Amino acid dipepetide frequency for Blautia sp. YL58

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.653AlaAla: 7.653 ± 0.106
1.26AlaCys: 1.26 ± 0.031
4.373AlaAsp: 4.373 ± 0.064
5.356AlaGlu: 5.356 ± 0.073
3.207AlaPhe: 3.207 ± 0.056
6.464AlaGly: 6.464 ± 0.086
1.141AlaHis: 1.141 ± 0.029
4.316AlaIle: 4.316 ± 0.055
4.353AlaLys: 4.353 ± 0.055
6.83AlaLeu: 6.83 ± 0.077
2.432AlaMet: 2.432 ± 0.051
2.306AlaAsn: 2.306 ± 0.044
2.005AlaPro: 2.005 ± 0.037
2.242AlaGln: 2.242 ± 0.043
2.891AlaArg: 2.891 ± 0.055
3.914AlaSer: 3.914 ± 0.061
2.585AlaThr: 2.585 ± 0.045
6.794AlaVal: 6.794 ± 0.084
0.729AlaTrp: 0.729 ± 0.024
2.819AlaTyr: 2.819 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.088CysAla: 1.088 ± 0.027
0.338CysCys: 0.338 ± 0.018
0.834CysAsp: 0.834 ± 0.028
0.955CysGlu: 0.955 ± 0.028
0.698CysPhe: 0.698 ± 0.02
1.691CysGly: 1.691 ± 0.039
0.334CysHis: 0.334 ± 0.018
1.188CysIle: 1.188 ± 0.03
0.748CysLys: 0.748 ± 0.024
1.337CysLeu: 1.337 ± 0.031
0.534CysMet: 0.534 ± 0.018
0.543CysAsn: 0.543 ± 0.02
0.698CysPro: 0.698 ± 0.021
0.464CysGln: 0.464 ± 0.017
1.007CysArg: 1.007 ± 0.03
1.048CysSer: 1.048 ± 0.025
0.834CysThr: 0.834 ± 0.024
1.12CysVal: 1.12 ± 0.03
0.165CysTrp: 0.165 ± 0.011
0.627CysTyr: 0.627 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.947AspAla: 3.947 ± 0.055
0.854AspCys: 0.854 ± 0.023
2.569AspAsp: 2.569 ± 0.047
4.029AspGlu: 4.029 ± 0.063
2.661AspPhe: 2.661 ± 0.048
4.373AspGly: 4.373 ± 0.063
0.93AspHis: 0.93 ± 0.031
4.25AspIle: 4.25 ± 0.054
3.529AspLys: 3.529 ± 0.057
4.364AspLeu: 4.364 ± 0.053
1.992AspMet: 1.992 ± 0.038
2.172AspAsn: 2.172 ± 0.043
1.742AspPro: 1.742 ± 0.048
1.291AspGln: 1.291 ± 0.028
2.517AspArg: 2.517 ± 0.046
3.047AspSer: 3.047 ± 0.053
3.17AspThr: 3.17 ± 0.053
3.649AspVal: 3.649 ± 0.053
0.665AspTrp: 0.665 ± 0.024
2.648AspTyr: 2.648 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.568GluAla: 5.568 ± 0.081
0.834GluCys: 0.834 ± 0.028
4.302GluAsp: 4.302 ± 0.064
7.634GluGlu: 7.634 ± 0.106
2.648GluPhe: 2.648 ± 0.046
4.7GluGly: 4.7 ± 0.068
1.389GluHis: 1.389 ± 0.032
5.563GluIle: 5.563 ± 0.064
6.894GluLys: 6.894 ± 0.086
6.482GluLeu: 6.482 ± 0.085
2.474GluMet: 2.474 ± 0.042
4.209GluAsn: 4.209 ± 0.065
1.968GluPro: 1.968 ± 0.04
2.93GluGln: 2.93 ± 0.054
3.395GluArg: 3.395 ± 0.062
3.35GluSer: 3.35 ± 0.056
3.744GluThr: 3.744 ± 0.057
4.306GluVal: 4.306 ± 0.054
0.661GluTrp: 0.661 ± 0.022
3.096GluTyr: 3.096 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.024PheAla: 3.024 ± 0.061
0.844PheCys: 0.844 ± 0.022
2.344PheAsp: 2.344 ± 0.041
2.588PheGlu: 2.588 ± 0.05
2.059PhePhe: 2.059 ± 0.043
3.114PheGly: 3.114 ± 0.053
0.908PheHis: 0.908 ± 0.027
2.882PheIle: 2.882 ± 0.055
1.985PheLys: 1.985 ± 0.043
4.377PheLeu: 4.377 ± 0.06
1.286PheMet: 1.286 ± 0.033
1.457PheAsn: 1.457 ± 0.031
1.56PhePro: 1.56 ± 0.034
1.431PheGln: 1.431 ± 0.031
1.894PheArg: 1.894 ± 0.034
3.12PheSer: 3.12 ± 0.05
2.465PheThr: 2.465 ± 0.041
2.808PheVal: 2.808 ± 0.05
0.497PheTrp: 0.497 ± 0.019
1.887PheTyr: 1.887 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.02GlyAla: 5.02 ± 0.072
1.481GlyCys: 1.481 ± 0.036
3.595GlyAsp: 3.595 ± 0.063
5.036GlyGlu: 5.036 ± 0.074
3.231GlyPhe: 3.231 ± 0.045
5.087GlyGly: 5.087 ± 0.078
1.308GlyHis: 1.308 ± 0.03
6.508GlyIle: 6.508 ± 0.076
5.401GlyLys: 5.401 ± 0.061
5.971GlyLeu: 5.971 ± 0.07
2.669GlyMet: 2.669 ± 0.048
3.101GlyAsn: 3.101 ± 0.054
1.507GlyPro: 1.507 ± 0.034
2.264GlyGln: 2.264 ± 0.04
3.461GlyArg: 3.461 ± 0.053
4.366GlySer: 4.366 ± 0.061
4.246GlyThr: 4.246 ± 0.065
4.888GlyVal: 4.888 ± 0.067
0.83GlyTrp: 0.83 ± 0.038
3.402GlyTyr: 3.402 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
1.154HisAla: 1.154 ± 0.029
0.314HisCys: 0.314 ± 0.015
0.907HisAsp: 0.907 ± 0.026
1.077HisGlu: 1.077 ± 0.028
0.843HisPhe: 0.843 ± 0.026
1.358HisGly: 1.358 ± 0.035
0.443HisHis: 0.443 ± 0.022
1.466HisIle: 1.466 ± 0.031
0.978HisLys: 0.978 ± 0.027
1.672HisLeu: 1.672 ± 0.035
0.646HisMet: 0.646 ± 0.022
0.705HisAsn: 0.705 ± 0.022
0.879HisPro: 0.879 ± 0.027
0.566HisGln: 0.566 ± 0.022
0.854HisArg: 0.854 ± 0.025
0.948HisSer: 0.948 ± 0.028
1.02HisThr: 1.02 ± 0.031
1.193HisVal: 1.193 ± 0.025
0.216HisTrp: 0.216 ± 0.012
0.777HisTyr: 0.777 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.133IleAla: 5.133 ± 0.052
1.452IleCys: 1.452 ± 0.033
3.469IleAsp: 3.469 ± 0.054
4.373IleGlu: 4.373 ± 0.066
3.061IlePhe: 3.061 ± 0.052
4.846IleGly: 4.846 ± 0.067
1.412IleHis: 1.412 ± 0.033
4.632IleIle: 4.632 ± 0.069
3.895IleLys: 3.895 ± 0.056
7.464IleLeu: 7.464 ± 0.09
2.117IleMet: 2.117 ± 0.04
2.603IleAsn: 2.603 ± 0.043
3.4IlePro: 3.4 ± 0.05
2.364IleGln: 2.364 ± 0.045
3.736IleArg: 3.736 ± 0.053
4.833IleSer: 4.833 ± 0.071
4.098IleThr: 4.098 ± 0.057
4.435IleVal: 4.435 ± 0.071
0.726IleTrp: 0.726 ± 0.026
2.852IleTyr: 2.852 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.906LysAla: 4.906 ± 0.061
0.801LysCys: 0.801 ± 0.025
3.781LysAsp: 3.781 ± 0.052
6.644LysGlu: 6.644 ± 0.082
1.828LysPhe: 1.828 ± 0.038
4.345LysGly: 4.345 ± 0.057
0.99LysHis: 0.99 ± 0.026
4.876LysIle: 4.876 ± 0.064
6.101LysLys: 6.101 ± 0.077
5.045LysLeu: 5.045 ± 0.053
2.248LysMet: 2.248 ± 0.037
3.523LysAsn: 3.523 ± 0.053
1.97LysPro: 1.97 ± 0.043
2.233LysGln: 2.233 ± 0.043
3.199LysArg: 3.199 ± 0.052
3.307LysSer: 3.307 ± 0.049
3.614LysThr: 3.614 ± 0.05
4.044LysVal: 4.044 ± 0.049
0.663LysTrp: 0.663 ± 0.022
2.847LysTyr: 2.847 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
6.753LeuAla: 6.753 ± 0.065
1.646LeuCys: 1.646 ± 0.032
5.108LeuAsp: 5.108 ± 0.071
6.683LeuGlu: 6.683 ± 0.088
4.139LeuPhe: 4.139 ± 0.062
6.162LeuGly: 6.162 ± 0.079
1.731LeuHis: 1.731 ± 0.038
5.767LeuIle: 5.767 ± 0.078
6.102LeuLys: 6.102 ± 0.08
9.228LeuLeu: 9.228 ± 0.111
2.674LeuMet: 2.674 ± 0.041
3.597LeuAsn: 3.597 ± 0.046
3.689LeuPro: 3.689 ± 0.053
2.918LeuGln: 2.918 ± 0.05
3.856LeuArg: 3.856 ± 0.062
6.036LeuSer: 6.036 ± 0.07
4.991LeuThr: 4.991 ± 0.06
5.562LeuVal: 5.562 ± 0.066
0.884LeuTrp: 0.884 ± 0.024
3.513LeuTyr: 3.513 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.521MetAla: 2.521 ± 0.042
0.398MetCys: 0.398 ± 0.017
1.992MetAsp: 1.992 ± 0.045
3.015MetGlu: 3.015 ± 0.048
1.058MetPhe: 1.058 ± 0.03
2.381MetGly: 2.381 ± 0.041
0.504MetHis: 0.504 ± 0.018
2.113MetIle: 2.113 ± 0.039
2.602MetLys: 2.602 ± 0.051
2.878MetLeu: 2.878 ± 0.048
1.007MetMet: 1.007 ± 0.025
1.45MetAsn: 1.45 ± 0.028
1.252MetPro: 1.252 ± 0.027
1.158MetGln: 1.158 ± 0.028
1.418MetArg: 1.418 ± 0.036
1.748MetSer: 1.748 ± 0.03
1.787MetThr: 1.787 ± 0.04
2.085MetVal: 2.085 ± 0.039
0.266MetTrp: 0.266 ± 0.015
0.98MetTyr: 0.98 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.979AsnAla: 2.979 ± 0.048
0.652AsnCys: 0.652 ± 0.024
1.863AsnAsp: 1.863 ± 0.037
2.462AsnGlu: 2.462 ± 0.044
1.573AsnPhe: 1.573 ± 0.035
3.359AsnGly: 3.359 ± 0.058
0.786AsnHis: 0.786 ± 0.023
3.159AsnIle: 3.159 ± 0.053
2.511AsnLys: 2.511 ± 0.045
3.631AsnLeu: 3.631 ± 0.042
1.431AsnMet: 1.431 ± 0.033
1.653AsnAsn: 1.653 ± 0.042
2.028AsnPro: 2.028 ± 0.042
1.308AsnGln: 1.308 ± 0.03
2.093AsnArg: 2.093 ± 0.044
2.265AsnSer: 2.265 ± 0.048
2.385AsnThr: 2.385 ± 0.043
2.643AsnVal: 2.643 ± 0.045
0.472AsnTrp: 0.472 ± 0.018
1.791AsnTyr: 1.791 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.613ProAla: 2.613 ± 0.046
0.523ProCys: 0.523 ± 0.02
2.484ProAsp: 2.484 ± 0.045
3.307ProGlu: 3.307 ± 0.056
1.668ProPhe: 1.668 ± 0.034
2.547ProGly: 2.547 ± 0.044
0.657ProHis: 0.657 ± 0.024
1.985ProIle: 1.985 ± 0.041
1.971ProLys: 1.971 ± 0.035
2.935ProLeu: 2.935 ± 0.046
1.009ProMet: 1.009 ± 0.026
1.201ProAsn: 1.201 ± 0.031
0.808ProPro: 0.808 ± 0.028
1.136ProGln: 1.136 ± 0.026
1.144ProArg: 1.144 ± 0.029
1.789ProSer: 1.789 ± 0.04
1.467ProThr: 1.467 ± 0.031
3.18ProVal: 3.18 ± 0.049
0.383ProTrp: 0.383 ± 0.018
1.516ProTyr: 1.516 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.512GlnAla: 2.512 ± 0.045
0.392GlnCys: 0.392 ± 0.018
1.767GlnAsp: 1.767 ± 0.037
2.928GlnGlu: 2.928 ± 0.047
1.228GlnPhe: 1.228 ± 0.031
2.158GlnGly: 2.158 ± 0.041
0.464GlnHis: 0.464 ± 0.017
2.523GlnIle: 2.523 ± 0.044
2.638GlnLys: 2.638 ± 0.053
2.524GlnLeu: 2.524 ± 0.049
1.228GlnMet: 1.228 ± 0.032
1.569GlnAsn: 1.569 ± 0.035
0.918GlnPro: 0.918 ± 0.025
1.184GlnGln: 1.184 ± 0.034
1.407GlnArg: 1.407 ± 0.036
1.638GlnSer: 1.638 ± 0.037
1.638GlnThr: 1.638 ± 0.034
2.267GlnVal: 2.267 ± 0.04
0.339GlnTrp: 0.339 ± 0.015
1.4GlnTyr: 1.4 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.755ArgAla: 2.755 ± 0.049
0.642ArgCys: 0.642 ± 0.023
2.414ArgAsp: 2.414 ± 0.052
4.36ArgGlu: 4.36 ± 0.074
1.989ArgPhe: 1.989 ± 0.038
2.689ArgGly: 2.689 ± 0.051
0.851ArgHis: 0.851 ± 0.023
3.645ArgIle: 3.645 ± 0.063
3.558ArgLys: 3.558 ± 0.063
4.069ArgLeu: 4.069 ± 0.061
1.704ArgMet: 1.704 ± 0.037
2.092ArgAsn: 2.092 ± 0.043
1.339ArgPro: 1.339 ± 0.037
1.784ArgGln: 1.784 ± 0.036
2.509ArgArg: 2.509 ± 0.05
2.24ArgSer: 2.24 ± 0.041
2.281ArgThr: 2.281 ± 0.044
2.7ArgVal: 2.7 ± 0.042
0.423ArgTrp: 0.423 ± 0.017
1.964ArgTyr: 1.964 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.213SerAla: 4.213 ± 0.061
0.964SerCys: 0.964 ± 0.029
2.949SerAsp: 2.949 ± 0.054
3.525SerGlu: 3.525 ± 0.055
2.686SerPhe: 2.686 ± 0.042
5.094SerGly: 5.094 ± 0.076
1.095SerHis: 1.095 ± 0.032
4.001SerIle: 4.001 ± 0.057
3.059SerLys: 3.059 ± 0.049
5.455SerLeu: 5.455 ± 0.07
1.964SerMet: 1.964 ± 0.033
2.016SerAsn: 2.016 ± 0.04
1.978SerPro: 1.978 ± 0.04
1.949SerGln: 1.949 ± 0.038
2.885SerArg: 2.885 ± 0.049
3.482SerSer: 3.482 ± 0.057
2.637SerThr: 2.637 ± 0.052
4.379SerVal: 4.379 ± 0.061
0.663SerTrp: 0.663 ± 0.025
2.438SerTyr: 2.438 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.43ThrAla: 4.43 ± 0.056
0.714ThrCys: 0.714 ± 0.019
3.083ThrAsp: 3.083 ± 0.051
3.761ThrGlu: 3.761 ± 0.059
2.266ThrPhe: 2.266 ± 0.043
4.832ThrGly: 4.832 ± 0.068
0.859ThrHis: 0.859 ± 0.02
3.516ThrIle: 3.516 ± 0.053
2.877ThrLys: 2.877 ± 0.048
4.829ThrLeu: 4.829 ± 0.06
1.415ThrMet: 1.415 ± 0.031
1.815ThrAsn: 1.815 ± 0.039
2.159ThrPro: 2.159 ± 0.043
1.466ThrGln: 1.466 ± 0.031
1.954ThrArg: 1.954 ± 0.037
2.816ThrSer: 2.816 ± 0.05
2.484ThrThr: 2.484 ± 0.044
4.362ThrVal: 4.362 ± 0.06
0.552ThrTrp: 0.552 ± 0.026
2.049ThrTyr: 2.049 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
4.097ValAla: 4.097 ± 0.065
1.285ValCys: 1.285 ± 0.031
3.588ValAsp: 3.588 ± 0.05
4.524ValGlu: 4.524 ± 0.064
3.259ValPhe: 3.259 ± 0.048
4.209ValGly: 4.209 ± 0.064
1.115ValHis: 1.115 ± 0.026
5.002ValIle: 5.002 ± 0.067
4.585ValLys: 4.585 ± 0.061
6.99ValLeu: 6.99 ± 0.072
2.168ValMet: 2.168 ± 0.045
2.74ValAsn: 2.74 ± 0.048
2.634ValPro: 2.634 ± 0.046
2.099ValGln: 2.099 ± 0.038
3.181ValArg: 3.181 ± 0.05
4.531ValSer: 4.531 ± 0.058
3.998ValThr: 3.998 ± 0.055
4.619ValVal: 4.619 ± 0.069
0.755ValTrp: 0.755 ± 0.023
2.746ValTyr: 2.746 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.594TrpAla: 0.594 ± 0.021
0.183TrpCys: 0.183 ± 0.011
0.636TrpAsp: 0.636 ± 0.024
0.867TrpGlu: 0.867 ± 0.024
0.461TrpPhe: 0.461 ± 0.019
0.786TrpGly: 0.786 ± 0.025
0.196TrpHis: 0.196 ± 0.011
0.709TrpIle: 0.709 ± 0.023
0.805TrpLys: 0.805 ± 0.023
0.949TrpLeu: 0.949 ± 0.029
0.374TrpMet: 0.374 ± 0.015
0.573TrpAsn: 0.573 ± 0.023
0.233TrpPro: 0.233 ± 0.014
0.41TrpGln: 0.41 ± 0.016
0.418TrpArg: 0.418 ± 0.015
0.549TrpSer: 0.549 ± 0.02
0.474TrpThr: 0.474 ± 0.018
0.595TrpVal: 0.595 ± 0.017
0.148TrpTrp: 0.148 ± 0.011
0.467TrpTyr: 0.467 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.708TyrAla: 2.708 ± 0.045
0.676TyrCys: 0.676 ± 0.022
2.341TyrAsp: 2.341 ± 0.042
3.022TyrGlu: 3.022 ± 0.047
1.967TyrPhe: 1.967 ± 0.037
3.18TyrGly: 3.18 ± 0.049
0.902TyrHis: 0.902 ± 0.025
2.801TyrIle: 2.801 ± 0.045
2.377TyrLys: 2.377 ± 0.045
4.01TyrLeu: 4.01 ± 0.06
1.24TyrMet: 1.24 ± 0.031
1.719TyrAsn: 1.719 ± 0.04
1.555TyrPro: 1.555 ± 0.032
1.526TyrGln: 1.526 ± 0.034
2.187TyrArg: 2.187 ± 0.045
2.403TyrSer: 2.403 ± 0.043
2.318TyrThr: 2.318 ± 0.04
2.498TyrVal: 2.498 ± 0.044
0.387TyrTrp: 0.387 ± 0.018
1.964TyrTyr: 1.964 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4518 proteins (1457493 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski