Amino acid dipepetide frequency for Lactobacillus vini DSM 20605

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.882AlaAla: 8.882 ± 0.168	0.572AlaCys: 0.572 ± 0.033	4.731AlaAsp: 4.731 ± 0.102	4.4AlaGlu: 4.4 ± 0.08	3.21AlaPhe: 3.21 ± 0.086	6.116AlaGly: 6.116 ± 0.116	1.394AlaHis: 1.394 ± 0.052	5.961AlaIle: 5.961 ± 0.119	6.219AlaLys: 6.219 ± 0.104	7.727AlaLeu: 7.727 ± 0.125	1.771AlaMet: 1.771 ± 0.055	3.543AlaAsn: 3.543 ± 0.077	2.009AlaPro: 2.009 ± 0.054	3.991AlaGln: 3.991 ± 0.091	2.77AlaArg: 2.77 ± 0.077	4.346AlaSer: 4.346 ± 0.082	4.558AlaThr: 4.558 ± 0.085	5.78AlaVal: 5.78 ± 0.103	0.762AlaTrp: 0.762 ± 0.038	2.436AlaTyr: 2.436 ± 0.066	0.003AlaXaa: 0.003 ± 0.002
Cys	0.42CysAla: 0.42 ± 0.024	0.107CysCys: 0.107 ± 0.014	0.311CysAsp: 0.311 ± 0.022	0.257CysGlu: 0.257 ± 0.021	0.35CysPhe: 0.35 ± 0.024	0.605CysGly: 0.605 ± 0.035	0.195CysHis: 0.195 ± 0.02	0.321CysIle: 0.321 ± 0.021	0.187CysLys: 0.187 ± 0.018	0.874CysLeu: 0.874 ± 0.04	0.131CysMet: 0.131 ± 0.015	0.241CysAsn: 0.241 ± 0.019	0.294CysPro: 0.294 ± 0.023	0.525CysGln: 0.525 ± 0.031	0.295CysArg: 0.295 ± 0.021	0.383CysSer: 0.383 ± 0.027	0.252CysThr: 0.252 ± 0.024	0.371CysVal: 0.371 ± 0.026	0.139CysTrp: 0.139 ± 0.016	0.311CysTyr: 0.311 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.015AspAla: 3.015 ± 0.071	0.335AspCys: 0.335 ± 0.022	2.349AspAsp: 2.349 ± 0.067	2.939AspGlu: 2.939 ± 0.075	2.929AspPhe: 2.929 ± 0.067	2.888AspGly: 2.888 ± 0.077	1.223AspHis: 1.223 ± 0.045	2.773AspIle: 2.773 ± 0.075	2.528AspLys: 2.528 ± 0.069	5.966AspLeu: 5.966 ± 0.112	0.962AspMet: 0.962 ± 0.03	1.913AspAsn: 1.913 ± 0.068	2.439AspPro: 2.439 ± 0.06	4.052AspGln: 4.052 ± 0.083	2.043AspArg: 2.043 ± 0.056	2.607AspSer: 2.607 ± 0.064	2.022AspThr: 2.022 ± 0.067	2.945AspVal: 2.945 ± 0.068	0.698AspTrp: 0.698 ± 0.034	2.158AspTyr: 2.158 ± 0.054	0.005AspXaa: 0.005 ± 0.003
Glu	3.415GluAla: 3.415 ± 0.095	0.238GluCys: 0.238 ± 0.019	2.088GluAsp: 2.088 ± 0.069	2.554GluGlu: 2.554 ± 0.077	2.258GluPhe: 2.258 ± 0.064	2.195GluGly: 2.195 ± 0.072	1.038GluHis: 1.038 ± 0.046	4.394GluIle: 4.394 ± 0.095	4.819GluLys: 4.819 ± 0.097	5.865GluLeu: 5.865 ± 0.118	1.482GluMet: 1.482 ± 0.059	2.979GluAsn: 2.979 ± 0.077	1.508GluPro: 1.508 ± 0.048	2.653GluGln: 2.653 ± 0.072	2.319GluArg: 2.319 ± 0.068	2.18GluSer: 2.18 ± 0.066	2.738GluThr: 2.738 ± 0.07	3.392GluVal: 3.392 ± 0.085	0.387GluTrp: 0.387 ± 0.023	1.597GluTyr: 1.597 ± 0.055	0.003GluXaa: 0.003 ± 0.002
Phe	3.621PheAla: 3.621 ± 0.082	0.433PheCys: 0.433 ± 0.026	2.552PheAsp: 2.552 ± 0.057	2.31PheGlu: 2.31 ± 0.056	2.297PhePhe: 2.297 ± 0.075	3.236PheGly: 3.236 ± 0.077	0.87PheHis: 0.87 ± 0.034	3.145PheIle: 3.145 ± 0.085	3.159PheLys: 3.159 ± 0.067	4.737PheLeu: 4.737 ± 0.116	1.059PheMet: 1.059 ± 0.041	2.185PheAsn: 2.185 ± 0.055	1.618PhePro: 1.618 ± 0.057	1.837PheGln: 1.837 ± 0.056	1.372PheArg: 1.372 ± 0.049	3.493PheSer: 3.493 ± 0.08	2.191PheThr: 2.191 ± 0.059	2.913PheVal: 2.913 ± 0.082	0.642PheTrp: 0.642 ± 0.035	1.746PheTyr: 1.746 ± 0.06	0.005PheXaa: 0.005 ± 0.002
Gly	4.471GlyAla: 4.471 ± 0.091	0.575GlyCys: 0.575 ± 0.031	2.765GlyAsp: 2.765 ± 0.079	2.899GlyGlu: 2.899 ± 0.078	3.23GlyPhe: 3.23 ± 0.084	4.181GlyGly: 4.181 ± 0.098	1.295GlyHis: 1.295 ± 0.049	5.699GlyIle: 5.699 ± 0.117	4.803GlyLys: 4.803 ± 0.097	6.654GlyLeu: 6.654 ± 0.112	1.691GlyMet: 1.691 ± 0.05	2.746GlyAsn: 2.746 ± 0.059	1.591GlyPro: 1.591 ± 0.048	3.368GlyGln: 3.368 ± 0.082	2.5GlyArg: 2.5 ± 0.07	3.873GlySer: 3.873 ± 0.089	3.773GlyThr: 3.773 ± 0.081	4.418GlyVal: 4.418 ± 0.08	0.778GlyTrp: 0.778 ± 0.039	2.591GlyTyr: 2.591 ± 0.075	0.01GlyXaa: 0.01 ± 0.004
His	1.311HisAla: 1.311 ± 0.05	0.145HisCys: 0.145 ± 0.016	1.171HisAsp: 1.171 ± 0.046	1.033HisGlu: 1.033 ± 0.045	1.132HisPhe: 1.132 ± 0.043	1.541HisGly: 1.541 ± 0.05	0.687HisHis: 0.687 ± 0.036	0.995HisIle: 0.995 ± 0.042	0.893HisLys: 0.893 ± 0.041	2.346HisLeu: 2.346 ± 0.064	0.305HisMet: 0.305 ± 0.024	0.816HisAsn: 0.816 ± 0.038	1.069HisPro: 1.069 ± 0.041	1.56HisGln: 1.56 ± 0.056	0.912HisArg: 0.912 ± 0.039	1.053HisSer: 1.053 ± 0.036	0.789HisThr: 0.789 ± 0.04	1.084HisVal: 1.084 ± 0.042	0.268HisTrp: 0.268 ± 0.02	0.958HisTyr: 0.958 ± 0.044	0.005HisXaa: 0.005 ± 0.002
Ile	6.073IleAla: 6.073 ± 0.113	0.66IleCys: 0.66 ± 0.035	4.082IleAsp: 4.082 ± 0.08	3.8IleGlu: 3.8 ± 0.085	3.573IlePhe: 3.573 ± 0.084	5.405IleGly: 5.405 ± 0.118	1.236IleHis: 1.236 ± 0.047	5.87IleIle: 5.87 ± 0.119	5.686IleLys: 5.686 ± 0.096	7.35IleLeu: 7.35 ± 0.126	1.658IleMet: 1.658 ± 0.049	3.728IleAsn: 3.728 ± 0.073	2.734IlePro: 2.734 ± 0.067	2.702IleGln: 2.702 ± 0.072	2.671IleArg: 2.671 ± 0.079	5.069IleSer: 5.069 ± 0.104	3.999IleThr: 3.999 ± 0.087	4.886IleVal: 4.886 ± 0.097	0.663IleTrp: 0.663 ± 0.032	2.463IleTyr: 2.463 ± 0.065	0.003IleXaa: 0.003 ± 0.002
Lys	4.812LysAla: 4.812 ± 0.088	0.294LysCys: 0.294 ± 0.024	3.089LysAsp: 3.089 ± 0.069	3.806LysGlu: 3.806 ± 0.083	2.736LysPhe: 2.736 ± 0.057	2.993LysGly: 2.993 ± 0.07	1.314LysHis: 1.314 ± 0.046	6.283LysIle: 6.283 ± 0.105	6.411LysLys: 6.411 ± 0.122	7.467LysLeu: 7.467 ± 0.121	2.37LysMet: 2.37 ± 0.063	4.228LysAsn: 4.228 ± 0.095	2.102LysPro: 2.102 ± 0.052	4.49LysGln: 4.49 ± 0.093	3.17LysArg: 3.17 ± 0.081	3.674LysSer: 3.674 ± 0.079	4.153LysThr: 4.153 ± 0.077	4.686LysVal: 4.686 ± 0.112	0.688LysTrp: 0.688 ± 0.032	2.672LysTyr: 2.672 ± 0.065	0.01LysXaa: 0.01 ± 0.004
Leu	10.283LeuAla: 10.283 ± 0.151	0.637LeuCys: 0.637 ± 0.031	4.943LeuAsp: 4.943 ± 0.085	5.042LeuGlu: 5.042 ± 0.106	4.372LeuPhe: 4.372 ± 0.108	7.008LeuGly: 7.008 ± 0.15	1.88LeuHis: 1.88 ± 0.054	8.452LeuIle: 8.452 ± 0.131	8.503LeuLys: 8.503 ± 0.124	11.698LeuLeu: 11.698 ± 0.183	2.393LeuMet: 2.393 ± 0.061	5.494LeuAsn: 5.494 ± 0.1	4.788LeuPro: 4.788 ± 0.091	5.279LeuGln: 5.279 ± 0.104	4.023LeuArg: 4.023 ± 0.094	6.593LeuSer: 6.593 ± 0.12	7.336LeuThr: 7.336 ± 0.111	6.881LeuVal: 6.881 ± 0.108	0.875LeuTrp: 0.875 ± 0.042	2.722LeuTyr: 2.722 ± 0.069	0.002LeuXaa: 0.002 ± 0.001
Met	1.923MetAla: 1.923 ± 0.054	0.109MetCys: 0.109 ± 0.012	1.051MetAsp: 1.051 ± 0.037	1.037MetGlu: 1.037 ± 0.041	0.818MetPhe: 0.818 ± 0.032	1.506MetGly: 1.506 ± 0.045	0.364MetHis: 0.364 ± 0.026	2.065MetIle: 2.065 ± 0.062	1.923MetLys: 1.923 ± 0.055	2.346MetLeu: 2.346 ± 0.064	0.645MetMet: 0.645 ± 0.036	1.177MetAsn: 1.177 ± 0.042	0.912MetPro: 0.912 ± 0.037	1.096MetGln: 1.096 ± 0.045	0.866MetArg: 0.866 ± 0.034	1.41MetSer: 1.41 ± 0.05	1.543MetThr: 1.543 ± 0.044	1.6MetVal: 1.6 ± 0.051	0.113MetTrp: 0.113 ± 0.015	0.557MetTyr: 0.557 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.822AsnAla: 2.822 ± 0.075	0.348AsnCys: 0.348 ± 0.028	2.514AsnAsp: 2.514 ± 0.064	2.53AsnGlu: 2.53 ± 0.066	2.445AsnPhe: 2.445 ± 0.061	3.341AsnGly: 3.341 ± 0.077	1.223AsnHis: 1.223 ± 0.05	2.734AsnIle: 2.734 ± 0.073	2.675AsnLys: 2.675 ± 0.069	5.561AsnLeu: 5.561 ± 0.089	1.08AsnMet: 1.08 ± 0.042	2.226AsnAsn: 2.226 ± 0.068	1.889AsnPro: 1.889 ± 0.056	3.434AsnGln: 3.434 ± 0.077	1.861AsnArg: 1.861 ± 0.056	3.156AsnSer: 3.156 ± 0.09	1.901AsnThr: 1.901 ± 0.057	2.718AsnVal: 2.718 ± 0.075	0.749AsnTrp: 0.749 ± 0.036	2.214AsnTyr: 2.214 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	3.418ProAla: 3.418 ± 0.069	0.204ProCys: 0.204 ± 0.019	1.918ProAsp: 1.918 ± 0.06	2.204ProGlu: 2.204 ± 0.059	1.682ProPhe: 1.682 ± 0.059	2.111ProGly: 2.111 ± 0.055	0.76ProHis: 0.76 ± 0.035	2.554ProIle: 2.554 ± 0.057	2.195ProLys: 2.195 ± 0.068	3.728ProLeu: 3.728 ± 0.083	0.626ProMet: 0.626 ± 0.033	1.672ProAsn: 1.672 ± 0.047	0.759ProPro: 0.759 ± 0.032	2.127ProGln: 2.127 ± 0.055	1.214ProArg: 1.214 ± 0.044	1.84ProSer: 1.84 ± 0.054	2.402ProThr: 2.402 ± 0.059	2.755ProVal: 2.755 ± 0.069	0.377ProTrp: 0.377 ± 0.024	1.233ProTyr: 1.233 ± 0.041	0.002ProXaa: 0.002 ± 0.002
Gln	5.504GlnAla: 5.504 ± 0.103	0.168GlnCys: 0.168 ± 0.015	2.001GlnAsp: 2.001 ± 0.059	2.592GlnGlu: 2.592 ± 0.078	1.797GlnPhe: 1.797 ± 0.051	2.623GlnGly: 2.623 ± 0.066	1.204GlnHis: 1.204 ± 0.044	4.197GlnIle: 4.197 ± 0.085	4.424GlnLys: 4.424 ± 0.093	7.192GlnLeu: 7.192 ± 0.156	1.161GlnMet: 1.161 ± 0.043	2.482GlnAsn: 2.482 ± 0.077	2.158GlnPro: 2.158 ± 0.066	5.042GlnGln: 5.042 ± 0.162	2.731GlnArg: 2.731 ± 0.074	2.578GlnSer: 2.578 ± 0.071	3.474GlnThr: 3.474 ± 0.083	4.255GlnVal: 4.255 ± 0.105	0.434GlnTrp: 0.434 ± 0.029	1.431GlnTyr: 1.431 ± 0.049	0.002GlnXaa: 0.002 ± 0.002
Arg	2.453ArgAla: 2.453 ± 0.06	0.235ArgCys: 0.235 ± 0.018	1.762ArgAsp: 1.762 ± 0.062	2.097ArgGlu: 2.097 ± 0.065	1.822ArgPhe: 1.822 ± 0.055	2.14ArgGly: 2.14 ± 0.068	0.866ArgHis: 0.866 ± 0.037	3.115ArgIle: 3.115 ± 0.082	2.784ArgLys: 2.784 ± 0.063	4.402ArgLeu: 4.402 ± 0.087	0.933ArgMet: 0.933 ± 0.035	1.683ArgAsn: 1.683 ± 0.061	1.514ArgPro: 1.514 ± 0.051	3.132ArgGln: 3.132 ± 0.084	2.043ArgArg: 2.043 ± 0.074	2.148ArgSer: 2.148 ± 0.06	1.877ArgThr: 1.877 ± 0.057	2.445ArgVal: 2.445 ± 0.066	0.356ArgTrp: 0.356 ± 0.027	1.524ArgTyr: 1.524 ± 0.055	0.005ArgXaa: 0.005 ± 0.003
Ser	4.67SerAla: 4.67 ± 0.11	0.38SerCys: 0.38 ± 0.029	2.714SerAsp: 2.714 ± 0.074	2.694SerGlu: 2.694 ± 0.065	3.079SerPhe: 3.079 ± 0.078	4.317SerGly: 4.317 ± 0.097	1.19SerHis: 1.19 ± 0.041	3.701SerIle: 3.701 ± 0.084	3.701SerLys: 3.701 ± 0.085	7.026SerLeu: 7.026 ± 0.118	1.27SerMet: 1.27 ± 0.049	2.72SerAsn: 2.72 ± 0.074	1.877SerPro: 1.877 ± 0.056	3.531SerGln: 3.531 ± 0.087	2.321SerArg: 2.321 ± 0.064	4.52SerSer: 4.52 ± 0.182	3.121SerThr: 3.121 ± 0.086	3.638SerVal: 3.638 ± 0.085	0.771SerTrp: 0.771 ± 0.036	2.078SerTyr: 2.078 ± 0.063	0.006SerXaa: 0.006 ± 0.003
Thr	5.343ThrAla: 5.343 ± 0.095	0.291ThrCys: 0.291 ± 0.024	3.041ThrAsp: 3.041 ± 0.071	2.75ThrGlu: 2.75 ± 0.066	2.418ThrPhe: 2.418 ± 0.057	4.217ThrGly: 4.217 ± 0.082	0.985ThrHis: 0.985 ± 0.039	4.012ThrIle: 4.012 ± 0.079	3.776ThrLys: 3.776 ± 0.08	5.448ThrLeu: 5.448 ± 0.097	1.11ThrMet: 1.11 ± 0.046	2.734ThrAsn: 2.734 ± 0.071	2.242ThrPro: 2.242 ± 0.054	2.201ThrGln: 2.201 ± 0.061	1.715ThrArg: 1.715 ± 0.054	3.554ThrSer: 3.554 ± 0.095	3.522ThrThr: 3.522 ± 0.097	4.129ThrVal: 4.129 ± 0.089	0.567ThrTrp: 0.567 ± 0.032	1.763ThrTyr: 1.763 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	5.994ValAla: 5.994 ± 0.119	0.513ValCys: 0.513 ± 0.027	3.498ValAsp: 3.498 ± 0.069	3.279ValGlu: 3.279 ± 0.071	2.821ValPhe: 2.821 ± 0.072	4.482ValGly: 4.482 ± 0.087	1.1ValHis: 1.1 ± 0.051	5.507ValIle: 5.507 ± 0.105	4.947ValLys: 4.947 ± 0.107	6.611ValLeu: 6.611 ± 0.123	1.589ValMet: 1.589 ± 0.057	2.974ValAsn: 2.974 ± 0.067	2.468ValPro: 2.468 ± 0.063	2.295ValGln: 2.295 ± 0.066	2.226ValArg: 2.226 ± 0.062	4.274ValSer: 4.274 ± 0.085	4.081ValThr: 4.081 ± 0.08	4.669ValVal: 4.669 ± 0.1	0.586ValTrp: 0.586 ± 0.028	2.06ValTyr: 2.06 ± 0.054	0.002ValXaa: 0.002 ± 0.002
Trp	0.517TrpAla: 0.517 ± 0.027	0.065TrpCys: 0.065 ± 0.01	0.433TrpAsp: 0.433 ± 0.026	0.415TrpGlu: 0.415 ± 0.024	0.514TrpPhe: 0.514 ± 0.031	0.644TrpGly: 0.644 ± 0.035	0.284TrpHis: 0.284 ± 0.02	0.706TrpIle: 0.706 ± 0.033	0.602TrpLys: 0.602 ± 0.037	1.626TrpLeu: 1.626 ± 0.06	0.268TrpMet: 0.268 ± 0.021	0.527TrpAsn: 0.527 ± 0.025	0.326TrpPro: 0.326 ± 0.019	0.938TrpGln: 0.938 ± 0.045	0.465TrpArg: 0.465 ± 0.024	0.613TrpSer: 0.613 ± 0.032	0.471TrpThr: 0.471 ± 0.027	0.503TrpVal: 0.503 ± 0.028	0.142TrpTrp: 0.142 ± 0.014	0.351TrpTyr: 0.351 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.23TyrAla: 2.23 ± 0.058	0.262TyrCys: 0.262 ± 0.022	1.774TyrAsp: 1.774 ± 0.059	1.46TyrGlu: 1.46 ± 0.049	1.933TyrPhe: 1.933 ± 0.055	2.357TyrGly: 2.357 ± 0.06	0.962TyrHis: 0.962 ± 0.039	1.822TyrIle: 1.822 ± 0.056	1.212TyrLys: 1.212 ± 0.05	4.57TyrLeu: 4.57 ± 0.095	0.548TyrMet: 0.548 ± 0.03	1.35TyrAsn: 1.35 ± 0.053	1.484TyrPro: 1.484 ± 0.052	3.193TyrGln: 3.193 ± 0.092	1.819TyrArg: 1.819 ± 0.062	1.957TyrSer: 1.957 ± 0.049	1.615TyrThr: 1.615 ± 0.047	1.902TyrVal: 1.902 ± 0.051	0.415TyrTrp: 0.415 ± 0.029	1.46TyrTyr: 1.46 ± 0.054	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.005XaaAla: 0.005 ± 0.003	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.005XaaPhe: 0.005 ± 0.003	0.002XaaGly: 0.002 ± 0.002	0.002XaaHis: 0.002 ± 0.001	0.005XaaIle: 0.005 ± 0.003	0.002XaaLys: 0.002 ± 0.002	0.011XaaLeu: 0.011 ± 0.004	0.008XaaMet: 0.008 ± 0.004	0.005XaaAsn: 0.005 ± 0.003	0.002XaaPro: 0.002 ± 0.001	0.003XaaGln: 0.003 ± 0.002	0.0XaaArg: 0.0 ± 0.0	0.006XaaSer: 0.006 ± 0.003	0.002XaaThr: 0.002 ± 0.001	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.007

Statistics based on 2108 proteins (626100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---