Amino acid dipepetide frequency for Tobacco necrosis virus (strain A) (TNV-A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.589AlaAla: 7.589 ± 4.137
0.843AlaCys: 0.843 ± 2.032
2.53AlaAsp: 2.53 ± 0.73
4.216AlaGlu: 4.216 ± 1.959
6.745AlaPhe: 6.745 ± 2.032
5.902AlaGly: 5.902 ± 4.925
0.843AlaHis: 0.843 ± 0.495
4.216AlaIle: 4.216 ± 4.113
4.216AlaLys: 4.216 ± 2.362
6.745AlaLeu: 6.745 ± 2.07
1.686AlaMet: 1.686 ± 0.725
1.686AlaAsn: 1.686 ± 0.991
5.059AlaPro: 5.059 ± 2.174
3.373AlaGln: 3.373 ± 1.45
5.059AlaArg: 5.059 ± 2.442
4.216AlaSer: 4.216 ± 2.384
2.53AlaThr: 2.53 ± 1.68
5.902AlaVal: 5.902 ± 1.507
0.0AlaTrp: 0.0 ± 0.0
1.686AlaTyr: 1.686 ± 0.725
0.0AlaXaa: 0.0 ± 0.0
Cys
0.843CysAla: 0.843 ± 0.495
0.843CysCys: 0.843 ± 2.032
0.843CysAsp: 0.843 ± 2.032
1.686CysGlu: 1.686 ± 0.725
1.686CysPhe: 1.686 ± 0.991
0.843CysGly: 0.843 ± 0.495
0.0CysHis: 0.0 ± 0.0
0.843CysIle: 0.843 ± 0.495
0.843CysLys: 0.843 ± 0.495
1.686CysLeu: 1.686 ± 0.991
0.0CysMet: 0.0 ± 0.0
1.686CysAsn: 1.686 ± 0.991
1.686CysPro: 1.686 ± 2.008
1.686CysGln: 1.686 ± 0.991
1.686CysArg: 1.686 ± 1.845
0.0CysSer: 0.0 ± 0.0
0.843CysThr: 0.843 ± 1.674
0.843CysVal: 0.843 ± 0.495
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.373AspAla: 3.373 ± 1.016
0.843AspCys: 0.843 ± 0.495
3.373AspAsp: 3.373 ± 1.981
0.0AspGlu: 0.0 ± 0.0
0.0AspPhe: 0.0 ± 0.0
5.059AspGly: 5.059 ± 1.582
0.0AspHis: 0.0 ± 0.0
1.686AspIle: 1.686 ± 0.991
2.53AspLys: 2.53 ± 0.73
6.745AspLeu: 6.745 ± 2.032
0.843AspMet: 0.843 ± 0.495
1.686AspAsn: 1.686 ± 1.559
0.843AspPro: 0.843 ± 0.495
2.53AspGln: 2.53 ± 1.68
0.843AspArg: 0.843 ± 1.004
2.53AspSer: 2.53 ± 0.73
2.53AspThr: 2.53 ± 1.781
3.373AspVal: 3.373 ± 1.256
0.843AspTrp: 0.843 ± 0.495
1.686AspTyr: 1.686 ± 1.559
0.0AspXaa: 0.0 ± 0.0
Glu
4.216GluAla: 4.216 ± 2.477
1.686GluCys: 1.686 ± 0.991
2.53GluAsp: 2.53 ± 1.552
1.686GluGlu: 1.686 ± 1.559
4.216GluPhe: 4.216 ± 1.422
3.373GluGly: 3.373 ± 1.696
5.059GluHis: 5.059 ± 2.972
5.059GluIle: 5.059 ± 2.174
3.373GluLys: 3.373 ± 1.981
1.686GluLeu: 1.686 ± 0.991
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
1.686GluPro: 1.686 ± 0.725
3.373GluGln: 3.373 ± 1.256
2.53GluArg: 2.53 ± 1.486
1.686GluSer: 1.686 ± 1.506
1.686GluThr: 1.686 ± 1.559
0.843GluVal: 0.843 ± 0.495
0.843GluTrp: 0.843 ± 0.495
1.686GluTyr: 1.686 ± 1.845
0.0GluXaa: 0.0 ± 0.0
Phe
1.686PheAla: 1.686 ± 1.845
1.686PheCys: 1.686 ± 0.725
1.686PheAsp: 1.686 ± 0.991
1.686PheGlu: 1.686 ± 0.991
0.0PhePhe: 0.0 ± 0.0
4.216PheGly: 4.216 ± 1.422
0.0PheHis: 0.0 ± 0.0
2.53PheIle: 2.53 ± 1.68
3.373PheLys: 3.373 ± 1.981
2.53PheLeu: 2.53 ± 1.486
0.843PheMet: 0.843 ± 1.43
1.686PheAsn: 1.686 ± 1.889
1.686PhePro: 1.686 ± 2.24
1.686PheGln: 1.686 ± 0.991
2.53PheArg: 2.53 ± 1.486
1.686PheSer: 1.686 ± 0.725
2.53PheThr: 2.53 ± 0.73
2.53PheVal: 2.53 ± 1.486
0.0PheTrp: 0.0 ± 0.0
4.216PheTyr: 4.216 ± 2.477
0.0PheXaa: 0.0 ± 0.0
Gly
5.902GlyAla: 5.902 ± 3.098
1.686GlyCys: 1.686 ± 0.991
3.373GlyAsp: 3.373 ± 1.45
5.902GlyGlu: 5.902 ± 3.467
4.216GlyPhe: 4.216 ± 1.422
7.589GlyGly: 7.589 ± 4.869
0.843GlyHis: 0.843 ± 0.495
6.745GlyIle: 6.745 ± 3.061
1.686GlyLys: 1.686 ± 1.889
9.275GlyLeu: 9.275 ± 2.049
1.686GlyMet: 1.686 ± 1.305
3.373GlyAsn: 3.373 ± 2.301
1.686GlyPro: 1.686 ± 0.725
1.686GlyGln: 1.686 ± 0.725
5.902GlyArg: 5.902 ± 2.013
4.216GlySer: 4.216 ± 2.842
3.373GlyThr: 3.373 ± 4.302
3.373GlyVal: 3.373 ± 2.466
0.843GlyTrp: 0.843 ± 0.495
3.373GlyTyr: 3.373 ± 2.24
0.0GlyXaa: 0.0 ± 0.0
His
2.53HisAla: 2.53 ± 1.552
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.843HisGlu: 0.843 ± 0.495
0.843HisPhe: 0.843 ± 0.495
1.686HisGly: 1.686 ± 0.725
3.373HisHis: 3.373 ± 4.054
0.843HisIle: 0.843 ± 2.032
2.53HisLys: 2.53 ± 1.486
3.373HisLeu: 3.373 ± 1.981
0.0HisMet: 0.0 ± 0.0
1.686HisAsn: 1.686 ± 1.559
0.843HisPro: 0.843 ± 0.495
0.843HisGln: 0.843 ± 0.495
0.843HisArg: 0.843 ± 0.495
2.53HisSer: 2.53 ± 2.668
0.843HisThr: 0.843 ± 0.495
1.686HisVal: 1.686 ± 0.991
0.843HisTrp: 0.843 ± 1.674
0.843HisTyr: 0.843 ± 0.495
0.0HisXaa: 0.0 ± 0.0
Ile
5.902IleAla: 5.902 ± 4.384
0.0IleCys: 0.0 ± 0.0
0.843IleAsp: 0.843 ± 1.004
4.216IleGlu: 4.216 ± 1.368
1.686IlePhe: 1.686 ± 0.991
2.53IleGly: 2.53 ± 1.486
0.843IleHis: 0.843 ± 0.495
2.53IleIle: 2.53 ± 1.68
1.686IleLys: 1.686 ± 0.725
7.589IleLeu: 7.589 ± 8.77
1.686IleMet: 1.686 ± 0.991
5.059IleAsn: 5.059 ± 1.461
5.059IlePro: 5.059 ± 1.872
0.843IleGln: 0.843 ± 0.495
1.686IleArg: 1.686 ± 1.559
1.686IleSer: 1.686 ± 2.24
3.373IleThr: 3.373 ± 2.65
3.373IleVal: 3.373 ± 2.671
0.0IleTrp: 0.0 ± 0.0
1.686IleTyr: 1.686 ± 0.725
0.0IleXaa: 0.0 ± 0.0
Lys
4.216LysAla: 4.216 ± 1.368
1.686LysCys: 1.686 ± 0.725
2.53LysAsp: 2.53 ± 1.486
0.843LysGlu: 0.843 ± 0.495
3.373LysPhe: 3.373 ± 1.016
2.53LysGly: 2.53 ± 1.486
1.686LysHis: 1.686 ± 1.559
0.0LysIle: 0.0 ± 0.0
6.745LysLys: 6.745 ± 1.128
5.902LysLeu: 5.902 ± 2.34
1.686LysMet: 1.686 ± 1.438
2.53LysAsn: 2.53 ± 1.623
5.059LysPro: 5.059 ± 1.872
5.059LysGln: 5.059 ± 2.972
1.686LysArg: 1.686 ± 2.719
1.686LysSer: 1.686 ± 1.559
3.373LysThr: 3.373 ± 1.852
2.53LysVal: 2.53 ± 3.146
1.686LysTrp: 1.686 ± 0.991
4.216LysTyr: 4.216 ± 1.368
0.843LysXaa: 0.843 ± 0.495
Leu
6.745LeuAla: 6.745 ± 1.391
2.53LeuCys: 2.53 ± 1.491
6.745LeuAsp: 6.745 ± 2.049
4.216LeuGlu: 4.216 ± 2.477
1.686LeuPhe: 1.686 ± 2.24
5.059LeuGly: 5.059 ± 1.336
0.0LeuHis: 0.0 ± 0.0
5.059LeuIle: 5.059 ± 3.391
4.216LeuLys: 4.216 ± 2.477
5.059LeuLeu: 5.059 ± 2.972
4.216LeuMet: 4.216 ± 2.477
4.216LeuAsn: 4.216 ± 1.368
3.373LeuPro: 3.373 ± 1.981
4.216LeuGln: 4.216 ± 1.422
5.902LeuArg: 5.902 ± 1.699
9.275LeuSer: 9.275 ± 2.787
2.53LeuThr: 2.53 ± 1.552
4.216LeuVal: 4.216 ± 1.462
0.0LeuTrp: 0.0 ± 0.0
1.686LeuTyr: 1.686 ± 0.725
0.0LeuXaa: 0.0 ± 0.0
Met
3.373MetAla: 3.373 ± 3.548
0.843MetCys: 0.843 ± 0.495
1.686MetAsp: 1.686 ± 1.559
2.53MetGlu: 2.53 ± 1.486
0.0MetPhe: 0.0 ± 0.0
0.843MetGly: 0.843 ± 1.004
0.843MetHis: 0.843 ± 0.495
0.0MetIle: 0.0 ± 0.0
0.843MetLys: 0.843 ± 1.004
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
3.373MetAsn: 3.373 ± 1.016
0.843MetPro: 0.843 ± 1.674
0.843MetGln: 0.843 ± 0.495
0.843MetArg: 0.843 ± 0.495
1.686MetSer: 1.686 ± 0.991
0.843MetThr: 0.843 ± 1.716
2.53MetVal: 2.53 ± 1.486
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.686AsnAla: 1.686 ± 0.725
0.843AsnCys: 0.843 ± 0.495
1.686AsnAsp: 1.686 ± 0.725
1.686AsnGlu: 1.686 ± 0.991
3.373AsnPhe: 3.373 ± 3.165
7.589AsnGly: 7.589 ± 2.355
0.0AsnHis: 0.0 ± 0.0
1.686AsnIle: 1.686 ± 1.559
0.843AsnLys: 0.843 ± 0.495
2.53AsnLeu: 2.53 ± 1.486
0.843AsnMet: 0.843 ± 0.469
5.902AsnAsn: 5.902 ± 3.098
3.373AsnPro: 3.373 ± 1.364
4.216AsnGln: 4.216 ± 3.152
4.216AsnArg: 4.216 ± 1.256
3.373AsnSer: 3.373 ± 1.45
3.373AsnThr: 3.373 ± 1.45
5.059AsnVal: 5.059 ± 1.245
0.843AsnTrp: 0.843 ± 0.495
0.843AsnTyr: 0.843 ± 0.495
0.0AsnXaa: 0.0 ± 0.0
Pro
4.216ProAla: 4.216 ± 2.384
0.843ProCys: 0.843 ± 0.495
2.53ProAsp: 2.53 ± 1.486
2.53ProGlu: 2.53 ± 0.73
0.0ProPhe: 0.0 ± 0.0
1.686ProGly: 1.686 ± 1.845
0.0ProHis: 0.0 ± 0.0
1.686ProIle: 1.686 ± 2.008
4.216ProLys: 4.216 ± 1.875
1.686ProLeu: 1.686 ± 0.991
0.0ProMet: 0.0 ± 0.0
4.216ProAsn: 4.216 ± 2.045
1.686ProPro: 1.686 ± 1.974
0.0ProGln: 0.0 ± 0.0
2.53ProArg: 2.53 ± 1.486
4.216ProSer: 4.216 ± 1.462
7.589ProThr: 7.589 ± 4.169
5.902ProVal: 5.902 ± 2.34
2.53ProTrp: 2.53 ± 1.623
2.53ProTyr: 2.53 ± 1.888
0.0ProXaa: 0.0 ± 0.0
Gln
0.843GlnAla: 0.843 ± 0.495
0.0GlnCys: 0.0 ± 0.0
0.843GlnAsp: 0.843 ± 0.495
0.843GlnGlu: 0.843 ± 0.495
2.53GlnPhe: 2.53 ± 0.73
3.373GlnGly: 3.373 ± 1.256
4.216GlnHis: 4.216 ± 1.462
1.686GlnIle: 1.686 ± 1.889
3.373GlnLys: 3.373 ± 1.696
4.216GlnLeu: 4.216 ± 1.368
0.843GlnMet: 0.843 ± 1.004
1.686GlnAsn: 1.686 ± 0.725
3.373GlnPro: 3.373 ± 1.016
5.059GlnGln: 5.059 ± 2.671
4.216GlnArg: 4.216 ± 1.368
1.686GlnSer: 1.686 ± 0.725
5.902GlnThr: 5.902 ± 3.214
2.53GlnVal: 2.53 ± 0.73
0.843GlnTrp: 0.843 ± 1.674
3.373GlnTyr: 3.373 ± 1.614
0.0GlnXaa: 0.0 ± 0.0
Arg
5.059ArgAla: 5.059 ± 1.332
0.843ArgCys: 0.843 ± 2.032
2.53ArgAsp: 2.53 ± 1.486
0.843ArgGlu: 0.843 ± 0.495
0.843ArgPhe: 0.843 ± 0.495
6.745ArgGly: 6.745 ± 3.454
2.53ArgHis: 2.53 ± 1.552
1.686ArgIle: 1.686 ± 1.506
2.53ArgLys: 2.53 ± 1.486
3.373ArgLeu: 3.373 ± 1.633
1.686ArgMet: 1.686 ± 0.725
3.373ArgAsn: 3.373 ± 4.016
2.53ArgPro: 2.53 ± 0.73
2.53ArgGln: 2.53 ± 0.73
7.589ArgArg: 7.589 ± 4.156
3.373ArgSer: 3.373 ± 1.696
5.059ArgThr: 5.059 ± 1.872
5.059ArgVal: 5.059 ± 2.972
0.843ArgTrp: 0.843 ± 1.004
4.216ArgTyr: 4.216 ± 1.422
0.0ArgXaa: 0.0 ± 0.0
Ser
4.216SerAla: 4.216 ± 3.068
0.843SerCys: 0.843 ± 1.004
1.686SerAsp: 1.686 ± 0.725
2.53SerGlu: 2.53 ± 1.552
1.686SerPhe: 1.686 ± 0.991
7.589SerGly: 7.589 ± 2.145
1.686SerHis: 1.686 ± 1.506
4.216SerIle: 4.216 ± 2.014
4.216SerLys: 4.216 ± 1.422
5.059SerLeu: 5.059 ± 1.872
0.0SerMet: 0.0 ± 0.0
3.373SerAsn: 3.373 ± 1.45
3.373SerPro: 3.373 ± 3.691
4.216SerGln: 4.216 ± 2.917
4.216SerArg: 4.216 ± 2.477
2.53SerSer: 2.53 ± 0.73
2.53SerThr: 2.53 ± 1.888
4.216SerVal: 4.216 ± 1.148
1.686SerTrp: 1.686 ± 0.725
0.843SerTyr: 0.843 ± 1.004
0.0SerXaa: 0.0 ± 0.0
Thr
4.216ThrAla: 4.216 ± 1.368
0.0ThrCys: 0.0 ± 0.0
1.686ThrAsp: 1.686 ± 1.559
3.373ThrGlu: 3.373 ± 1.256
0.843ThrPhe: 0.843 ± 0.495
4.216ThrGly: 4.216 ± 3.072
2.53ThrHis: 2.53 ± 1.491
4.216ThrIle: 4.216 ± 1.662
5.902ThrLys: 5.902 ± 1.576
2.53ThrLeu: 2.53 ± 1.781
2.53ThrMet: 2.53 ± 2.846
2.53ThrAsn: 2.53 ± 1.526
4.216ThrPro: 4.216 ± 2.014
1.686ThrGln: 1.686 ± 1.845
3.373ThrArg: 3.373 ± 1.016
8.432ThrSer: 8.432 ± 1.503
4.216ThrThr: 4.216 ± 4.561
2.53ThrVal: 2.53 ± 1.552
0.0ThrTrp: 0.0 ± 0.0
3.373ThrTyr: 3.373 ± 2.791
0.0ThrXaa: 0.0 ± 0.0
Val
5.902ValAla: 5.902 ± 1.699
2.53ValCys: 2.53 ± 1.486
1.686ValAsp: 1.686 ± 0.991
5.059ValGlu: 5.059 ± 1.873
3.373ValPhe: 3.373 ± 1.981
4.216ValGly: 4.216 ± 2.045
0.843ValHis: 0.843 ± 0.495
4.216ValIle: 4.216 ± 1.422
3.373ValLys: 3.373 ± 1.696
1.686ValLeu: 1.686 ± 1.974
1.686ValMet: 1.686 ± 0.673
2.53ValAsn: 2.53 ± 1.486
2.53ValPro: 2.53 ± 1.623
4.216ValGln: 4.216 ± 1.662
3.373ValArg: 3.373 ± 1.016
4.216ValSer: 4.216 ± 1.959
6.745ValThr: 6.745 ± 2.512
6.745ValVal: 6.745 ± 1.921
0.0ValTrp: 0.0 ± 0.0
0.843ValTyr: 0.843 ± 0.495
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.843TrpGly: 0.843 ± 0.495
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.843TrpLys: 0.843 ± 1.674
4.216TrpLeu: 4.216 ± 1.368
0.0TrpMet: 0.0 ± 0.0
1.686TrpAsn: 1.686 ± 0.991
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
2.53TrpArg: 2.53 ± 1.491
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.843TrpTrp: 0.843 ± 0.495
1.686TrpTyr: 1.686 ± 1.974
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.53TyrAla: 2.53 ± 0.73
0.0TyrCys: 0.0 ± 0.0
2.53TyrAsp: 2.53 ± 1.68
2.53TyrGlu: 2.53 ± 1.781
1.686TyrPhe: 1.686 ± 1.845
0.843TyrGly: 0.843 ± 0.495
1.686TyrHis: 1.686 ± 1.845
3.373TyrIle: 3.373 ± 2.671
2.53TyrLys: 2.53 ± 1.888
5.059TyrLeu: 5.059 ± 1.461
0.843TyrMet: 0.843 ± 0.495
1.686TyrAsn: 1.686 ± 1.559
1.686TyrPro: 1.686 ± 0.725
3.373TyrGln: 3.373 ± 2.301
1.686TyrArg: 1.686 ± 0.725
1.686TyrSer: 1.686 ± 0.725
2.53TyrThr: 2.53 ± 1.491
2.53TyrVal: 2.53 ± 0.73
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.843XaaGly: 0.843 ± 0.495
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski