Amino acid dipepetide frequency for Brevifollis gellanilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.287AlaAla: 12.287 ± 0.107
0.968AlaCys: 0.968 ± 0.02
5.751AlaAsp: 5.751 ± 0.059
6.322AlaGlu: 6.322 ± 0.084
3.569AlaPhe: 3.569 ± 0.044
8.797AlaGly: 8.797 ± 0.123
1.977AlaHis: 1.977 ± 0.036
4.357AlaIle: 4.357 ± 0.047
5.01AlaLys: 5.01 ± 0.084
10.278AlaLeu: 10.278 ± 0.098
2.553AlaMet: 2.553 ± 0.039
3.251AlaAsn: 3.251 ± 0.077
5.321AlaPro: 5.321 ± 0.078
3.797AlaGln: 3.797 ± 0.044
5.688AlaArg: 5.688 ± 0.066
6.514AlaSer: 6.514 ± 0.071
6.105AlaThr: 6.105 ± 0.12
6.732AlaVal: 6.732 ± 0.064
1.65AlaTrp: 1.65 ± 0.031
2.162AlaTyr: 2.162 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.868CysAla: 0.868 ± 0.021
0.125CysCys: 0.125 ± 0.008
0.506CysAsp: 0.506 ± 0.017
0.527CysGlu: 0.527 ± 0.018
0.41CysPhe: 0.41 ± 0.013
0.862CysGly: 0.862 ± 0.024
0.383CysHis: 0.383 ± 0.016
0.429CysIle: 0.429 ± 0.016
0.258CysLys: 0.258 ± 0.011
1.061CysLeu: 1.061 ± 0.027
0.185CysMet: 0.185 ± 0.01
0.212CysAsn: 0.212 ± 0.01
0.474CysPro: 0.474 ± 0.023
0.328CysGln: 0.328 ± 0.013
0.514CysArg: 0.514 ± 0.017
0.528CysSer: 0.528 ± 0.017
0.5CysThr: 0.5 ± 0.015
0.666CysVal: 0.666 ± 0.02
0.163CysTrp: 0.163 ± 0.009
0.274CysTyr: 0.274 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
5.676AspAla: 5.676 ± 0.066
0.452AspCys: 0.452 ± 0.015
2.936AspAsp: 2.936 ± 0.057
3.401AspGlu: 3.401 ± 0.055
2.364AspPhe: 2.364 ± 0.036
5.193AspGly: 5.193 ± 0.085
1.41AspHis: 1.41 ± 0.025
2.459AspIle: 2.459 ± 0.042
2.331AspLys: 2.331 ± 0.044
5.557AspLeu: 5.557 ± 0.056
1.108AspMet: 1.108 ± 0.023
1.633AspAsn: 1.633 ± 0.05
3.122AspPro: 3.122 ± 0.051
1.795AspGln: 1.795 ± 0.033
2.85AspArg: 2.85 ± 0.049
2.911AspSer: 2.911 ± 0.06
2.781AspThr: 2.781 ± 0.051
3.688AspVal: 3.688 ± 0.047
1.007AspTrp: 1.007 ± 0.024
1.599AspTyr: 1.599 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
6.426GluAla: 6.426 ± 0.101
0.461GluCys: 0.461 ± 0.015
2.727GluAsp: 2.727 ± 0.042
3.389GluGlu: 3.389 ± 0.069
2.138GluPhe: 2.138 ± 0.036
4.358GluGly: 4.358 ± 0.054
1.37GluHis: 1.37 ± 0.033
3.07GluIle: 3.07 ± 0.048
3.443GluLys: 3.443 ± 0.066
5.524GluLeu: 5.524 ± 0.06
1.59GluMet: 1.59 ± 0.033
1.776GluAsn: 1.776 ± 0.034
2.648GluPro: 2.648 ± 0.042
2.205GluGln: 2.205 ± 0.043
3.497GluArg: 3.497 ± 0.066
3.087GluSer: 3.087 ± 0.042
3.139GluThr: 3.139 ± 0.044
4.232GluVal: 4.232 ± 0.054
0.956GluTrp: 0.956 ± 0.024
1.184GluTyr: 1.184 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.619PheAla: 3.619 ± 0.043
0.398PheCys: 0.398 ± 0.014
2.395PheAsp: 2.395 ± 0.038
2.141PheGlu: 2.141 ± 0.04
1.528PhePhe: 1.528 ± 0.033
3.3PheGly: 3.3 ± 0.04
0.864PheHis: 0.864 ± 0.022
1.888PheIle: 1.888 ± 0.032
1.446PheLys: 1.446 ± 0.028
3.405PheLeu: 3.405 ± 0.049
0.807PheMet: 0.807 ± 0.024
1.358PheAsn: 1.358 ± 0.035
1.727PhePro: 1.727 ± 0.029
1.289PheGln: 1.289 ± 0.025
2.099PheArg: 2.099 ± 0.036
2.565PheSer: 2.565 ± 0.036
2.792PheThr: 2.792 ± 0.059
2.482PheVal: 2.482 ± 0.037
0.57PheTrp: 0.57 ± 0.019
1.023PheTyr: 1.023 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
7.515GlyAla: 7.515 ± 0.109
0.859GlyCys: 0.859 ± 0.026
4.394GlyAsp: 4.394 ± 0.058
4.298GlyGlu: 4.298 ± 0.053
3.339GlyPhe: 3.339 ± 0.044
7.696GlyGly: 7.696 ± 0.161
1.83GlyHis: 1.83 ± 0.034
4.16GlyIle: 4.16 ± 0.046
4.547GlyLys: 4.547 ± 0.069
7.478GlyLeu: 7.478 ± 0.072
2.051GlyMet: 2.051 ± 0.034
2.925GlyAsn: 2.925 ± 0.092
3.07GlyPro: 3.07 ± 0.039
2.967GlyGln: 2.967 ± 0.044
4.579GlyArg: 4.579 ± 0.057
5.8GlySer: 5.8 ± 0.123
6.068GlyThr: 6.068 ± 0.21
5.799GlyVal: 5.799 ± 0.085
1.535GlyTrp: 1.535 ± 0.027
2.347GlyTyr: 2.347 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.249HisAla: 2.249 ± 0.036
0.274HisCys: 0.274 ± 0.012
1.254HisAsp: 1.254 ± 0.025
1.409HisGlu: 1.409 ± 0.032
1.012HisPhe: 1.012 ± 0.023
2.047HisGly: 2.047 ± 0.04
0.711HisHis: 0.711 ± 0.02
0.962HisIle: 0.962 ± 0.023
0.65HisLys: 0.65 ± 0.02
2.468HisLeu: 2.468 ± 0.04
0.452HisMet: 0.452 ± 0.016
0.617HisAsn: 0.617 ± 0.017
1.59HisPro: 1.59 ± 0.033
0.797HisGln: 0.797 ± 0.021
1.359HisArg: 1.359 ± 0.03
1.219HisSer: 1.219 ± 0.022
1.191HisThr: 1.191 ± 0.023
1.572HisVal: 1.572 ± 0.031
0.46HisTrp: 0.46 ± 0.015
0.673HisTyr: 0.673 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
5.096IleAla: 5.096 ± 0.053
0.527IleCys: 0.527 ± 0.016
2.715IleAsp: 2.715 ± 0.039
2.996IleGlu: 2.996 ± 0.052
1.615IlePhe: 1.615 ± 0.028
3.789IleGly: 3.789 ± 0.052
1.12IleHis: 1.12 ± 0.028
2.355IleIle: 2.355 ± 0.038
1.807IleLys: 1.807 ± 0.036
4.078IleLeu: 4.078 ± 0.055
0.873IleMet: 0.873 ± 0.02
1.599IleAsn: 1.599 ± 0.052
2.428IlePro: 2.428 ± 0.039
1.71IleGln: 1.71 ± 0.029
2.663IleArg: 2.663 ± 0.034
3.259IleSer: 3.259 ± 0.054
3.788IleThr: 3.788 ± 0.076
3.367IleVal: 3.367 ± 0.036
0.591IleTrp: 0.591 ± 0.016
1.202IleTyr: 1.202 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
5.041LysAla: 5.041 ± 0.076
0.289LysCys: 0.289 ± 0.013
2.742LysAsp: 2.742 ± 0.053
2.72LysGlu: 2.72 ± 0.052
1.353LysPhe: 1.353 ± 0.029
3.362LysGly: 3.362 ± 0.051
1.092LysHis: 1.092 ± 0.026
2.133LysIle: 2.133 ± 0.036
2.626LysLys: 2.626 ± 0.056
4.76LysLeu: 4.76 ± 0.073
1.226LysMet: 1.226 ± 0.028
1.425LysAsn: 1.425 ± 0.027
3.205LysPro: 3.205 ± 0.063
1.631LysGln: 1.631 ± 0.032
2.543LysArg: 2.543 ± 0.05
2.425LysSer: 2.425 ± 0.045
2.732LysThr: 2.732 ± 0.044
3.204LysVal: 3.204 ± 0.05
0.627LysTrp: 0.627 ± 0.018
0.862LysTyr: 0.862 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
10.538LeuAla: 10.538 ± 0.087
1.061LeuCys: 1.061 ± 0.025
5.297LeuAsp: 5.297 ± 0.051
5.346LeuGlu: 5.346 ± 0.074
3.333LeuPhe: 3.333 ± 0.042
7.615LeuGly: 7.615 ± 0.078
2.273LeuHis: 2.273 ± 0.035
4.49LeuIle: 4.49 ± 0.051
4.749LeuLys: 4.749 ± 0.069
9.67LeuLeu: 9.67 ± 0.108
2.302LeuMet: 2.302 ± 0.038
3.359LeuAsn: 3.359 ± 0.057
6.017LeuPro: 6.017 ± 0.066
3.374LeuGln: 3.374 ± 0.042
6.2LeuArg: 6.2 ± 0.072
6.412LeuSer: 6.412 ± 0.06
6.635LeuThr: 6.635 ± 0.107
6.487LeuVal: 6.487 ± 0.061
1.394LeuTrp: 1.394 ± 0.032
2.104LeuTyr: 2.104 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.291MetAla: 2.291 ± 0.042
0.173MetCys: 0.173 ± 0.008
1.165MetAsp: 1.165 ± 0.021
1.248MetGlu: 1.248 ± 0.025
0.677MetPhe: 0.677 ± 0.019
1.593MetGly: 1.593 ± 0.03
0.557MetHis: 0.557 ± 0.02
1.199MetIle: 1.199 ± 0.028
1.546MetLys: 1.546 ± 0.033
2.31MetLeu: 2.31 ± 0.04
0.599MetMet: 0.599 ± 0.018
0.964MetAsn: 0.964 ± 0.024
1.599MetPro: 1.599 ± 0.031
0.882MetGln: 0.882 ± 0.022
1.53MetArg: 1.53 ± 0.033
1.592MetSer: 1.592 ± 0.029
1.523MetThr: 1.523 ± 0.028
1.439MetVal: 1.439 ± 0.026
0.251MetTrp: 0.251 ± 0.012
0.324MetTyr: 0.324 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.455AsnAla: 3.455 ± 0.076
0.297AsnCys: 0.297 ± 0.012
1.862AsnAsp: 1.862 ± 0.049
1.673AsnGlu: 1.673 ± 0.028
1.268AsnPhe: 1.268 ± 0.032
3.359AsnGly: 3.359 ± 0.106
0.707AsnHis: 0.707 ± 0.018
1.573AsnIle: 1.573 ± 0.039
1.128AsnLys: 1.128 ± 0.024
3.204AsnLeu: 3.204 ± 0.057
0.592AsnMet: 0.592 ± 0.015
1.325AsnAsn: 1.325 ± 0.059
2.22AsnPro: 2.22 ± 0.039
1.127AsnGln: 1.127 ± 0.027
1.692AsnArg: 1.692 ± 0.025
1.938AsnSer: 1.938 ± 0.057
2.107AsnThr: 2.107 ± 0.079
2.294AsnVal: 2.294 ± 0.056
0.53AsnTrp: 0.53 ± 0.014
0.956AsnTyr: 0.956 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.556ProAla: 6.556 ± 0.087
0.362ProCys: 0.362 ± 0.013
3.374ProAsp: 3.374 ± 0.048
4.059ProGlu: 4.059 ± 0.065
1.879ProPhe: 1.879 ± 0.035
4.772ProGly: 4.772 ± 0.069
1.115ProHis: 1.115 ± 0.022
2.01ProIle: 2.01 ± 0.032
2.557ProLys: 2.557 ± 0.049
4.721ProLeu: 4.721 ± 0.055
1.318ProMet: 1.318 ± 0.026
1.861ProAsn: 1.861 ± 0.034
3.199ProPro: 3.199 ± 0.057
1.938ProGln: 1.938 ± 0.032
2.409ProArg: 2.409 ± 0.04
3.159ProSer: 3.159 ± 0.047
3.065ProThr: 3.065 ± 0.06
4.397ProVal: 4.397 ± 0.061
0.805ProTrp: 0.805 ± 0.02
1.153ProTyr: 1.153 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.803GlnAla: 3.803 ± 0.059
0.279GlnCys: 0.279 ± 0.014
1.638GlnAsp: 1.638 ± 0.027
1.875GlnGlu: 1.875 ± 0.036
1.296GlnPhe: 1.296 ± 0.021
2.716GlnGly: 2.716 ± 0.038
0.878GlnHis: 0.878 ± 0.023
1.99GlnIle: 1.99 ± 0.034
1.779GlnLys: 1.779 ± 0.032
3.274GlnLeu: 3.274 ± 0.044
0.964GlnMet: 0.964 ± 0.024
1.171GlnAsn: 1.171 ± 0.025
2.244GlnPro: 2.244 ± 0.035
1.616GlnGln: 1.616 ± 0.044
2.496GlnArg: 2.496 ± 0.045
2.093GlnSer: 2.093 ± 0.031
2.212GlnThr: 2.212 ± 0.038
2.556GlnVal: 2.556 ± 0.033
0.662GlnTrp: 0.662 ± 0.019
0.661GlnTyr: 0.661 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
5.123ArgAla: 5.123 ± 0.053
0.571ArgCys: 0.571 ± 0.019
3.301ArgAsp: 3.301 ± 0.049
3.878ArgGlu: 3.878 ± 0.063
2.485ArgPhe: 2.485 ± 0.038
3.925ArgGly: 3.925 ± 0.05
1.452ArgHis: 1.452 ± 0.034
3.027ArgIle: 3.027 ± 0.042
2.247ArgLys: 2.247 ± 0.042
6.329ArgLeu: 6.329 ± 0.075
1.571ArgMet: 1.571 ± 0.032
1.632ArgAsn: 1.632 ± 0.03
2.601ArgPro: 2.601 ± 0.044
2.292ArgGln: 2.292 ± 0.043
3.755ArgArg: 3.755 ± 0.059
3.189ArgSer: 3.189 ± 0.042
2.887ArgThr: 2.887 ± 0.042
4.191ArgVal: 4.191 ± 0.05
1.115ArgTrp: 1.115 ± 0.025
1.6ArgTyr: 1.6 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.374SerAla: 6.374 ± 0.071
0.559SerCys: 0.559 ± 0.016
3.112SerAsp: 3.112 ± 0.051
2.934SerGlu: 2.934 ± 0.043
2.631SerPhe: 2.631 ± 0.043
6.312SerGly: 6.312 ± 0.152
1.368SerHis: 1.368 ± 0.028
3.041SerIle: 3.041 ± 0.047
2.352SerLys: 2.352 ± 0.038
6.39SerLeu: 6.39 ± 0.063
1.41SerMet: 1.41 ± 0.025
2.067SerAsn: 2.067 ± 0.058
3.49SerPro: 3.49 ± 0.048
2.114SerGln: 2.114 ± 0.033
3.283SerArg: 3.283 ± 0.048
4.365SerSer: 4.365 ± 0.078
3.99SerThr: 3.99 ± 0.097
4.118SerVal: 4.118 ± 0.056
0.973SerTrp: 0.973 ± 0.023
1.547SerTyr: 1.547 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
6.429ThrAla: 6.429 ± 0.113
0.493ThrCys: 0.493 ± 0.017
3.191ThrAsp: 3.191 ± 0.067
2.889ThrGlu: 2.889 ± 0.042
2.555ThrPhe: 2.555 ± 0.048
5.898ThrGly: 5.898 ± 0.167
1.299ThrHis: 1.299 ± 0.026
2.914ThrIle: 2.914 ± 0.077
2.447ThrLys: 2.447 ± 0.037
7.137ThrLeu: 7.137 ± 0.151
1.201ThrMet: 1.201 ± 0.025
2.108ThrAsn: 2.108 ± 0.074
4.071ThrPro: 4.071 ± 0.066
2.141ThrGln: 2.141 ± 0.03
3.081ThrArg: 3.081 ± 0.041
4.106ThrSer: 4.106 ± 0.099
4.302ThrThr: 4.302 ± 0.157
4.581ThrVal: 4.581 ± 0.111
1.011ThrTrp: 1.011 ± 0.027
1.573ThrTyr: 1.573 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.328ValAla: 6.328 ± 0.059
0.727ValCys: 0.727 ± 0.019
3.575ValAsp: 3.575 ± 0.045
3.916ValGlu: 3.916 ± 0.053
2.596ValPhe: 2.596 ± 0.039
4.651ValGly: 4.651 ± 0.06
1.446ValHis: 1.446 ± 0.027
3.825ValIle: 3.825 ± 0.044
3.373ValLys: 3.373 ± 0.056
6.789ValLeu: 6.789 ± 0.058
1.756ValMet: 1.756 ± 0.036
2.556ValAsn: 2.556 ± 0.057
3.814ValPro: 3.814 ± 0.048
2.393ValGln: 2.393 ± 0.033
4.18ValArg: 4.18 ± 0.046
4.746ValSer: 4.746 ± 0.061
5.157ValThr: 5.157 ± 0.115
4.963ValVal: 4.963 ± 0.066
1.043ValTrp: 1.043 ± 0.029
1.566ValTyr: 1.566 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.17TrpAla: 1.17 ± 0.026
0.158TrpCys: 0.158 ± 0.008
0.837TrpAsp: 0.837 ± 0.022
0.79TrpGlu: 0.79 ± 0.02
0.617TrpPhe: 0.617 ± 0.019
1.005TrpGly: 1.005 ± 0.028
0.447TrpHis: 0.447 ± 0.014
0.775TrpIle: 0.775 ± 0.021
0.916TrpLys: 0.916 ± 0.025
1.882TrpLeu: 1.882 ± 0.038
0.49TrpMet: 0.49 ± 0.014
0.62TrpAsn: 0.62 ± 0.018
0.695TrpPro: 0.695 ± 0.021
0.819TrpGln: 0.819 ± 0.019
1.131TrpArg: 1.131 ± 0.023
1.085TrpSer: 1.085 ± 0.029
0.985TrpThr: 0.985 ± 0.024
0.977TrpVal: 0.977 ± 0.024
0.306TrpTrp: 0.306 ± 0.013
0.321TrpTyr: 0.321 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.25TyrAla: 2.25 ± 0.035
0.237TyrCys: 0.237 ± 0.011
1.502TyrAsp: 1.502 ± 0.034
1.411TyrGlu: 1.411 ± 0.03
1.035TyrPhe: 1.035 ± 0.025
2.008TyrGly: 2.008 ± 0.028
0.663TyrHis: 0.663 ± 0.019
0.922TyrIle: 0.922 ± 0.022
0.785TyrLys: 0.785 ± 0.019
2.339TyrLeu: 2.339 ± 0.039
0.415TyrMet: 0.415 ± 0.014
0.846TyrAsn: 0.846 ± 0.024
1.173TyrPro: 1.173 ± 0.027
0.988TyrGln: 0.988 ± 0.023
1.621TyrArg: 1.621 ± 0.032
1.439TyrSer: 1.439 ± 0.044
1.47TyrThr: 1.47 ± 0.045
1.652TyrVal: 1.652 ± 0.028
0.374TyrTrp: 0.374 ± 0.012
0.743TyrTyr: 0.743 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5783 proteins (2267602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski