Amino acid dipepetide frequency for Rickettsia amblyommatis str. Darkwater

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.07AlaAla: 5.07 ± 0.152
0.768AlaCys: 0.768 ± 0.054
2.976AlaAsp: 2.976 ± 0.088
4.159AlaGlu: 4.159 ± 0.121
2.473AlaPhe: 2.473 ± 0.096
4.011AlaGly: 4.011 ± 0.122
1.113AlaHis: 1.113 ± 0.056
5.992AlaIle: 5.992 ± 0.142
5.9AlaLys: 5.9 ± 0.139
6.559AlaLeu: 6.559 ± 0.124
1.605AlaMet: 1.605 ± 0.066
3.43AlaAsn: 3.43 ± 0.135
1.746AlaPro: 1.746 ± 0.074
1.822AlaGln: 1.822 ± 0.084
2.673AlaArg: 2.673 ± 0.087
4.451AlaSer: 4.451 ± 0.099
3.268AlaThr: 3.268 ± 0.125
4.197AlaVal: 4.197 ± 0.14
0.446AlaTrp: 0.446 ± 0.039
2.251AlaTyr: 2.251 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.497CysAla: 0.497 ± 0.037
0.211CysCys: 0.211 ± 0.028
0.505CysAsp: 0.505 ± 0.034
0.524CysGlu: 0.524 ± 0.038
0.611CysPhe: 0.611 ± 0.042
0.678CysGly: 0.678 ± 0.048
0.319CysHis: 0.319 ± 0.031
0.913CysIle: 0.913 ± 0.049
0.662CysLys: 0.662 ± 0.044
1.108CysLeu: 1.108 ± 0.056
0.232CysMet: 0.232 ± 0.026
0.668CysAsn: 0.668 ± 0.044
0.416CysPro: 0.416 ± 0.037
0.265CysGln: 0.265 ± 0.026
0.389CysArg: 0.389 ± 0.031
0.968CysSer: 0.968 ± 0.048
0.484CysThr: 0.484 ± 0.041
0.538CysVal: 0.538 ± 0.041
0.097CysTrp: 0.097 ± 0.017
0.514CysTyr: 0.514 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
2.659AspAla: 2.659 ± 0.094
0.562AspCys: 0.562 ± 0.037
2.359AspAsp: 2.359 ± 0.086
3.035AspGlu: 3.035 ± 0.091
2.411AspPhe: 2.411 ± 0.077
2.37AspGly: 2.37 ± 0.096
0.973AspHis: 0.973 ± 0.05
5.278AspIle: 5.278 ± 0.126
4.957AspLys: 4.957 ± 0.142
5.267AspLeu: 5.267 ± 0.122
1.065AspMet: 1.065 ± 0.056
3.359AspAsn: 3.359 ± 0.109
1.465AspPro: 1.465 ± 0.06
1.603AspGln: 1.603 ± 0.068
1.616AspArg: 1.616 ± 0.073
3.138AspSer: 3.138 ± 0.09
2.446AspThr: 2.446 ± 0.102
2.497AspVal: 2.497 ± 0.088
0.427AspTrp: 0.427 ± 0.036
2.278AspTyr: 2.278 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
4.349GluAla: 4.349 ± 0.131
0.473GluCys: 0.473 ± 0.034
2.732GluAsp: 2.732 ± 0.094
5.049GluGlu: 5.049 ± 0.159
2.878GluPhe: 2.878 ± 0.095
2.586GluGly: 2.586 ± 0.086
1.186GluHis: 1.186 ± 0.05
6.462GluIle: 6.462 ± 0.165
5.6GluLys: 5.6 ± 0.139
6.403GluLeu: 6.403 ± 0.158
1.457GluMet: 1.457 ± 0.065
3.808GluAsn: 3.808 ± 0.102
1.503GluPro: 1.503 ± 0.058
2.749GluGln: 2.749 ± 0.093
2.473GluArg: 2.473 ± 0.092
3.076GluSer: 3.076 ± 0.1
2.505GluThr: 2.505 ± 0.083
3.705GluVal: 3.705 ± 0.108
0.446GluTrp: 0.446 ± 0.04
2.441GluTyr: 2.441 ± 0.091
0.0GluXaa: 0.0 ± 0.0
Phe
3.113PheAla: 3.113 ± 0.106
0.662PheCys: 0.662 ± 0.042
2.524PheAsp: 2.524 ± 0.092
2.446PheGlu: 2.446 ± 0.08
2.459PhePhe: 2.459 ± 0.108
2.684PheGly: 2.684 ± 0.093
0.724PheHis: 0.724 ± 0.048
4.635PheIle: 4.635 ± 0.135
3.365PheLys: 3.365 ± 0.097
4.392PheLeu: 4.392 ± 0.136
1.103PheMet: 1.103 ± 0.052
2.865PheAsn: 2.865 ± 0.087
1.33PhePro: 1.33 ± 0.071
1.084PheGln: 1.084 ± 0.048
1.322PheArg: 1.322 ± 0.061
3.53PheSer: 3.53 ± 0.103
2.627PheThr: 2.627 ± 0.093
2.608PheVal: 2.608 ± 0.1
0.473PheTrp: 0.473 ± 0.031
1.8PheTyr: 1.8 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.549GlyAla: 3.549 ± 0.167
0.595GlyCys: 0.595 ± 0.04
2.451GlyAsp: 2.451 ± 0.084
2.986GlyGlu: 2.986 ± 0.104
2.705GlyPhe: 2.705 ± 0.093
3.505GlyGly: 3.505 ± 0.121
1.046GlyHis: 1.046 ± 0.056
5.016GlyIle: 5.016 ± 0.141
4.535GlyLys: 4.535 ± 0.103
4.9GlyLeu: 4.9 ± 0.117
1.481GlyMet: 1.481 ± 0.07
3.124GlyAsn: 3.124 ± 0.119
1.116GlyPro: 1.116 ± 0.056
1.659GlyGln: 1.659 ± 0.069
2.073GlyArg: 2.073 ± 0.081
3.646GlySer: 3.646 ± 0.108
2.922GlyThr: 2.922 ± 0.14
3.57GlyVal: 3.57 ± 0.116
0.541GlyTrp: 0.541 ± 0.04
2.113GlyTyr: 2.113 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.103HisAla: 1.103 ± 0.057
0.249HisCys: 0.249 ± 0.024
0.992HisAsp: 0.992 ± 0.053
1.143HisGlu: 1.143 ± 0.057
0.981HisPhe: 0.981 ± 0.053
1.027HisGly: 1.027 ± 0.054
0.505HisHis: 0.505 ± 0.034
1.63HisIle: 1.63 ± 0.074
1.576HisLys: 1.576 ± 0.074
1.857HisLeu: 1.857 ± 0.068
0.308HisMet: 0.308 ± 0.028
1.359HisAsn: 1.359 ± 0.055
0.795HisPro: 0.795 ± 0.054
0.616HisGln: 0.616 ± 0.043
0.724HisArg: 0.724 ± 0.041
1.246HisSer: 1.246 ± 0.057
0.878HisThr: 0.878 ± 0.05
0.892HisVal: 0.892 ± 0.052
0.13HisTrp: 0.13 ± 0.02
0.851HisTyr: 0.851 ± 0.053
0.0HisXaa: 0.0 ± 0.0
Ile
7.065IleAla: 7.065 ± 0.139
1.159IleCys: 1.159 ± 0.066
5.359IleAsp: 5.359 ± 0.137
5.908IleGlu: 5.908 ± 0.142
4.459IlePhe: 4.459 ± 0.133
5.449IleGly: 5.449 ± 0.154
1.513IleHis: 1.513 ± 0.067
9.924IleIle: 9.924 ± 0.2
8.232IleLys: 8.232 ± 0.175
9.311IleLeu: 9.311 ± 0.187
2.095IleMet: 2.095 ± 0.075
6.267IleAsn: 6.267 ± 0.145
3.335IlePro: 3.335 ± 0.101
2.354IleGln: 2.354 ± 0.086
3.0IleArg: 3.0 ± 0.103
6.978IleSer: 6.978 ± 0.125
5.846IleThr: 5.846 ± 0.137
5.213IleVal: 5.213 ± 0.126
0.654IleTrp: 0.654 ± 0.039
3.497IleTyr: 3.497 ± 0.107
0.0IleXaa: 0.0 ± 0.0
Lys
5.719LysAla: 5.719 ± 0.146
0.584LysCys: 0.584 ± 0.039
4.573LysAsp: 4.573 ± 0.131
6.122LysGlu: 6.122 ± 0.156
3.557LysPhe: 3.557 ± 0.101
3.651LysGly: 3.651 ± 0.11
1.627LysHis: 1.627 ± 0.071
8.643LysIle: 8.643 ± 0.173
6.381LysLys: 6.381 ± 0.163
8.832LysLeu: 8.832 ± 0.183
2.005LysMet: 2.005 ± 0.079
5.913LysAsn: 5.913 ± 0.139
2.551LysPro: 2.551 ± 0.089
3.313LysGln: 3.313 ± 0.112
2.727LysArg: 2.727 ± 0.091
5.138LysSer: 5.138 ± 0.116
4.205LysThr: 4.205 ± 0.114
4.608LysVal: 4.608 ± 0.131
0.554LysTrp: 0.554 ± 0.042
3.565LysTyr: 3.565 ± 0.113
0.0LysXaa: 0.0 ± 0.0
Leu
6.513LeuAla: 6.513 ± 0.118
1.0LeuCys: 1.0 ± 0.055
4.919LeuAsp: 4.919 ± 0.137
6.608LeuGlu: 6.608 ± 0.146
4.216LeuPhe: 4.216 ± 0.116
5.246LeuGly: 5.246 ± 0.168
1.795LeuHis: 1.795 ± 0.079
8.854LeuIle: 8.854 ± 0.19
8.74LeuLys: 8.74 ± 0.161
10.192LeuLeu: 10.192 ± 0.195
2.408LeuMet: 2.408 ± 0.078
5.992LeuAsn: 5.992 ± 0.12
4.276LeuPro: 4.276 ± 0.112
3.832LeuGln: 3.832 ± 0.111
3.562LeuArg: 3.562 ± 0.101
7.613LeuSer: 7.613 ± 0.154
5.532LeuThr: 5.532 ± 0.155
5.473LeuVal: 5.473 ± 0.132
0.816LeuTrp: 0.816 ± 0.054
3.216LeuTyr: 3.216 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
1.481MetAla: 1.481 ± 0.065
0.2MetCys: 0.2 ± 0.02
0.989MetAsp: 0.989 ± 0.053
1.038MetGlu: 1.038 ± 0.051
0.919MetPhe: 0.919 ± 0.055
1.089MetGly: 1.089 ± 0.062
0.57MetHis: 0.57 ± 0.046
2.105MetIle: 2.105 ± 0.083
1.7MetLys: 1.7 ± 0.058
2.989MetLeu: 2.989 ± 0.099
0.562MetMet: 0.562 ± 0.036
1.303MetAsn: 1.303 ± 0.063
1.032MetPro: 1.032 ± 0.054
1.17MetGln: 1.17 ± 0.064
0.973MetArg: 0.973 ± 0.052
1.762MetSer: 1.762 ± 0.075
1.319MetThr: 1.319 ± 0.053
1.273MetVal: 1.273 ± 0.061
0.168MetTrp: 0.168 ± 0.023
0.657MetTyr: 0.657 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.478AsnAla: 3.478 ± 0.163
0.727AsnCys: 0.727 ± 0.047
3.273AsnAsp: 3.273 ± 0.093
3.186AsnGlu: 3.186 ± 0.095
3.132AsnPhe: 3.132 ± 0.096
2.581AsnGly: 2.581 ± 0.103
1.119AsnHis: 1.119 ± 0.055
7.651AsnIle: 7.651 ± 0.168
5.589AsnLys: 5.589 ± 0.129
6.713AsnLeu: 6.713 ± 0.164
1.446AsnMet: 1.446 ± 0.057
5.597AsnAsn: 5.597 ± 0.163
2.373AsnPro: 2.373 ± 0.082
1.946AsnGln: 1.946 ± 0.086
1.916AsnArg: 1.916 ± 0.085
4.265AsnSer: 4.265 ± 0.122
3.154AsnThr: 3.154 ± 0.115
2.862AsnVal: 2.862 ± 0.105
0.557AsnTrp: 0.557 ± 0.04
2.784AsnTyr: 2.784 ± 0.088
0.0AsnXaa: 0.0 ± 0.0
Pro
2.176ProAla: 2.176 ± 0.082
0.362ProCys: 0.362 ± 0.031
1.7ProAsp: 1.7 ± 0.065
2.476ProGlu: 2.476 ± 0.087
1.368ProPhe: 1.368 ± 0.067
1.316ProGly: 1.316 ± 0.07
0.678ProHis: 0.678 ± 0.043
3.122ProIle: 3.122 ± 0.104
2.581ProLys: 2.581 ± 0.098
3.249ProLeu: 3.249 ± 0.093
0.714ProMet: 0.714 ± 0.045
2.022ProAsn: 2.022 ± 0.078
1.211ProPro: 1.211 ± 0.105
1.127ProGln: 1.127 ± 0.063
1.108ProArg: 1.108 ± 0.062
2.1ProSer: 2.1 ± 0.087
1.857ProThr: 1.857 ± 0.07
2.054ProVal: 2.054 ± 0.073
0.311ProTrp: 0.311 ± 0.027
1.251ProTyr: 1.251 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
2.303GlnAla: 2.303 ± 0.083
0.262GlnCys: 0.262 ± 0.031
1.854GlnAsp: 1.854 ± 0.066
2.716GlnGlu: 2.716 ± 0.108
1.27GlnPhe: 1.27 ± 0.063
1.932GlnGly: 1.932 ± 0.069
0.643GlnHis: 0.643 ± 0.038
3.049GlnIle: 3.049 ± 0.083
3.135GlnLys: 3.135 ± 0.099
2.946GlnLeu: 2.946 ± 0.099
0.789GlnMet: 0.789 ± 0.046
2.427GlnAsn: 2.427 ± 0.087
0.876GlnPro: 0.876 ± 0.057
1.597GlnGln: 1.597 ± 0.092
1.189GlnArg: 1.189 ± 0.051
1.854GlnSer: 1.854 ± 0.072
1.581GlnThr: 1.581 ± 0.071
1.749GlnVal: 1.749 ± 0.079
0.186GlnTrp: 0.186 ± 0.027
1.197GlnTyr: 1.197 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
2.197ArgAla: 2.197 ± 0.083
0.346ArgCys: 0.346 ± 0.032
1.711ArgAsp: 1.711 ± 0.071
2.408ArgGlu: 2.408 ± 0.093
1.659ArgPhe: 1.659 ± 0.069
1.959ArgGly: 1.959 ± 0.078
0.768ArgHis: 0.768 ± 0.054
3.278ArgIle: 3.278 ± 0.105
2.746ArgLys: 2.746 ± 0.097
3.67ArgLeu: 3.67 ± 0.11
0.905ArgMet: 0.905 ± 0.048
2.141ArgAsn: 2.141 ± 0.081
0.992ArgPro: 0.992 ± 0.058
1.368ArgGln: 1.368 ± 0.065
1.341ArgArg: 1.341 ± 0.075
2.343ArgSer: 2.343 ± 0.093
1.649ArgThr: 1.649 ± 0.065
2.062ArgVal: 2.062 ± 0.087
0.3ArgTrp: 0.3 ± 0.03
1.368ArgTyr: 1.368 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
3.519SerAla: 3.519 ± 0.092
0.808SerCys: 0.808 ± 0.051
3.411SerAsp: 3.411 ± 0.099
3.638SerGlu: 3.638 ± 0.105
3.638SerPhe: 3.638 ± 0.103
4.343SerGly: 4.343 ± 0.103
1.376SerHis: 1.376 ± 0.068
6.049SerIle: 6.049 ± 0.129
5.711SerLys: 5.711 ± 0.134
7.197SerLeu: 7.197 ± 0.128
1.576SerMet: 1.576 ± 0.071
4.338SerAsn: 4.338 ± 0.128
2.105SerPro: 2.105 ± 0.09
2.03SerGln: 2.03 ± 0.073
2.47SerArg: 2.47 ± 0.088
5.716SerSer: 5.716 ± 0.158
3.527SerThr: 3.527 ± 0.09
3.846SerVal: 3.846 ± 0.099
0.581SerTrp: 0.581 ± 0.046
2.822SerTyr: 2.822 ± 0.09
0.0SerXaa: 0.0 ± 0.0
Thr
3.632ThrAla: 3.632 ± 0.126
0.451ThrCys: 0.451 ± 0.035
2.546ThrAsp: 2.546 ± 0.099
2.884ThrGlu: 2.884 ± 0.091
2.149ThrPhe: 2.149 ± 0.077
3.265ThrGly: 3.265 ± 0.133
0.962ThrHis: 0.962 ± 0.056
5.23ThrIle: 5.23 ± 0.132
4.459ThrLys: 4.459 ± 0.112
5.116ThrLeu: 5.116 ± 0.136
1.076ThrMet: 1.076 ± 0.052
3.278ThrAsn: 3.278 ± 0.125
2.273ThrPro: 2.273 ± 0.081
1.459ThrGln: 1.459 ± 0.074
1.773ThrArg: 1.773 ± 0.074
3.732ThrSer: 3.732 ± 0.108
3.243ThrThr: 3.243 ± 0.147
2.886ThrVal: 2.886 ± 0.092
0.297ThrTrp: 0.297 ± 0.033
1.732ThrTyr: 1.732 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
3.913ValAla: 3.913 ± 0.123
0.592ValCys: 0.592 ± 0.045
2.63ValAsp: 2.63 ± 0.091
3.181ValGlu: 3.181 ± 0.103
2.427ValPhe: 2.427 ± 0.087
3.378ValGly: 3.378 ± 0.13
0.897ValHis: 0.897 ± 0.054
5.849ValIle: 5.849 ± 0.137
4.713ValLys: 4.713 ± 0.133
4.908ValLeu: 4.908 ± 0.138
1.462ValMet: 1.462 ± 0.067
3.276ValAsn: 3.276 ± 0.111
2.011ValPro: 2.011 ± 0.076
1.686ValGln: 1.686 ± 0.075
2.016ValArg: 2.016 ± 0.071
3.83ValSer: 3.83 ± 0.105
3.413ValThr: 3.413 ± 0.115
3.489ValVal: 3.489 ± 0.111
0.368ValTrp: 0.368 ± 0.035
1.711ValTyr: 1.711 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.403TrpAla: 0.403 ± 0.036
0.1TrpCys: 0.1 ± 0.017
0.33TrpAsp: 0.33 ± 0.031
0.368TrpGlu: 0.368 ± 0.032
0.43TrpPhe: 0.43 ± 0.037
0.438TrpGly: 0.438 ± 0.039
0.243TrpHis: 0.243 ± 0.024
0.573TrpIle: 0.573 ± 0.041
0.468TrpLys: 0.468 ± 0.035
0.981TrpLeu: 0.981 ± 0.057
0.17TrpMet: 0.17 ± 0.022
0.386TrpAsn: 0.386 ± 0.033
0.184TrpPro: 0.184 ± 0.024
0.589TrpGln: 0.589 ± 0.044
0.362TrpArg: 0.362 ± 0.031
0.635TrpSer: 0.635 ± 0.047
0.265TrpThr: 0.265 ± 0.025
0.416TrpVal: 0.416 ± 0.031
0.103TrpTrp: 0.103 ± 0.015
0.37TrpTyr: 0.37 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.17TyrAla: 2.17 ± 0.082
0.489TyrCys: 0.489 ± 0.044
1.932TyrAsp: 1.932 ± 0.078
2.008TyrGlu: 2.008 ± 0.079
2.003TyrPhe: 2.003 ± 0.078
2.024TyrGly: 2.024 ± 0.063
0.803TyrHis: 0.803 ± 0.051
3.368TyrIle: 3.368 ± 0.095
3.219TyrLys: 3.219 ± 0.094
4.213TyrLeu: 4.213 ± 0.105
0.838TyrMet: 0.838 ± 0.043
2.797TyrAsn: 2.797 ± 0.084
1.192TyrPro: 1.192 ± 0.06
1.286TyrGln: 1.286 ± 0.063
1.503TyrArg: 1.503 ± 0.061
2.678TyrSer: 2.678 ± 0.092
1.724TyrThr: 1.724 ± 0.067
1.811TyrVal: 1.811 ± 0.068
0.359TyrTrp: 0.359 ± 0.033
1.686TyrTyr: 1.686 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1902 proteins (370007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski