Amino acid dipepetide frequency for Muribaculum sp. An287

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.876AlaAla: 7.876 ± 0.143
1.03AlaCys: 1.03 ± 0.042
4.885AlaAsp: 4.885 ± 0.093
5.609AlaGlu: 5.609 ± 0.105
3.53AlaPhe: 3.53 ± 0.076
6.736AlaGly: 6.736 ± 0.111
1.072AlaHis: 1.072 ± 0.038
5.185AlaIle: 5.185 ± 0.102
3.997AlaLys: 3.997 ± 0.091
7.088AlaLeu: 7.088 ± 0.118
2.275AlaMet: 2.275 ± 0.059
2.557AlaAsn: 2.557 ± 0.07
2.504AlaPro: 2.504 ± 0.069
2.045AlaGln: 2.045 ± 0.065
3.816AlaArg: 3.816 ± 0.076
5.205AlaSer: 5.205 ± 0.105
3.564AlaThr: 3.564 ± 0.078
6.602AlaVal: 6.602 ± 0.119
0.704AlaTrp: 0.704 ± 0.032
2.938AlaTyr: 2.938 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.887CysAla: 0.887 ± 0.036
0.247CysCys: 0.247 ± 0.02
0.839CysAsp: 0.839 ± 0.038
0.844CysGlu: 0.844 ± 0.036
0.621CysPhe: 0.621 ± 0.034
1.411CysGly: 1.411 ± 0.047
0.25CysHis: 0.25 ± 0.019
0.88CysIle: 0.88 ± 0.034
0.71CysLys: 0.71 ± 0.029
0.915CysLeu: 0.915 ± 0.039
0.341CysMet: 0.341 ± 0.023
0.527CysAsn: 0.527 ± 0.028
0.655CysPro: 0.655 ± 0.04
0.25CysGln: 0.25 ± 0.021
0.911CysArg: 0.911 ± 0.04
0.865CysSer: 0.865 ± 0.031
0.74CysThr: 0.74 ± 0.031
0.815CysVal: 0.815 ± 0.033
0.121CysTrp: 0.121 ± 0.011
0.487CysTyr: 0.487 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.135AspAla: 4.135 ± 0.079
0.796AspCys: 0.796 ± 0.031
3.081AspAsp: 3.081 ± 0.074
4.209AspGlu: 4.209 ± 0.091
3.462AspPhe: 3.462 ± 0.076
5.389AspGly: 5.389 ± 0.109
0.641AspHis: 0.641 ± 0.031
4.758AspIle: 4.758 ± 0.093
3.353AspLys: 3.353 ± 0.078
4.299AspLeu: 4.299 ± 0.073
1.917AspMet: 1.917 ± 0.051
2.708AspAsn: 2.708 ± 0.072
2.144AspPro: 2.144 ± 0.063
0.786AspGln: 0.786 ± 0.033
3.403AspArg: 3.403 ± 0.08
4.0AspSer: 4.0 ± 0.107
3.235AspThr: 3.235 ± 0.073
3.735AspVal: 3.735 ± 0.082
0.798AspTrp: 0.798 ± 0.036
2.935AspTyr: 2.935 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.606GluAla: 5.606 ± 0.091
0.844GluCys: 0.844 ± 0.036
3.852GluAsp: 3.852 ± 0.08
4.922GluGlu: 4.922 ± 0.111
2.481GluPhe: 2.481 ± 0.063
4.72GluGly: 4.72 ± 0.086
1.161GluHis: 1.161 ± 0.039
5.287GluIle: 5.287 ± 0.089
5.076GluLys: 5.076 ± 0.099
5.838GluLeu: 5.838 ± 0.097
2.228GluMet: 2.228 ± 0.052
3.88GluAsn: 3.88 ± 0.067
2.156GluPro: 2.156 ± 0.057
1.965GluGln: 1.965 ± 0.058
3.806GluArg: 3.806 ± 0.078
3.755GluSer: 3.755 ± 0.074
3.53GluThr: 3.53 ± 0.071
3.79GluVal: 3.79 ± 0.077
0.828GluTrp: 0.828 ± 0.036
3.146GluTyr: 3.146 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
3.328PheAla: 3.328 ± 0.072
0.638PheCys: 0.638 ± 0.034
2.861PheAsp: 2.861 ± 0.062
2.531PheGlu: 2.531 ± 0.066
2.161PhePhe: 2.161 ± 0.067
3.591PheGly: 3.591 ± 0.068
0.729PheHis: 0.729 ± 0.032
3.086PheIle: 3.086 ± 0.08
2.197PheLys: 2.197 ± 0.063
3.724PheLeu: 3.724 ± 0.081
1.387PheMet: 1.387 ± 0.042
2.111PheAsn: 2.111 ± 0.059
1.855PhePro: 1.855 ± 0.059
0.926PheGln: 0.926 ± 0.036
2.531PheArg: 2.531 ± 0.067
3.889PheSer: 3.889 ± 0.083
2.607PheThr: 2.607 ± 0.062
3.087PheVal: 3.087 ± 0.066
0.533PheTrp: 0.533 ± 0.032
1.888PheTyr: 1.888 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.266GlyAla: 5.266 ± 0.095
1.148GlyCys: 1.148 ± 0.043
4.106GlyAsp: 4.106 ± 0.09
4.931GlyGlu: 4.931 ± 0.096
3.581GlyPhe: 3.581 ± 0.076
5.672GlyGly: 5.672 ± 0.109
1.408GlyHis: 1.408 ± 0.051
5.937GlyIle: 5.937 ± 0.09
5.833GlyLys: 5.833 ± 0.1
6.41GlyLeu: 6.41 ± 0.103
2.522GlyMet: 2.522 ± 0.059
3.712GlyAsn: 3.712 ± 0.075
1.588GlyPro: 1.588 ± 0.045
1.953GlyGln: 1.953 ± 0.051
4.069GlyArg: 4.069 ± 0.077
4.449GlySer: 4.449 ± 0.083
4.586GlyThr: 4.586 ± 0.091
4.96GlyVal: 4.96 ± 0.084
0.936GlyTrp: 0.936 ± 0.037
3.544GlyTyr: 3.544 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.995HisAla: 0.995 ± 0.04
0.29HisCys: 0.29 ± 0.022
0.854HisAsp: 0.854 ± 0.032
0.949HisGlu: 0.949 ± 0.036
0.92HisPhe: 0.92 ± 0.039
1.258HisGly: 1.258 ± 0.042
0.362HisHis: 0.362 ± 0.026
1.276HisIle: 1.276 ± 0.045
0.871HisLys: 0.871 ± 0.038
1.426HisLeu: 1.426 ± 0.049
0.213HisMet: 0.213 ± 0.02
0.749HisAsn: 0.749 ± 0.032
0.897HisPro: 0.897 ± 0.034
0.335HisGln: 0.335 ± 0.023
0.923HisArg: 0.923 ± 0.032
1.026HisSer: 1.026 ± 0.041
0.888HisThr: 0.888 ± 0.037
0.956HisVal: 0.956 ± 0.036
0.17HisTrp: 0.17 ± 0.017
0.76HisTyr: 0.76 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.72IleAla: 5.72 ± 0.1
0.986IleCys: 0.986 ± 0.041
4.559IleAsp: 4.559 ± 0.09
4.783IleGlu: 4.783 ± 0.102
3.073IlePhe: 3.073 ± 0.081
4.862IleGly: 4.862 ± 0.106
1.033IleHis: 1.033 ± 0.042
4.784IleIle: 4.784 ± 0.101
3.689IleLys: 3.689 ± 0.087
5.651IleLeu: 5.651 ± 0.099
1.815IleMet: 1.815 ± 0.047
2.86IleAsn: 2.86 ± 0.061
3.262IlePro: 3.262 ± 0.079
1.559IleGln: 1.559 ± 0.047
3.727IleArg: 3.727 ± 0.083
5.26IleSer: 5.26 ± 0.092
3.88IleThr: 3.88 ± 0.068
4.79IleVal: 4.79 ± 0.089
0.573IleTrp: 0.573 ± 0.029
2.603IleTyr: 2.603 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.916LysAla: 4.916 ± 0.099
0.665LysCys: 0.665 ± 0.032
3.712LysAsp: 3.712 ± 0.073
4.806LysGlu: 4.806 ± 0.112
1.932LysPhe: 1.932 ± 0.063
4.432LysGly: 4.432 ± 0.085
0.923LysHis: 0.923 ± 0.036
4.304LysIle: 4.304 ± 0.083
3.876LysLys: 3.876 ± 0.091
4.191LysLeu: 4.191 ± 0.085
1.993LysMet: 1.993 ± 0.048
2.723LysAsn: 2.723 ± 0.059
1.863LysPro: 1.863 ± 0.053
1.594LysGln: 1.594 ± 0.06
3.083LysArg: 3.083 ± 0.075
3.354LysSer: 3.354 ± 0.08
3.205LysThr: 3.205 ± 0.086
3.679LysVal: 3.679 ± 0.069
0.681LysTrp: 0.681 ± 0.031
2.647LysTyr: 2.647 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
7.023LeuAla: 7.023 ± 0.123
1.26LeuCys: 1.26 ± 0.047
4.835LeuAsp: 4.835 ± 0.086
5.464LeuGlu: 5.464 ± 0.093
3.889LeuPhe: 3.889 ± 0.08
5.94LeuGly: 5.94 ± 0.106
1.519LeuHis: 1.519 ± 0.045
5.033LeuIle: 5.033 ± 0.087
5.362LeuLys: 5.362 ± 0.092
7.758LeuLeu: 7.758 ± 0.139
2.473LeuMet: 2.473 ± 0.067
3.435LeuAsn: 3.435 ± 0.074
3.941LeuPro: 3.941 ± 0.08
2.295LeuGln: 2.295 ± 0.061
4.326LeuArg: 4.326 ± 0.082
7.146LeuSer: 7.146 ± 0.108
4.322LeuThr: 4.322 ± 0.081
5.213LeuVal: 5.213 ± 0.106
0.829LeuTrp: 0.829 ± 0.034
3.476LeuTyr: 3.476 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.593MetAla: 2.593 ± 0.064
0.289MetCys: 0.289 ± 0.022
1.888MetAsp: 1.888 ± 0.055
2.138MetGlu: 2.138 ± 0.055
1.131MetPhe: 1.131 ± 0.04
1.86MetGly: 1.86 ± 0.058
0.424MetHis: 0.424 ± 0.023
1.674MetIle: 1.674 ± 0.05
2.334MetLys: 2.334 ± 0.056
2.555MetLeu: 2.555 ± 0.068
0.829MetMet: 0.829 ± 0.042
1.345MetAsn: 1.345 ± 0.04
1.309MetPro: 1.309 ± 0.045
0.849MetGln: 0.849 ± 0.04
1.513MetArg: 1.513 ± 0.05
1.832MetSer: 1.832 ± 0.057
1.509MetThr: 1.509 ± 0.044
1.712MetVal: 1.712 ± 0.051
0.216MetTrp: 0.216 ± 0.018
0.864MetTyr: 0.864 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.458AsnAla: 3.458 ± 0.082
0.526AsnCys: 0.526 ± 0.03
2.452AsnAsp: 2.452 ± 0.065
2.531AsnGlu: 2.531 ± 0.061
1.861AsnPhe: 1.861 ± 0.056
3.761AsnGly: 3.761 ± 0.08
0.664AsnHis: 0.664 ± 0.036
3.632AsnIle: 3.632 ± 0.081
2.015AsnLys: 2.015 ± 0.06
3.471AsnLeu: 3.471 ± 0.073
1.223AsnMet: 1.223 ± 0.047
1.855AsnAsn: 1.855 ± 0.057
2.276AsnPro: 2.276 ± 0.056
0.949AsnGln: 0.949 ± 0.045
2.215AsnArg: 2.215 ± 0.052
2.412AsnSer: 2.412 ± 0.055
2.229AsnThr: 2.229 ± 0.063
2.894AsnVal: 2.894 ± 0.069
0.444AsnTrp: 0.444 ± 0.026
1.808AsnTyr: 1.808 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
3.277ProAla: 3.277 ± 0.082
0.377ProCys: 0.377 ± 0.023
3.091ProAsp: 3.091 ± 0.075
3.863ProGlu: 3.863 ± 0.072
1.72ProPhe: 1.72 ± 0.044
2.881ProGly: 2.881 ± 0.067
0.637ProHis: 0.637 ± 0.035
1.88ProIle: 1.88 ± 0.053
1.761ProLys: 1.761 ± 0.057
3.083ProLeu: 3.083 ± 0.084
0.897ProMet: 0.897 ± 0.037
1.247ProAsn: 1.247 ± 0.042
0.944ProPro: 0.944 ± 0.046
1.28ProGln: 1.28 ± 0.046
1.367ProArg: 1.367 ± 0.049
2.541ProSer: 2.541 ± 0.062
1.513ProThr: 1.513 ± 0.051
3.567ProVal: 3.567 ± 0.077
0.377ProTrp: 0.377 ± 0.027
1.792ProTyr: 1.792 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
2.041GlnAla: 2.041 ± 0.065
0.285GlnCys: 0.285 ± 0.021
1.348GlnAsp: 1.348 ± 0.046
1.842GlnGlu: 1.842 ± 0.058
1.009GlnPhe: 1.009 ± 0.038
1.694GlnGly: 1.694 ± 0.053
0.379GlnHis: 0.379 ± 0.022
1.818GlnIle: 1.818 ± 0.064
1.692GlnLys: 1.692 ± 0.057
2.196GlnLeu: 2.196 ± 0.072
0.753GlnMet: 0.753 ± 0.03
1.137GlnAsn: 1.137 ± 0.038
0.903GlnPro: 0.903 ± 0.039
0.908GlnGln: 0.908 ± 0.051
1.311GlnArg: 1.311 ± 0.047
1.575GlnSer: 1.575 ± 0.049
1.26GlnThr: 1.26 ± 0.046
1.525GlnVal: 1.525 ± 0.053
0.354GlnTrp: 0.354 ± 0.025
1.166GlnTyr: 1.166 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
3.199ArgAla: 3.199 ± 0.06
0.586ArgCys: 0.586 ± 0.03
2.741ArgAsp: 2.741 ± 0.062
3.752ArgGlu: 3.752 ± 0.083
2.663ArgPhe: 2.663 ± 0.072
2.89ArgGly: 2.89 ± 0.07
1.101ArgHis: 1.101 ± 0.045
4.251ArgIle: 4.251 ± 0.08
3.9ArgLys: 3.9 ± 0.087
5.25ArgLeu: 5.25 ± 0.1
1.681ArgMet: 1.681 ± 0.045
2.565ArgAsn: 2.565 ± 0.055
1.863ArgPro: 1.863 ± 0.058
1.646ArgGln: 1.646 ± 0.053
2.88ArgArg: 2.88 ± 0.068
2.841ArgSer: 2.841 ± 0.065
2.585ArgThr: 2.585 ± 0.071
2.718ArgVal: 2.718 ± 0.068
0.553ArgTrp: 0.553 ± 0.025
2.351ArgTyr: 2.351 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
5.317SerAla: 5.317 ± 0.094
0.983SerCys: 0.983 ± 0.039
4.097SerAsp: 4.097 ± 0.081
4.459SerGlu: 4.459 ± 0.088
3.196SerPhe: 3.196 ± 0.084
6.3SerGly: 6.3 ± 0.112
1.132SerHis: 1.132 ± 0.05
4.257SerIle: 4.257 ± 0.081
3.15SerLys: 3.15 ± 0.084
6.463SerLeu: 6.463 ± 0.11
1.779SerMet: 1.779 ± 0.049
2.236SerAsn: 2.236 ± 0.056
2.64SerPro: 2.64 ± 0.066
1.703SerGln: 1.703 ± 0.055
3.418SerArg: 3.418 ± 0.079
4.71SerSer: 4.71 ± 0.102
3.019SerThr: 3.019 ± 0.063
5.116SerVal: 5.116 ± 0.088
0.697SerTrp: 0.697 ± 0.028
2.767SerTyr: 2.767 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.63ThrAla: 4.63 ± 0.084
0.56ThrCys: 0.56 ± 0.027
3.42ThrAsp: 3.42 ± 0.086
3.488ThrGlu: 3.488 ± 0.071
2.334ThrPhe: 2.334 ± 0.067
4.875ThrGly: 4.875 ± 0.093
0.776ThrHis: 0.776 ± 0.034
3.443ThrIle: 3.443 ± 0.08
2.242ThrLys: 2.242 ± 0.053
4.651ThrLeu: 4.651 ± 0.085
1.138ThrMet: 1.138 ± 0.043
1.709ThrAsn: 1.709 ± 0.059
2.256ThrPro: 2.256 ± 0.062
1.145ThrGln: 1.145 ± 0.044
1.976ThrArg: 1.976 ± 0.056
3.114ThrSer: 3.114 ± 0.075
2.58ThrThr: 2.58 ± 0.082
4.967ThrVal: 4.967 ± 0.097
0.499ThrTrp: 0.499 ± 0.025
2.062ThrTyr: 2.062 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
5.236ValAla: 5.236 ± 0.098
1.03ValCys: 1.03 ± 0.04
3.731ValAsp: 3.731 ± 0.081
4.419ValGlu: 4.419 ± 0.087
3.482ValPhe: 3.482 ± 0.08
4.112ValGly: 4.112 ± 0.082
1.032ValHis: 1.032 ± 0.043
4.54ValIle: 4.54 ± 0.09
3.824ValLys: 3.824 ± 0.081
6.073ValLeu: 6.073 ± 0.105
1.811ValMet: 1.811 ± 0.057
2.777ValAsn: 2.777 ± 0.061
3.034ValPro: 3.034 ± 0.063
1.709ValGln: 1.709 ± 0.051
3.724ValArg: 3.724 ± 0.073
5.805ValSer: 5.805 ± 0.107
3.912ValThr: 3.912 ± 0.081
4.306ValVal: 4.306 ± 0.083
0.688ValTrp: 0.688 ± 0.033
2.588ValTyr: 2.588 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.697TrpAla: 0.697 ± 0.03
0.164TrpCys: 0.164 ± 0.018
0.642TrpAsp: 0.642 ± 0.031
0.675TrpGlu: 0.675 ± 0.033
0.512TrpPhe: 0.512 ± 0.027
0.819TrpGly: 0.819 ± 0.035
0.191TrpHis: 0.191 ± 0.016
0.747TrpIle: 0.747 ± 0.034
0.697TrpLys: 0.697 ± 0.035
1.068TrpLeu: 1.068 ± 0.047
0.369TrpMet: 0.369 ± 0.023
0.594TrpAsn: 0.594 ± 0.032
0.266TrpPro: 0.266 ± 0.02
0.364TrpGln: 0.364 ± 0.02
0.438TrpArg: 0.438 ± 0.027
0.641TrpSer: 0.641 ± 0.034
0.586TrpThr: 0.586 ± 0.032
0.579TrpVal: 0.579 ± 0.034
0.167TrpTrp: 0.167 ± 0.016
0.438TrpTyr: 0.438 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.018TyrAla: 3.018 ± 0.072
0.611TyrCys: 0.611 ± 0.035
2.79TyrAsp: 2.79 ± 0.07
2.652TyrGlu: 2.652 ± 0.06
2.104TyrPhe: 2.104 ± 0.066
3.407TyrGly: 3.407 ± 0.082
0.68TyrHis: 0.68 ± 0.034
2.696TyrIle: 2.696 ± 0.057
2.001TyrLys: 2.001 ± 0.055
3.432TyrLeu: 3.432 ± 0.067
1.219TyrMet: 1.219 ± 0.044
1.947TyrAsn: 1.947 ± 0.061
1.739TyrPro: 1.739 ± 0.059
0.934TyrGln: 0.934 ± 0.036
2.584TyrArg: 2.584 ± 0.068
3.021TyrSer: 3.021 ± 0.067
2.115TyrThr: 2.115 ± 0.061
2.823TyrVal: 2.823 ± 0.078
0.489TyrTrp: 0.489 ± 0.026
1.939TyrTyr: 1.939 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2021 proteins (695823 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski