Amino acid dipepetide frequency for Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.504AlaAla: 6.504 ± 0.921
1.979AlaCys: 1.979 ± 0.438
2.686AlaAsp: 2.686 ± 0.536
2.192AlaGlu: 2.192 ± 0.567
3.181AlaPhe: 3.181 ± 0.877
4.525AlaGly: 4.525 ± 1.031
0.919AlaHis: 0.919 ± 0.392
4.312AlaIle: 4.312 ± 0.643
4.807AlaLys: 4.807 ± 1.231
7.565AlaLeu: 7.565 ± 1.142
2.545AlaMet: 2.545 ± 0.543
3.888AlaAsn: 3.888 ± 0.914
2.404AlaPro: 2.404 ± 0.454
2.262AlaGln: 2.262 ± 0.434
3.181AlaArg: 3.181 ± 0.901
5.019AlaSer: 5.019 ± 1.584
4.807AlaThr: 4.807 ± 0.561
4.807AlaVal: 4.807 ± 0.954
1.06AlaTrp: 1.06 ± 0.357
4.03AlaTyr: 4.03 ± 0.729
0.0AlaXaa: 0.0 ± 0.0
Cys
2.545CysAla: 2.545 ± 0.56
1.626CysCys: 1.626 ± 0.416
2.262CysAsp: 2.262 ± 0.657
1.485CysGlu: 1.485 ± 1.135
1.202CysPhe: 1.202 ± 0.734
2.474CysGly: 2.474 ± 0.71
0.566CysHis: 0.566 ± 0.164
2.121CysIle: 2.121 ± 0.617
0.778CysLys: 0.778 ± 0.246
2.616CysLeu: 2.616 ± 0.8
0.778CysMet: 0.778 ± 0.259
1.273CysAsn: 1.273 ± 0.568
0.919CysPro: 0.919 ± 0.51
0.566CysGln: 0.566 ± 0.384
1.131CysArg: 1.131 ± 0.458
1.909CysSer: 1.909 ± 0.805
2.121CysThr: 2.121 ± 0.654
2.969CysVal: 2.969 ± 0.714
0.353CysTrp: 0.353 ± 0.761
1.697CysTyr: 1.697 ± 0.604
0.0CysXaa: 0.0 ± 0.0
Asp
3.888AspAla: 3.888 ± 0.817
1.131AspCys: 1.131 ± 0.361
2.262AspAsp: 2.262 ± 0.527
2.616AspGlu: 2.616 ± 0.335
2.757AspPhe: 2.757 ± 1.213
3.888AspGly: 3.888 ± 0.687
0.919AspHis: 0.919 ± 0.364
2.686AspIle: 2.686 ± 0.618
2.545AspLys: 2.545 ± 0.498
4.807AspLeu: 4.807 ± 0.756
1.273AspMet: 1.273 ± 0.422
2.969AspAsn: 2.969 ± 0.538
1.414AspPro: 1.414 ± 1.143
1.697AspGln: 1.697 ± 0.316
1.414AspArg: 1.414 ± 0.349
3.252AspSer: 3.252 ± 0.574
3.747AspThr: 3.747 ± 0.906
4.383AspVal: 4.383 ± 0.852
0.707AspTrp: 0.707 ± 0.45
3.464AspTyr: 3.464 ± 0.772
0.0AspXaa: 0.0 ± 0.0
Glu
3.393GluAla: 3.393 ± 0.722
1.979GluCys: 1.979 ± 0.83
2.757GluAsp: 2.757 ± 0.571
5.232GluGlu: 5.232 ± 1.06
1.767GluPhe: 1.767 ± 0.587
2.828GluGly: 2.828 ± 0.59
1.343GluHis: 1.343 ± 0.408
2.828GluIle: 2.828 ± 0.292
2.333GluLys: 2.333 ± 0.668
5.302GluLeu: 5.302 ± 1.047
0.99GluMet: 0.99 ± 0.505
2.05GluAsn: 2.05 ± 0.52
1.838GluPro: 1.838 ± 1.095
1.979GluGln: 1.979 ± 0.416
1.343GluArg: 1.343 ± 0.406
2.545GluSer: 2.545 ± 0.372
3.393GluThr: 3.393 ± 0.881
4.1GluVal: 4.1 ± 0.858
0.283GluTrp: 0.283 ± 0.126
2.262GluTyr: 2.262 ± 0.73
0.0GluXaa: 0.0 ± 0.0
Phe
2.899PheAla: 2.899 ± 0.952
2.262PheCys: 2.262 ± 0.578
2.969PheAsp: 2.969 ± 0.702
1.485PheGlu: 1.485 ± 0.434
2.333PhePhe: 2.333 ± 0.611
2.899PheGly: 2.899 ± 1.238
0.636PheHis: 0.636 ± 0.388
2.333PheIle: 2.333 ± 0.938
3.181PheLys: 3.181 ± 0.672
5.444PheLeu: 5.444 ± 1.348
0.848PheMet: 0.848 ± 0.23
2.757PheAsn: 2.757 ± 1.604
1.767PhePro: 1.767 ± 0.532
0.919PheGln: 0.919 ± 0.801
1.202PheArg: 1.202 ± 0.264
3.181PheSer: 3.181 ± 0.638
4.242PheThr: 4.242 ± 0.686
3.606PheVal: 3.606 ± 1.135
0.353PheTrp: 0.353 ± 0.45
2.474PheTyr: 2.474 ± 0.436
0.0PheXaa: 0.0 ± 0.0
Gly
4.807GlyAla: 4.807 ± 0.823
1.626GlyCys: 1.626 ± 0.463
3.606GlyAsp: 3.606 ± 0.357
2.121GlyGlu: 2.121 ± 0.507
3.111GlyPhe: 3.111 ± 0.662
4.171GlyGly: 4.171 ± 0.824
1.131GlyHis: 1.131 ± 0.404
3.181GlyIle: 3.181 ± 0.746
2.686GlyLys: 2.686 ± 0.615
3.888GlyLeu: 3.888 ± 0.785
1.06GlyMet: 1.06 ± 0.418
2.757GlyAsn: 2.757 ± 0.639
2.192GlyPro: 2.192 ± 0.652
2.333GlyGln: 2.333 ± 0.583
1.909GlyArg: 1.909 ± 0.382
3.959GlySer: 3.959 ± 0.959
5.514GlyThr: 5.514 ± 0.994
6.928GlyVal: 6.928 ± 1.127
0.353GlyTrp: 0.353 ± 0.365
2.828GlyTyr: 2.828 ± 0.645
0.0GlyXaa: 0.0 ± 0.0
His
1.555HisAla: 1.555 ± 0.384
0.424HisCys: 0.424 ± 0.178
0.778HisAsp: 0.778 ± 0.432
1.06HisGlu: 1.06 ± 0.337
1.202HisPhe: 1.202 ± 0.463
1.485HisGly: 1.485 ± 0.559
0.566HisHis: 0.566 ± 0.378
0.919HisIle: 0.919 ± 0.314
0.636HisLys: 0.636 ± 0.45
2.121HisLeu: 2.121 ± 0.311
0.353HisMet: 0.353 ± 0.171
0.848HisAsn: 0.848 ± 0.355
0.566HisPro: 0.566 ± 0.291
0.283HisGln: 0.283 ± 0.29
0.283HisArg: 0.283 ± 0.128
1.838HisSer: 1.838 ± 0.55
1.626HisThr: 1.626 ± 0.509
1.767HisVal: 1.767 ± 0.367
0.283HisTrp: 0.283 ± 0.126
0.919HisTyr: 0.919 ± 0.916
0.0HisXaa: 0.0 ± 0.0
Ile
3.04IleAla: 3.04 ± 1.339
1.131IleCys: 1.131 ± 0.468
2.616IleAsp: 2.616 ± 0.389
2.121IleGlu: 2.121 ± 0.72
1.555IlePhe: 1.555 ± 0.464
3.323IleGly: 3.323 ± 0.761
0.636IleHis: 0.636 ± 1.429
3.464IleIle: 3.464 ± 1.295
3.393IleLys: 3.393 ± 0.416
4.312IleLeu: 4.312 ± 0.854
1.767IleMet: 1.767 ± 0.747
2.686IleAsn: 2.686 ± 0.372
2.121IlePro: 2.121 ± 0.451
2.262IleGln: 2.262 ± 0.496
1.909IleArg: 1.909 ± 0.615
3.393IleSer: 3.393 ± 0.811
4.1IleThr: 4.1 ± 0.636
4.595IleVal: 4.595 ± 1.256
0.424IleTrp: 0.424 ± 0.189
1.343IleTyr: 1.343 ± 1.388
0.0IleXaa: 0.0 ± 0.0
Lys
3.323LysAla: 3.323 ± 0.886
1.838LysCys: 1.838 ± 0.397
2.686LysAsp: 2.686 ± 0.978
3.111LysGlu: 3.111 ± 0.385
2.828LysPhe: 2.828 ± 0.781
4.807LysGly: 4.807 ± 0.93
1.626LysHis: 1.626 ± 0.549
1.979LysIle: 1.979 ± 0.616
3.323LysLys: 3.323 ± 1.64
6.575LysLeu: 6.575 ± 0.353
1.909LysMet: 1.909 ± 0.652
2.333LysAsn: 2.333 ± 0.596
3.464LysPro: 3.464 ± 0.653
1.131LysGln: 1.131 ± 0.646
2.545LysArg: 2.545 ± 0.396
3.818LysSer: 3.818 ± 0.752
3.111LysThr: 3.111 ± 0.391
3.818LysVal: 3.818 ± 0.469
0.707LysTrp: 0.707 ± 0.208
1.979LysTyr: 1.979 ± 0.468
0.0LysXaa: 0.0 ± 0.0
Leu
7.14LeuAla: 7.14 ± 1.043
2.686LeuCys: 2.686 ± 0.897
5.585LeuAsp: 5.585 ± 0.874
5.302LeuGlu: 5.302 ± 0.978
3.252LeuPhe: 3.252 ± 1.365
5.444LeuGly: 5.444 ± 0.675
1.626LeuHis: 1.626 ± 0.405
3.676LeuIle: 3.676 ± 2.823
6.928LeuLys: 6.928 ± 1.724
10.604LeuLeu: 10.604 ± 2.46
2.828LeuMet: 2.828 ± 0.796
6.575LeuAsn: 6.575 ± 1.274
5.019LeuPro: 5.019 ± 0.932
4.242LeuGln: 4.242 ± 0.372
5.161LeuArg: 5.161 ± 0.731
6.858LeuSer: 6.858 ± 1.041
5.656LeuThr: 5.656 ± 1.055
5.585LeuVal: 5.585 ± 1.384
1.06LeuTrp: 1.06 ± 0.399
3.252LeuTyr: 3.252 ± 0.868
0.0LeuXaa: 0.0 ± 0.0
Met
1.555MetAla: 1.555 ± 0.465
0.99MetCys: 0.99 ± 0.416
1.414MetAsp: 1.414 ± 0.604
0.99MetGlu: 0.99 ± 0.634
1.131MetPhe: 1.131 ± 0.358
0.778MetGly: 0.778 ± 0.323
0.566MetHis: 0.566 ± 0.235
0.495MetIle: 0.495 ± 0.262
1.131MetLys: 1.131 ± 0.701
3.181MetLeu: 3.181 ± 0.846
0.707MetMet: 0.707 ± 0.304
0.848MetAsn: 0.848 ± 0.419
1.202MetPro: 1.202 ± 0.392
1.202MetGln: 1.202 ± 0.402
0.636MetArg: 0.636 ± 0.226
2.262MetSer: 2.262 ± 0.41
1.555MetThr: 1.555 ± 0.318
1.273MetVal: 1.273 ± 0.423
0.566MetTrp: 0.566 ± 0.333
1.555MetTyr: 1.555 ± 0.343
0.0MetXaa: 0.0 ± 0.0
Asn
3.959AsnAla: 3.959 ± 0.566
1.626AsnCys: 1.626 ± 0.356
2.121AsnAsp: 2.121 ± 0.507
1.767AsnGlu: 1.767 ± 0.424
1.979AsnPhe: 1.979 ± 1.554
4.454AsnGly: 4.454 ± 1.093
1.202AsnHis: 1.202 ± 0.402
2.404AsnIle: 2.404 ± 0.55
2.545AsnLys: 2.545 ± 0.5
5.161AsnLeu: 5.161 ± 0.697
1.414AsnMet: 1.414 ± 0.586
3.04AsnAsn: 3.04 ± 0.618
1.555AsnPro: 1.555 ± 0.488
1.273AsnGln: 1.273 ± 0.728
2.121AsnArg: 2.121 ± 0.573
3.747AsnSer: 3.747 ± 0.998
2.828AsnThr: 2.828 ± 0.624
4.242AsnVal: 4.242 ± 0.749
0.424AsnTrp: 0.424 ± 0.174
2.05AsnTyr: 2.05 ± 0.484
0.0AsnXaa: 0.0 ± 0.0
Pro
3.393ProAla: 3.393 ± 0.605
1.06ProCys: 1.06 ± 0.946
1.555ProAsp: 1.555 ± 0.388
1.767ProGlu: 1.767 ± 0.337
1.838ProPhe: 1.838 ± 0.528
1.909ProGly: 1.909 ± 0.465
0.636ProHis: 0.636 ± 0.207
2.474ProIle: 2.474 ± 1.188
2.828ProLys: 2.828 ± 1.216
4.595ProLeu: 4.595 ± 0.988
0.495ProMet: 0.495 ± 0.422
1.909ProAsn: 1.909 ± 0.356
1.414ProPro: 1.414 ± 0.593
1.555ProGln: 1.555 ± 1.49
1.555ProArg: 1.555 ± 0.666
2.262ProSer: 2.262 ± 0.371
2.828ProThr: 2.828 ± 0.396
3.818ProVal: 3.818 ± 1.03
0.283ProTrp: 0.283 ± 0.117
1.06ProTyr: 1.06 ± 0.464
0.0ProXaa: 0.0 ± 0.0
Gln
2.969GlnAla: 2.969 ± 0.361
1.131GlnCys: 1.131 ± 0.386
1.979GlnAsp: 1.979 ± 0.617
2.616GlnGlu: 2.616 ± 1.017
1.697GlnPhe: 1.697 ± 0.653
2.05GlnGly: 2.05 ± 1.039
0.707GlnHis: 0.707 ± 0.253
2.262GlnIle: 2.262 ± 1.251
1.06GlnLys: 1.06 ± 0.459
3.888GlnLeu: 3.888 ± 1.558
0.919GlnMet: 0.919 ± 0.253
1.343GlnAsn: 1.343 ± 0.296
2.333GlnPro: 2.333 ± 0.504
1.909GlnGln: 1.909 ± 0.536
1.273GlnArg: 1.273 ± 0.56
1.979GlnSer: 1.979 ± 0.931
2.333GlnThr: 2.333 ± 0.479
2.333GlnVal: 2.333 ± 0.628
0.636GlnTrp: 0.636 ± 0.22
1.202GlnTyr: 1.202 ± 0.596
0.0GlnXaa: 0.0 ± 0.0
Arg
3.676ArgAla: 3.676 ± 0.618
1.202ArgCys: 1.202 ± 0.398
2.121ArgAsp: 2.121 ± 0.637
2.404ArgGlu: 2.404 ± 0.783
1.555ArgPhe: 1.555 ± 0.467
2.545ArgGly: 2.545 ± 1.268
1.06ArgHis: 1.06 ± 0.375
1.626ArgIle: 1.626 ± 0.569
2.192ArgLys: 2.192 ± 0.427
2.686ArgLeu: 2.686 ± 0.63
0.566ArgMet: 0.566 ± 0.524
1.555ArgAsn: 1.555 ± 0.631
0.919ArgPro: 0.919 ± 0.407
1.909ArgGln: 1.909 ± 0.758
1.273ArgArg: 1.273 ± 0.954
2.828ArgSer: 2.828 ± 0.83
1.838ArgThr: 1.838 ± 0.43
3.535ArgVal: 3.535 ± 0.6
0.424ArgTrp: 0.424 ± 0.329
1.414ArgTyr: 1.414 ± 0.498
0.0ArgXaa: 0.0 ± 0.0
Ser
5.656SerAla: 5.656 ± 0.654
1.626SerCys: 1.626 ± 0.478
3.606SerAsp: 3.606 ± 0.664
4.1SerGlu: 4.1 ± 0.726
3.888SerPhe: 3.888 ± 1.199
3.252SerGly: 3.252 ± 1.527
1.485SerHis: 1.485 ± 0.508
2.899SerIle: 2.899 ± 0.683
3.535SerLys: 3.535 ± 0.521
6.504SerLeu: 6.504 ± 0.83
1.273SerMet: 1.273 ± 0.429
2.828SerAsn: 2.828 ± 0.905
1.909SerPro: 1.909 ± 1.092
2.192SerGln: 2.192 ± 0.555
2.05SerArg: 2.05 ± 1.938
4.312SerSer: 4.312 ± 1.088
4.666SerThr: 4.666 ± 0.733
6.08SerVal: 6.08 ± 0.778
1.131SerTrp: 1.131 ± 0.203
3.606SerTyr: 3.606 ± 0.537
0.0SerXaa: 0.0 ± 0.0
Thr
3.464ThrAla: 3.464 ± 1.186
2.969ThrCys: 2.969 ± 1.078
3.04ThrAsp: 3.04 ± 0.749
3.393ThrGlu: 3.393 ± 0.466
4.242ThrPhe: 4.242 ± 0.867
4.03ThrGly: 4.03 ± 0.694
1.343ThrHis: 1.343 ± 0.351
4.242ThrIle: 4.242 ± 1.009
3.111ThrLys: 3.111 ± 0.516
6.151ThrLeu: 6.151 ± 0.752
1.414ThrMet: 1.414 ± 0.485
3.04ThrAsn: 3.04 ± 0.493
3.181ThrPro: 3.181 ± 0.578
3.959ThrGln: 3.959 ± 1.289
2.828ThrArg: 2.828 ± 0.726
5.373ThrSer: 5.373 ± 0.998
5.797ThrThr: 5.797 ± 0.759
5.232ThrVal: 5.232 ± 0.621
0.778ThrTrp: 0.778 ± 0.262
2.686ThrTyr: 2.686 ± 0.61
0.0ThrXaa: 0.0 ± 0.0
Val
6.009ValAla: 6.009 ± 0.947
2.192ValCys: 2.192 ± 0.475
5.09ValAsp: 5.09 ± 1.114
4.454ValGlu: 4.454 ± 1.004
4.03ValPhe: 4.03 ± 0.498
3.04ValGly: 3.04 ± 0.651
1.343ValHis: 1.343 ± 0.498
4.383ValIle: 4.383 ± 0.701
5.444ValLys: 5.444 ± 0.974
8.059ValLeu: 8.059 ± 1.012
1.555ValMet: 1.555 ± 0.436
3.464ValAsn: 3.464 ± 0.926
2.969ValPro: 2.969 ± 0.692
3.111ValGln: 3.111 ± 0.751
2.828ValArg: 2.828 ± 0.759
4.595ValSer: 4.595 ± 0.635
6.504ValThr: 6.504 ± 0.757
6.504ValVal: 6.504 ± 1.607
0.566ValTrp: 0.566 ± 0.175
4.454ValTyr: 4.454 ± 0.821
0.0ValXaa: 0.0 ± 0.0
Trp
0.707TrpAla: 0.707 ± 0.294
0.212TrpCys: 0.212 ± 0.089
0.353TrpAsp: 0.353 ± 0.237
0.495TrpGlu: 0.495 ± 0.144
1.414TrpPhe: 1.414 ± 0.761
0.141TrpGly: 0.141 ± 0.095
0.353TrpHis: 0.353 ± 0.479
0.424TrpIle: 0.424 ± 0.199
0.566TrpLys: 0.566 ± 0.219
1.485TrpLeu: 1.485 ± 0.636
0.141TrpMet: 0.141 ± 0.063
1.273TrpAsn: 1.273 ± 0.263
0.353TrpPro: 0.353 ± 0.344
0.283TrpGln: 0.283 ± 0.223
0.212TrpArg: 0.212 ± 0.142
0.848TrpSer: 0.848 ± 0.296
0.424TrpThr: 0.424 ± 0.153
0.778TrpVal: 0.778 ± 0.254
0.071TrpTrp: 0.071 ± 0.047
0.283TrpTyr: 0.283 ± 0.24
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.192TyrAla: 2.192 ± 0.393
1.697TyrCys: 1.697 ± 0.577
2.333TyrAsp: 2.333 ± 0.811
1.838TyrGlu: 1.838 ± 0.473
2.828TyrPhe: 2.828 ± 0.564
2.121TyrGly: 2.121 ± 0.346
0.848TyrHis: 0.848 ± 0.346
1.485TyrIle: 1.485 ± 0.426
3.888TyrLys: 3.888 ± 0.761
3.535TyrLeu: 3.535 ± 1.084
1.131TyrMet: 1.131 ± 0.506
2.474TyrAsn: 2.474 ± 0.378
1.697TyrPro: 1.697 ± 0.421
1.555TyrGln: 1.555 ± 1.195
2.474TyrArg: 2.474 ± 0.481
2.616TyrSer: 2.616 ± 1.292
3.252TyrThr: 3.252 ± 0.955
4.242TyrVal: 4.242 ± 0.91
0.353TyrTrp: 0.353 ± 0.183
2.545TyrTyr: 2.545 ± 0.363
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (14146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski