ArgTrp: 0.942 ± 0.03
2.516ArgTyr: 2.516 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
5.701SerAla: 5.701 ± 0.089
0.437SerCys: 0.437 ± 0.024
3.121SerAsp: 3.121 ± 0.113
2.81SerGlu: 2.81 ± 0.07
1.707SerPhe: 1.707 ± 0.049
5.462SerGly: 5.462 ± 0.128
1.206SerHis: 1.206 ± 0.036
2.846SerIle: 2.846 ± 0.069
1.98SerLys: 1.98 ± 0.057
5.204SerLeu: 5.204 ± 0.096
0.961SerMet: 0.961 ± 0.031
1.627SerAsn: 1.627 ± 0.055
2.364SerPro: 2.364 ± 0.054
1.656SerGln: 1.656 ± 0.05
3.165SerArg: 3.165 ± 0.071
2.605SerSer: 2.605 ± 0.062
2.589SerThr: 2.589 ± 0.054
3.157SerVal: 3.157 ± 0.081
0.627SerTrp: 0.627 ± 0.033
1.552SerTyr: 1.552 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
7.155ThrAla: 7.155 ± 0.117
0.516ThrCys: 0.516 ± 0.026
3.009ThrAsp: 3.009 ± 0.113
2.367ThrGlu: 2.367 ± 0.075
2.077ThrPhe: 2.077 ± 0.06
4.119ThrGly: 4.119 ± 0.147
1.266ThrHis: 1.266 ± 0.039
3.541ThrIle: 3.541 ± 0.078
1.364ThrLys: 1.364 ± 0.049
7.772ThrLeu: 7.772 ± 0.119
1.051ThrMet: 1.051 ± 0.036
1.605ThrAsn: 1.605 ± 0.054
3.507ThrPro: 3.507 ± 0.086
1.787ThrGln: 1.787 ± 0.051
3.194ThrArg: 3.194 ± 0.075
2.474ThrSer: 2.474 ± 0.053
3.346ThrThr: 3.346 ± 0.096
4.007ThrVal: 4.007 ± 0.115
0.671ThrTrp: 0.671 ± 0.038
1.85ThrTyr: 1.85 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
6.396ValAla: 6.396 ± 0.108
0.676ValCys: 0.676 ± 0.029
3.097ValAsp: 3.097 ± 0.095
3.02ValGlu: 3.02 ± 0.073
2.257ValPhe: 2.257 ± 0.068
3.719ValGly: 3.719 ± 0.084
1.351ValHis: 1.351 ± 0.044
3.781ValIle: 3.781 ± 0.078
2.507ValLys: 2.507 ± 0.096
6.069ValLeu: 6.069 ± 0.121
1.427ValMet: 1.427 ± 0.046
2.207ValAsn: 2.207 ± 0.065
2.789ValPro: 2.789 ± 0.06
2.157ValGln: 2.157 ± 0.051
3.446ValArg: 3.446 ± 0.066
3.39ValSer: 3.39 ± 0.082
3.16ValThr: 3.16 ± 0.118
3.832ValVal: 3.832 ± 0.085
0.722ValTrp: 0.722 ± 0.03
1.634ValTyr: 1.634 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
1.124TrpAla: 1.124 ± 0.041
0.15TrpCys: 0.15 ± 0.014
0.582TrpAsp: 0.582 ± 0.029
0.532TrpGlu: 0.532 ± 0.029
0.534TrpPhe: 0.534 ± 0.026
0.777TrpGly: 0.777 ± 0.033
0.522TrpHis: 0.522 ± 0.027
0.631TrpIle: 0.631 ± 0.029
0.471TrpLys: 0.471 ± 0.028
2.216TrpLeu: 2.216 ± 0.073
0.274TrpMet: 0.274 ± 0.02
0.377TrpAsn: 0.377 ± 0.021
0.402TrpPro: 0.402 ± 0.02
1.299TrpGln: 1.299 ± 0.048
1.109TrpArg: 1.109 ± 0.048
0.496TrpSer: 0.496 ± 0.037
0.589TrpThr: 0.589 ± 0.03
0.676TrpVal: 0.676 ± 0.03
0.235TrpTrp: 0.235 ± 0.018
0.516TrpTyr: 0.516 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.14TyrAla: 3.14 ± 0.068
0.401TyrCys: 0.401 ± 0.022
2.034TyrAsp: 2.034 ± 0.055
1.466TyrGlu: 1.466 ± 0.05
1.275TyrPhe: 1.275 ± 0.042
2.589TyrGly: 2.589 ± 0.065
1.04TyrHis: 1.04 ± 0.039
1.674TyrIle: 1.674 ± 0.049
1.08TyrLys: 1.08 ± 0.041
3.701TyrLeu: 3.701 ± 0.086
0.55TyrMet: 0.55 ± 0.024
1.192TyrAsn: 1.192 ± 0.051
1.775TyrPro: 1.775 ± 0.054
1.622TyrGln: 1.622 ± 0.052
2.817TyrArg: 2.817 ± 0.071
1.761TyrSer: 1.761 ± 0.061
1.934TyrThr: 1.934 ± 0.075
1.424TyrVal: 1.424 ± 0.047
0.54TyrTrp: 0.54 ± 0.026
1.439TyrTyr: 1.439 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2618 proteins (800029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski