Amino acid dipepetide frequency for Blastomyces silverae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.156AlaAla: 8.156 ± 0.07	0.959AlaCys: 0.959 ± 0.018	4.004AlaAsp: 4.004 ± 0.035	4.985AlaGlu: 4.985 ± 0.052	2.888AlaPhe: 2.888 ± 0.028	5.512AlaGly: 5.512 ± 0.041	1.66AlaHis: 1.66 ± 0.022	4.134AlaIle: 4.134 ± 0.036	3.996AlaLys: 3.996 ± 0.044	7.267AlaLeu: 7.267 ± 0.057	1.746AlaMet: 1.746 ± 0.023	2.929AlaAsn: 2.929 ± 0.029	4.437AlaPro: 4.437 ± 0.044	3.109AlaGln: 3.109 ± 0.033	4.797AlaArg: 4.797 ± 0.039	7.039AlaSer: 7.039 ± 0.056	4.981AlaThr: 4.981 ± 0.041	4.932AlaVal: 4.932 ± 0.039	0.977AlaTrp: 0.977 ± 0.018	1.904AlaTyr: 1.904 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.882CysAla: 0.882 ± 0.016	0.241CysCys: 0.241 ± 0.009	0.636CysAsp: 0.636 ± 0.015	0.619CysGlu: 0.619 ± 0.014	0.517CysPhe: 0.517 ± 0.011	0.89CysGly: 0.89 ± 0.016	0.316CysHis: 0.316 ± 0.01	0.692CysIle: 0.692 ± 0.015	0.536CysLys: 0.536 ± 0.013	1.229CysLeu: 1.229 ± 0.022	0.264CysMet: 0.264 ± 0.008	0.42CysAsn: 0.42 ± 0.013	0.683CysPro: 0.683 ± 0.016	0.469CysGln: 0.469 ± 0.012	0.768CysArg: 0.768 ± 0.018	0.929CysSer: 0.929 ± 0.018	0.65CysThr: 0.65 ± 0.016	0.73CysVal: 0.73 ± 0.014	0.189CysTrp: 0.189 ± 0.007	0.348CysTyr: 0.348 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.257AspAla: 4.257 ± 0.037	0.608AspCys: 0.608 ± 0.013	4.537AspAsp: 4.537 ± 0.066	4.501AspGlu: 4.501 ± 0.053	2.114AspPhe: 2.114 ± 0.026	4.114AspGly: 4.114 ± 0.043	1.207AspHis: 1.207 ± 0.016	3.357AspIle: 3.357 ± 0.031	2.43AspLys: 2.43 ± 0.028	4.831AspLeu: 4.831 ± 0.041	1.27AspMet: 1.27 ± 0.02	2.048AspAsn: 2.048 ± 0.026	3.334AspPro: 3.334 ± 0.032	1.825AspGln: 1.825 ± 0.023	3.108AspArg: 3.108 ± 0.031	4.326AspSer: 4.326 ± 0.039	2.939AspThr: 2.939 ± 0.027	3.534AspVal: 3.534 ± 0.031	0.776AspTrp: 0.776 ± 0.016	1.521AspTyr: 1.521 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.041GluAla: 5.041 ± 0.043	0.639GluCys: 0.639 ± 0.014	4.164GluAsp: 4.164 ± 0.053	5.606GluGlu: 5.606 ± 0.085	1.993GluPhe: 1.993 ± 0.023	3.806GluGly: 3.806 ± 0.037	1.38GluHis: 1.38 ± 0.02	3.271GluIle: 3.271 ± 0.031	3.883GluLys: 3.883 ± 0.045	5.246GluLeu: 5.246 ± 0.043	1.492GluMet: 1.492 ± 0.024	2.579GluAsn: 2.579 ± 0.03	2.926GluPro: 2.926 ± 0.043	2.501GluGln: 2.501 ± 0.033	4.145GluArg: 4.145 ± 0.042	4.467GluSer: 4.467 ± 0.039	3.459GluThr: 3.459 ± 0.038	3.345GluVal: 3.345 ± 0.035	0.854GluTrp: 0.854 ± 0.018	1.709GluTyr: 1.709 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	2.813PheAla: 2.813 ± 0.03	0.546PheCys: 0.546 ± 0.013	2.193PheAsp: 2.193 ± 0.023	2.165PheGlu: 2.165 ± 0.025	1.517PhePhe: 1.517 ± 0.024	2.676PheGly: 2.676 ± 0.036	0.928PheHis: 0.928 ± 0.017	1.8PheIle: 1.8 ± 0.025	1.574PheLys: 1.574 ± 0.023	3.423PheLeu: 3.423 ± 0.035	0.759PheMet: 0.759 ± 0.016	1.424PheAsn: 1.424 ± 0.019	2.068PhePro: 2.068 ± 0.024	1.362PheGln: 1.362 ± 0.021	2.064PheArg: 2.064 ± 0.024	3.165PheSer: 3.165 ± 0.032	2.08PheThr: 2.08 ± 0.027	2.222PheVal: 2.222 ± 0.029	0.584PheTrp: 0.584 ± 0.013	1.079PheTyr: 1.079 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.845GlyAla: 4.845 ± 0.039	0.818GlyCys: 0.818 ± 0.017	3.781GlyAsp: 3.781 ± 0.031	3.887GlyGlu: 3.887 ± 0.038	2.562GlyPhe: 2.562 ± 0.027	5.855GlyGly: 5.855 ± 0.064	1.622GlyHis: 1.622 ± 0.025	3.511GlyIle: 3.511 ± 0.027	3.609GlyLys: 3.609 ± 0.04	5.618GlyLeu: 5.618 ± 0.046	1.608GlyMet: 1.608 ± 0.023	2.67GlyAsn: 2.67 ± 0.034	3.178GlyPro: 3.178 ± 0.033	2.436GlyGln: 2.436 ± 0.028	4.153GlyArg: 4.153 ± 0.034	5.716GlySer: 5.716 ± 0.045	3.758GlyThr: 3.758 ± 0.039	4.151GlyVal: 4.151 ± 0.037	1.074GlyTrp: 1.074 ± 0.019	1.998GlyTyr: 1.998 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.807HisAla: 1.807 ± 0.024	0.331HisCys: 0.331 ± 0.009	1.312HisAsp: 1.312 ± 0.021	1.299HisGlu: 1.299 ± 0.02	0.928HisPhe: 0.928 ± 0.017	1.665HisGly: 1.665 ± 0.024	0.98HisHis: 0.98 ± 0.023	1.304HisIle: 1.304 ± 0.02	0.924HisLys: 0.924 ± 0.017	2.267HisLeu: 2.267 ± 0.026	0.484HisMet: 0.484 ± 0.012	0.912HisAsn: 0.912 ± 0.016	1.87HisPro: 1.87 ± 0.028	1.092HisGln: 1.092 ± 0.023	1.642HisArg: 1.642 ± 0.025	2.069HisSer: 2.069 ± 0.026	1.279HisThr: 1.279 ± 0.019	1.338HisVal: 1.338 ± 0.019	0.299HisTrp: 0.299 ± 0.009	0.683HisTyr: 0.683 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.941IleAla: 3.941 ± 0.033	0.783IleCys: 0.783 ± 0.015	2.994IleAsp: 2.994 ± 0.032	2.945IleGlu: 2.945 ± 0.03	2.116IlePhe: 2.116 ± 0.028	3.084IleGly: 3.084 ± 0.035	1.291IleHis: 1.291 ± 0.018	2.691IleIle: 2.691 ± 0.032	2.284IleLys: 2.284 ± 0.03	4.806IleLeu: 4.806 ± 0.046	1.014IleMet: 1.014 ± 0.017	1.913IleAsn: 1.913 ± 0.025	3.408IlePro: 3.408 ± 0.034	1.948IleGln: 1.948 ± 0.025	2.989IleArg: 2.989 ± 0.031	4.445IleSer: 4.445 ± 0.042	2.897IleThr: 2.897 ± 0.031	3.084IleVal: 3.084 ± 0.031	0.687IleTrp: 0.687 ± 0.015	1.498IleTyr: 1.498 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.048LysAla: 4.048 ± 0.041	0.552LysCys: 0.552 ± 0.013	2.731LysAsp: 2.731 ± 0.031	3.527LysGlu: 3.527 ± 0.041	1.594LysPhe: 1.594 ± 0.021	3.065LysGly: 3.065 ± 0.035	1.176LysHis: 1.176 ± 0.018	2.498LysIle: 2.498 ± 0.026	3.491LysLys: 3.491 ± 0.059	4.404LysLeu: 4.404 ± 0.039	1.033LysMet: 1.033 ± 0.017	1.902LysAsn: 1.902 ± 0.022	2.992LysPro: 2.992 ± 0.031	1.975LysGln: 1.975 ± 0.028	3.746LysArg: 3.746 ± 0.04	3.854LysSer: 3.854 ± 0.039	2.766LysThr: 2.766 ± 0.029	2.732LysVal: 2.732 ± 0.03	0.643LysTrp: 0.643 ± 0.013	1.46LysTyr: 1.46 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.334LeuAla: 7.334 ± 0.05	1.179LeuCys: 1.179 ± 0.021	5.046LeuAsp: 5.046 ± 0.036	5.621LeuGlu: 5.621 ± 0.049	3.312LeuPhe: 3.312 ± 0.038	5.571LeuGly: 5.571 ± 0.047	2.28LeuHis: 2.28 ± 0.025	4.062LeuIle: 4.062 ± 0.043	4.486LeuLys: 4.486 ± 0.039	8.543LeuLeu: 8.543 ± 0.079	1.734LeuMet: 1.734 ± 0.024	3.256LeuAsn: 3.256 ± 0.03	5.627LeuPro: 5.627 ± 0.04	3.831LeuGln: 3.831 ± 0.038	5.916LeuArg: 5.916 ± 0.042	7.661LeuSer: 7.661 ± 0.061	4.711LeuThr: 4.711 ± 0.042	5.068LeuVal: 5.068 ± 0.043	1.087LeuTrp: 1.087 ± 0.019	2.306LeuTyr: 2.306 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.066MetAla: 2.066 ± 0.024	0.245MetCys: 0.245 ± 0.009	1.266MetAsp: 1.266 ± 0.018	1.393MetGlu: 1.393 ± 0.019	0.733MetPhe: 0.733 ± 0.014	1.439MetGly: 1.439 ± 0.022	0.432MetHis: 0.432 ± 0.011	1.02MetIle: 1.02 ± 0.018	1.119MetLys: 1.119 ± 0.018	1.789MetLeu: 1.789 ± 0.023	0.54MetMet: 0.54 ± 0.015	0.792MetAsn: 0.792 ± 0.014	1.196MetPro: 1.196 ± 0.02	0.807MetGln: 0.807 ± 0.015	1.242MetArg: 1.242 ± 0.021	1.82MetSer: 1.82 ± 0.025	1.253MetThr: 1.253 ± 0.018	1.283MetVal: 1.283 ± 0.021	0.25MetTrp: 0.25 ± 0.008	0.471MetTyr: 0.471 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.051AsnAla: 3.051 ± 0.03	0.461AsnCys: 0.461 ± 0.012	2.168AsnAsp: 2.168 ± 0.029	2.161AsnGlu: 2.161 ± 0.026	1.374AsnPhe: 1.374 ± 0.02	3.062AsnGly: 3.062 ± 0.035	0.954AsnHis: 0.954 ± 0.017	2.319AsnIle: 2.319 ± 0.025	1.678AsnLys: 1.678 ± 0.024	3.389AsnLeu: 3.389 ± 0.037	0.86AsnMet: 0.86 ± 0.017	2.082AsnAsn: 2.082 ± 0.068	2.721AsnPro: 2.721 ± 0.031	1.44AsnGln: 1.44 ± 0.023	2.185AsnArg: 2.185 ± 0.027	3.163AsnSer: 3.163 ± 0.033	2.282AsnThr: 2.282 ± 0.029	2.266AsnVal: 2.266 ± 0.026	0.5AsnTrp: 0.5 ± 0.011	1.035AsnTyr: 1.035 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.105ProAla: 5.105 ± 0.052	0.538ProCys: 0.538 ± 0.013	3.246ProAsp: 3.246 ± 0.029	3.86ProGlu: 3.86 ± 0.041	2.127ProPhe: 2.127 ± 0.024	3.868ProGly: 3.868 ± 0.041	1.492ProHis: 1.492 ± 0.026	2.747ProIle: 2.747 ± 0.027	2.821ProLys: 2.821 ± 0.037	5.08ProLeu: 5.08 ± 0.039	1.052ProMet: 1.052 ± 0.018	2.45ProAsn: 2.45 ± 0.027	5.972ProPro: 5.972 ± 0.082	2.694ProGln: 2.694 ± 0.037	3.601ProArg: 3.601 ± 0.041	6.718ProSer: 6.718 ± 0.068	4.319ProThr: 4.319 ± 0.045	3.436ProVal: 3.436 ± 0.04	0.674ProTrp: 0.674 ± 0.014	1.509ProTyr: 1.509 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.153GlnAla: 3.153 ± 0.031	0.435GlnCys: 0.435 ± 0.012	1.946GlnAsp: 1.946 ± 0.023	2.393GlnGlu: 2.393 ± 0.029	1.303GlnPhe: 1.303 ± 0.021	2.293GlnGly: 2.293 ± 0.028	1.185GlnHis: 1.185 ± 0.022	1.959GlnIle: 1.959 ± 0.028	2.084GlnLys: 2.084 ± 0.026	3.504GlnLeu: 3.504 ± 0.034	0.842GlnMet: 0.842 ± 0.018	1.726GlnAsn: 1.726 ± 0.027	2.797GlnPro: 2.797 ± 0.036	2.871GlnGln: 2.871 ± 0.07	2.779GlnArg: 2.779 ± 0.031	3.252GlnSer: 3.252 ± 0.037	2.271GlnThr: 2.271 ± 0.03	2.006GlnVal: 2.006 ± 0.023	0.49GlnTrp: 0.49 ± 0.012	1.081GlnTyr: 1.081 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.699ArgAla: 4.699 ± 0.045	0.743ArgCys: 0.743 ± 0.015	3.431ArgAsp: 3.431 ± 0.032	4.043ArgGlu: 4.043 ± 0.043	2.173ArgPhe: 2.173 ± 0.025	3.887ArgGly: 3.887 ± 0.038	1.643ArgHis: 1.643 ± 0.024	3.081ArgIle: 3.081 ± 0.03	3.779ArgLys: 3.779 ± 0.039	5.56ArgLeu: 5.56 ± 0.041	1.364ArgMet: 1.364 ± 0.018	2.569ArgAsn: 2.569 ± 0.03	3.626ArgPro: 3.626 ± 0.042	2.719ArgGln: 2.719 ± 0.032	5.528ArgArg: 5.528 ± 0.051	5.145ArgSer: 5.145 ± 0.052	3.432ArgThr: 3.432 ± 0.036	3.367ArgVal: 3.367 ± 0.031	0.893ArgTrp: 0.893 ± 0.016	1.688ArgTyr: 1.688 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.564SerAla: 6.564 ± 0.044	0.896SerCys: 0.896 ± 0.015	4.302SerAsp: 4.302 ± 0.037	4.271SerGlu: 4.271 ± 0.041	3.101SerPhe: 3.101 ± 0.034	5.653SerGly: 5.653 ± 0.049	2.177SerHis: 2.177 ± 0.027	4.218SerIle: 4.218 ± 0.042	4.075SerLys: 4.075 ± 0.036	7.497SerLeu: 7.497 ± 0.056	1.769SerMet: 1.769 ± 0.023	3.416SerAsn: 3.416 ± 0.034	6.367SerPro: 6.367 ± 0.078	3.514SerGln: 3.514 ± 0.043	5.571SerArg: 5.571 ± 0.057	10.043SerSer: 10.043 ± 0.104	5.973SerThr: 5.973 ± 0.058	4.464SerVal: 4.464 ± 0.04	1.073SerTrp: 1.073 ± 0.018	2.046SerTyr: 2.046 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.032ThrAla: 5.032 ± 0.041	0.715ThrCys: 0.715 ± 0.018	2.807ThrAsp: 2.807 ± 0.03	3.122ThrGlu: 3.122 ± 0.036	2.177ThrPhe: 2.177 ± 0.026	3.936ThrGly: 3.936 ± 0.039	1.338ThrHis: 1.338 ± 0.02	3.045ThrIle: 3.045 ± 0.031	2.686ThrLys: 2.686 ± 0.025	5.139ThrLeu: 5.139 ± 0.042	1.135ThrMet: 1.135 ± 0.016	2.198ThrAsn: 2.198 ± 0.025	4.553ThrPro: 4.553 ± 0.048	2.086ThrGln: 2.086 ± 0.025	3.228ThrArg: 3.228 ± 0.028	5.633ThrSer: 5.633 ± 0.056	4.663ThrThr: 4.663 ± 0.103	3.488ThrVal: 3.488 ± 0.033	0.728ThrTrp: 0.728 ± 0.015	1.481ThrTyr: 1.481 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.669ValAla: 4.669 ± 0.035	0.751ValCys: 0.751 ± 0.014	3.667ValAsp: 3.667 ± 0.032	3.818ValGlu: 3.818 ± 0.033	2.267ValPhe: 2.267 ± 0.026	3.798ValGly: 3.798 ± 0.033	1.339ValHis: 1.339 ± 0.019	2.932ValIle: 2.932 ± 0.031	2.875ValLys: 2.875 ± 0.03	5.225ValLeu: 5.225 ± 0.045	1.249ValMet: 1.249 ± 0.018	2.203ValAsn: 2.203 ± 0.024	3.413ValPro: 3.413 ± 0.033	2.124ValGln: 2.124 ± 0.026	3.37ValArg: 3.37 ± 0.03	4.525ValSer: 4.525 ± 0.039	3.23ValThr: 3.23 ± 0.03	3.947ValVal: 3.947 ± 0.044	0.772ValTrp: 0.772 ± 0.015	1.543ValTyr: 1.543 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.013TrpAla: 1.013 ± 0.018	0.177TrpCys: 0.177 ± 0.007	0.831TrpAsp: 0.831 ± 0.018	0.813TrpGlu: 0.813 ± 0.017	0.475TrpPhe: 0.475 ± 0.011	0.83TrpGly: 0.83 ± 0.015	0.314TrpHis: 0.314 ± 0.009	0.718TrpIle: 0.718 ± 0.015	0.781TrpLys: 0.781 ± 0.015	1.21TrpLeu: 1.21 ± 0.02	0.34TrpMet: 0.34 ± 0.009	0.585TrpAsn: 0.585 ± 0.013	0.542TrpPro: 0.542 ± 0.013	0.491TrpGln: 0.491 ± 0.012	0.939TrpArg: 0.939 ± 0.016	0.947TrpSer: 0.947 ± 0.017	0.772TrpThr: 0.772 ± 0.014	0.79TrpVal: 0.79 ± 0.016	0.248TrpTrp: 0.248 ± 0.01	0.362TrpTyr: 0.362 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.932TyrAla: 1.932 ± 0.024	0.389TyrCys: 0.389 ± 0.011	1.577TyrAsp: 1.577 ± 0.02	1.478TyrGlu: 1.478 ± 0.018	1.169TyrPhe: 1.169 ± 0.021	1.848TyrGly: 1.848 ± 0.023	0.769TyrHis: 0.769 ± 0.015	1.462TyrIle: 1.462 ± 0.02	1.077TyrLys: 1.077 ± 0.018	2.608TyrLeu: 2.608 ± 0.027	0.601TyrMet: 0.601 ± 0.014	1.078TyrAsn: 1.078 ± 0.018	1.602TyrPro: 1.602 ± 0.033	1.076TyrGln: 1.076 ± 0.016	1.599TyrArg: 1.599 ± 0.022	2.073TyrSer: 2.073 ± 0.028	1.474TyrThr: 1.474 ± 0.02	1.534TyrVal: 1.534 ± 0.021	0.379TyrTrp: 0.379 ± 0.011	0.862TyrTyr: 0.862 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8561 proteins (3669030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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