Amino acid dipepetide frequency for Streptococcus virus 7201

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.285AlaAla: 3.285 ± 1.135
0.274AlaCys: 0.274 ± 0.159
4.927AlaAsp: 4.927 ± 0.8
4.654AlaGlu: 4.654 ± 0.665
3.011AlaPhe: 3.011 ± 0.547
4.471AlaGly: 4.471 ± 0.768
0.456AlaHis: 0.456 ± 0.184
4.106AlaIle: 4.106 ± 0.7
5.566AlaLys: 5.566 ± 0.734
6.022AlaLeu: 6.022 ± 0.737
1.551AlaMet: 1.551 ± 0.503
5.475AlaAsn: 5.475 ± 0.767
1.369AlaPro: 1.369 ± 0.317
3.194AlaGln: 3.194 ± 0.607
2.646AlaArg: 2.646 ± 0.439
4.289AlaSer: 4.289 ± 0.77
4.015AlaThr: 4.015 ± 0.619
4.471AlaVal: 4.471 ± 0.674
1.186AlaTrp: 1.186 ± 0.277
2.646AlaTyr: 2.646 ± 0.562
0.0AlaXaa: 0.0 ± 0.0
Cys
0.182CysAla: 0.182 ± 0.14
0.0CysCys: 0.0 ± 0.0
0.73CysAsp: 0.73 ± 0.271
0.547CysGlu: 0.547 ± 0.205
0.547CysPhe: 0.547 ± 0.275
0.182CysGly: 0.182 ± 0.149
0.091CysHis: 0.091 ± 0.087
0.0CysIle: 0.0 ± 0.0
0.274CysLys: 0.274 ± 0.161
0.547CysLeu: 0.547 ± 0.264
0.0CysMet: 0.0 ± 0.0
0.182CysAsn: 0.182 ± 0.12
0.0CysPro: 0.0 ± 0.0
0.182CysGln: 0.182 ± 0.141
0.456CysArg: 0.456 ± 0.231
0.456CysSer: 0.456 ± 0.219
0.639CysThr: 0.639 ± 0.248
0.365CysVal: 0.365 ± 0.211
0.274CysTrp: 0.274 ± 0.161
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.285AspAla: 3.285 ± 0.685
0.456AspCys: 0.456 ± 0.226
3.741AspAsp: 3.741 ± 0.468
3.924AspGlu: 3.924 ± 0.633
3.559AspPhe: 3.559 ± 0.59
6.479AspGly: 6.479 ± 1.188
0.912AspHis: 0.912 ± 0.306
5.292AspIle: 5.292 ± 0.553
4.471AspLys: 4.471 ± 0.722
4.197AspLeu: 4.197 ± 0.906
2.372AspMet: 2.372 ± 0.53
4.289AspAsn: 4.289 ± 0.689
2.281AspPro: 2.281 ± 0.474
1.369AspGln: 1.369 ± 0.293
2.281AspArg: 2.281 ± 0.398
3.559AspSer: 3.559 ± 0.937
3.741AspThr: 3.741 ± 0.717
3.376AspVal: 3.376 ± 0.632
0.912AspTrp: 0.912 ± 0.285
2.281AspTyr: 2.281 ± 0.452
0.0AspXaa: 0.0 ± 0.0
Glu
4.015GluAla: 4.015 ± 0.598
0.365GluCys: 0.365 ± 0.163
3.376GluAsp: 3.376 ± 0.551
5.201GluGlu: 5.201 ± 1.007
2.099GluPhe: 2.099 ± 0.502
2.829GluGly: 2.829 ± 0.508
1.46GluHis: 1.46 ± 0.517
5.384GluIle: 5.384 ± 1.008
4.106GluLys: 4.106 ± 0.861
6.844GluLeu: 6.844 ± 1.12
2.19GluMet: 2.19 ± 0.516
4.015GluAsn: 4.015 ± 0.582
1.642GluPro: 1.642 ± 0.539
2.737GluGln: 2.737 ± 0.469
2.555GluArg: 2.555 ± 0.545
2.646GluSer: 2.646 ± 0.463
3.741GluThr: 3.741 ± 0.675
4.927GluVal: 4.927 ± 0.497
0.912GluTrp: 0.912 ± 0.296
2.555GluTyr: 2.555 ± 0.542
0.0GluXaa: 0.0 ± 0.0
Phe
3.011PheAla: 3.011 ± 0.467
0.274PheCys: 0.274 ± 0.167
3.376PheAsp: 3.376 ± 0.7
2.281PheGlu: 2.281 ± 0.506
1.825PhePhe: 1.825 ± 0.351
3.011PheGly: 3.011 ± 0.518
0.547PheHis: 0.547 ± 0.182
2.464PheIle: 2.464 ± 0.479
4.289PheLys: 4.289 ± 0.475
2.646PheLeu: 2.646 ± 0.522
0.73PheMet: 0.73 ± 0.253
3.011PheAsn: 3.011 ± 0.768
0.73PhePro: 0.73 ± 0.287
1.004PheGln: 1.004 ± 0.272
1.277PheArg: 1.277 ± 0.423
3.924PheSer: 3.924 ± 0.586
2.099PheThr: 2.099 ± 0.536
2.829PheVal: 2.829 ± 0.515
0.547PheTrp: 0.547 ± 0.283
2.372PheTyr: 2.372 ± 0.56
0.0PheXaa: 0.0 ± 0.0
Gly
3.467GlyAla: 3.467 ± 0.695
0.274GlyCys: 0.274 ± 0.161
4.106GlyAsp: 4.106 ± 0.683
2.92GlyGlu: 2.92 ± 0.63
3.194GlyPhe: 3.194 ± 0.511
4.38GlyGly: 4.38 ± 0.961
0.912GlyHis: 0.912 ± 0.275
5.931GlyIle: 5.931 ± 0.807
5.292GlyLys: 5.292 ± 0.651
6.022GlyLeu: 6.022 ± 0.834
1.642GlyMet: 1.642 ± 0.278
4.015GlyAsn: 4.015 ± 0.894
1.369GlyPro: 1.369 ± 0.521
3.559GlyGln: 3.559 ± 0.71
2.555GlyArg: 2.555 ± 0.72
5.292GlySer: 5.292 ± 0.957
4.562GlyThr: 4.562 ± 0.599
3.65GlyVal: 3.65 ± 0.66
1.369GlyTrp: 1.369 ± 0.546
2.646GlyTyr: 2.646 ± 0.421
0.0GlyXaa: 0.0 ± 0.0
His
0.456HisAla: 0.456 ± 0.212
0.091HisCys: 0.091 ± 0.104
0.547HisAsp: 0.547 ± 0.307
0.456HisGlu: 0.456 ± 0.199
1.004HisPhe: 1.004 ± 0.281
1.004HisGly: 1.004 ± 0.271
0.547HisHis: 0.547 ± 0.211
0.547HisIle: 0.547 ± 0.27
1.186HisLys: 1.186 ± 0.371
1.46HisLeu: 1.46 ± 0.38
0.639HisMet: 0.639 ± 0.215
0.821HisAsn: 0.821 ± 0.377
0.456HisPro: 0.456 ± 0.198
1.095HisGln: 1.095 ± 0.328
0.639HisArg: 0.639 ± 0.214
0.73HisSer: 0.73 ± 0.223
0.912HisThr: 0.912 ± 0.3
1.369HisVal: 1.369 ± 0.333
0.091HisTrp: 0.091 ± 0.097
0.639HisTyr: 0.639 ± 0.301
0.0HisXaa: 0.0 ± 0.0
Ile
4.745IleAla: 4.745 ± 0.637
0.274IleCys: 0.274 ± 0.157
4.927IleAsp: 4.927 ± 0.741
5.019IleGlu: 5.019 ± 0.886
1.916IlePhe: 1.916 ± 0.521
4.38IleGly: 4.38 ± 0.599
1.095IleHis: 1.095 ± 0.292
3.194IleIle: 3.194 ± 0.608
5.931IleLys: 5.931 ± 0.62
3.559IleLeu: 3.559 ± 0.685
1.46IleMet: 1.46 ± 0.288
4.927IleAsn: 4.927 ± 0.679
2.646IlePro: 2.646 ± 0.471
3.194IleGln: 3.194 ± 0.62
2.555IleArg: 2.555 ± 0.468
4.654IleSer: 4.654 ± 0.452
4.562IleThr: 4.562 ± 0.659
3.285IleVal: 3.285 ± 0.519
1.369IleTrp: 1.369 ± 0.41
1.734IleTyr: 1.734 ± 0.39
0.0IleXaa: 0.0 ± 0.0
Lys
5.657LysAla: 5.657 ± 0.686
0.365LysCys: 0.365 ± 0.173
5.11LysAsp: 5.11 ± 0.798
5.657LysGlu: 5.657 ± 0.841
3.467LysPhe: 3.467 ± 0.698
5.201LysGly: 5.201 ± 0.621
1.369LysHis: 1.369 ± 0.406
4.927LysIle: 4.927 ± 0.686
6.479LysLys: 6.479 ± 1.188
6.479LysLeu: 6.479 ± 0.721
2.099LysMet: 2.099 ± 0.343
5.201LysAsn: 5.201 ± 0.852
2.737LysPro: 2.737 ± 0.485
4.289LysGln: 4.289 ± 0.705
3.741LysArg: 3.741 ± 0.583
4.015LysSer: 4.015 ± 0.47
4.927LysThr: 4.927 ± 0.89
4.562LysVal: 4.562 ± 0.576
1.004LysTrp: 1.004 ± 0.258
3.741LysTyr: 3.741 ± 0.877
0.0LysXaa: 0.0 ± 0.0
Leu
6.844LeuAla: 6.844 ± 0.71
0.365LeuCys: 0.365 ± 0.173
5.292LeuAsp: 5.292 ± 0.856
6.205LeuGlu: 6.205 ± 1.0
2.829LeuPhe: 2.829 ± 0.487
5.384LeuGly: 5.384 ± 1.06
0.73LeuHis: 0.73 ± 0.309
4.289LeuIle: 4.289 ± 0.591
7.391LeuLys: 7.391 ± 0.977
5.019LeuLeu: 5.019 ± 0.592
1.916LeuMet: 1.916 ± 0.331
5.019LeuAsn: 5.019 ± 0.638
2.281LeuPro: 2.281 ± 0.381
2.829LeuGln: 2.829 ± 0.594
2.646LeuArg: 2.646 ± 0.614
6.205LeuSer: 6.205 ± 0.717
6.387LeuThr: 6.387 ± 1.148
3.832LeuVal: 3.832 ± 0.443
0.547LeuTrp: 0.547 ± 0.251
2.92LeuTyr: 2.92 ± 0.472
0.0LeuXaa: 0.0 ± 0.0
Met
1.551MetAla: 1.551 ± 0.443
0.0MetCys: 0.0 ± 0.0
0.73MetAsp: 0.73 ± 0.234
1.004MetGlu: 1.004 ± 0.356
0.912MetPhe: 0.912 ± 0.199
1.277MetGly: 1.277 ± 0.346
0.547MetHis: 0.547 ± 0.235
1.734MetIle: 1.734 ± 0.397
2.829MetLys: 2.829 ± 0.523
1.642MetLeu: 1.642 ± 0.261
0.639MetMet: 0.639 ± 0.18
1.095MetAsn: 1.095 ± 0.286
0.821MetPro: 0.821 ± 0.226
0.821MetGln: 0.821 ± 0.248
0.73MetArg: 0.73 ± 0.206
2.007MetSer: 2.007 ± 0.453
2.099MetThr: 2.099 ± 0.386
1.642MetVal: 1.642 ± 0.495
0.182MetTrp: 0.182 ± 0.105
1.186MetTyr: 1.186 ± 0.258
0.0MetXaa: 0.0 ± 0.0
Asn
5.475AsnAla: 5.475 ± 1.074
0.274AsnCys: 0.274 ± 0.152
3.194AsnAsp: 3.194 ± 0.659
3.65AsnGlu: 3.65 ± 0.565
3.011AsnPhe: 3.011 ± 0.444
6.296AsnGly: 6.296 ± 0.975
1.004AsnHis: 1.004 ± 0.303
3.559AsnIle: 3.559 ± 0.48
3.741AsnLys: 3.741 ± 0.454
4.927AsnLeu: 4.927 ± 0.621
0.912AsnMet: 0.912 ± 0.28
4.836AsnAsn: 4.836 ± 0.852
2.92AsnPro: 2.92 ± 0.514
3.102AsnGln: 3.102 ± 0.562
1.825AsnArg: 1.825 ± 0.487
4.38AsnSer: 4.38 ± 0.721
4.38AsnThr: 4.38 ± 0.713
3.65AsnVal: 3.65 ± 0.614
1.095AsnTrp: 1.095 ± 0.36
2.19AsnTyr: 2.19 ± 0.387
0.0AsnXaa: 0.0 ± 0.0
Pro
2.281ProAla: 2.281 ± 0.422
0.0ProCys: 0.0 ± 0.0
1.46ProAsp: 1.46 ± 0.379
1.916ProGlu: 1.916 ± 0.466
1.369ProPhe: 1.369 ± 0.333
1.369ProGly: 1.369 ± 0.411
0.274ProHis: 0.274 ± 0.128
2.007ProIle: 2.007 ± 0.396
3.559ProLys: 3.559 ± 0.557
2.464ProLeu: 2.464 ± 0.463
0.182ProMet: 0.182 ± 0.121
2.464ProAsn: 2.464 ± 0.497
0.456ProPro: 0.456 ± 0.246
1.825ProGln: 1.825 ± 0.345
0.912ProArg: 0.912 ± 0.362
2.099ProSer: 2.099 ± 0.512
2.372ProThr: 2.372 ± 0.61
1.46ProVal: 1.46 ± 0.431
0.456ProTrp: 0.456 ± 0.16
1.095ProTyr: 1.095 ± 0.329
0.0ProXaa: 0.0 ± 0.0
Gln
4.106GlnAla: 4.106 ± 0.731
0.274GlnCys: 0.274 ± 0.163
2.92GlnAsp: 2.92 ± 0.552
2.829GlnGlu: 2.829 ± 0.586
1.277GlnPhe: 1.277 ± 0.39
3.559GlnGly: 3.559 ± 0.903
0.639GlnHis: 0.639 ± 0.241
2.829GlnIle: 2.829 ± 0.682
3.376GlnLys: 3.376 ± 0.717
4.106GlnLeu: 4.106 ± 0.504
1.551GlnMet: 1.551 ± 0.362
1.916GlnAsn: 1.916 ± 0.432
0.912GlnPro: 0.912 ± 0.332
3.559GlnGln: 3.559 ± 0.735
1.825GlnArg: 1.825 ± 0.429
2.737GlnSer: 2.737 ± 0.451
2.829GlnThr: 2.829 ± 0.449
1.916GlnVal: 1.916 ± 0.45
1.004GlnTrp: 1.004 ± 0.348
2.281GlnTyr: 2.281 ± 0.475
0.0GlnXaa: 0.0 ± 0.0
Arg
1.734ArgAla: 1.734 ± 0.334
0.091ArgCys: 0.091 ± 0.093
2.555ArgAsp: 2.555 ± 0.524
2.464ArgGlu: 2.464 ± 0.369
2.099ArgPhe: 2.099 ± 0.459
1.916ArgGly: 1.916 ± 0.51
0.821ArgHis: 0.821 ± 0.246
2.281ArgIle: 2.281 ± 0.481
3.011ArgLys: 3.011 ± 0.652
3.467ArgLeu: 3.467 ± 0.472
0.365ArgMet: 0.365 ± 0.203
2.281ArgAsn: 2.281 ± 0.34
1.186ArgPro: 1.186 ± 0.344
1.916ArgGln: 1.916 ± 0.394
1.186ArgArg: 1.186 ± 0.387
1.46ArgSer: 1.46 ± 0.341
2.829ArgThr: 2.829 ± 0.648
2.737ArgVal: 2.737 ± 0.463
0.821ArgTrp: 0.821 ± 0.228
2.464ArgTyr: 2.464 ± 0.511
0.0ArgXaa: 0.0 ± 0.0
Ser
3.467SerAla: 3.467 ± 0.682
0.73SerCys: 0.73 ± 0.268
4.38SerAsp: 4.38 ± 0.748
4.015SerGlu: 4.015 ± 0.433
2.92SerPhe: 2.92 ± 0.523
4.654SerGly: 4.654 ± 0.902
0.73SerHis: 0.73 ± 0.213
5.657SerIle: 5.657 ± 0.49
5.201SerLys: 5.201 ± 0.831
4.106SerLeu: 4.106 ± 0.532
2.007SerMet: 2.007 ± 0.37
4.197SerAsn: 4.197 ± 0.642
2.372SerPro: 2.372 ± 0.452
3.194SerGln: 3.194 ± 0.641
3.102SerArg: 3.102 ± 0.595
5.019SerSer: 5.019 ± 0.677
4.197SerThr: 4.197 ± 0.663
4.927SerVal: 4.927 ± 0.768
0.547SerTrp: 0.547 ± 0.205
2.281SerTyr: 2.281 ± 0.587
0.0SerXaa: 0.0 ± 0.0
Thr
4.562ThrAla: 4.562 ± 0.641
0.456ThrCys: 0.456 ± 0.262
3.832ThrAsp: 3.832 ± 0.633
3.741ThrGlu: 3.741 ± 0.584
2.646ThrPhe: 2.646 ± 0.499
4.106ThrGly: 4.106 ± 0.761
0.821ThrHis: 0.821 ± 0.268
4.654ThrIle: 4.654 ± 0.809
4.745ThrLys: 4.745 ± 0.796
6.661ThrLeu: 6.661 ± 0.907
0.73ThrMet: 0.73 ± 0.243
4.654ThrAsn: 4.654 ± 1.052
1.642ThrPro: 1.642 ± 0.452
2.92ThrGln: 2.92 ± 0.471
2.099ThrArg: 2.099 ± 0.474
4.471ThrSer: 4.471 ± 0.769
3.741ThrThr: 3.741 ± 0.747
4.015ThrVal: 4.015 ± 0.566
1.277ThrTrp: 1.277 ± 0.281
3.376ThrTyr: 3.376 ± 0.638
0.0ThrXaa: 0.0 ± 0.0
Val
4.927ValAla: 4.927 ± 1.284
0.365ValCys: 0.365 ± 0.194
4.015ValAsp: 4.015 ± 0.599
3.559ValGlu: 3.559 ± 0.737
2.737ValPhe: 2.737 ± 0.428
3.832ValGly: 3.832 ± 0.679
0.73ValHis: 0.73 ± 0.215
3.65ValIle: 3.65 ± 0.522
5.657ValLys: 5.657 ± 0.643
4.471ValLeu: 4.471 ± 0.807
1.277ValMet: 1.277 ± 0.302
3.194ValAsn: 3.194 ± 0.519
2.646ValPro: 2.646 ± 0.364
2.19ValGln: 2.19 ± 0.426
1.916ValArg: 1.916 ± 0.566
4.654ValSer: 4.654 ± 0.976
4.106ValThr: 4.106 ± 0.706
3.65ValVal: 3.65 ± 0.576
1.186ValTrp: 1.186 ± 0.304
1.551ValTyr: 1.551 ± 0.408
0.0ValXaa: 0.0 ± 0.0
Trp
1.095TrpAla: 1.095 ± 0.294
0.0TrpCys: 0.0 ± 0.0
0.821TrpAsp: 0.821 ± 0.313
1.277TrpGlu: 1.277 ± 0.327
0.456TrpPhe: 0.456 ± 0.242
0.547TrpGly: 0.547 ± 0.23
0.456TrpHis: 0.456 ± 0.191
0.639TrpIle: 0.639 ± 0.226
0.73TrpLys: 0.73 ± 0.218
1.369TrpLeu: 1.369 ± 0.297
0.091TrpMet: 0.091 ± 0.097
1.004TrpAsn: 1.004 ± 0.431
0.091TrpPro: 0.091 ± 0.104
0.821TrpGln: 0.821 ± 0.219
0.821TrpArg: 0.821 ± 0.22
2.099TrpSer: 2.099 ± 0.743
1.004TrpThr: 1.004 ± 0.547
1.186TrpVal: 1.186 ± 0.297
0.365TrpTrp: 0.365 ± 0.198
0.456TrpTyr: 0.456 ± 0.306
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.467TyrAla: 3.467 ± 0.529
0.73TyrCys: 0.73 ± 0.349
2.737TyrAsp: 2.737 ± 0.597
2.281TyrGlu: 2.281 ± 0.452
1.46TyrPhe: 1.46 ± 0.307
2.281TyrGly: 2.281 ± 0.603
0.547TyrHis: 0.547 ± 0.229
2.281TyrIle: 2.281 ± 0.556
3.194TyrLys: 3.194 ± 0.55
2.92TyrLeu: 2.92 ± 0.443
1.004TyrMet: 1.004 ± 0.337
1.825TyrAsn: 1.825 ± 0.331
1.46TyrPro: 1.46 ± 0.4
2.646TyrGln: 2.646 ± 0.423
1.916TyrArg: 1.916 ± 0.405
3.011TyrSer: 3.011 ± 0.602
2.007TyrThr: 2.007 ± 0.437
2.464TyrVal: 2.464 ± 0.452
0.182TyrTrp: 0.182 ± 0.128
1.916TyrTyr: 1.916 ± 0.627
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (10960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski