Amino acid dipepetide frequency for Prevotella nigrescens ATCC 33563

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.673AlaAla: 5.673 ± 0.128	0.928AlaCys: 0.928 ± 0.036	4.343AlaAsp: 4.343 ± 0.073	4.588AlaGlu: 4.588 ± 0.084	3.24AlaPhe: 3.24 ± 0.066	4.583AlaGly: 4.583 ± 0.09	1.326AlaHis: 1.326 ± 0.042	5.093AlaIle: 5.093 ± 0.09	5.162AlaLys: 5.162 ± 0.092	6.419AlaLeu: 6.419 ± 0.126	2.073AlaMet: 2.073 ± 0.06	3.691AlaAsn: 3.691 ± 0.077	2.196AlaPro: 2.196 ± 0.057	3.111AlaGln: 3.111 ± 0.067	3.104AlaArg: 3.104 ± 0.063	3.836AlaSer: 3.836 ± 0.073	4.267AlaThr: 4.267 ± 0.089	4.591AlaVal: 4.591 ± 0.074	0.675AlaTrp: 0.675 ± 0.029	3.024AlaTyr: 3.024 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.853CysAla: 0.853 ± 0.03	0.199CysCys: 0.199 ± 0.015	0.701CysAsp: 0.701 ± 0.032	0.651CysGlu: 0.651 ± 0.029	0.648CysPhe: 0.648 ± 0.031	0.958CysGly: 0.958 ± 0.035	0.323CysHis: 0.323 ± 0.024	0.957CysIle: 0.957 ± 0.037	0.944CysLys: 0.944 ± 0.036	1.091CysLeu: 1.091 ± 0.041	0.333CysMet: 0.333 ± 0.02	0.833CysAsn: 0.833 ± 0.035	0.497CysPro: 0.497 ± 0.029	0.365CysGln: 0.365 ± 0.019	0.58CysArg: 0.58 ± 0.027	0.708CysSer: 0.708 ± 0.033	0.725CysThr: 0.725 ± 0.03	0.749CysVal: 0.749 ± 0.037	0.145CysTrp: 0.145 ± 0.012	0.569CysTyr: 0.569 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	3.95AspAla: 3.95 ± 0.075	0.681AspCys: 0.681 ± 0.033	2.872AspAsp: 2.872 ± 0.063	3.7AspGlu: 3.7 ± 0.08	2.992AspPhe: 2.992 ± 0.065	3.987AspGly: 3.987 ± 0.089	0.826AspHis: 0.826 ± 0.032	4.255AspIle: 4.255 ± 0.074	4.238AspLys: 4.238 ± 0.078	4.401AspLeu: 4.401 ± 0.08	1.565AspMet: 1.565 ± 0.042	3.194AspAsn: 3.194 ± 0.068	1.677AspPro: 1.677 ± 0.048	1.062AspGln: 1.062 ± 0.039	2.213AspArg: 2.213 ± 0.055	2.914AspSer: 2.914 ± 0.079	2.847AspThr: 2.847 ± 0.064	3.575AspVal: 3.575 ± 0.071	0.735AspTrp: 0.735 ± 0.031	2.647AspTyr: 2.647 ± 0.071	0.0AspXaa: 0.0 ± 0.0
Glu	4.48GluAla: 4.48 ± 0.084	0.639GluCys: 0.639 ± 0.032	2.991GluAsp: 2.991 ± 0.077	4.576GluGlu: 4.576 ± 0.11	2.358GluPhe: 2.358 ± 0.061	3.817GluGly: 3.817 ± 0.082	1.338GluHis: 1.338 ± 0.042	4.347GluIle: 4.347 ± 0.091	5.158GluLys: 5.158 ± 0.099	5.644GluLeu: 5.644 ± 0.111	1.977GluMet: 1.977 ± 0.055	3.528GluAsn: 3.528 ± 0.076	1.736GluPro: 1.736 ± 0.047	2.789GluGln: 2.789 ± 0.068	3.306GluArg: 3.306 ± 0.078	2.782GluSer: 2.782 ± 0.06	3.596GluThr: 3.596 ± 0.073	3.948GluVal: 3.948 ± 0.079	0.726GluTrp: 0.726 ± 0.032	2.589GluTyr: 2.589 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.394PheAla: 3.394 ± 0.062	0.857PheCys: 0.857 ± 0.034	2.735PheAsp: 2.735 ± 0.058	2.38PheGlu: 2.38 ± 0.053	2.321PhePhe: 2.321 ± 0.065	3.354PheGly: 3.354 ± 0.073	0.981PheHis: 0.981 ± 0.038	3.116PheIle: 3.116 ± 0.075	2.705PheLys: 2.705 ± 0.06	3.954PheLeu: 3.954 ± 0.09	1.259PheMet: 1.259 ± 0.045	2.478PheAsn: 2.478 ± 0.061	1.509PhePro: 1.509 ± 0.041	1.265PheGln: 1.265 ± 0.042	2.127PheArg: 2.127 ± 0.054	3.328PheSer: 3.328 ± 0.066	2.885PheThr: 2.885 ± 0.066	3.136PheVal: 3.136 ± 0.064	0.485PheTrp: 0.485 ± 0.028	1.939PheTyr: 1.939 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.298GlyAla: 4.298 ± 0.09	0.858GlyCys: 0.858 ± 0.033	3.254GlyAsp: 3.254 ± 0.07	3.904GlyGlu: 3.904 ± 0.08	3.059GlyPhe: 3.059 ± 0.07	4.447GlyGly: 4.447 ± 0.098	1.202GlyHis: 1.202 ± 0.04	5.317GlyIle: 5.317 ± 0.083	5.854GlyLys: 5.854 ± 0.087	5.499GlyLeu: 5.499 ± 0.08	1.989GlyMet: 1.989 ± 0.053	3.697GlyAsn: 3.697 ± 0.077	1.082GlyPro: 1.082 ± 0.035	2.106GlyGln: 2.106 ± 0.058	2.85GlyArg: 2.85 ± 0.061	3.739GlySer: 3.739 ± 0.082	4.173GlyThr: 4.173 ± 0.085	4.277GlyVal: 4.277 ± 0.082	0.77GlyTrp: 0.77 ± 0.033	2.995GlyTyr: 2.995 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.198HisAla: 1.198 ± 0.04	0.308HisCys: 0.308 ± 0.02	0.999HisAsp: 0.999 ± 0.038	1.078HisGlu: 1.078 ± 0.041	1.087HisPhe: 1.087 ± 0.039	1.247HisGly: 1.247 ± 0.041	0.517HisHis: 0.517 ± 0.031	1.615HisIle: 1.615 ± 0.049	1.235HisLys: 1.235 ± 0.041	1.926HisLeu: 1.926 ± 0.053	0.31HisMet: 0.31 ± 0.019	1.132HisAsn: 1.132 ± 0.039	0.793HisPro: 0.793 ± 0.029	0.666HisGln: 0.666 ± 0.029	1.003HisArg: 1.003 ± 0.04	1.19HisSer: 1.19 ± 0.041	1.128HisThr: 1.128 ± 0.042	1.103HisVal: 1.103 ± 0.037	0.256HisTrp: 0.256 ± 0.017	0.96HisTyr: 0.96 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.657IleAla: 5.657 ± 0.086	0.942IleCys: 0.942 ± 0.04	4.75IleAsp: 4.75 ± 0.081	4.736IleGlu: 4.736 ± 0.086	2.888IlePhe: 2.888 ± 0.07	4.617IleGly: 4.617 ± 0.092	1.261IleHis: 1.261 ± 0.036	4.81IleIle: 4.81 ± 0.098	4.887IleLys: 4.887 ± 0.09	5.755IleLeu: 5.755 ± 0.102	1.698IleMet: 1.698 ± 0.05	3.804IleAsn: 3.804 ± 0.083	3.009IlePro: 3.009 ± 0.07	2.121IleGln: 2.121 ± 0.057	3.086IleArg: 3.086 ± 0.066	4.422IleSer: 4.422 ± 0.093	4.188IleThr: 4.188 ± 0.085	4.961IleVal: 4.961 ± 0.091	0.584IleTrp: 0.584 ± 0.033	2.789IleTyr: 2.789 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.52LysAla: 5.52 ± 0.094	0.631LysCys: 0.631 ± 0.028	4.054LysAsp: 4.054 ± 0.08	5.728LysGlu: 5.728 ± 0.093	2.552LysPhe: 2.552 ± 0.057	4.866LysGly: 4.866 ± 0.085	1.5LysHis: 1.5 ± 0.044	4.778LysIle: 4.778 ± 0.075	5.728LysLys: 5.728 ± 0.11	5.867LysLeu: 5.867 ± 0.099	2.32LysMet: 2.32 ± 0.053	4.054LysAsn: 4.054 ± 0.09	2.369LysPro: 2.369 ± 0.054	3.202LysGln: 3.202 ± 0.076	3.638LysArg: 3.638 ± 0.092	3.66LysSer: 3.66 ± 0.067	4.222LysThr: 4.222 ± 0.074	4.725LysVal: 4.725 ± 0.085	0.834LysTrp: 0.834 ± 0.035	3.117LysTyr: 3.117 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	6.058LeuAla: 6.058 ± 0.101	1.355LeuCys: 1.355 ± 0.043	4.368LeuAsp: 4.368 ± 0.081	4.724LeuGlu: 4.724 ± 0.091	4.319LeuPhe: 4.319 ± 0.083	5.387LeuGly: 5.387 ± 0.094	1.926LeuHis: 1.926 ± 0.053	5.268LeuIle: 5.268 ± 0.089	6.27LeuLys: 6.27 ± 0.097	8.662LeuLeu: 8.662 ± 0.177	2.523LeuMet: 2.523 ± 0.066	4.795LeuAsn: 4.795 ± 0.099	3.92LeuPro: 3.92 ± 0.078	3.519LeuGln: 3.519 ± 0.071	4.425LeuArg: 4.425 ± 0.068	6.634LeuSer: 6.634 ± 0.107	5.264LeuThr: 5.264 ± 0.09	5.173LeuVal: 5.173 ± 0.09	0.938LeuTrp: 0.938 ± 0.036	3.517LeuTyr: 3.517 ± 0.081	0.0LeuXaa: 0.0 ± 0.0
Met	2.274MetAla: 2.274 ± 0.053	0.297MetCys: 0.297 ± 0.02	1.368MetAsp: 1.368 ± 0.047	1.785MetGlu: 1.785 ± 0.048	1.178MetPhe: 1.178 ± 0.048	1.905MetGly: 1.905 ± 0.049	0.51MetHis: 0.51 ± 0.025	1.574MetIle: 1.574 ± 0.048	2.525MetLys: 2.525 ± 0.06	2.577MetLeu: 2.577 ± 0.064	0.803MetMet: 0.803 ± 0.037	1.521MetAsn: 1.521 ± 0.039	1.255MetPro: 1.255 ± 0.048	1.217MetGln: 1.217 ± 0.042	1.363MetArg: 1.363 ± 0.042	1.455MetSer: 1.455 ± 0.042	1.355MetThr: 1.355 ± 0.044	1.681MetVal: 1.681 ± 0.051	0.219MetTrp: 0.219 ± 0.016	0.874MetTyr: 0.874 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	3.937AsnAla: 3.937 ± 0.078	0.677AsnCys: 0.677 ± 0.036	2.937AsnAsp: 2.937 ± 0.069	3.241AsnGlu: 3.241 ± 0.073	2.487AsnPhe: 2.487 ± 0.062	4.165AsnGly: 4.165 ± 0.092	1.012AsnHis: 1.012 ± 0.036	4.441AsnIle: 4.441 ± 0.068	4.104AsnLys: 4.104 ± 0.086	4.45AsnLeu: 4.45 ± 0.082	1.352AsnMet: 1.352 ± 0.044	3.358AsnAsn: 3.358 ± 0.09	2.266AsnPro: 2.266 ± 0.055	1.615AsnGln: 1.615 ± 0.044	2.396AsnArg: 2.396 ± 0.063	3.02AsnSer: 3.02 ± 0.068	3.091AsnThr: 3.091 ± 0.078	3.602AsnVal: 3.602 ± 0.077	0.635AsnTrp: 0.635 ± 0.028	2.38AsnTyr: 2.38 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	2.507ProAla: 2.507 ± 0.066	0.373ProCys: 0.373 ± 0.026	2.15ProAsp: 2.15 ± 0.063	2.541ProGlu: 2.541 ± 0.055	1.752ProPhe: 1.752 ± 0.05	1.833ProGly: 1.833 ± 0.054	0.724ProHis: 0.724 ± 0.03	2.477ProIle: 2.477 ± 0.061	2.373ProLys: 2.373 ± 0.051	3.017ProLeu: 3.017 ± 0.07	0.971ProMet: 0.971 ± 0.035	1.96ProAsn: 1.96 ± 0.056	0.733ProPro: 0.733 ± 0.038	1.406ProGln: 1.406 ± 0.046	1.215ProArg: 1.215 ± 0.048	2.108ProSer: 2.108 ± 0.059	2.354ProThr: 2.354 ± 0.057	2.247ProVal: 2.247 ± 0.048	0.352ProTrp: 0.352 ± 0.022	1.662ProTyr: 1.662 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.441GlnAla: 2.441 ± 0.061	0.393GlnCys: 0.393 ± 0.021	1.482GlnAsp: 1.482 ± 0.043	2.127GlnGlu: 2.127 ± 0.051	1.442GlnPhe: 1.442 ± 0.046	2.087GlnGly: 2.087 ± 0.059	0.83GlnHis: 0.83 ± 0.032	2.589GlnIle: 2.589 ± 0.062	2.63GlnLys: 2.63 ± 0.071	3.56GlnLeu: 3.56 ± 0.059	1.13GlnMet: 1.13 ± 0.04	1.895GlnAsn: 1.895 ± 0.058	1.41GlnPro: 1.41 ± 0.044	1.887GlnGln: 1.887 ± 0.058	1.967GlnArg: 1.967 ± 0.056	1.882GlnSer: 1.882 ± 0.05	2.177GlnThr: 2.177 ± 0.056	1.953GlnVal: 1.953 ± 0.054	0.452GlnTrp: 0.452 ± 0.028	1.478GlnTyr: 1.478 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.747ArgAla: 2.747 ± 0.062	0.565ArgCys: 0.565 ± 0.025	1.989ArgAsp: 1.989 ± 0.053	2.715ArgGlu: 2.715 ± 0.067	2.148ArgPhe: 2.148 ± 0.059	2.409ArgGly: 2.409 ± 0.051	1.073ArgHis: 1.073 ± 0.044	3.622ArgIle: 3.622 ± 0.077	3.684ArgLys: 3.684 ± 0.087	4.425ArgLeu: 4.425 ± 0.086	1.513ArgMet: 1.513 ± 0.048	2.781ArgAsn: 2.781 ± 0.059	1.637ArgPro: 1.637 ± 0.049	1.944ArgGln: 1.944 ± 0.061	2.399ArgArg: 2.399 ± 0.066	2.358ArgSer: 2.358 ± 0.059	2.652ArgThr: 2.652 ± 0.058	2.424ArgVal: 2.424 ± 0.059	0.559ArgTrp: 0.559 ± 0.028	2.148ArgTyr: 2.148 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	4.065SerAla: 4.065 ± 0.087	0.716SerCys: 0.716 ± 0.033	3.091SerAsp: 3.091 ± 0.069	3.391SerGlu: 3.391 ± 0.066	3.266SerPhe: 3.266 ± 0.077	3.99SerGly: 3.99 ± 0.08	1.137SerHis: 1.137 ± 0.039	4.31SerIle: 4.31 ± 0.074	3.774SerLys: 3.774 ± 0.072	5.571SerLeu: 5.571 ± 0.093	1.529SerMet: 1.529 ± 0.048	3.022SerAsn: 3.022 ± 0.066	2.032SerPro: 2.032 ± 0.055	1.832SerGln: 1.832 ± 0.047	2.328SerArg: 2.328 ± 0.06	3.522SerSer: 3.522 ± 0.074	3.224SerThr: 3.224 ± 0.066	4.135SerVal: 4.135 ± 0.083	0.699SerTrp: 0.699 ± 0.034	2.586SerTyr: 2.586 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	4.447ThrAla: 4.447 ± 0.09	0.617ThrCys: 0.617 ± 0.029	3.536ThrAsp: 3.536 ± 0.07	3.597ThrGlu: 3.597 ± 0.077	2.868ThrPhe: 2.868 ± 0.071	3.787ThrGly: 3.787 ± 0.076	1.072ThrHis: 1.072 ± 0.038	4.529ThrIle: 4.529 ± 0.085	3.662ThrLys: 3.662 ± 0.073	5.607ThrLeu: 5.607 ± 0.091	1.447ThrMet: 1.447 ± 0.045	2.856ThrAsn: 2.856 ± 0.07	2.624ThrPro: 2.624 ± 0.064	1.81ThrGln: 1.81 ± 0.05	2.105ThrArg: 2.105 ± 0.055	3.32ThrSer: 3.32 ± 0.062	3.875ThrThr: 3.875 ± 0.084	3.887ThrVal: 3.887 ± 0.085	0.577ThrTrp: 0.577 ± 0.03	2.461ThrTyr: 2.461 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.86ValAla: 4.86 ± 0.094	1.047ValCys: 1.047 ± 0.041	3.54ValAsp: 3.54 ± 0.074	3.857ValGlu: 3.857 ± 0.085	2.884ValPhe: 2.884 ± 0.061	4.177ValGly: 4.177 ± 0.079	1.07ValHis: 1.07 ± 0.037	3.957ValIle: 3.957 ± 0.086	4.485ValLys: 4.485 ± 0.087	5.84ValLeu: 5.84 ± 0.101	1.686ValMet: 1.686 ± 0.053	3.136ValAsn: 3.136 ± 0.064	2.395ValPro: 2.395 ± 0.055	1.972ValGln: 1.972 ± 0.045	3.096ValArg: 3.096 ± 0.058	4.338ValSer: 4.338 ± 0.079	3.484ValThr: 3.484 ± 0.075	4.636ValVal: 4.636 ± 0.092	0.679ValTrp: 0.679 ± 0.029	2.652ValTyr: 2.652 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.703TrpAla: 0.703 ± 0.03	0.14TrpCys: 0.14 ± 0.014	0.621TrpAsp: 0.621 ± 0.029	0.61TrpGlu: 0.61 ± 0.034	0.564TrpPhe: 0.564 ± 0.025	0.763TrpGly: 0.763 ± 0.032	0.249TrpHis: 0.249 ± 0.016	0.821TrpIle: 0.821 ± 0.037	0.902TrpLys: 0.902 ± 0.033	1.149TrpLeu: 1.149 ± 0.044	0.211TrpMet: 0.211 ± 0.016	0.7TrpAsn: 0.7 ± 0.03	0.158TrpPro: 0.158 ± 0.017	0.539TrpGln: 0.539 ± 0.028	0.494TrpArg: 0.494 ± 0.025	0.514TrpSer: 0.514 ± 0.03	0.627TrpThr: 0.627 ± 0.027	0.614TrpVal: 0.614 ± 0.029	0.181TrpTrp: 0.181 ± 0.017	0.442TrpTyr: 0.442 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.859TyrAla: 2.859 ± 0.067	0.606TyrCys: 0.606 ± 0.03	2.549TyrAsp: 2.549 ± 0.068	2.394TyrGlu: 2.394 ± 0.056	2.155TyrPhe: 2.155 ± 0.051	2.991TyrGly: 2.991 ± 0.063	0.874TyrHis: 0.874 ± 0.035	3.091TyrIle: 3.091 ± 0.073	3.049TyrLys: 3.049 ± 0.069	3.631TyrLeu: 3.631 ± 0.07	1.044TyrMet: 1.044 ± 0.038	2.731TyrAsn: 2.731 ± 0.064	1.456TyrPro: 1.456 ± 0.043	1.384TyrGln: 1.384 ± 0.052	2.1TyrArg: 2.1 ± 0.052	2.49TyrSer: 2.49 ± 0.063	2.55TyrThr: 2.55 ± 0.061	2.373TyrVal: 2.373 ± 0.057	0.501TyrTrp: 0.501 ± 0.026	2.097TyrTyr: 2.097 ± 0.07	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2420 proteins (758684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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