Amino acid dipepetide frequency for Caldicoprobacter faecalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.854AlaAla: 5.854 ± 0.115
0.938AlaCys: 0.938 ± 0.037
3.361AlaAsp: 3.361 ± 0.08
4.685AlaGlu: 4.685 ± 0.087
3.016AlaPhe: 3.016 ± 0.068
5.254AlaGly: 5.254 ± 0.089
1.245AlaHis: 1.245 ± 0.042
5.888AlaIle: 5.888 ± 0.101
4.261AlaLys: 4.261 ± 0.084
7.513AlaLeu: 7.513 ± 0.122
2.111AlaMet: 2.111 ± 0.061
2.332AlaAsn: 2.332 ± 0.055
1.96AlaPro: 1.96 ± 0.048
2.709AlaGln: 2.709 ± 0.065
3.924AlaArg: 3.924 ± 0.085
3.687AlaSer: 3.687 ± 0.077
2.958AlaThr: 2.958 ± 0.062
6.338AlaVal: 6.338 ± 0.09
0.618AlaTrp: 0.618 ± 0.027
2.634AlaTyr: 2.634 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.715CysAla: 0.715 ± 0.031
0.219CysCys: 0.219 ± 0.018
0.592CysAsp: 0.592 ± 0.031
0.615CysGlu: 0.615 ± 0.031
0.437CysPhe: 0.437 ± 0.025
1.094CysGly: 1.094 ± 0.042
0.307CysHis: 0.307 ± 0.021
0.964CysIle: 0.964 ± 0.039
0.664CysLys: 0.664 ± 0.032
0.935CysLeu: 0.935 ± 0.04
0.299CysMet: 0.299 ± 0.02
0.448CysAsn: 0.448 ± 0.027
0.605CysPro: 0.605 ± 0.032
0.362CysGln: 0.362 ± 0.02
0.672CysArg: 0.672 ± 0.031
0.674CysSer: 0.674 ± 0.034
0.56CysThr: 0.56 ± 0.026
0.737CysVal: 0.737 ± 0.035
0.118CysTrp: 0.118 ± 0.014
0.479CysTyr: 0.479 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.538AspAla: 3.538 ± 0.086
0.56AspCys: 0.56 ± 0.033
2.808AspAsp: 2.808 ± 0.065
4.546AspGlu: 4.546 ± 0.096
2.357AspPhe: 2.357 ± 0.057
3.962AspGly: 3.962 ± 0.08
0.796AspHis: 0.796 ± 0.03
5.181AspIle: 5.181 ± 0.086
3.502AspLys: 3.502 ± 0.073
4.559AspLeu: 4.559 ± 0.08
1.567AspMet: 1.567 ± 0.047
1.92AspAsn: 1.92 ± 0.044
2.239AspPro: 2.239 ± 0.069
1.308AspGln: 1.308 ± 0.048
2.743AspArg: 2.743 ± 0.066
2.519AspSer: 2.519 ± 0.057
2.331AspThr: 2.331 ± 0.056
4.531AspVal: 4.531 ± 0.079
0.608AspTrp: 0.608 ± 0.032
2.304AspTyr: 2.304 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
5.425GluAla: 5.425 ± 0.103
0.672GluCys: 0.672 ± 0.031
3.875GluAsp: 3.875 ± 0.087
6.388GluGlu: 6.388 ± 0.128
2.636GluPhe: 2.636 ± 0.068
5.15GluGly: 5.15 ± 0.097
1.196GluHis: 1.196 ± 0.042
5.752GluIle: 5.752 ± 0.098
5.675GluLys: 5.675 ± 0.104
6.744GluLeu: 6.744 ± 0.094
2.295GluMet: 2.295 ± 0.057
3.157GluAsn: 3.157 ± 0.073
2.065GluPro: 2.065 ± 0.054
2.731GluGln: 2.731 ± 0.073
4.298GluArg: 4.298 ± 0.084
2.928GluSer: 2.928 ± 0.061
2.575GluThr: 2.575 ± 0.065
5.762GluVal: 5.762 ± 0.105
0.741GluTrp: 0.741 ± 0.039
3.025GluTyr: 3.025 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
2.688PheAla: 2.688 ± 0.061
0.522PheCys: 0.522 ± 0.027
2.415PheAsp: 2.415 ± 0.055
2.864PheGlu: 2.864 ± 0.062
1.924PhePhe: 1.924 ± 0.06
2.906PheGly: 2.906 ± 0.079
0.653PheHis: 0.653 ± 0.03
3.473PheIle: 3.473 ± 0.076
2.782PheLys: 2.782 ± 0.07
3.74PheLeu: 3.74 ± 0.084
1.182PheMet: 1.182 ± 0.039
1.817PheAsn: 1.817 ± 0.055
1.554PhePro: 1.554 ± 0.049
1.024PheGln: 1.024 ± 0.037
1.674PheArg: 1.674 ± 0.047
2.625PheSer: 2.625 ± 0.06
2.038PheThr: 2.038 ± 0.051
3.065PheVal: 3.065 ± 0.069
0.437PheTrp: 0.437 ± 0.025
1.767PheTyr: 1.767 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.715GlyAla: 4.715 ± 0.106
1.075GlyCys: 1.075 ± 0.042
3.621GlyAsp: 3.621 ± 0.077
4.552GlyGlu: 4.552 ± 0.081
3.287GlyPhe: 3.287 ± 0.069
5.078GlyGly: 5.078 ± 0.104
1.279GlyHis: 1.279 ± 0.042
6.726GlyIle: 6.726 ± 0.091
5.073GlyLys: 5.073 ± 0.095
6.67GlyLeu: 6.67 ± 0.109
2.28GlyMet: 2.28 ± 0.059
2.767GlyAsn: 2.767 ± 0.065
1.917GlyPro: 1.917 ± 0.051
2.501GlyGln: 2.501 ± 0.065
3.954GlyArg: 3.954 ± 0.071
3.428GlySer: 3.428 ± 0.074
3.557GlyThr: 3.557 ± 0.072
5.692GlyVal: 5.692 ± 0.105
0.846GlyTrp: 0.846 ± 0.036
3.097GlyTyr: 3.097 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.089HisAla: 1.089 ± 0.041
0.268HisCys: 0.268 ± 0.019
0.79HisAsp: 0.79 ± 0.03
1.078HisGlu: 1.078 ± 0.034
0.857HisPhe: 0.857 ± 0.035
1.293HisGly: 1.293 ± 0.043
0.418HisHis: 0.418 ± 0.028
1.498HisIle: 1.498 ± 0.041
0.889HisLys: 0.889 ± 0.034
1.502HisLeu: 1.502 ± 0.049
0.489HisMet: 0.489 ± 0.027
0.76HisAsn: 0.76 ± 0.036
1.12HisPro: 1.12 ± 0.041
0.549HisGln: 0.549 ± 0.028
1.034HisArg: 1.034 ± 0.046
0.979HisSer: 0.979 ± 0.038
0.846HisThr: 0.846 ± 0.039
1.187HisVal: 1.187 ± 0.039
0.205HisTrp: 0.205 ± 0.019
0.697HisTyr: 0.697 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.182IleAla: 6.182 ± 0.09
0.874IleCys: 0.874 ± 0.035
4.761IleAsp: 4.761 ± 0.089
6.045IleGlu: 6.045 ± 0.088
3.146IlePhe: 3.146 ± 0.076
5.365IleGly: 5.365 ± 0.098
1.391IleHis: 1.391 ± 0.051
6.264IleIle: 6.264 ± 0.122
5.543IleLys: 5.543 ± 0.099
7.27IleLeu: 7.27 ± 0.118
2.106IleMet: 2.106 ± 0.061
3.36IleAsn: 3.36 ± 0.069
3.853IlePro: 3.853 ± 0.074
2.434IleGln: 2.434 ± 0.056
4.184IleArg: 4.184 ± 0.079
4.826IleSer: 4.826 ± 0.08
3.977IleThr: 3.977 ± 0.077
5.63IleVal: 5.63 ± 0.086
0.66IleTrp: 0.66 ± 0.034
2.888IleTyr: 2.888 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.132LysAla: 5.132 ± 0.092
0.548LysCys: 0.548 ± 0.028
3.766LysAsp: 3.766 ± 0.079
5.869LysGlu: 5.869 ± 0.098
2.041LysPhe: 2.041 ± 0.051
4.895LysGly: 4.895 ± 0.091
1.066LysHis: 1.066 ± 0.04
4.655LysIle: 4.655 ± 0.094
4.928LysLys: 4.928 ± 0.081
5.6LysLeu: 5.6 ± 0.096
1.782LysMet: 1.782 ± 0.055
3.145LysAsn: 3.145 ± 0.066
2.479LysPro: 2.479 ± 0.061
2.265LysGln: 2.265 ± 0.056
3.851LysArg: 3.851 ± 0.076
3.062LysSer: 3.062 ± 0.074
2.736LysThr: 2.736 ± 0.067
5.266LysVal: 5.266 ± 0.092
0.701LysTrp: 0.701 ± 0.031
2.697LysTyr: 2.697 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
6.703LeuAla: 6.703 ± 0.108
1.074LeuCys: 1.074 ± 0.042
5.162LeuAsp: 5.162 ± 0.087
6.996LeuGlu: 6.996 ± 0.112
3.78LeuPhe: 3.78 ± 0.082
6.497LeuGly: 6.497 ± 0.101
1.487LeuHis: 1.487 ± 0.049
6.826LeuIle: 6.826 ± 0.112
7.479LeuLys: 7.479 ± 0.115
8.828LeuLeu: 8.828 ± 0.132
2.53LeuMet: 2.53 ± 0.069
4.022LeuAsn: 4.022 ± 0.084
3.924LeuPro: 3.924 ± 0.072
2.665LeuGln: 2.665 ± 0.063
4.54LeuArg: 4.54 ± 0.077
5.726LeuSer: 5.726 ± 0.094
4.448LeuThr: 4.448 ± 0.072
6.485LeuVal: 6.485 ± 0.093
0.86LeuTrp: 0.86 ± 0.036
3.494LeuTyr: 3.494 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.523MetAla: 2.523 ± 0.058
0.227MetCys: 0.227 ± 0.018
1.728MetAsp: 1.728 ± 0.04
2.213MetGlu: 2.213 ± 0.054
0.887MetPhe: 0.887 ± 0.027
2.261MetGly: 2.261 ± 0.052
0.389MetHis: 0.389 ± 0.02
1.779MetIle: 1.779 ± 0.052
1.894MetLys: 1.894 ± 0.057
2.769MetLeu: 2.769 ± 0.071
0.768MetMet: 0.768 ± 0.033
1.108MetAsn: 1.108 ± 0.039
1.22MetPro: 1.22 ± 0.045
0.855MetGln: 0.855 ± 0.032
1.483MetArg: 1.483 ± 0.046
1.386MetSer: 1.386 ± 0.05
1.123MetThr: 1.123 ± 0.042
2.28MetVal: 2.28 ± 0.059
0.249MetTrp: 0.249 ± 0.02
0.793MetTyr: 0.793 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.871AsnAla: 2.871 ± 0.071
0.511AsnCys: 0.511 ± 0.027
1.839AsnAsp: 1.839 ± 0.051
2.547AsnGlu: 2.547 ± 0.059
1.66AsnPhe: 1.66 ± 0.056
2.865AsnGly: 2.865 ± 0.066
0.631AsnHis: 0.631 ± 0.029
3.698AsnIle: 3.698 ± 0.073
2.336AsnLys: 2.336 ± 0.056
3.758AsnLeu: 3.758 ± 0.085
1.139AsnMet: 1.139 ± 0.033
1.687AsnAsn: 1.687 ± 0.055
2.316AsnPro: 2.316 ± 0.059
1.305AsnGln: 1.305 ± 0.043
2.271AsnArg: 2.271 ± 0.054
2.13AsnSer: 2.13 ± 0.059
1.995AsnThr: 1.995 ± 0.058
2.821AsnVal: 2.821 ± 0.061
0.475AsnTrp: 0.475 ± 0.029
1.637AsnTyr: 1.637 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.516ProAla: 2.516 ± 0.063
0.42ProCys: 0.42 ± 0.026
2.462ProAsp: 2.462 ± 0.064
3.32ProGlu: 3.32 ± 0.074
1.798ProPhe: 1.798 ± 0.047
3.009ProGly: 3.009 ± 0.069
0.934ProHis: 0.934 ± 0.035
2.665ProIle: 2.665 ± 0.065
2.043ProLys: 2.043 ± 0.056
3.421ProLeu: 3.421 ± 0.065
0.885ProMet: 0.885 ± 0.035
1.528ProAsn: 1.528 ± 0.047
1.47ProPro: 1.47 ± 0.048
1.445ProGln: 1.445 ± 0.049
1.764ProArg: 1.764 ± 0.049
2.138ProSer: 2.138 ± 0.06
1.663ProThr: 1.663 ± 0.052
3.546ProVal: 3.546 ± 0.074
0.456ProTrp: 0.456 ± 0.026
1.804ProTyr: 1.804 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.588GlnAla: 2.588 ± 0.067
0.263GlnCys: 0.263 ± 0.019
1.724GlnAsp: 1.724 ± 0.046
2.65GlnGlu: 2.65 ± 0.067
1.03GlnPhe: 1.03 ± 0.039
2.176GlnGly: 2.176 ± 0.048
0.653GlnHis: 0.653 ± 0.027
2.33GlnIle: 2.33 ± 0.057
2.412GlnLys: 2.412 ± 0.064
3.128GlnLeu: 3.128 ± 0.072
0.896GlnMet: 0.896 ± 0.033
1.46GlnAsn: 1.46 ± 0.047
1.402GlnPro: 1.402 ± 0.051
1.619GlnGln: 1.619 ± 0.063
2.121GlnArg: 2.121 ± 0.061
1.413GlnSer: 1.413 ± 0.04
1.292GlnThr: 1.292 ± 0.048
2.345GlnVal: 2.345 ± 0.062
0.345GlnTrp: 0.345 ± 0.024
1.196GlnTyr: 1.196 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.436ArgAla: 3.436 ± 0.068
0.608ArgCys: 0.608 ± 0.027
2.854ArgAsp: 2.854 ± 0.06
4.306ArgGlu: 4.306 ± 0.085
2.304ArgPhe: 2.304 ± 0.053
3.373ArgGly: 3.373 ± 0.068
0.916ArgHis: 0.916 ± 0.036
4.667ArgIle: 4.667 ± 0.076
3.498ArgLys: 3.498 ± 0.077
5.213ArgLeu: 5.213 ± 0.099
1.571ArgMet: 1.571 ± 0.048
2.126ArgAsn: 2.126 ± 0.053
1.843ArgPro: 1.843 ± 0.056
2.182ArgGln: 2.182 ± 0.055
3.054ArgArg: 3.054 ± 0.073
2.264ArgSer: 2.264 ± 0.06
2.178ArgThr: 2.178 ± 0.057
3.976ArgVal: 3.976 ± 0.076
0.635ArgTrp: 0.635 ± 0.034
2.379ArgTyr: 2.379 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
3.424SerAla: 3.424 ± 0.066
0.672SerCys: 0.672 ± 0.03
2.586SerAsp: 2.586 ± 0.062
2.969SerGlu: 2.969 ± 0.071
2.472SerPhe: 2.472 ± 0.06
4.173SerGly: 4.173 ± 0.081
0.967SerHis: 0.967 ± 0.034
4.594SerIle: 4.594 ± 0.092
3.134SerLys: 3.134 ± 0.059
5.251SerLeu: 5.251 ± 0.091
1.494SerMet: 1.494 ± 0.045
1.939SerAsn: 1.939 ± 0.052
2.083SerPro: 2.083 ± 0.052
1.99SerGln: 1.99 ± 0.062
2.975SerArg: 2.975 ± 0.073
3.172SerSer: 3.172 ± 0.072
2.506SerThr: 2.506 ± 0.061
3.654SerVal: 3.654 ± 0.075
0.564SerTrp: 0.564 ± 0.029
2.001SerTyr: 2.001 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
3.472ThrAla: 3.472 ± 0.067
0.479ThrCys: 0.479 ± 0.027
2.205ThrAsp: 2.205 ± 0.053
2.412ThrGlu: 2.412 ± 0.071
1.937ThrPhe: 1.937 ± 0.05
4.025ThrGly: 4.025 ± 0.084
0.894ThrHis: 0.894 ± 0.041
3.602ThrIle: 3.602 ± 0.068
2.232ThrLys: 2.232 ± 0.055
4.326ThrLeu: 4.326 ± 0.076
1.1ThrMet: 1.1 ± 0.045
1.663ThrAsn: 1.663 ± 0.055
2.163ThrPro: 2.163 ± 0.059
1.411ThrGln: 1.411 ± 0.04
2.273ThrArg: 2.273 ± 0.057
2.523ThrSer: 2.523 ± 0.064
2.29ThrThr: 2.29 ± 0.062
3.909ThrVal: 3.909 ± 0.078
0.389ThrTrp: 0.389 ± 0.024
1.601ThrTyr: 1.601 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.291ValAla: 5.291 ± 0.101
0.908ValCys: 0.908 ± 0.035
4.561ValAsp: 4.561 ± 0.092
5.988ValGlu: 5.988 ± 0.107
3.247ValPhe: 3.247 ± 0.067
5.026ValGly: 5.026 ± 0.098
1.32ValHis: 1.32 ± 0.044
6.259ValIle: 6.259 ± 0.102
5.072ValLys: 5.072 ± 0.086
7.67ValLeu: 7.67 ± 0.105
2.121ValMet: 2.121 ± 0.054
2.951ValAsn: 2.951 ± 0.066
3.031ValPro: 3.031 ± 0.06
2.076ValGln: 2.076 ± 0.072
3.654ValArg: 3.654 ± 0.076
4.306ValSer: 4.306 ± 0.08
3.538ValThr: 3.538 ± 0.074
6.585ValVal: 6.585 ± 0.094
0.696ValTrp: 0.696 ± 0.031
2.951ValTyr: 2.951 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.688TrpAla: 0.688 ± 0.034
0.122TrpCys: 0.122 ± 0.014
0.548TrpAsp: 0.548 ± 0.03
0.751TrpGlu: 0.751 ± 0.032
0.449TrpPhe: 0.449 ± 0.026
0.772TrpGly: 0.772 ± 0.034
0.237TrpHis: 0.237 ± 0.021
0.725TrpIle: 0.725 ± 0.032
0.66TrpLys: 0.66 ± 0.03
1.05TrpLeu: 1.05 ± 0.046
0.315TrpMet: 0.315 ± 0.022
0.5TrpAsn: 0.5 ± 0.029
0.322TrpPro: 0.322 ± 0.022
0.363TrpGln: 0.363 ± 0.023
0.533TrpArg: 0.533 ± 0.032
0.489TrpSer: 0.489 ± 0.025
0.345TrpThr: 0.345 ± 0.028
0.759TrpVal: 0.759 ± 0.036
0.155TrpTrp: 0.155 ± 0.016
0.375TrpTyr: 0.375 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.436TyrAla: 2.436 ± 0.058
0.534TyrCys: 0.534 ± 0.025
2.22TyrAsp: 2.22 ± 0.06
2.297TyrGlu: 2.297 ± 0.059
1.886TyrPhe: 1.886 ± 0.053
2.94TyrGly: 2.94 ± 0.067
0.771TyrHis: 0.771 ± 0.033
3.213TyrIle: 3.213 ± 0.064
2.406TyrLys: 2.406 ± 0.057
3.577TyrLeu: 3.577 ± 0.083
1.007TyrMet: 1.007 ± 0.044
1.805TyrAsn: 1.805 ± 0.054
1.72TyrPro: 1.72 ± 0.055
1.25TyrGln: 1.25 ± 0.037
2.38TyrArg: 2.38 ± 0.06
2.345TyrSer: 2.345 ± 0.059
1.949TyrThr: 1.949 ± 0.058
2.683TyrVal: 2.683 ± 0.055
0.397TyrTrp: 0.397 ± 0.026
1.767TyrTyr: 1.767 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2413 proteins (730157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski