Amino acid dipepetide frequency for Pelagicola litoralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.434AlaAla: 13.434 ± 0.151	1.057AlaCys: 1.057 ± 0.029	6.537AlaAsp: 6.537 ± 0.083	6.801AlaGlu: 6.801 ± 0.09	4.133AlaPhe: 4.133 ± 0.067	9.161AlaGly: 9.161 ± 0.109	2.493AlaHis: 2.493 ± 0.052	5.918AlaIle: 5.918 ± 0.082	4.497AlaLys: 4.497 ± 0.079	12.228AlaLeu: 12.228 ± 0.144	3.602AlaMet: 3.602 ± 0.064	3.005AlaAsn: 3.005 ± 0.051	5.258AlaPro: 5.258 ± 0.083	4.864AlaGln: 4.864 ± 0.069	7.125AlaArg: 7.125 ± 0.097	5.825AlaSer: 5.825 ± 0.067	5.907AlaThr: 5.907 ± 0.073	7.642AlaVal: 7.642 ± 0.093	1.344AlaTrp: 1.344 ± 0.041	2.636AlaTyr: 2.636 ± 0.054	0.001AlaXaa: 0.001 ± 0.001
Cys	1.089CysAla: 1.089 ± 0.035	0.13CysCys: 0.13 ± 0.011	0.637CysAsp: 0.637 ± 0.024	0.508CysGlu: 0.508 ± 0.023	0.353CysPhe: 0.353 ± 0.02	0.922CysGly: 0.922 ± 0.035	0.301CysHis: 0.301 ± 0.017	0.441CysIle: 0.441 ± 0.019	0.272CysLys: 0.272 ± 0.016	0.886CysLeu: 0.886 ± 0.032	0.217CysMet: 0.217 ± 0.015	0.261CysAsn: 0.261 ± 0.018	0.494CysPro: 0.494 ± 0.024	0.291CysGln: 0.291 ± 0.016	0.496CysArg: 0.496 ± 0.022	0.507CysSer: 0.507 ± 0.022	0.467CysThr: 0.467 ± 0.022	0.675CysVal: 0.675 ± 0.028	0.119CysTrp: 0.119 ± 0.011	0.243CysTyr: 0.243 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.365AspAla: 7.365 ± 0.09	0.546AspCys: 0.546 ± 0.024	3.667AspAsp: 3.667 ± 0.093	3.341AspGlu: 3.341 ± 0.065	2.395AspPhe: 2.395 ± 0.049	5.491AspGly: 5.491 ± 0.095	1.484AspHis: 1.484 ± 0.037	3.751AspIle: 3.751 ± 0.054	1.954AspLys: 1.954 ± 0.051	6.513AspLeu: 6.513 ± 0.087	1.954AspMet: 1.954 ± 0.043	1.427AspAsn: 1.427 ± 0.045	3.36AspPro: 3.36 ± 0.053	2.304AspGln: 2.304 ± 0.045	3.789AspArg: 3.789 ± 0.067	2.302AspSer: 2.302 ± 0.054	3.625AspThr: 3.625 ± 0.074	5.019AspVal: 5.019 ± 0.078	1.099AspTrp: 1.099 ± 0.029	1.477AspTyr: 1.477 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.593GluAla: 6.593 ± 0.102	0.393GluCys: 0.393 ± 0.019	3.36GluAsp: 3.36 ± 0.071	3.081GluGlu: 3.081 ± 0.069	2.009GluPhe: 2.009 ± 0.041	4.204GluGly: 4.204 ± 0.081	1.274GluHis: 1.274 ± 0.035	3.805GluIle: 3.805 ± 0.06	2.372GluLys: 2.372 ± 0.061	5.015GluLeu: 5.015 ± 0.073	1.893GluMet: 1.893 ± 0.045	2.149GluAsn: 2.149 ± 0.044	2.202GluPro: 2.202 ± 0.045	2.112GluGln: 2.112 ± 0.046	3.785GluArg: 3.785 ± 0.072	2.293GluSer: 2.293 ± 0.054	3.9GluThr: 3.9 ± 0.059	3.829GluVal: 3.829 ± 0.059	0.727GluTrp: 0.727 ± 0.029	1.267GluTyr: 1.267 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.254PheAla: 4.254 ± 0.065	0.461PheCys: 0.461 ± 0.022	3.033PheAsp: 3.033 ± 0.054	2.368PheGlu: 2.368 ± 0.049	1.506PhePhe: 1.506 ± 0.05	3.899PheGly: 3.899 ± 0.066	0.816PheHis: 0.816 ± 0.031	1.677PheIle: 1.677 ± 0.046	1.116PheLys: 1.116 ± 0.033	3.563PheLeu: 3.563 ± 0.062	0.966PheMet: 0.966 ± 0.034	1.113PheAsn: 1.113 ± 0.034	1.566PhePro: 1.566 ± 0.041	1.233PheGln: 1.233 ± 0.033	2.052PheArg: 2.052 ± 0.043	2.409PheSer: 2.409 ± 0.052	2.049PheThr: 2.049 ± 0.049	2.926PheVal: 2.926 ± 0.06	0.566PheTrp: 0.566 ± 0.027	0.949PheTyr: 0.949 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.008GlyAla: 9.008 ± 0.115	0.831GlyCys: 0.831 ± 0.027	4.907GlyAsp: 4.907 ± 0.107	4.186GlyGlu: 4.186 ± 0.075	3.763GlyPhe: 3.763 ± 0.057	6.809GlyGly: 6.809 ± 0.121	2.013GlyHis: 2.013 ± 0.041	4.382GlyIle: 4.382 ± 0.072	3.393GlyLys: 3.393 ± 0.065	8.587GlyLeu: 8.587 ± 0.105	2.706GlyMet: 2.706 ± 0.055	2.208GlyAsn: 2.208 ± 0.052	3.329GlyPro: 3.329 ± 0.057	3.256GlyGln: 3.256 ± 0.055	4.868GlyArg: 4.868 ± 0.073	4.13GlySer: 4.13 ± 0.077	4.663GlyThr: 4.663 ± 0.073	6.435GlyVal: 6.435 ± 0.078	1.381GlyTrp: 1.381 ± 0.038	2.383GlyTyr: 2.383 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.441HisAla: 2.441 ± 0.049	0.251HisCys: 0.251 ± 0.015	1.369HisAsp: 1.369 ± 0.036	1.038HisGlu: 1.038 ± 0.031	0.902HisPhe: 0.902 ± 0.03	1.955HisGly: 1.955 ± 0.042	0.592HisHis: 0.592 ± 0.026	1.185HisIle: 1.185 ± 0.033	0.743HisLys: 0.743 ± 0.027	2.183HisLeu: 2.183 ± 0.051	0.635HisMet: 0.635 ± 0.027	0.559HisAsn: 0.559 ± 0.025	1.413HisPro: 1.413 ± 0.04	0.72HisGln: 0.72 ± 0.026	1.256HisArg: 1.256 ± 0.035	1.11HisSer: 1.11 ± 0.037	1.072HisThr: 1.072 ± 0.033	1.685HisVal: 1.685 ± 0.036	0.366HisTrp: 0.366 ± 0.019	0.607HisTyr: 0.607 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.587IleAla: 6.587 ± 0.077	0.65IleCys: 0.65 ± 0.026	3.615IleAsp: 3.615 ± 0.054	3.56IleGlu: 3.56 ± 0.06	1.9IlePhe: 1.9 ± 0.049	4.833IleGly: 4.833 ± 0.082	1.008IleHis: 1.008 ± 0.029	2.402IleIle: 2.402 ± 0.056	1.879IleLys: 1.879 ± 0.044	5.205IleLeu: 5.205 ± 0.092	1.189IleMet: 1.189 ± 0.033	1.516IleAsn: 1.516 ± 0.046	2.476IlePro: 2.476 ± 0.043	1.593IleGln: 1.593 ± 0.039	3.067IleArg: 3.067 ± 0.065	3.585IleSer: 3.585 ± 0.065	2.949IleThr: 2.949 ± 0.058	4.029IleVal: 4.029 ± 0.069	0.8IleTrp: 0.8 ± 0.027	1.191IleTyr: 1.191 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.264LysAla: 4.264 ± 0.076	0.239LysCys: 0.239 ± 0.016	2.247LysAsp: 2.247 ± 0.051	1.808LysGlu: 1.808 ± 0.049	1.243LysPhe: 1.243 ± 0.038	3.044LysGly: 3.044 ± 0.062	0.768LysHis: 0.768 ± 0.027	2.17LysIle: 2.17 ± 0.054	1.502LysLys: 1.502 ± 0.052	3.397LysLeu: 3.397 ± 0.06	1.15LysMet: 1.15 ± 0.035	1.119LysAsn: 1.119 ± 0.04	1.922LysPro: 1.922 ± 0.05	1.178LysGln: 1.178 ± 0.033	2.48LysArg: 2.48 ± 0.054	2.308LysSer: 2.308 ± 0.052	2.358LysThr: 2.358 ± 0.046	2.605LysVal: 2.605 ± 0.056	0.492LysTrp: 0.492 ± 0.024	0.846LysTyr: 0.846 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.666LeuAla: 11.666 ± 0.121	0.977LeuCys: 0.977 ± 0.026	5.969LeuAsp: 5.969 ± 0.082	5.66LeuGlu: 5.66 ± 0.081	3.527LeuPhe: 3.527 ± 0.07	8.308LeuGly: 8.308 ± 0.102	1.85LeuHis: 1.85 ± 0.043	5.118LeuIle: 5.118 ± 0.085	3.729LeuLys: 3.729 ± 0.061	8.198LeuLeu: 8.198 ± 0.12	2.8LeuMet: 2.8 ± 0.054	2.91LeuAsn: 2.91 ± 0.054	4.876LeuPro: 4.876 ± 0.07	2.986LeuGln: 2.986 ± 0.056	6.296LeuArg: 6.296 ± 0.097	6.825LeuSer: 6.825 ± 0.087	5.786LeuThr: 5.786 ± 0.078	6.941LeuVal: 6.941 ± 0.089	1.216LeuTrp: 1.216 ± 0.032	1.926LeuTyr: 1.926 ± 0.044	0.001LeuXaa: 0.001 ± 0.001
Met	3.46MetAla: 3.46 ± 0.065	0.226MetCys: 0.226 ± 0.015	1.615MetAsp: 1.615 ± 0.037	1.289MetGlu: 1.289 ± 0.035	0.959MetPhe: 0.959 ± 0.036	2.401MetGly: 2.401 ± 0.05	0.581MetHis: 0.581 ± 0.023	1.662MetIle: 1.662 ± 0.044	1.156MetLys: 1.156 ± 0.03	2.712MetLeu: 2.712 ± 0.051	0.908MetMet: 0.908 ± 0.036	0.902MetAsn: 0.902 ± 0.031	1.56MetPro: 1.56 ± 0.04	1.149MetGln: 1.149 ± 0.034	1.929MetArg: 1.929 ± 0.039	2.06MetSer: 2.06 ± 0.041	2.157MetThr: 2.157 ± 0.042	1.983MetVal: 1.983 ± 0.045	0.274MetTrp: 0.274 ± 0.018	0.425MetTyr: 0.425 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.344AsnAla: 3.344 ± 0.056	0.317AsnCys: 0.317 ± 0.017	1.726AsnAsp: 1.726 ± 0.043	1.311AsnGlu: 1.311 ± 0.037	1.039AsnPhe: 1.039 ± 0.03	2.685AsnGly: 2.685 ± 0.062	0.61AsnHis: 0.61 ± 0.026	1.612AsnIle: 1.612 ± 0.039	0.921AsnLys: 0.921 ± 0.031	2.778AsnLeu: 2.778 ± 0.059	0.792AsnMet: 0.792 ± 0.028	0.76AsnAsn: 0.76 ± 0.028	1.932AsnPro: 1.932 ± 0.043	0.88AsnGln: 0.88 ± 0.027	1.694AsnArg: 1.694 ± 0.044	1.453AsnSer: 1.453 ± 0.036	1.656AsnThr: 1.656 ± 0.044	2.103AsnVal: 2.103 ± 0.045	0.531AsnTrp: 0.531 ± 0.025	0.69AsnTyr: 0.69 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.774ProAla: 4.774 ± 0.07	0.351ProCys: 0.351 ± 0.018	3.884ProAsp: 3.884 ± 0.065	3.796ProGlu: 3.796 ± 0.065	1.979ProPhe: 1.979 ± 0.045	3.219ProGly: 3.219 ± 0.063	1.087ProHis: 1.087 ± 0.031	2.425ProIle: 2.425 ± 0.047	2.007ProLys: 2.007 ± 0.047	4.325ProLeu: 4.325 ± 0.07	1.414ProMet: 1.414 ± 0.039	1.605ProAsn: 1.605 ± 0.041	1.892ProPro: 1.892 ± 0.049	1.783ProGln: 1.783 ± 0.042	2.356ProArg: 2.356 ± 0.06	2.703ProSer: 2.703 ± 0.05	2.575ProThr: 2.575 ± 0.048	3.989ProVal: 3.989 ± 0.062	0.619ProTrp: 0.619 ± 0.024	1.205ProTyr: 1.205 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.402GlnAla: 4.402 ± 0.064	0.25GlnCys: 0.25 ± 0.015	2.338GlnAsp: 2.338 ± 0.053	1.911GlnGlu: 1.911 ± 0.042	1.217GlnPhe: 1.217 ± 0.032	2.948GlnGly: 2.948 ± 0.043	0.696GlnHis: 0.696 ± 0.026	2.276GlnIle: 2.276 ± 0.046	1.403GlnLys: 1.403 ± 0.036	2.929GlnLeu: 2.929 ± 0.054	1.157GlnMet: 1.157 ± 0.032	1.19GlnAsn: 1.19 ± 0.036	1.545GlnPro: 1.545 ± 0.041	1.169GlnGln: 1.169 ± 0.036	2.133GlnArg: 2.133 ± 0.054	2.275GlnSer: 2.275 ± 0.06	2.162GlnThr: 2.162 ± 0.046	2.508GlnVal: 2.508 ± 0.048	0.445GlnTrp: 0.445 ± 0.021	0.693GlnTyr: 0.693 ± 0.025	0.001GlnXaa: 0.001 ± 0.001
Arg	6.72ArgAla: 6.72 ± 0.093	0.469ArgCys: 0.469 ± 0.022	3.9ArgAsp: 3.9 ± 0.064	3.383ArgGlu: 3.383 ± 0.06	2.462ArgPhe: 2.462 ± 0.051	3.966ArgGly: 3.966 ± 0.065	1.494ArgHis: 1.494 ± 0.038	3.54ArgIle: 3.54 ± 0.065	2.592ArgLys: 2.592 ± 0.055	6.412ArgLeu: 6.412 ± 0.086	1.851ArgMet: 1.851 ± 0.038	1.865ArgAsn: 1.865 ± 0.047	2.799ArgPro: 2.799 ± 0.05	2.225ArgGln: 2.225 ± 0.046	4.134ArgArg: 4.134 ± 0.08	3.141ArgSer: 3.141 ± 0.061	2.878ArgThr: 2.878 ± 0.053	4.271ArgVal: 4.271 ± 0.067	0.855ArgTrp: 0.855 ± 0.026	1.472ArgTyr: 1.472 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.005SerAla: 6.005 ± 0.068	0.474SerCys: 0.474 ± 0.024	3.766SerAsp: 3.766 ± 0.074	3.254SerGlu: 3.254 ± 0.054	2.438SerPhe: 2.438 ± 0.045	5.696SerGly: 5.696 ± 0.084	1.279SerHis: 1.279 ± 0.04	2.759SerIle: 2.759 ± 0.057	2.052SerLys: 2.052 ± 0.047	5.239SerLeu: 5.239 ± 0.08	1.573SerMet: 1.573 ± 0.04	1.667SerAsn: 1.667 ± 0.041	2.628SerPro: 2.628 ± 0.057	2.01SerGln: 2.01 ± 0.045	3.124SerArg: 3.124 ± 0.06	2.924SerSer: 2.924 ± 0.057	2.836SerThr: 2.836 ± 0.054	4.079SerVal: 4.079 ± 0.061	0.752SerTrp: 0.752 ± 0.029	1.431SerTyr: 1.431 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.905ThrAla: 5.905 ± 0.09	0.574ThrCys: 0.574 ± 0.022	3.419ThrAsp: 3.419 ± 0.067	2.888ThrGlu: 2.888 ± 0.052	2.106ThrPhe: 2.106 ± 0.048	5.078ThrGly: 5.078 ± 0.078	1.361ThrHis: 1.361 ± 0.038	2.924ThrIle: 2.924 ± 0.061	1.959ThrLys: 1.959 ± 0.04	6.005ThrLeu: 6.005 ± 0.081	1.426ThrMet: 1.426 ± 0.034	1.466ThrAsn: 1.466 ± 0.038	3.544ThrPro: 3.544 ± 0.061	2.033ThrGln: 2.033 ± 0.042	3.338ThrArg: 3.338 ± 0.052	3.248ThrSer: 3.248 ± 0.06	3.005ThrThr: 3.005 ± 0.053	4.162ThrVal: 4.162 ± 0.068	0.708ThrTrp: 0.708 ± 0.027	1.421ThrTyr: 1.421 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.159ValAla: 8.159 ± 0.095	0.698ValCys: 0.698 ± 0.029	4.395ValAsp: 4.395 ± 0.066	4.099ValGlu: 4.099 ± 0.063	3.062ValPhe: 3.062 ± 0.066	5.475ValGly: 5.475 ± 0.08	1.469ValHis: 1.469 ± 0.036	4.248ValIle: 4.248 ± 0.076	2.375ValLys: 2.375 ± 0.052	7.531ValLeu: 7.531 ± 0.099	2.187ValMet: 2.187 ± 0.045	2.045ValAsn: 2.045 ± 0.047	3.437ValPro: 3.437 ± 0.062	2.38ValGln: 2.38 ± 0.045	4.026ValArg: 4.026 ± 0.072	4.746ValSer: 4.746 ± 0.074	4.628ValThr: 4.628 ± 0.078	5.868ValVal: 5.868 ± 0.09	0.983ValTrp: 0.983 ± 0.03	1.575ValTyr: 1.575 ± 0.037	0.001ValXaa: 0.001 ± 0.001
Trp	1.398TrpAla: 1.398 ± 0.04	0.141TrpCys: 0.141 ± 0.011	0.788TrpAsp: 0.788 ± 0.03	0.607TrpGlu: 0.607 ± 0.026	0.548TrpPhe: 0.548 ± 0.021	1.017TrpGly: 1.017 ± 0.035	0.352TrpHis: 0.352 ± 0.018	0.749TrpIle: 0.749 ± 0.029	0.515TrpLys: 0.515 ± 0.021	1.533TrpLeu: 1.533 ± 0.042	0.449TrpMet: 0.449 ± 0.023	0.434TrpAsn: 0.434 ± 0.022	0.69TrpPro: 0.69 ± 0.025	0.662TrpGln: 0.662 ± 0.028	1.013TrpArg: 1.013 ± 0.033	0.804TrpSer: 0.804 ± 0.027	0.736TrpThr: 0.736 ± 0.027	0.953TrpVal: 0.953 ± 0.029	0.212TrpTrp: 0.212 ± 0.013	0.287TrpTyr: 0.287 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.598TyrAla: 2.598 ± 0.056	0.273TyrCys: 0.273 ± 0.017	1.688TyrAsp: 1.688 ± 0.045	1.377TyrGlu: 1.377 ± 0.034	0.981TyrPhe: 0.981 ± 0.032	2.125TyrGly: 2.125 ± 0.047	0.554TyrHis: 0.554 ± 0.025	0.992TyrIle: 0.992 ± 0.031	0.708TyrLys: 0.708 ± 0.028	2.324TyrLeu: 2.324 ± 0.05	0.538TyrMet: 0.538 ± 0.02	0.632TyrAsn: 0.632 ± 0.027	1.065TyrPro: 1.065 ± 0.034	0.822TyrGln: 0.822 ± 0.031	1.468TyrArg: 1.468 ± 0.037	1.339TyrSer: 1.339 ± 0.037	1.161TyrThr: 1.161 ± 0.031	1.682TyrVal: 1.682 ± 0.038	0.397TyrTrp: 0.397 ± 0.022	0.659TyrTyr: 0.659 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3367 proteins (1051415 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---