Amino acid dipepetide frequency for Nanoarchaeum equitans (strain Kin4-M)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.72AlaAla: 2.72 ± 0.191
0.337AlaCys: 0.337 ± 0.059
1.869AlaAsp: 1.869 ± 0.104
2.892AlaGlu: 2.892 ± 0.16
2.37AlaPhe: 2.37 ± 0.151
2.509AlaGly: 2.509 ± 0.141
0.779AlaHis: 0.779 ± 0.084
6.629AlaIle: 6.629 ± 0.22
6.207AlaLys: 6.207 ± 0.209
6.675AlaLeu: 6.675 ± 0.236
0.977AlaMet: 0.977 ± 0.08
2.648AlaAsn: 2.648 ± 0.138
1.426AlaPro: 1.426 ± 0.102
1.393AlaGln: 1.393 ± 0.115
2.384AlaArg: 2.384 ± 0.142
2.146AlaSer: 2.146 ± 0.132
1.783AlaThr: 1.783 ± 0.106
3.103AlaVal: 3.103 ± 0.15
0.475AlaTrp: 0.475 ± 0.054
2.535AlaTyr: 2.535 ± 0.152
0.0AlaXaa: 0.0 ± 0.0
Cys
0.324CysAla: 0.324 ± 0.049
0.106CysCys: 0.106 ± 0.026
0.469CysAsp: 0.469 ± 0.071
0.588CysGlu: 0.588 ± 0.071
0.31CysPhe: 0.31 ± 0.043
0.733CysGly: 0.733 ± 0.079
0.132CysHis: 0.132 ± 0.027
0.614CysIle: 0.614 ± 0.085
0.806CysLys: 0.806 ± 0.086
0.581CysLeu: 0.581 ± 0.065
0.099CysMet: 0.099 ± 0.025
0.555CysAsn: 0.555 ± 0.064
0.607CysPro: 0.607 ± 0.069
0.132CysGln: 0.132 ± 0.033
0.178CysArg: 0.178 ± 0.039
0.508CysSer: 0.508 ± 0.064
0.363CysThr: 0.363 ± 0.067
0.376CysVal: 0.376 ± 0.056
0.106CysTrp: 0.106 ± 0.03
0.515CysTyr: 0.515 ± 0.071
0.0CysXaa: 0.0 ± 0.0
Asp
2.053AspAla: 2.053 ± 0.143
0.456AspCys: 0.456 ± 0.061
1.743AspAsp: 1.743 ± 0.109
3.202AspGlu: 3.202 ± 0.168
2.384AspPhe: 2.384 ± 0.119
2.417AspGly: 2.417 ± 0.158
0.548AspHis: 0.548 ± 0.064
5.718AspIle: 5.718 ± 0.188
5.394AspLys: 5.394 ± 0.192
5.857AspLeu: 5.857 ± 0.218
0.799AspMet: 0.799 ± 0.07
2.489AspAsn: 2.489 ± 0.158
2.258AspPro: 2.258 ± 0.138
0.806AspGln: 0.806 ± 0.083
1.981AspArg: 1.981 ± 0.122
2.443AspSer: 2.443 ± 0.171
2.02AspThr: 2.02 ± 0.122
3.255AspVal: 3.255 ± 0.164
0.693AspTrp: 0.693 ± 0.066
3.202AspTyr: 3.202 ± 0.16
0.0AspXaa: 0.0 ± 0.0
Glu
3.717GluAla: 3.717 ± 0.184
0.429GluCys: 0.429 ± 0.062
3.097GluAsp: 3.097 ± 0.144
7.705GluGlu: 7.705 ± 0.346
3.46GluPhe: 3.46 ± 0.162
4.1GluGly: 4.1 ± 0.166
0.997GluHis: 0.997 ± 0.081
8.451GluIle: 8.451 ± 0.273
10.313GluLys: 10.313 ± 0.375
8.425GluLeu: 8.425 ± 0.285
1.301GluMet: 1.301 ± 0.096
4.351GluAsn: 4.351 ± 0.164
2.086GluPro: 2.086 ± 0.122
2.219GluGln: 2.219 ± 0.133
3.183GluArg: 3.183 ± 0.17
2.932GluSer: 2.932 ± 0.141
2.965GluThr: 2.965 ± 0.164
4.061GluVal: 4.061 ± 0.202
0.898GluTrp: 0.898 ± 0.076
4.113GluTyr: 4.113 ± 0.165
0.0GluXaa: 0.0 ± 0.0
Phe
2.417PheAla: 2.417 ± 0.142
0.423PheCys: 0.423 ± 0.054
2.628PheAsp: 2.628 ± 0.138
3.011PheGlu: 3.011 ± 0.134
2.185PhePhe: 2.185 ± 0.128
2.463PheGly: 2.463 ± 0.12
0.568PheHis: 0.568 ± 0.07
4.133PheIle: 4.133 ± 0.216
3.288PheLys: 3.288 ± 0.135
4.853PheLeu: 4.853 ± 0.211
0.806PheMet: 0.806 ± 0.072
2.337PheAsn: 2.337 ± 0.146
1.71PhePro: 1.71 ± 0.114
0.673PheGln: 0.673 ± 0.064
1.789PheArg: 1.789 ± 0.104
2.535PheSer: 2.535 ± 0.122
1.723PheThr: 1.723 ± 0.106
3.433PheVal: 3.433 ± 0.164
0.39PheTrp: 0.39 ± 0.054
2.978PheTyr: 2.978 ± 0.158
0.0PheXaa: 0.0 ± 0.0
Gly
2.146GlyAla: 2.146 ± 0.149
0.403GlyCys: 0.403 ± 0.051
2.582GlyAsp: 2.582 ± 0.157
4.186GlyGlu: 4.186 ± 0.167
2.727GlyPhe: 2.727 ± 0.13
2.595GlyGly: 2.595 ± 0.188
0.924GlyHis: 0.924 ± 0.077
5.777GlyIle: 5.777 ± 0.182
6.537GlyLys: 6.537 ± 0.209
5.295GlyLeu: 5.295 ± 0.193
0.733GlyMet: 0.733 ± 0.078
2.905GlyAsn: 2.905 ± 0.134
1.505GlyPro: 1.505 ± 0.118
1.175GlyGln: 1.175 ± 0.093
2.185GlyArg: 2.185 ± 0.144
2.344GlySer: 2.344 ± 0.145
2.357GlyThr: 2.357 ± 0.146
2.938GlyVal: 2.938 ± 0.152
0.495GlyTrp: 0.495 ± 0.05
3.222GlyTyr: 3.222 ± 0.146
0.0GlyXaa: 0.0 ± 0.0
His
0.72HisAla: 0.72 ± 0.075
0.152HisCys: 0.152 ± 0.031
0.39HisAsp: 0.39 ± 0.056
0.621HisGlu: 0.621 ± 0.059
0.621HisPhe: 0.621 ± 0.065
0.885HisGly: 0.885 ± 0.073
0.244HisHis: 0.244 ± 0.036
1.466HisIle: 1.466 ± 0.107
1.155HisLys: 1.155 ± 0.093
1.499HisLeu: 1.499 ± 0.098
0.264HisMet: 0.264 ± 0.043
0.64HisAsn: 0.64 ± 0.07
0.759HisPro: 0.759 ± 0.066
0.224HisGln: 0.224 ± 0.04
0.621HisArg: 0.621 ± 0.067
0.654HisSer: 0.654 ± 0.061
0.614HisThr: 0.614 ± 0.064
0.839HisVal: 0.839 ± 0.09
0.172HisTrp: 0.172 ± 0.03
0.891HisTyr: 0.891 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
6.755IleAla: 6.755 ± 0.201
0.555IleCys: 0.555 ± 0.069
6.913IleAsp: 6.913 ± 0.236
10.564IleGlu: 10.564 ± 0.275
3.579IlePhe: 3.579 ± 0.141
5.368IleGly: 5.368 ± 0.225
1.334IleHis: 1.334 ± 0.103
9.937IleIle: 9.937 ± 0.317
11.759IleLys: 11.759 ± 0.312
9.151IleLeu: 9.151 ± 0.328
1.684IleMet: 1.684 ± 0.103
5.52IleAsn: 5.52 ± 0.232
4.807IlePro: 4.807 ± 0.196
1.71IleGln: 1.71 ± 0.096
3.816IleArg: 3.816 ± 0.184
4.437IleSer: 4.437 ± 0.196
4.054IleThr: 4.054 ± 0.186
6.966IleVal: 6.966 ± 0.247
0.693IleTrp: 0.693 ± 0.076
4.959IleTyr: 4.959 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
6.141LysAla: 6.141 ± 0.194
1.004LysCys: 1.004 ± 0.111
6.141LysAsp: 6.141 ± 0.233
11.931LysGlu: 11.931 ± 0.376
3.499LysPhe: 3.499 ± 0.173
5.441LysGly: 5.441 ± 0.197
1.73LysHis: 1.73 ± 0.113
10.828LysIle: 10.828 ± 0.277
11.205LysLys: 11.205 ± 0.369
9.765LysLeu: 9.765 ± 0.267
2.166LysMet: 2.166 ± 0.122
5.183LysAsn: 5.183 ± 0.187
4.562LysPro: 4.562 ± 0.188
3.05LysGln: 3.05 ± 0.144
4.279LysArg: 4.279 ± 0.172
3.651LysSer: 3.651 ± 0.149
5.038LysThr: 5.038 ± 0.184
6.081LysVal: 6.081 ± 0.239
0.891LysTrp: 0.891 ± 0.078
5.678LysTyr: 5.678 ± 0.191
0.0LysXaa: 0.0 ± 0.0
Leu
6.596LeuAla: 6.596 ± 0.247
0.581LeuCys: 0.581 ± 0.066
6.114LeuAsp: 6.114 ± 0.233
8.729LeuGlu: 8.729 ± 0.329
4.906LeuPhe: 4.906 ± 0.245
5.612LeuGly: 5.612 ± 0.211
1.202LeuHis: 1.202 ± 0.095
8.94LeuIle: 8.94 ± 0.298
10.894LeuLys: 10.894 ± 0.264
11.271LeuLeu: 11.271 ± 0.383
1.796LeuMet: 1.796 ± 0.128
4.833LeuAsn: 4.833 ± 0.202
4.371LeuPro: 4.371 ± 0.16
1.921LeuGln: 1.921 ± 0.111
3.777LeuArg: 3.777 ± 0.164
5.923LeuSer: 5.923 ± 0.243
4.094LeuThr: 4.094 ± 0.157
6.015LeuVal: 6.015 ± 0.195
0.806LeuTrp: 0.806 ± 0.074
5.843LeuTyr: 5.843 ± 0.22
0.0LeuXaa: 0.0 ± 0.0
Met
1.063MetAla: 1.063 ± 0.078
0.066MetCys: 0.066 ± 0.023
1.07MetAsp: 1.07 ± 0.083
1.367MetGlu: 1.367 ± 0.103
0.858MetPhe: 0.858 ± 0.07
1.103MetGly: 1.103 ± 0.097
0.291MetHis: 0.291 ± 0.048
1.122MetIle: 1.122 ± 0.086
1.624MetLys: 1.624 ± 0.112
1.71MetLeu: 1.71 ± 0.116
0.277MetMet: 0.277 ± 0.053
0.687MetAsn: 0.687 ± 0.066
1.05MetPro: 1.05 ± 0.087
0.574MetGln: 0.574 ± 0.059
1.05MetArg: 1.05 ± 0.077
0.627MetSer: 0.627 ± 0.063
0.357MetThr: 0.357 ± 0.057
1.439MetVal: 1.439 ± 0.1
0.125MetTrp: 0.125 ± 0.028
0.568MetTyr: 0.568 ± 0.06
0.0MetXaa: 0.0 ± 0.0
Asn
2.384AsnAla: 2.384 ± 0.128
0.555AsnCys: 0.555 ± 0.07
2.126AsnAsp: 2.126 ± 0.125
3.222AsnGlu: 3.222 ± 0.151
2.034AsnPhe: 2.034 ± 0.123
2.727AsnGly: 2.727 ± 0.163
0.482AsnHis: 0.482 ± 0.051
5.949AsnIle: 5.949 ± 0.285
6.286AsnLys: 6.286 ± 0.224
5.064AsnLeu: 5.064 ± 0.214
0.792AsnMet: 0.792 ± 0.067
3.513AsnAsn: 3.513 ± 0.257
2.839AsnPro: 2.839 ± 0.138
1.321AsnGln: 1.321 ± 0.097
1.968AsnArg: 1.968 ± 0.113
2.39AsnSer: 2.39 ± 0.147
2.377AsnThr: 2.377 ± 0.14
3.143AsnVal: 3.143 ± 0.161
0.475AsnTrp: 0.475 ± 0.052
2.978AsnTyr: 2.978 ± 0.163
0.0AsnXaa: 0.0 ± 0.0
Pro
1.512ProAla: 1.512 ± 0.115
0.291ProCys: 0.291 ± 0.045
1.532ProAsp: 1.532 ± 0.101
2.502ProGlu: 2.502 ± 0.151
2.252ProPhe: 2.252 ± 0.124
2.034ProGly: 2.034 ± 0.143
0.66ProHis: 0.66 ± 0.063
5.11ProIle: 5.11 ± 0.176
4.265ProLys: 4.265 ± 0.191
4.127ProLeu: 4.127 ± 0.186
0.667ProMet: 0.667 ± 0.074
2.133ProAsn: 2.133 ± 0.112
1.525ProPro: 1.525 ± 0.124
0.839ProGln: 0.839 ± 0.06
1.268ProArg: 1.268 ± 0.084
2.179ProSer: 2.179 ± 0.123
2.199ProThr: 2.199 ± 0.125
1.954ProVal: 1.954 ± 0.127
0.489ProTrp: 0.489 ± 0.05
2.516ProTyr: 2.516 ± 0.13
0.0ProXaa: 0.0 ± 0.0
Gln
1.017GlnAla: 1.017 ± 0.09
0.185GlnCys: 0.185 ± 0.038
0.68GlnAsp: 0.68 ± 0.071
1.228GlnGlu: 1.228 ± 0.1
1.076GlnPhe: 1.076 ± 0.092
1.07GlnGly: 1.07 ± 0.079
0.211GlnHis: 0.211 ± 0.038
2.436GlnIle: 2.436 ± 0.109
2.324GlnLys: 2.324 ± 0.123
2.661GlnLeu: 2.661 ± 0.135
0.746GlnMet: 0.746 ± 0.068
1.129GlnAsn: 1.129 ± 0.087
0.713GlnPro: 0.713 ± 0.068
0.687GlnGln: 0.687 ± 0.096
0.819GlnArg: 0.819 ± 0.064
1.076GlnSer: 1.076 ± 0.1
1.089GlnThr: 1.089 ± 0.078
0.872GlnVal: 0.872 ± 0.074
0.291GlnTrp: 0.291 ± 0.037
1.849GlnTyr: 1.849 ± 0.105
0.0GlnXaa: 0.0 ± 0.0
Arg
2.192ArgAla: 2.192 ± 0.131
0.35ArgCys: 0.35 ± 0.051
2.278ArgAsp: 2.278 ± 0.119
3.737ArgGlu: 3.737 ± 0.176
1.816ArgPhe: 1.816 ± 0.133
2.291ArgGly: 2.291 ± 0.152
0.568ArgHis: 0.568 ± 0.063
3.618ArgIle: 3.618 ± 0.155
4.239ArgLys: 4.239 ± 0.206
3.691ArgLeu: 3.691 ± 0.178
0.574ArgMet: 0.574 ± 0.062
1.624ArgAsn: 1.624 ± 0.101
1.38ArgPro: 1.38 ± 0.103
0.872ArgGln: 0.872 ± 0.08
1.796ArgArg: 1.796 ± 0.131
1.261ArgSer: 1.261 ± 0.096
1.38ArgThr: 1.38 ± 0.085
2.965ArgVal: 2.965 ± 0.147
0.383ArgTrp: 0.383 ± 0.046
1.994ArgTyr: 1.994 ± 0.122
0.0ArgXaa: 0.0 ± 0.0
Ser
2.139SerAla: 2.139 ± 0.131
0.423SerCys: 0.423 ± 0.063
2.172SerAsp: 2.172 ± 0.132
2.615SerGlu: 2.615 ± 0.124
2.469SerPhe: 2.469 ± 0.147
2.258SerGly: 2.258 ± 0.125
0.555SerHis: 0.555 ± 0.061
5.632SerIle: 5.632 ± 0.23
4.932SerLys: 4.932 ± 0.212
5.929SerLeu: 5.929 ± 0.237
0.977SerMet: 0.977 ± 0.076
2.555SerAsn: 2.555 ± 0.136
1.968SerPro: 1.968 ± 0.118
1.195SerGln: 1.195 ± 0.096
1.274SerArg: 1.274 ± 0.09
2.238SerSer: 2.238 ± 0.194
1.657SerThr: 1.657 ± 0.122
2.245SerVal: 2.245 ± 0.132
0.469SerTrp: 0.469 ± 0.055
2.516SerTyr: 2.516 ± 0.149
0.0SerXaa: 0.0 ± 0.0
Thr
1.961ThrAla: 1.961 ± 0.11
0.251ThrCys: 0.251 ± 0.045
1.895ThrAsp: 1.895 ± 0.13
2.192ThrGlu: 2.192 ± 0.108
1.69ThrPhe: 1.69 ± 0.124
2.397ThrGly: 2.397 ± 0.151
0.706ThrHis: 0.706 ± 0.076
5.989ThrIle: 5.989 ± 0.227
4.305ThrLys: 4.305 ± 0.209
4.213ThrLeu: 4.213 ± 0.173
0.706ThrMet: 0.706 ± 0.069
2.364ThrAsn: 2.364 ± 0.15
1.888ThrPro: 1.888 ± 0.114
0.964ThrGln: 0.964 ± 0.072
1.274ThrArg: 1.274 ± 0.1
1.908ThrSer: 1.908 ± 0.114
1.809ThrThr: 1.809 ± 0.132
2.291ThrVal: 2.291 ± 0.143
0.337ThrTrp: 0.337 ± 0.049
1.921ThrTyr: 1.921 ± 0.127
0.0ThrXaa: 0.0 ± 0.0
Val
3.031ValAla: 3.031 ± 0.154
0.667ValCys: 0.667 ± 0.087
2.773ValAsp: 2.773 ± 0.146
3.975ValGlu: 3.975 ± 0.188
2.813ValPhe: 2.813 ± 0.114
3.552ValGly: 3.552 ± 0.171
0.687ValHis: 0.687 ± 0.078
5.751ValIle: 5.751 ± 0.249
6.008ValLys: 6.008 ± 0.219
6.18ValLeu: 6.18 ± 0.204
0.832ValMet: 0.832 ± 0.08
3.083ValAsn: 3.083 ± 0.172
2.139ValPro: 2.139 ± 0.116
0.984ValGln: 0.984 ± 0.073
2.806ValArg: 2.806 ± 0.157
3.631ValSer: 3.631 ± 0.174
2.879ValThr: 2.879 ± 0.154
3.282ValVal: 3.282 ± 0.172
0.66ValTrp: 0.66 ± 0.068
3.691ValTyr: 3.691 ± 0.195
0.0ValXaa: 0.0 ± 0.0
Trp
0.528TrpAla: 0.528 ± 0.067
0.066TrpCys: 0.066 ± 0.022
0.66TrpAsp: 0.66 ± 0.072
0.852TrpGlu: 0.852 ± 0.073
0.508TrpPhe: 0.508 ± 0.06
0.528TrpGly: 0.528 ± 0.059
0.178TrpHis: 0.178 ± 0.033
0.693TrpIle: 0.693 ± 0.075
0.825TrpLys: 0.825 ± 0.076
1.182TrpLeu: 1.182 ± 0.082
0.086TrpMet: 0.086 ± 0.019
0.403TrpAsn: 0.403 ± 0.062
0.31TrpPro: 0.31 ± 0.054
0.271TrpGln: 0.271 ± 0.042
0.416TrpArg: 0.416 ± 0.057
0.35TrpSer: 0.35 ± 0.05
0.185TrpThr: 0.185 ± 0.033
0.918TrpVal: 0.918 ± 0.092
0.092TrpTrp: 0.092 ± 0.028
0.574TrpTyr: 0.574 ± 0.062
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.443TyrAla: 2.443 ± 0.13
0.806TyrCys: 0.806 ± 0.087
2.595TyrAsp: 2.595 ± 0.129
3.684TyrGlu: 3.684 ± 0.156
2.786TyrPhe: 2.786 ± 0.134
2.951TyrGly: 2.951 ± 0.139
0.634TyrHis: 0.634 ± 0.064
5.764TyrIle: 5.764 ± 0.21
5.896TyrLys: 5.896 ± 0.2
6.094TyrLeu: 6.094 ± 0.223
0.74TyrMet: 0.74 ± 0.079
3.671TyrAsn: 3.671 ± 0.178
2.146TyrPro: 2.146 ± 0.125
1.149TyrGln: 1.149 ± 0.09
2.146TyrArg: 2.146 ± 0.102
2.984TyrSer: 2.984 ± 0.139
2.119TyrThr: 2.119 ± 0.119
3.249TyrVal: 3.249 ± 0.148
0.687TyrTrp: 0.687 ± 0.076
3.915TyrTyr: 3.915 ± 0.181
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 536 proteins (151454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski