Amino acid dipepetide frequency for Parendozoicomonas haliclonae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.539AlaAla: 8.539 ± 0.101	1.085AlaCys: 1.085 ± 0.03	4.899AlaAsp: 4.899 ± 0.064	5.862AlaGlu: 5.862 ± 0.075	3.431AlaPhe: 3.431 ± 0.05	7.413AlaGly: 7.413 ± 0.083	1.694AlaHis: 1.694 ± 0.032	5.359AlaIle: 5.359 ± 0.064	3.522AlaLys: 3.522 ± 0.061	10.155AlaLeu: 10.155 ± 0.109	2.829AlaMet: 2.829 ± 0.048	2.958AlaAsn: 2.958 ± 0.051	3.286AlaPro: 3.286 ± 0.054	3.441AlaGln: 3.441 ± 0.056	4.961AlaArg: 4.961 ± 0.066	5.764AlaSer: 5.764 ± 0.061	4.424AlaThr: 4.424 ± 0.064	6.158AlaVal: 6.158 ± 0.07	1.106AlaTrp: 1.106 ± 0.024	2.205AlaTyr: 2.205 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.847CysAla: 0.847 ± 0.025	0.189CysCys: 0.189 ± 0.012	0.604CysAsp: 0.604 ± 0.021	0.64CysGlu: 0.64 ± 0.025	0.434CysPhe: 0.434 ± 0.018	0.981CysGly: 0.981 ± 0.031	0.327CysHis: 0.327 ± 0.014	0.544CysIle: 0.544 ± 0.016	0.414CysLys: 0.414 ± 0.017	1.196CysLeu: 1.196 ± 0.03	0.245CysMet: 0.245 ± 0.012	0.359CysAsn: 0.359 ± 0.016	0.577CysPro: 0.577 ± 0.018	0.534CysGln: 0.534 ± 0.019	0.714CysArg: 0.714 ± 0.028	0.787CysSer: 0.787 ± 0.023	0.58CysThr: 0.58 ± 0.02	0.6CysVal: 0.6 ± 0.019	0.157CysTrp: 0.157 ± 0.01	0.326CysTyr: 0.326 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.647AspAla: 4.647 ± 0.066	0.568AspCys: 0.568 ± 0.022	3.342AspAsp: 3.342 ± 0.059	3.764AspGlu: 3.764 ± 0.056	2.238AspPhe: 2.238 ± 0.041	4.072AspGly: 4.072 ± 0.066	1.25AspHis: 1.25 ± 0.028	3.736AspIle: 3.736 ± 0.045	2.798AspLys: 2.798 ± 0.045	5.255AspLeu: 5.255 ± 0.061	1.49AspMet: 1.49 ± 0.033	2.411AspAsn: 2.411 ± 0.048	2.317AspPro: 2.317 ± 0.041	2.349AspGln: 2.349 ± 0.038	2.993AspArg: 2.993 ± 0.051	3.544AspSer: 3.544 ± 0.058	2.936AspThr: 2.936 ± 0.061	3.527AspVal: 3.527 ± 0.048	0.83AspTrp: 0.83 ± 0.025	1.937AspTyr: 1.937 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.775GluAla: 5.775 ± 0.081	0.556GluCys: 0.556 ± 0.023	3.128GluAsp: 3.128 ± 0.047	4.289GluGlu: 4.289 ± 0.071	2.018GluPhe: 2.018 ± 0.04	4.137GluGly: 4.137 ± 0.056	1.598GluHis: 1.598 ± 0.031	3.356GluIle: 3.356 ± 0.046	3.385GluLys: 3.385 ± 0.054	7.012GluLeu: 7.012 ± 0.077	1.633GluMet: 1.633 ± 0.033	2.453GluAsn: 2.453 ± 0.042	2.566GluPro: 2.566 ± 0.056	4.319GluGln: 4.319 ± 0.057	3.776GluArg: 3.776 ± 0.058	3.777GluSer: 3.777 ± 0.055	3.385GluThr: 3.385 ± 0.054	3.955GluVal: 3.955 ± 0.057	0.82GluTrp: 0.82 ± 0.025	1.668GluTyr: 1.668 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.169PheAla: 3.169 ± 0.049	0.52PheCys: 0.52 ± 0.02	2.392PheAsp: 2.392 ± 0.042	2.121PheGlu: 2.121 ± 0.034	1.555PhePhe: 1.555 ± 0.031	2.976PheGly: 2.976 ± 0.05	0.918PheHis: 0.918 ± 0.025	2.256PheIle: 2.256 ± 0.045	1.488PheLys: 1.488 ± 0.035	3.465PheLeu: 3.465 ± 0.056	1.009PheMet: 1.009 ± 0.025	1.552PheAsn: 1.552 ± 0.033	1.527PhePro: 1.527 ± 0.037	1.537PheGln: 1.537 ± 0.032	1.889PheArg: 1.889 ± 0.035	3.035PheSer: 3.035 ± 0.045	2.248PheThr: 2.248 ± 0.046	2.362PheVal: 2.362 ± 0.042	0.541PheTrp: 0.541 ± 0.019	1.251PheTyr: 1.251 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	5.658GlyAla: 5.658 ± 0.074	1.001GlyCys: 1.001 ± 0.028	3.914GlyAsp: 3.914 ± 0.067	4.589GlyGlu: 4.589 ± 0.057	3.273GlyPhe: 3.273 ± 0.049	5.212GlyGly: 5.212 ± 0.078	1.761GlyHis: 1.761 ± 0.034	4.591GlyIle: 4.591 ± 0.064	3.779GlyLys: 3.779 ± 0.059	7.717GlyLeu: 7.717 ± 0.077	2.329GlyMet: 2.329 ± 0.041	2.761GlyAsn: 2.761 ± 0.06	1.895GlyPro: 1.895 ± 0.034	3.362GlyGln: 3.362 ± 0.053	3.8GlyArg: 3.8 ± 0.054	4.736GlySer: 4.736 ± 0.062	3.747GlyThr: 3.747 ± 0.061	5.177GlyVal: 5.177 ± 0.063	1.115GlyTrp: 1.115 ± 0.031	2.553GlyTyr: 2.553 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.643HisAla: 1.643 ± 0.032	0.376HisCys: 0.376 ± 0.016	1.168HisAsp: 1.168 ± 0.025	1.211HisGlu: 1.211 ± 0.03	0.978HisPhe: 0.978 ± 0.026	1.628HisGly: 1.628 ± 0.036	0.702HisHis: 0.702 ± 0.026	1.367HisIle: 1.367 ± 0.027	1.056HisLys: 1.056 ± 0.029	2.262HisLeu: 2.262 ± 0.042	0.551HisMet: 0.551 ± 0.018	0.93HisAsn: 0.93 ± 0.026	1.323HisPro: 1.323 ± 0.028	1.136HisGln: 1.136 ± 0.028	1.262HisArg: 1.262 ± 0.026	1.475HisSer: 1.475 ± 0.029	1.19HisThr: 1.19 ± 0.03	1.113HisVal: 1.113 ± 0.025	0.377HisTrp: 0.377 ± 0.015	0.832HisTyr: 0.832 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.44IleAla: 5.44 ± 0.063	0.682IleCys: 0.682 ± 0.023	3.406IleAsp: 3.406 ± 0.051	3.62IleGlu: 3.62 ± 0.05	1.881IlePhe: 1.881 ± 0.04	4.065IleGly: 4.065 ± 0.062	1.314IleHis: 1.314 ± 0.027	2.955IleIle: 2.955 ± 0.053	2.537IleLys: 2.537 ± 0.047	4.865IleLeu: 4.865 ± 0.065	1.237IleMet: 1.237 ± 0.029	2.555IleAsn: 2.555 ± 0.039	2.926IlePro: 2.926 ± 0.046	2.144IleGln: 2.144 ± 0.042	3.078IleArg: 3.078 ± 0.047	4.096IleSer: 4.096 ± 0.055	3.698IleThr: 3.698 ± 0.059	3.473IleVal: 3.473 ± 0.056	0.623IleTrp: 0.623 ± 0.02	1.528IleTyr: 1.528 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.809LysAla: 4.809 ± 0.07	0.298LysCys: 0.298 ± 0.014	2.695LysAsp: 2.695 ± 0.049	3.114LysGlu: 3.114 ± 0.052	1.103LysPhe: 1.103 ± 0.029	3.314LysGly: 3.314 ± 0.053	0.983LysHis: 0.983 ± 0.025	2.201LysIle: 2.201 ± 0.038	2.736LysLys: 2.736 ± 0.062	4.332LysLeu: 4.332 ± 0.055	1.144LysMet: 1.144 ± 0.027	1.812LysAsn: 1.812 ± 0.036	2.555LysPro: 2.555 ± 0.049	2.17LysGln: 2.17 ± 0.043	2.462LysArg: 2.462 ± 0.043	2.728LysSer: 2.728 ± 0.05	2.829LysThr: 2.829 ± 0.049	3.289LysVal: 3.289 ± 0.045	0.422LysTrp: 0.422 ± 0.017	1.06LysTyr: 1.06 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.141LeuAla: 10.141 ± 0.091	1.22LeuCys: 1.22 ± 0.032	5.875LeuAsp: 5.875 ± 0.071	6.509LeuGlu: 6.509 ± 0.077	4.081LeuPhe: 4.081 ± 0.059	7.135LeuGly: 7.135 ± 0.083	2.133LeuHis: 2.133 ± 0.043	5.561LeuIle: 5.561 ± 0.069	5.212LeuLys: 5.212 ± 0.065	10.592LeuLeu: 10.592 ± 0.122	2.88LeuMet: 2.88 ± 0.046	4.141LeuAsn: 4.141 ± 0.047	5.464LeuPro: 5.464 ± 0.07	4.318LeuGln: 4.318 ± 0.063	5.035LeuArg: 5.035 ± 0.067	7.69LeuSer: 7.69 ± 0.08	6.14LeuThr: 6.14 ± 0.071	6.959LeuVal: 6.959 ± 0.072	1.173LeuTrp: 1.173 ± 0.033	2.575LeuTyr: 2.575 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.931MetAla: 2.931 ± 0.05	0.189MetCys: 0.189 ± 0.01	1.551MetAsp: 1.551 ± 0.032	1.595MetGlu: 1.595 ± 0.032	0.815MetPhe: 0.815 ± 0.025	2.004MetGly: 2.004 ± 0.037	0.528MetHis: 0.528 ± 0.019	1.492MetIle: 1.492 ± 0.038	1.336MetLys: 1.336 ± 0.03	2.664MetLeu: 2.664 ± 0.049	0.852MetMet: 0.852 ± 0.027	1.168MetAsn: 1.168 ± 0.025	1.385MetPro: 1.385 ± 0.03	1.055MetGln: 1.055 ± 0.029	1.231MetArg: 1.231 ± 0.029	1.972MetSer: 1.972 ± 0.037	1.716MetThr: 1.716 ± 0.034	1.873MetVal: 1.873 ± 0.038	0.173MetTrp: 0.173 ± 0.011	0.494MetTyr: 0.494 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.117AsnAla: 3.117 ± 0.046	0.386AsnCys: 0.386 ± 0.016	2.076AsnAsp: 2.076 ± 0.054	2.063AsnGlu: 2.063 ± 0.034	1.32AsnPhe: 1.32 ± 0.032	2.929AsnGly: 2.929 ± 0.061	0.946AsnHis: 0.946 ± 0.025	2.337AsnIle: 2.337 ± 0.046	1.831AsnLys: 1.831 ± 0.031	3.781AsnLeu: 3.781 ± 0.053	0.94AsnMet: 0.94 ± 0.026	1.798AsnAsn: 1.798 ± 0.045	2.302AsnPro: 2.302 ± 0.042	1.729AsnGln: 1.729 ± 0.041	2.251AsnArg: 2.251 ± 0.039	2.421AsnSer: 2.421 ± 0.053	2.347AsnThr: 2.347 ± 0.05	2.069AsnVal: 2.069 ± 0.04	0.584AsnTrp: 0.584 ± 0.019	1.157AsnTyr: 1.157 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.471ProAla: 4.471 ± 0.059	0.364ProCys: 0.364 ± 0.016	3.218ProAsp: 3.218 ± 0.052	4.285ProGlu: 4.285 ± 0.062	1.713ProPhe: 1.713 ± 0.035	3.256ProGly: 3.256 ± 0.052	0.914ProHis: 0.914 ± 0.022	1.941ProIle: 1.941 ± 0.039	1.871ProLys: 1.871 ± 0.042	4.586ProLeu: 4.586 ± 0.053	1.153ProMet: 1.153 ± 0.03	1.449ProAsn: 1.449 ± 0.029	1.809ProPro: 1.809 ± 0.049	1.809ProGln: 1.809 ± 0.042	1.756ProArg: 1.756 ± 0.035	2.719ProSer: 2.719 ± 0.046	2.074ProThr: 2.074 ± 0.043	4.273ProVal: 4.273 ± 0.056	0.654ProTrp: 0.654 ± 0.021	1.196ProTyr: 1.196 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.415GlnAla: 4.415 ± 0.057	0.436GlnCys: 0.436 ± 0.016	2.199GlnAsp: 2.199 ± 0.037	2.709GlnGlu: 2.709 ± 0.048	1.43GlnPhe: 1.43 ± 0.031	3.036GlnGly: 3.036 ± 0.045	1.088GlnHis: 1.088 ± 0.027	2.292GlnIle: 2.292 ± 0.039	2.247GlnLys: 2.247 ± 0.043	4.979GlnLeu: 4.979 ± 0.069	1.162GlnMet: 1.162 ± 0.027	1.619GlnAsn: 1.619 ± 0.034	2.376GlnPro: 2.376 ± 0.046	3.003GlnGln: 3.003 ± 0.062	2.499GlnArg: 2.499 ± 0.045	2.934GlnSer: 2.934 ± 0.045	2.487GlnThr: 2.487 ± 0.045	2.906GlnVal: 2.906 ± 0.044	0.648GlnTrp: 0.648 ± 0.021	1.096GlnTyr: 1.096 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.957ArgAla: 3.957 ± 0.049	0.568ArgCys: 0.568 ± 0.019	2.984ArgAsp: 2.984 ± 0.043	3.705ArgGlu: 3.705 ± 0.05	2.392ArgPhe: 2.392 ± 0.038	2.965ArgGly: 2.965 ± 0.049	1.342ArgHis: 1.342 ± 0.033	3.23ArgIle: 3.23 ± 0.044	2.817ArgLys: 2.817 ± 0.058	6.041ArgLeu: 6.041 ± 0.066	1.552ArgMet: 1.552 ± 0.037	2.099ArgAsn: 2.099 ± 0.041	2.125ArgPro: 2.125 ± 0.034	2.694ArgGln: 2.694 ± 0.051	3.008ArgArg: 3.008 ± 0.061	3.231ArgSer: 3.231 ± 0.049	2.681ArgThr: 2.681 ± 0.043	3.404ArgVal: 3.404 ± 0.041	0.758ArgTrp: 0.758 ± 0.022	1.825ArgTyr: 1.825 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.546SerAla: 5.546 ± 0.066	0.743SerCys: 0.743 ± 0.027	3.629SerAsp: 3.629 ± 0.051	4.009SerGlu: 4.009 ± 0.056	2.752SerPhe: 2.752 ± 0.042	5.696SerGly: 5.696 ± 0.067	1.593SerHis: 1.593 ± 0.032	3.424SerIle: 3.424 ± 0.051	2.583SerLys: 2.583 ± 0.044	7.4SerLeu: 7.4 ± 0.089	1.64SerMet: 1.64 ± 0.035	2.268SerAsn: 2.268 ± 0.043	2.995SerPro: 2.995 ± 0.049	2.963SerGln: 2.963 ± 0.049	3.749SerArg: 3.749 ± 0.048	4.955SerSer: 4.955 ± 0.074	3.466SerThr: 3.466 ± 0.059	4.487SerVal: 4.487 ± 0.056	0.972SerTrp: 0.972 ± 0.025	1.934SerTyr: 1.934 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.992ThrAla: 4.992 ± 0.071	0.594ThrCys: 0.594 ± 0.02	2.963ThrAsp: 2.963 ± 0.06	3.11ThrGlu: 3.11 ± 0.05	2.122ThrPhe: 2.122 ± 0.043	4.77ThrGly: 4.77 ± 0.086	1.136ThrHis: 1.136 ± 0.028	3.094ThrIle: 3.094 ± 0.051	1.812ThrLys: 1.812 ± 0.041	6.732ThrLeu: 6.732 ± 0.071	1.258ThrMet: 1.258 ± 0.03	1.803ThrAsn: 1.803 ± 0.044	3.184ThrPro: 3.184 ± 0.053	1.966ThrGln: 1.966 ± 0.039	2.915ThrArg: 2.915 ± 0.047	3.542ThrSer: 3.542 ± 0.055	3.086ThrThr: 3.086 ± 0.067	4.073ThrVal: 4.073 ± 0.061	0.609ThrTrp: 0.609 ± 0.022	1.344ThrTyr: 1.344 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	6.068ValAla: 6.068 ± 0.073	0.775ValCys: 0.775 ± 0.024	3.798ValAsp: 3.798 ± 0.053	4.228ValGlu: 4.228 ± 0.055	2.553ValPhe: 2.553 ± 0.039	4.33ValGly: 4.33 ± 0.062	1.314ValHis: 1.314 ± 0.035	4.314ValIle: 4.314 ± 0.055	2.881ValLys: 2.881 ± 0.049	6.854ValLeu: 6.854 ± 0.076	2.098ValMet: 2.098 ± 0.039	2.658ValAsn: 2.658 ± 0.045	2.902ValPro: 2.902 ± 0.044	2.479ValGln: 2.479 ± 0.041	3.427ValArg: 3.427 ± 0.053	4.768ValSer: 4.768 ± 0.051	3.95ValThr: 3.95 ± 0.069	5.083ValVal: 5.083 ± 0.07	0.768ValTrp: 0.768 ± 0.025	1.826ValTyr: 1.826 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.847TrpAla: 0.847 ± 0.022	0.167TrpCys: 0.167 ± 0.009	0.62TrpAsp: 0.62 ± 0.02	0.694TrpGlu: 0.694 ± 0.019	0.596TrpPhe: 0.596 ± 0.019	0.831TrpGly: 0.831 ± 0.024	0.367TrpHis: 0.367 ± 0.015	0.676TrpIle: 0.676 ± 0.022	0.548TrpLys: 0.548 ± 0.019	1.831TrpLeu: 1.831 ± 0.038	0.378TrpMet: 0.378 ± 0.02	0.542TrpAsn: 0.542 ± 0.02	0.572TrpPro: 0.572 ± 0.019	0.919TrpGln: 0.919 ± 0.027	0.686TrpArg: 0.686 ± 0.023	0.776TrpSer: 0.776 ± 0.025	0.563TrpThr: 0.563 ± 0.025	0.761TrpVal: 0.761 ± 0.019	0.176TrpTrp: 0.176 ± 0.01	0.4TrpTyr: 0.4 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.079TyrAla: 2.079 ± 0.04	0.342TyrCys: 0.342 ± 0.014	1.544TyrAsp: 1.544 ± 0.056	1.488TyrGlu: 1.488 ± 0.032	1.126TyrPhe: 1.126 ± 0.026	2.221TyrGly: 2.221 ± 0.039	0.675TyrHis: 0.675 ± 0.021	1.397TyrIle: 1.397 ± 0.029	1.2TyrLys: 1.2 ± 0.031	3.117TyrLeu: 3.117 ± 0.048	0.643TyrMet: 0.643 ± 0.021	1.044TyrAsn: 1.044 ± 0.033	1.426TyrPro: 1.426 ± 0.029	1.632TyrGln: 1.632 ± 0.029	1.885TyrArg: 1.885 ± 0.036	1.854TyrSer: 1.854 ± 0.035	1.559TyrThr: 1.559 ± 0.037	1.531TyrVal: 1.531 ± 0.034	0.445TyrTrp: 0.445 ± 0.015	0.865TyrTyr: 0.865 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4695 proteins (1626144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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