Amino acid dipepetide frequency for Aeromonas phage D6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.014AlaAla: 5.014 ± 0.391
0.504AlaCys: 0.504 ± 0.082
3.918AlaAsp: 3.918 ± 0.231
4.321AlaGlu: 4.321 ± 0.343
2.696AlaPhe: 2.696 ± 0.206
4.473AlaGly: 4.473 ± 0.338
1.046AlaHis: 1.046 ± 0.129
4.523AlaIle: 4.523 ± 0.263
4.258AlaLys: 4.258 ± 0.305
5.367AlaLeu: 5.367 ± 0.278
2.772AlaMet: 2.772 ± 0.219
3.629AlaAsn: 3.629 ± 0.231
2.23AlaPro: 2.23 ± 0.237
1.902AlaGln: 1.902 ± 0.17
3.276AlaArg: 3.276 ± 0.215
3.868AlaSer: 3.868 ± 0.28
3.566AlaThr: 3.566 ± 0.425
4.561AlaVal: 4.561 ± 0.284
0.869AlaTrp: 0.869 ± 0.121
2.079AlaTyr: 2.079 ± 0.178
0.0AlaXaa: 0.0 ± 0.0
Cys
0.491CysAla: 0.491 ± 0.081
0.113CysCys: 0.113 ± 0.038
0.592CysAsp: 0.592 ± 0.093
0.517CysGlu: 0.517 ± 0.081
0.479CysPhe: 0.479 ± 0.081
0.68CysGly: 0.68 ± 0.109
0.189CysHis: 0.189 ± 0.051
0.517CysIle: 0.517 ± 0.079
0.68CysLys: 0.68 ± 0.089
0.706CysLeu: 0.706 ± 0.096
0.239CysMet: 0.239 ± 0.058
0.416CysAsn: 0.416 ± 0.072
0.416CysPro: 0.416 ± 0.083
0.265CysGln: 0.265 ± 0.078
0.718CysArg: 0.718 ± 0.097
0.693CysSer: 0.693 ± 0.086
0.466CysThr: 0.466 ± 0.073
0.731CysVal: 0.731 ± 0.104
0.113CysTrp: 0.113 ± 0.042
0.416CysTyr: 0.416 ± 0.082
0.0CysXaa: 0.0 ± 0.0
Asp
3.78AspAla: 3.78 ± 0.229
0.706AspCys: 0.706 ± 0.106
3.515AspAsp: 3.515 ± 0.226
4.107AspGlu: 4.107 ± 0.261
2.847AspPhe: 2.847 ± 0.194
4.636AspGly: 4.636 ± 0.253
1.235AspHis: 1.235 ± 0.145
4.422AspIle: 4.422 ± 0.186
3.893AspLys: 3.893 ± 0.249
6.249AspLeu: 6.249 ± 0.316
2.028AspMet: 2.028 ± 0.158
3.263AspAsn: 3.263 ± 0.204
3.175AspPro: 3.175 ± 0.253
2.243AspGln: 2.243 ± 0.167
2.961AspArg: 2.961 ± 0.175
3.137AspSer: 3.137 ± 0.225
3.377AspThr: 3.377 ± 0.225
4.863AspVal: 4.863 ± 0.267
0.895AspTrp: 0.895 ± 0.097
2.495AspTyr: 2.495 ± 0.168
0.0AspXaa: 0.0 ± 0.0
Glu
3.591GluAla: 3.591 ± 0.264
0.706GluCys: 0.706 ± 0.104
3.553GluAsp: 3.553 ± 0.231
5.355GluGlu: 5.355 ± 0.38
3.15GluPhe: 3.15 ± 0.225
4.347GluGly: 4.347 ± 0.253
1.386GluHis: 1.386 ± 0.125
4.662GluIle: 4.662 ± 0.245
3.679GluLys: 3.679 ± 0.228
7.03GluLeu: 7.03 ± 0.371
2.356GluMet: 2.356 ± 0.197
2.885GluAsn: 2.885 ± 0.201
2.091GluPro: 2.091 ± 0.188
2.469GluGln: 2.469 ± 0.221
3.528GluArg: 3.528 ± 0.266
3.893GluSer: 3.893 ± 0.218
3.906GluThr: 3.906 ± 0.174
5.229GluVal: 5.229 ± 0.279
0.832GluTrp: 0.832 ± 0.105
2.734GluTyr: 2.734 ± 0.184
0.0GluXaa: 0.0 ± 0.0
Phe
2.482PheAla: 2.482 ± 0.174
0.428PheCys: 0.428 ± 0.077
3.414PheAsp: 3.414 ± 0.214
2.898PheGlu: 2.898 ± 0.203
2.079PhePhe: 2.079 ± 0.191
3.578PheGly: 3.578 ± 0.224
0.769PheHis: 0.769 ± 0.099
2.898PheIle: 2.898 ± 0.226
3.2PheLys: 3.2 ± 0.194
3.301PheLeu: 3.301 ± 0.196
1.373PheMet: 1.373 ± 0.113
3.112PheAsn: 3.112 ± 0.376
1.537PhePro: 1.537 ± 0.142
1.487PheGln: 1.487 ± 0.146
2.079PheArg: 2.079 ± 0.183
3.024PheSer: 3.024 ± 0.207
2.81PheThr: 2.81 ± 0.211
2.772PheVal: 2.772 ± 0.208
0.454PheTrp: 0.454 ± 0.084
1.965PheTyr: 1.965 ± 0.207
0.0PheXaa: 0.0 ± 0.0
Gly
3.868GlyAla: 3.868 ± 0.239
0.617GlyCys: 0.617 ± 0.092
4.12GlyAsp: 4.12 ± 0.267
4.485GlyGlu: 4.485 ± 0.245
3.503GlyPhe: 3.503 ± 0.217
4.699GlyGly: 4.699 ± 0.379
1.21GlyHis: 1.21 ± 0.127
4.271GlyIle: 4.271 ± 0.293
4.687GlyLys: 4.687 ± 0.273
5.695GlyLeu: 5.695 ± 0.298
2.532GlyMet: 2.532 ± 0.224
3.566GlyAsn: 3.566 ± 0.254
1.802GlyPro: 1.802 ± 0.147
2.016GlyGln: 2.016 ± 0.199
3.414GlyArg: 3.414 ± 0.244
4.397GlySer: 4.397 ± 0.285
4.737GlyThr: 4.737 ± 0.442
4.536GlyVal: 4.536 ± 0.251
1.058GlyTrp: 1.058 ± 0.125
3.074GlyTyr: 3.074 ± 0.223
0.0GlyXaa: 0.0 ± 0.0
His
1.021HisAla: 1.021 ± 0.107
0.265HisCys: 0.265 ± 0.052
1.461HisAsp: 1.461 ± 0.145
1.273HisGlu: 1.273 ± 0.122
1.159HisPhe: 1.159 ± 0.136
1.222HisGly: 1.222 ± 0.132
0.491HisHis: 0.491 ± 0.082
1.147HisIle: 1.147 ± 0.133
1.084HisLys: 1.084 ± 0.108
1.726HisLeu: 1.726 ± 0.166
0.567HisMet: 0.567 ± 0.084
1.096HisAsn: 1.096 ± 0.127
1.096HisPro: 1.096 ± 0.121
0.693HisGln: 0.693 ± 0.102
0.895HisArg: 0.895 ± 0.121
1.021HisSer: 1.021 ± 0.116
1.222HisThr: 1.222 ± 0.146
1.676HisVal: 1.676 ± 0.142
0.29HisTrp: 0.29 ± 0.064
0.806HisTyr: 0.806 ± 0.103
0.0HisXaa: 0.0 ± 0.0
Ile
4.674IleAla: 4.674 ± 0.271
0.68IleCys: 0.68 ± 0.095
4.51IleAsp: 4.51 ± 0.273
4.384IleGlu: 4.384 ± 0.22
2.18IlePhe: 2.18 ± 0.176
3.729IleGly: 3.729 ± 0.236
1.121IleHis: 1.121 ± 0.121
3.389IleIle: 3.389 ± 0.231
4.46IleLys: 4.46 ± 0.219
4.258IleLeu: 4.258 ± 0.291
1.713IleMet: 1.713 ± 0.164
4.158IleAsn: 4.158 ± 0.253
3.288IlePro: 3.288 ± 0.193
1.89IleGln: 1.89 ± 0.187
3.213IleArg: 3.213 ± 0.225
4.17IleSer: 4.17 ± 0.262
4.447IleThr: 4.447 ± 0.295
3.717IleVal: 3.717 ± 0.196
0.517IleTrp: 0.517 ± 0.088
2.104IleTyr: 2.104 ± 0.181
0.0IleXaa: 0.0 ± 0.0
Lys
4.951LysAla: 4.951 ± 0.334
0.416LysCys: 0.416 ± 0.081
4.46LysAsp: 4.46 ± 0.267
5.002LysGlu: 5.002 ± 0.293
2.457LysPhe: 2.457 ± 0.196
4.044LysGly: 4.044 ± 0.246
1.499LysHis: 1.499 ± 0.175
3.251LysIle: 3.251 ± 0.213
3.566LysLys: 3.566 ± 0.297
5.644LysLeu: 5.644 ± 0.293
1.915LysMet: 1.915 ± 0.167
2.772LysAsn: 2.772 ± 0.192
2.558LysPro: 2.558 ± 0.187
2.167LysGln: 2.167 ± 0.179
3.15LysArg: 3.15 ± 0.207
3.188LysSer: 3.188 ± 0.231
3.918LysThr: 3.918 ± 0.263
4.422LysVal: 4.422 ± 0.269
0.655LysTrp: 0.655 ± 0.117
2.457LysTyr: 2.457 ± 0.173
0.0LysXaa: 0.0 ± 0.0
Leu
5.405LeuAla: 5.405 ± 0.283
0.832LeuCys: 0.832 ± 0.105
6.022LeuAsp: 6.022 ± 0.241
5.959LeuGlu: 5.959 ± 0.299
4.007LeuPhe: 4.007 ± 0.227
5.266LeuGly: 5.266 ± 0.295
1.436LeuHis: 1.436 ± 0.158
4.649LeuIle: 4.649 ± 0.315
5.292LeuLys: 5.292 ± 0.232
5.934LeuLeu: 5.934 ± 0.312
2.507LeuMet: 2.507 ± 0.231
4.51LeuAsn: 4.51 ± 0.225
3.301LeuPro: 3.301 ± 0.191
2.419LeuGln: 2.419 ± 0.169
4.435LeuArg: 4.435 ± 0.266
5.279LeuSer: 5.279 ± 0.239
5.77LeuThr: 5.77 ± 0.339
6.085LeuVal: 6.085 ± 0.29
0.668LeuTrp: 0.668 ± 0.096
3.036LeuTyr: 3.036 ± 0.224
0.0LeuXaa: 0.0 ± 0.0
Met
2.091MetAla: 2.091 ± 0.18
0.353MetCys: 0.353 ± 0.06
1.978MetAsp: 1.978 ± 0.186
2.028MetGlu: 2.028 ± 0.162
2.066MetPhe: 2.066 ± 0.32
2.016MetGly: 2.016 ± 0.157
0.567MetHis: 0.567 ± 0.085
1.89MetIle: 1.89 ± 0.189
2.003MetLys: 2.003 ± 0.185
2.343MetLeu: 2.343 ± 0.199
0.907MetMet: 0.907 ± 0.102
2.079MetAsn: 2.079 ± 0.17
0.983MetPro: 0.983 ± 0.107
0.756MetGln: 0.756 ± 0.101
1.147MetArg: 1.147 ± 0.124
2.784MetSer: 2.784 ± 0.222
2.167MetThr: 2.167 ± 0.146
2.142MetVal: 2.142 ± 0.168
0.378MetTrp: 0.378 ± 0.082
1.147MetTyr: 1.147 ± 0.135
0.0MetXaa: 0.0 ± 0.0
Asn
3.918AsnAla: 3.918 ± 0.283
0.391AsnCys: 0.391 ± 0.072
3.225AsnAsp: 3.225 ± 0.199
3.326AsnGlu: 3.326 ± 0.267
2.343AsnPhe: 2.343 ± 0.179
4.384AsnGly: 4.384 ± 0.302
1.197AsnHis: 1.197 ± 0.131
2.91AsnIle: 2.91 ± 0.197
3.591AsnLys: 3.591 ± 0.25
4.384AsnLeu: 4.384 ± 0.279
1.537AsnMet: 1.537 ± 0.135
2.923AsnAsn: 2.923 ± 0.274
3.024AsnPro: 3.024 ± 0.2
2.079AsnGln: 2.079 ± 0.249
2.52AsnArg: 2.52 ± 0.168
2.709AsnSer: 2.709 ± 0.218
3.288AsnThr: 3.288 ± 0.207
3.452AsnVal: 3.452 ± 0.203
0.567AsnTrp: 0.567 ± 0.095
2.041AsnTyr: 2.041 ± 0.152
0.0AsnXaa: 0.0 ± 0.0
Pro
2.91ProAla: 2.91 ± 0.205
0.202ProCys: 0.202 ± 0.051
2.658ProAsp: 2.658 ± 0.228
3.074ProGlu: 3.074 ± 0.191
1.852ProPhe: 1.852 ± 0.165
3.251ProGly: 3.251 ± 0.252
0.832ProHis: 0.832 ± 0.111
2.394ProIle: 2.394 ± 0.191
2.457ProLys: 2.457 ± 0.169
2.684ProLeu: 2.684 ± 0.175
1.273ProMet: 1.273 ± 0.156
2.091ProAsn: 2.091 ± 0.178
1.147ProPro: 1.147 ± 0.134
1.046ProGln: 1.046 ± 0.127
1.638ProArg: 1.638 ± 0.157
2.621ProSer: 2.621 ± 0.204
2.646ProThr: 2.646 ± 0.224
3.603ProVal: 3.603 ± 0.305
0.416ProTrp: 0.416 ± 0.073
1.386ProTyr: 1.386 ± 0.157
0.0ProXaa: 0.0 ± 0.0
Gln
2.394GlnAla: 2.394 ± 0.222
0.252GlnCys: 0.252 ± 0.057
1.953GlnAsp: 1.953 ± 0.172
2.18GlnGlu: 2.18 ± 0.189
1.575GlnPhe: 1.575 ± 0.164
2.243GlnGly: 2.243 ± 0.164
0.794GlnHis: 0.794 ± 0.093
1.839GlnIle: 1.839 ± 0.16
1.449GlnLys: 1.449 ± 0.157
3.099GlnLeu: 3.099 ± 0.267
0.945GlnMet: 0.945 ± 0.126
1.474GlnAsn: 1.474 ± 0.148
1.411GlnPro: 1.411 ± 0.168
1.373GlnGln: 1.373 ± 0.21
1.701GlnArg: 1.701 ± 0.171
2.104GlnSer: 2.104 ± 0.166
1.802GlnThr: 1.802 ± 0.157
2.293GlnVal: 2.293 ± 0.168
0.466GlnTrp: 0.466 ± 0.087
1.461GlnTyr: 1.461 ± 0.122
0.0GlnXaa: 0.0 ± 0.0
Arg
3.112ArgAla: 3.112 ± 0.226
0.63ArgCys: 0.63 ± 0.109
3.112ArgAsp: 3.112 ± 0.195
3.276ArgGlu: 3.276 ± 0.241
2.255ArgPhe: 2.255 ± 0.151
3.024ArgGly: 3.024 ± 0.243
1.121ArgHis: 1.121 ± 0.132
3.364ArgIle: 3.364 ± 0.221
2.873ArgLys: 2.873 ± 0.197
4.321ArgLeu: 4.321 ± 0.26
1.487ArgMet: 1.487 ± 0.138
2.381ArgAsn: 2.381 ± 0.169
1.726ArgPro: 1.726 ± 0.148
1.902ArgGln: 1.902 ± 0.172
2.293ArgArg: 2.293 ± 0.16
2.81ArgSer: 2.81 ± 0.196
3.049ArgThr: 3.049 ± 0.193
3.314ArgVal: 3.314 ± 0.216
0.542ArgTrp: 0.542 ± 0.084
2.142ArgTyr: 2.142 ± 0.159
0.0ArgXaa: 0.0 ± 0.0
Ser
3.729SerAla: 3.729 ± 0.293
0.643SerCys: 0.643 ± 0.102
3.805SerAsp: 3.805 ± 0.233
3.44SerGlu: 3.44 ± 0.23
2.936SerPhe: 2.936 ± 0.17
4.271SerGly: 4.271 ± 0.248
1.298SerHis: 1.298 ± 0.121
4.233SerIle: 4.233 ± 0.273
3.566SerLys: 3.566 ± 0.22
5.317SerLeu: 5.317 ± 0.264
2.205SerMet: 2.205 ± 0.177
3.364SerAsn: 3.364 ± 0.224
2.482SerPro: 2.482 ± 0.154
1.89SerGln: 1.89 ± 0.156
2.847SerArg: 2.847 ± 0.177
3.427SerSer: 3.427 ± 0.231
3.099SerThr: 3.099 ± 0.194
4.762SerVal: 4.762 ± 0.251
0.668SerTrp: 0.668 ± 0.118
2.394SerTyr: 2.394 ± 0.186
0.0SerXaa: 0.0 ± 0.0
Thr
3.868ThrAla: 3.868 ± 0.254
0.58ThrCys: 0.58 ± 0.085
3.792ThrAsp: 3.792 ± 0.22
4.12ThrGlu: 4.12 ± 0.202
2.86ThrPhe: 2.86 ± 0.186
5.115ThrGly: 5.115 ± 0.47
1.323ThrHis: 1.323 ± 0.13
3.944ThrIle: 3.944 ± 0.284
3.641ThrLys: 3.641 ± 0.257
5.481ThrLeu: 5.481 ± 0.288
1.663ThrMet: 1.663 ± 0.134
3.074ThrAsn: 3.074 ± 0.295
3.339ThrPro: 3.339 ± 0.29
1.953ThrGln: 1.953 ± 0.205
2.696ThrArg: 2.696 ± 0.19
3.288ThrSer: 3.288 ± 0.184
4.132ThrThr: 4.132 ± 0.356
4.838ThrVal: 4.838 ± 0.453
0.92ThrTrp: 0.92 ± 0.12
2.205ThrTyr: 2.205 ± 0.205
0.0ThrXaa: 0.0 ± 0.0
Val
4.687ValAla: 4.687 ± 0.313
0.63ValCys: 0.63 ± 0.109
4.258ValAsp: 4.258 ± 0.266
4.75ValGlu: 4.75 ± 0.28
2.847ValPhe: 2.847 ± 0.213
4.687ValGly: 4.687 ± 0.239
1.424ValHis: 1.424 ± 0.139
5.103ValIle: 5.103 ± 0.28
5.09ValLys: 5.09 ± 0.278
5.103ValLeu: 5.103 ± 0.271
2.154ValMet: 2.154 ± 0.167
3.855ValAsn: 3.855 ± 0.26
2.696ValPro: 2.696 ± 0.187
2.583ValGln: 2.583 ± 0.177
3.477ValArg: 3.477 ± 0.203
4.926ValSer: 4.926 ± 0.26
4.888ValThr: 4.888 ± 0.411
4.977ValVal: 4.977 ± 0.301
0.769ValTrp: 0.769 ± 0.108
2.595ValTyr: 2.595 ± 0.22
0.0ValXaa: 0.0 ± 0.0
Trp
0.63TrpAla: 0.63 ± 0.097
0.139TrpCys: 0.139 ± 0.043
0.932TrpAsp: 0.932 ± 0.124
0.832TrpGlu: 0.832 ± 0.089
0.68TrpPhe: 0.68 ± 0.092
0.58TrpGly: 0.58 ± 0.095
0.214TrpHis: 0.214 ± 0.056
0.794TrpIle: 0.794 ± 0.092
0.655TrpLys: 0.655 ± 0.109
1.008TrpLeu: 1.008 ± 0.112
0.491TrpMet: 0.491 ± 0.072
0.794TrpAsn: 0.794 ± 0.18
0.239TrpPro: 0.239 ± 0.052
0.189TrpGln: 0.189 ± 0.047
0.554TrpArg: 0.554 ± 0.077
0.693TrpSer: 0.693 ± 0.094
0.832TrpThr: 0.832 ± 0.105
0.945TrpVal: 0.945 ± 0.116
0.139TrpTrp: 0.139 ± 0.043
0.454TrpTyr: 0.454 ± 0.066
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.255TyrAla: 2.255 ± 0.146
0.353TyrCys: 0.353 ± 0.068
2.558TyrAsp: 2.558 ± 0.255
2.054TyrGlu: 2.054 ± 0.148
1.688TyrPhe: 1.688 ± 0.163
2.041TyrGly: 2.041 ± 0.155
1.058TyrHis: 1.058 ± 0.114
2.406TyrIle: 2.406 ± 0.232
2.369TyrLys: 2.369 ± 0.184
3.162TyrLeu: 3.162 ± 0.232
1.147TyrMet: 1.147 ± 0.125
2.369TyrAsn: 2.369 ± 0.181
1.638TyrPro: 1.638 ± 0.152
1.487TyrGln: 1.487 ± 0.142
2.192TyrArg: 2.192 ± 0.191
2.343TyrSer: 2.343 ± 0.209
2.709TyrThr: 2.709 ± 0.181
2.583TyrVal: 2.583 ± 0.206
0.58TyrTrp: 0.58 ± 0.087
1.575TyrTyr: 1.575 ± 0.168
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 262 proteins (79372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski