Amino acid dipepetide frequency for Human adenovirus D37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.486AlaAla: 7.486 ± 1.567
1.069AlaCys: 1.069 ± 0.313
2.674AlaAsp: 2.674 ± 0.447
3.743AlaGlu: 3.743 ± 0.537
3.03AlaPhe: 3.03 ± 0.4
4.812AlaGly: 4.812 ± 0.625
1.961AlaHis: 1.961 ± 0.42
2.674AlaIle: 2.674 ± 0.552
2.05AlaLys: 2.05 ± 0.512
7.397AlaLeu: 7.397 ± 1.309
1.515AlaMet: 1.515 ± 0.34
2.852AlaAsn: 2.852 ± 0.623
4.723AlaPro: 4.723 ± 0.955
2.584AlaGln: 2.584 ± 0.353
5.347AlaArg: 5.347 ± 0.851
4.991AlaSer: 4.991 ± 0.698
4.189AlaThr: 4.189 ± 0.694
4.991AlaVal: 4.991 ± 0.613
0.624AlaTrp: 0.624 ± 0.231
2.584AlaTyr: 2.584 ± 0.443
0.0AlaXaa: 0.0 ± 0.0
Cys
0.891CysAla: 0.891 ± 0.321
1.159CysCys: 1.159 ± 0.32
0.891CysAsp: 0.891 ± 0.273
1.069CysGlu: 1.069 ± 0.297
0.624CysPhe: 0.624 ± 0.265
1.693CysGly: 1.693 ± 0.382
0.713CysHis: 0.713 ± 0.295
0.535CysIle: 0.535 ± 0.253
0.802CysLys: 0.802 ± 0.268
1.337CysLeu: 1.337 ± 0.397
0.624CysMet: 0.624 ± 0.239
1.248CysAsn: 1.248 ± 0.389
1.248CysPro: 1.248 ± 0.295
0.356CysGln: 0.356 ± 0.169
1.248CysArg: 1.248 ± 0.385
1.337CysSer: 1.337 ± 0.397
1.069CysThr: 1.069 ± 0.309
1.069CysVal: 1.069 ± 0.345
0.624CysTrp: 0.624 ± 0.277
1.337CysTyr: 1.337 ± 0.298
0.0CysXaa: 0.0 ± 0.0
Asp
3.565AspAla: 3.565 ± 0.589
1.069AspCys: 1.069 ± 0.338
2.406AspAsp: 2.406 ± 0.507
5.347AspGlu: 5.347 ± 0.744
1.693AspPhe: 1.693 ± 0.421
3.03AspGly: 3.03 ± 0.562
0.98AspHis: 0.98 ± 0.334
2.139AspIle: 2.139 ± 0.427
2.228AspLys: 2.228 ± 0.38
5.347AspLeu: 5.347 ± 0.758
1.782AspMet: 1.782 ± 0.339
1.693AspAsn: 1.693 ± 0.459
3.208AspPro: 3.208 ± 0.381
1.069AspGln: 1.069 ± 0.308
3.565AspArg: 3.565 ± 0.788
3.921AspSer: 3.921 ± 0.74
2.406AspThr: 2.406 ± 0.426
3.387AspVal: 3.387 ± 0.545
0.624AspTrp: 0.624 ± 0.231
2.139AspTyr: 2.139 ± 0.392
0.0AspXaa: 0.0 ± 0.0
Glu
3.832GluAla: 3.832 ± 0.611
1.159GluCys: 1.159 ± 0.415
4.189GluAsp: 4.189 ± 0.784
8.555GluGlu: 8.555 ± 1.869
1.426GluPhe: 1.426 ± 0.361
4.099GluGly: 4.099 ± 0.697
1.693GluHis: 1.693 ± 0.422
2.674GluIle: 2.674 ± 0.491
2.406GluLys: 2.406 ± 0.429
6.595GluLeu: 6.595 ± 1.041
1.871GluMet: 1.871 ± 0.472
2.763GluAsn: 2.763 ± 0.498
2.584GluPro: 2.584 ± 0.371
3.208GluGln: 3.208 ± 0.727
4.812GluArg: 4.812 ± 0.937
2.674GluSer: 2.674 ± 0.475
3.743GluThr: 3.743 ± 0.743
2.941GluVal: 2.941 ± 0.438
0.713GluTrp: 0.713 ± 0.341
1.693GluTyr: 1.693 ± 0.398
0.0GluXaa: 0.0 ± 0.0
Phe
2.763PheAla: 2.763 ± 0.6
0.802PheCys: 0.802 ± 0.303
2.05PheAsp: 2.05 ± 0.477
2.228PheGlu: 2.228 ± 0.399
1.782PhePhe: 1.782 ± 0.391
1.069PheGly: 1.069 ± 0.257
1.069PheHis: 1.069 ± 0.308
1.515PheIle: 1.515 ± 0.406
1.426PheLys: 1.426 ± 0.376
3.565PheLeu: 3.565 ± 0.568
1.515PheMet: 1.515 ± 0.271
2.406PheAsn: 2.406 ± 0.515
2.317PhePro: 2.317 ± 0.328
1.604PheGln: 1.604 ± 0.37
2.317PheArg: 2.317 ± 0.525
3.565PheSer: 3.565 ± 0.519
2.495PheThr: 2.495 ± 0.486
2.674PheVal: 2.674 ± 0.401
0.178PheTrp: 0.178 ± 0.127
1.159PheTyr: 1.159 ± 0.362
0.0PheXaa: 0.0 ± 0.0
Gly
4.278GlyAla: 4.278 ± 0.641
1.693GlyCys: 1.693 ± 0.474
3.03GlyAsp: 3.03 ± 0.58
3.387GlyGlu: 3.387 ± 0.515
2.763GlyPhe: 2.763 ± 0.437
5.169GlyGly: 5.169 ± 0.534
1.337GlyHis: 1.337 ± 0.366
2.139GlyIle: 2.139 ± 0.433
2.406GlyLys: 2.406 ± 0.577
5.793GlyLeu: 5.793 ± 0.716
1.248GlyMet: 1.248 ± 0.408
2.406GlyAsn: 2.406 ± 0.666
3.208GlyPro: 3.208 ± 0.574
2.495GlyGln: 2.495 ± 0.526
4.991GlyArg: 4.991 ± 0.706
3.743GlySer: 3.743 ± 0.647
3.743GlyThr: 3.743 ± 0.658
5.08GlyVal: 5.08 ± 0.93
0.802GlyTrp: 0.802 ± 0.219
2.228GlyTyr: 2.228 ± 0.332
0.0GlyXaa: 0.0 ± 0.0
His
1.961HisAla: 1.961 ± 0.462
1.069HisCys: 1.069 ± 0.309
1.159HisAsp: 1.159 ± 0.356
1.515HisGlu: 1.515 ± 0.429
0.802HisPhe: 0.802 ± 0.282
1.693HisGly: 1.693 ± 0.371
0.98HisHis: 0.98 ± 0.27
1.248HisIle: 1.248 ± 0.317
0.98HisLys: 0.98 ± 0.33
2.228HisLeu: 2.228 ± 0.481
0.356HisMet: 0.356 ± 0.22
1.069HisAsn: 1.069 ± 0.303
2.317HisPro: 2.317 ± 0.495
1.069HisGln: 1.069 ± 0.369
2.139HisArg: 2.139 ± 0.487
1.693HisSer: 1.693 ± 0.336
1.159HisThr: 1.159 ± 0.357
1.693HisVal: 1.693 ± 0.338
0.535HisTrp: 0.535 ± 0.207
0.535HisTyr: 0.535 ± 0.186
0.0HisXaa: 0.0 ± 0.0
Ile
3.03IleAla: 3.03 ± 0.505
0.891IleCys: 0.891 ± 0.32
1.248IleAsp: 1.248 ± 0.357
1.782IleGlu: 1.782 ± 0.402
1.782IlePhe: 1.782 ± 0.421
1.961IleGly: 1.961 ± 0.535
0.98IleHis: 0.98 ± 0.326
1.693IleIle: 1.693 ± 0.496
2.495IleLys: 2.495 ± 0.573
4.278IleLeu: 4.278 ± 0.677
1.426IleMet: 1.426 ± 0.309
2.139IleAsn: 2.139 ± 0.438
2.495IlePro: 2.495 ± 0.524
1.426IleGln: 1.426 ± 0.328
1.782IleArg: 1.782 ± 0.4
2.228IleSer: 2.228 ± 0.382
2.674IleThr: 2.674 ± 0.762
2.763IleVal: 2.763 ± 0.514
0.446IleTrp: 0.446 ± 0.174
1.337IleTyr: 1.337 ± 0.325
0.0IleXaa: 0.0 ± 0.0
Lys
3.119LysAla: 3.119 ± 0.783
0.802LysCys: 0.802 ± 0.245
2.495LysAsp: 2.495 ± 0.626
2.05LysGlu: 2.05 ± 0.469
2.05LysPhe: 2.05 ± 0.413
2.139LysGly: 2.139 ± 0.449
0.713LysHis: 0.713 ± 0.23
2.584LysIle: 2.584 ± 0.579
2.674LysLys: 2.674 ± 0.435
3.565LysLeu: 3.565 ± 0.674
0.98LysMet: 0.98 ± 0.369
2.139LysAsn: 2.139 ± 0.376
2.139LysPro: 2.139 ± 0.506
1.693LysGln: 1.693 ± 0.448
3.208LysArg: 3.208 ± 0.784
1.871LysSer: 1.871 ± 0.354
2.139LysThr: 2.139 ± 0.582
2.317LysVal: 2.317 ± 0.583
0.356LysTrp: 0.356 ± 0.144
1.069LysTyr: 1.069 ± 0.374
0.0LysXaa: 0.0 ± 0.0
Leu
6.862LeuAla: 6.862 ± 0.976
1.159LeuCys: 1.159 ± 0.35
4.991LeuAsp: 4.991 ± 0.595
5.169LeuGlu: 5.169 ± 0.771
2.852LeuPhe: 2.852 ± 0.581
5.258LeuGly: 5.258 ± 0.72
3.565LeuHis: 3.565 ± 0.655
3.297LeuIle: 3.297 ± 0.644
4.902LeuLys: 4.902 ± 0.923
9.714LeuLeu: 9.714 ± 1.024
3.208LeuMet: 3.208 ± 0.567
4.01LeuAsn: 4.01 ± 0.631
5.525LeuPro: 5.525 ± 0.895
5.347LeuGln: 5.347 ± 0.578
7.04LeuArg: 7.04 ± 0.642
5.704LeuSer: 5.704 ± 0.656
5.614LeuThr: 5.614 ± 0.593
6.951LeuVal: 6.951 ± 0.875
1.782LeuTrp: 1.782 ± 0.426
2.674LeuTyr: 2.674 ± 0.662
0.0LeuXaa: 0.0 ± 0.0
Met
2.495MetAla: 2.495 ± 0.501
0.624MetCys: 0.624 ± 0.229
1.871MetAsp: 1.871 ± 0.332
1.604MetGlu: 1.604 ± 0.37
0.535MetPhe: 0.535 ± 0.219
2.05MetGly: 2.05 ± 0.407
0.624MetHis: 0.624 ± 0.219
0.98MetIle: 0.98 ± 0.251
1.069MetLys: 1.069 ± 0.308
2.406MetLeu: 2.406 ± 0.459
0.446MetMet: 0.446 ± 0.2
1.426MetAsn: 1.426 ± 0.39
2.228MetPro: 2.228 ± 0.381
1.426MetGln: 1.426 ± 0.348
1.871MetArg: 1.871 ± 0.393
1.604MetSer: 1.604 ± 0.329
1.248MetThr: 1.248 ± 0.324
1.426MetVal: 1.426 ± 0.328
0.356MetTrp: 0.356 ± 0.199
1.069MetTyr: 1.069 ± 0.232
0.0MetXaa: 0.0 ± 0.0
Asn
1.961AsnAla: 1.961 ± 0.513
0.356AsnCys: 0.356 ± 0.137
3.03AsnAsp: 3.03 ± 0.641
1.782AsnGlu: 1.782 ± 0.326
2.674AsnPhe: 2.674 ± 0.54
2.763AsnGly: 2.763 ± 0.489
1.604AsnHis: 1.604 ± 0.489
2.495AsnIle: 2.495 ± 0.546
1.604AsnLys: 1.604 ± 0.38
4.367AsnLeu: 4.367 ± 0.623
2.228AsnMet: 2.228 ± 0.682
1.248AsnAsn: 1.248 ± 0.28
3.119AsnPro: 3.119 ± 0.573
1.693AsnGln: 1.693 ± 0.406
2.317AsnArg: 2.317 ± 0.432
2.763AsnSer: 2.763 ± 0.608
1.961AsnThr: 1.961 ± 0.503
2.852AsnVal: 2.852 ± 0.654
1.159AsnTrp: 1.159 ± 0.315
2.317AsnTyr: 2.317 ± 0.461
0.0AsnXaa: 0.0 ± 0.0
Pro
5.08ProAla: 5.08 ± 0.819
1.248ProCys: 1.248 ± 0.472
3.565ProAsp: 3.565 ± 0.578
4.723ProGlu: 4.723 ± 0.739
3.119ProPhe: 3.119 ± 0.555
3.832ProGly: 3.832 ± 0.487
1.069ProHis: 1.069 ± 0.277
1.871ProIle: 1.871 ± 0.432
2.139ProLys: 2.139 ± 0.618
4.545ProLeu: 4.545 ± 0.67
0.98ProMet: 0.98 ± 0.382
2.674ProAsn: 2.674 ± 0.459
7.397ProPro: 7.397 ± 1.574
2.852ProGln: 2.852 ± 0.637
5.08ProArg: 5.08 ± 0.769
5.704ProSer: 5.704 ± 0.823
4.189ProThr: 4.189 ± 0.891
4.099ProVal: 4.099 ± 0.562
0.624ProTrp: 0.624 ± 0.254
1.693ProTyr: 1.693 ± 0.439
0.0ProXaa: 0.0 ± 0.0
Gln
3.654GlnAla: 3.654 ± 0.581
0.98GlnCys: 0.98 ± 0.262
2.406GlnAsp: 2.406 ± 0.369
3.119GlnGlu: 3.119 ± 0.628
1.159GlnPhe: 1.159 ± 0.294
2.228GlnGly: 2.228 ± 0.533
1.248GlnHis: 1.248 ± 0.321
1.604GlnIle: 1.604 ± 0.295
1.871GlnLys: 1.871 ± 0.573
3.297GlnLeu: 3.297 ± 0.596
0.891GlnMet: 0.891 ± 0.245
2.05GlnAsn: 2.05 ± 0.49
4.278GlnPro: 4.278 ± 0.57
2.674GlnGln: 2.674 ± 0.686
2.852GlnArg: 2.852 ± 0.457
2.852GlnSer: 2.852 ± 0.615
2.852GlnThr: 2.852 ± 0.346
2.139GlnVal: 2.139 ± 0.437
0.356GlnTrp: 0.356 ± 0.194
0.802GlnTyr: 0.802 ± 0.261
0.0GlnXaa: 0.0 ± 0.0
Arg
6.951ArgAla: 6.951 ± 1.175
1.515ArgCys: 1.515 ± 0.324
3.832ArgAsp: 3.832 ± 0.843
4.01ArgGlu: 4.01 ± 0.67
2.139ArgPhe: 2.139 ± 0.482
5.169ArgGly: 5.169 ± 0.563
2.228ArgHis: 2.228 ± 0.525
2.406ArgIle: 2.406 ± 0.299
2.228ArgLys: 2.228 ± 0.46
5.704ArgLeu: 5.704 ± 0.887
1.248ArgMet: 1.248 ± 0.265
3.476ArgAsn: 3.476 ± 0.579
4.991ArgPro: 4.991 ± 0.801
3.208ArgGln: 3.208 ± 0.664
9.179ArgArg: 9.179 ± 2.564
4.01ArgSer: 4.01 ± 0.796
3.119ArgThr: 3.119 ± 0.682
4.812ArgVal: 4.812 ± 0.963
1.337ArgTrp: 1.337 ± 0.26
2.05ArgTyr: 2.05 ± 0.413
0.0ArgXaa: 0.0 ± 0.0
Ser
3.476SerAla: 3.476 ± 0.664
0.891SerCys: 0.891 ± 0.284
2.763SerAsp: 2.763 ± 0.389
3.387SerGlu: 3.387 ± 0.618
2.584SerPhe: 2.584 ± 0.579
5.258SerGly: 5.258 ± 0.757
1.693SerHis: 1.693 ± 0.478
2.317SerIle: 2.317 ± 0.553
2.139SerLys: 2.139 ± 0.533
6.951SerLeu: 6.951 ± 0.75
1.782SerMet: 1.782 ± 0.462
2.228SerAsn: 2.228 ± 0.421
3.476SerPro: 3.476 ± 0.636
2.941SerGln: 2.941 ± 0.658
4.367SerArg: 4.367 ± 0.585
6.862SerSer: 6.862 ± 1.066
4.456SerThr: 4.456 ± 0.777
4.367SerVal: 4.367 ± 0.579
0.624SerTrp: 0.624 ± 0.227
2.495SerTyr: 2.495 ± 0.547
0.0SerXaa: 0.0 ± 0.0
Thr
3.387ThrAla: 3.387 ± 0.666
1.515ThrCys: 1.515 ± 0.489
2.228ThrAsp: 2.228 ± 0.499
3.119ThrGlu: 3.119 ± 0.553
2.495ThrPhe: 2.495 ± 0.598
3.208ThrGly: 3.208 ± 0.565
1.248ThrHis: 1.248 ± 0.298
2.406ThrIle: 2.406 ± 0.595
1.871ThrLys: 1.871 ± 0.504
7.219ThrLeu: 7.219 ± 0.867
1.248ThrMet: 1.248 ± 0.339
2.674ThrAsn: 2.674 ± 0.658
4.812ThrPro: 4.812 ± 0.719
2.406ThrGln: 2.406 ± 0.472
3.476ThrArg: 3.476 ± 0.661
2.406ThrSer: 2.406 ± 0.505
4.812ThrThr: 4.812 ± 1.614
4.812ThrVal: 4.812 ± 0.709
1.248ThrTrp: 1.248 ± 0.477
2.852ThrTyr: 2.852 ± 0.511
0.0ThrXaa: 0.0 ± 0.0
Val
3.832ValAla: 3.832 ± 0.544
1.069ValCys: 1.069 ± 0.378
3.921ValAsp: 3.921 ± 0.774
3.832ValGlu: 3.832 ± 0.709
2.406ValPhe: 2.406 ± 0.444
3.476ValGly: 3.476 ± 0.672
1.159ValHis: 1.159 ± 0.418
2.584ValIle: 2.584 ± 0.428
2.495ValLys: 2.495 ± 0.658
6.238ValLeu: 6.238 ± 0.778
1.782ValMet: 1.782 ± 0.342
3.119ValAsn: 3.119 ± 0.56
4.189ValPro: 4.189 ± 0.591
2.941ValGln: 2.941 ± 0.582
5.258ValArg: 5.258 ± 0.834
4.099ValSer: 4.099 ± 0.613
4.456ValThr: 4.456 ± 0.663
4.991ValVal: 4.991 ± 0.81
0.891ValTrp: 0.891 ± 0.286
2.495ValTyr: 2.495 ± 0.511
0.0ValXaa: 0.0 ± 0.0
Trp
0.624TrpAla: 0.624 ± 0.226
0.178TrpCys: 0.178 ± 0.133
0.891TrpAsp: 0.891 ± 0.309
0.891TrpGlu: 0.891 ± 0.312
0.891TrpPhe: 0.891 ± 0.353
0.891TrpGly: 0.891 ± 0.268
0.178TrpHis: 0.178 ± 0.119
0.356TrpIle: 0.356 ± 0.154
0.624TrpLys: 0.624 ± 0.236
1.248TrpLeu: 1.248 ± 0.368
0.713TrpMet: 0.713 ± 0.327
0.98TrpAsn: 0.98 ± 0.394
0.535TrpPro: 0.535 ± 0.21
0.98TrpGln: 0.98 ± 0.28
0.446TrpArg: 0.446 ± 0.227
1.337TrpSer: 1.337 ± 0.283
1.069TrpThr: 1.069 ± 0.359
0.535TrpVal: 0.535 ± 0.273
0.178TrpTrp: 0.178 ± 0.124
0.356TrpTyr: 0.356 ± 0.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.05TyrAla: 2.05 ± 0.405
0.624TyrCys: 0.624 ± 0.279
2.05TyrAsp: 2.05 ± 0.364
2.317TyrGlu: 2.317 ± 0.441
1.693TyrPhe: 1.693 ± 0.465
2.139TyrGly: 2.139 ± 0.465
1.159TyrHis: 1.159 ± 0.32
1.337TyrIle: 1.337 ± 0.264
1.693TyrLys: 1.693 ± 0.535
3.832TyrLeu: 3.832 ± 0.663
1.426TyrMet: 1.426 ± 0.401
1.693TyrAsn: 1.693 ± 0.471
1.693TyrPro: 1.693 ± 0.417
1.337TyrGln: 1.337 ± 0.385
2.317TyrArg: 2.317 ± 0.435
1.693TyrSer: 1.693 ± 0.506
2.05TyrThr: 2.05 ± 0.316
1.337TyrVal: 1.337 ± 0.274
0.446TyrTrp: 0.446 ± 0.18
0.802TyrTyr: 0.802 ± 0.226
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 36 proteins (11222 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski