Amino acid dipepetide frequency for Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.278AlaAla: 22.278 ± 0.236	1.078AlaCys: 1.078 ± 0.034	8.685AlaAsp: 8.685 ± 0.097	8.116AlaGlu: 8.116 ± 0.105	4.449AlaPhe: 4.449 ± 0.066	11.775AlaGly: 11.775 ± 0.12	2.451AlaHis: 2.451 ± 0.054	7.321AlaIle: 7.321 ± 0.091	4.227AlaLys: 4.227 ± 0.088	14.392AlaLeu: 14.392 ± 0.166	4.296AlaMet: 4.296 ± 0.064	3.146AlaAsn: 3.146 ± 0.059	6.888AlaPro: 6.888 ± 0.095	4.003AlaGln: 4.003 ± 0.055	10.798AlaArg: 10.798 ± 0.118	6.705AlaSer: 6.705 ± 0.087	6.724AlaThr: 6.724 ± 0.094	8.823AlaVal: 8.823 ± 0.104	1.73AlaTrp: 1.73 ± 0.042	2.501AlaTyr: 2.501 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.055CysAla: 1.055 ± 0.035	0.112CysCys: 0.112 ± 0.011	0.53CysAsp: 0.53 ± 0.025	0.412CysGlu: 0.412 ± 0.022	0.283CysPhe: 0.283 ± 0.016	0.838CysGly: 0.838 ± 0.03	0.231CysHis: 0.231 ± 0.021	0.378CysIle: 0.378 ± 0.019	0.16CysLys: 0.16 ± 0.013	0.67CysLeu: 0.67 ± 0.024	0.147CysMet: 0.147 ± 0.013	0.211CysAsn: 0.211 ± 0.012	0.506CysPro: 0.506 ± 0.025	0.198CysGln: 0.198 ± 0.013	0.653CysArg: 0.653 ± 0.028	0.435CysSer: 0.435 ± 0.022	0.385CysThr: 0.385 ± 0.019	0.544CysVal: 0.544 ± 0.026	0.127CysTrp: 0.127 ± 0.01	0.174CysTyr: 0.174 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.699AspAla: 8.699 ± 0.103	0.502AspCys: 0.502 ± 0.026	3.573AspAsp: 3.573 ± 0.06	3.515AspGlu: 3.515 ± 0.073	2.298AspPhe: 2.298 ± 0.052	5.771AspGly: 5.771 ± 0.092	1.414AspHis: 1.414 ± 0.041	3.129AspIle: 3.129 ± 0.052	1.752AspLys: 1.752 ± 0.043	5.651AspLeu: 5.651 ± 0.073	1.541AspMet: 1.541 ± 0.036	1.404AspAsn: 1.404 ± 0.034	3.867AspPro: 3.867 ± 0.064	1.682AspGln: 1.682 ± 0.046	5.313AspArg: 5.313 ± 0.077	2.395AspSer: 2.395 ± 0.052	2.469AspThr: 2.469 ± 0.055	4.13AspVal: 4.13 ± 0.064	1.202AspTrp: 1.202 ± 0.037	1.666AspTyr: 1.666 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.044GluAla: 8.044 ± 0.107	0.342GluCys: 0.342 ± 0.019	2.576GluAsp: 2.576 ± 0.057	2.882GluGlu: 2.882 ± 0.069	1.381GluPhe: 1.381 ± 0.043	4.531GluGly: 4.531 ± 0.063	1.053GluHis: 1.053 ± 0.038	2.935GluIle: 2.935 ± 0.055	1.928GluLys: 1.928 ± 0.051	5.148GluLeu: 5.148 ± 0.081	1.465GluMet: 1.465 ± 0.041	1.3GluAsn: 1.3 ± 0.039	2.454GluPro: 2.454 ± 0.051	1.869GluGln: 1.869 ± 0.043	5.051GluArg: 5.051 ± 0.09	2.164GluSer: 2.164 ± 0.044	2.95GluThr: 2.95 ± 0.058	3.533GluVal: 3.533 ± 0.061	0.787GluTrp: 0.787 ± 0.027	0.972GluTyr: 0.972 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	5.119PheAla: 5.119 ± 0.07	0.303PheCys: 0.303 ± 0.017	2.804PheAsp: 2.804 ± 0.061	1.904PheGlu: 1.904 ± 0.047	1.297PhePhe: 1.297 ± 0.046	3.683PheGly: 3.683 ± 0.071	0.684PheHis: 0.684 ± 0.023	1.455PheIle: 1.455 ± 0.044	0.756PheLys: 0.756 ± 0.028	3.064PheLeu: 3.064 ± 0.066	0.721PheMet: 0.721 ± 0.028	0.942PheAsn: 0.942 ± 0.035	1.507PhePro: 1.507 ± 0.048	0.879PheGln: 0.879 ± 0.03	2.35PheArg: 2.35 ± 0.046	1.9PheSer: 1.9 ± 0.043	1.933PheThr: 1.933 ± 0.045	2.621PheVal: 2.621 ± 0.05	0.537PheTrp: 0.537 ± 0.027	0.835PheTyr: 0.835 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.669GlyAla: 10.669 ± 0.123	0.9GlyCys: 0.9 ± 0.034	5.314GlyAsp: 5.314 ± 0.081	5.096GlyGlu: 5.096 ± 0.073	3.576GlyPhe: 3.576 ± 0.061	8.437GlyGly: 8.437 ± 0.133	1.925GlyHis: 1.925 ± 0.046	4.534GlyIle: 4.534 ± 0.068	3.247GlyLys: 3.247 ± 0.057	8.415GlyLeu: 8.415 ± 0.091	2.327GlyMet: 2.327 ± 0.053	2.183GlyAsn: 2.183 ± 0.055	3.64GlyPro: 3.64 ± 0.063	2.964GlyGln: 2.964 ± 0.058	6.789GlyArg: 6.789 ± 0.086	4.575GlySer: 4.575 ± 0.078	4.587GlyThr: 4.587 ± 0.081	6.182GlyVal: 6.182 ± 0.086	1.643GlyTrp: 1.643 ± 0.045	2.212GlyTyr: 2.212 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.362HisAla: 2.362 ± 0.048	0.255HisCys: 0.255 ± 0.018	1.283HisAsp: 1.283 ± 0.037	0.944HisGlu: 0.944 ± 0.032	0.841HisPhe: 0.841 ± 0.031	2.062HisGly: 2.062 ± 0.048	0.588HisHis: 0.588 ± 0.027	1.06HisIle: 1.06 ± 0.039	0.441HisLys: 0.441 ± 0.022	1.837HisLeu: 1.837 ± 0.046	0.506HisMet: 0.506 ± 0.021	0.439HisAsn: 0.439 ± 0.022	1.378HisPro: 1.378 ± 0.042	0.553HisGln: 0.553 ± 0.025	1.609HisArg: 1.609 ± 0.043	0.958HisSer: 0.958 ± 0.031	0.623HisThr: 0.623 ± 0.023	1.493HisVal: 1.493 ± 0.043	0.354HisTrp: 0.354 ± 0.019	0.562HisTyr: 0.562 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.382IleAla: 8.382 ± 0.086	0.438IleCys: 0.438 ± 0.022	4.276IleAsp: 4.276 ± 0.077	3.532IleGlu: 3.532 ± 0.061	1.702IlePhe: 1.702 ± 0.048	5.105IleGly: 5.105 ± 0.078	0.933IleHis: 0.933 ± 0.031	2.126IleIle: 2.126 ± 0.052	1.171IleLys: 1.171 ± 0.037	4.104IleLeu: 4.104 ± 0.075	0.886IleMet: 0.886 ± 0.031	1.259IleAsn: 1.259 ± 0.041	2.26IlePro: 2.26 ± 0.049	1.006IleGln: 1.006 ± 0.032	3.324IleArg: 3.324 ± 0.056	2.348IleSer: 2.348 ± 0.048	2.313IleThr: 2.313 ± 0.047	4.344IleVal: 4.344 ± 0.07	0.659IleTrp: 0.659 ± 0.024	0.96IleTyr: 0.96 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.178LysAla: 4.178 ± 0.08	0.167LysCys: 0.167 ± 0.013	1.593LysAsp: 1.593 ± 0.049	1.261LysGlu: 1.261 ± 0.038	0.731LysPhe: 0.731 ± 0.031	2.573LysGly: 2.573 ± 0.05	0.54LysHis: 0.54 ± 0.025	1.367LysIle: 1.367 ± 0.037	1.154LysLys: 1.154 ± 0.041	3.087LysLeu: 3.087 ± 0.06	0.745LysMet: 0.745 ± 0.029	0.645LysAsn: 0.645 ± 0.023	1.853LysPro: 1.853 ± 0.042	0.847LysGln: 0.847 ± 0.029	2.196LysArg: 2.196 ± 0.05	1.598LysSer: 1.598 ± 0.044	1.527LysThr: 1.527 ± 0.04	2.034LysVal: 2.034 ± 0.051	0.423LysTrp: 0.423 ± 0.02	0.601LysTyr: 0.601 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.018LeuAla: 15.018 ± 0.154	0.757LeuCys: 0.757 ± 0.03	6.168LeuAsp: 6.168 ± 0.081	4.319LeuGlu: 4.319 ± 0.076	3.771LeuPhe: 3.771 ± 0.065	8.185LeuGly: 8.185 ± 0.094	1.792LeuHis: 1.792 ± 0.042	4.887LeuIle: 4.887 ± 0.082	2.879LeuLys: 2.879 ± 0.057	9.48LeuLeu: 9.48 ± 0.137	2.165LeuMet: 2.165 ± 0.047	2.189LeuAsn: 2.189 ± 0.056	5.586LeuPro: 5.586 ± 0.083	2.232LeuGln: 2.232 ± 0.048	6.706LeuArg: 6.706 ± 0.084	5.551LeuSer: 5.551 ± 0.083	5.512LeuThr: 5.512 ± 0.071	7.224LeuVal: 7.224 ± 0.095	1.325LeuTrp: 1.325 ± 0.043	1.904LeuTyr: 1.904 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.462MetAla: 3.462 ± 0.059	0.154MetCys: 0.154 ± 0.012	1.085MetAsp: 1.085 ± 0.033	1.091MetGlu: 1.091 ± 0.034	0.71MetPhe: 0.71 ± 0.024	1.876MetGly: 1.876 ± 0.043	0.427MetHis: 0.427 ± 0.02	1.418MetIle: 1.418 ± 0.04	0.925MetLys: 0.925 ± 0.031	2.74MetLeu: 2.74 ± 0.052	0.717MetMet: 0.717 ± 0.031	0.658MetAsn: 0.658 ± 0.026	1.491MetPro: 1.491 ± 0.035	0.752MetGln: 0.752 ± 0.024	1.892MetArg: 1.892 ± 0.045	1.446MetSer: 1.446 ± 0.035	1.866MetThr: 1.866 ± 0.043	1.647MetVal: 1.647 ± 0.04	0.24MetTrp: 0.24 ± 0.014	0.244MetTyr: 0.244 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.033AsnAla: 3.033 ± 0.06	0.241AsnCys: 0.241 ± 0.016	1.375AsnAsp: 1.375 ± 0.038	1.091AsnGlu: 1.091 ± 0.029	0.903AsnPhe: 0.903 ± 0.028	2.297AsnGly: 2.297 ± 0.056	0.458AsnHis: 0.458 ± 0.021	1.358AsnIle: 1.358 ± 0.046	0.604AsnLys: 0.604 ± 0.025	2.287AsnLeu: 2.287 ± 0.047	0.552AsnMet: 0.552 ± 0.019	0.641AsnAsn: 0.641 ± 0.03	1.722AsnPro: 1.722 ± 0.044	0.672AsnGln: 0.672 ± 0.028	1.921AsnArg: 1.921 ± 0.048	1.14AsnSer: 1.14 ± 0.035	0.905AsnThr: 0.905 ± 0.034	1.666AsnVal: 1.666 ± 0.04	0.423AsnTrp: 0.423 ± 0.024	0.619AsnTyr: 0.619 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.476ProAla: 7.476 ± 0.102	0.365ProCys: 0.365 ± 0.018	3.955ProAsp: 3.955 ± 0.063	3.09ProGlu: 3.09 ± 0.06	1.919ProPhe: 1.919 ± 0.045	5.095ProGly: 5.095 ± 0.07	1.105ProHis: 1.105 ± 0.034	2.36ProIle: 2.36 ± 0.052	1.429ProLys: 1.429 ± 0.044	5.104ProLeu: 5.104 ± 0.08	1.262ProMet: 1.262 ± 0.034	1.152ProAsn: 1.152 ± 0.033	3.136ProPro: 3.136 ± 0.069	1.521ProGln: 1.521 ± 0.041	3.426ProArg: 3.426 ± 0.063	2.525ProSer: 2.525 ± 0.052	2.659ProThr: 2.659 ± 0.054	4.495ProVal: 4.495 ± 0.068	0.697ProTrp: 0.697 ± 0.027	1.056ProTyr: 1.056 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.906GlnAla: 3.906 ± 0.063	0.22GlnCys: 0.22 ± 0.017	1.295GlnAsp: 1.295 ± 0.038	1.134GlnGlu: 1.134 ± 0.038	1.069GlnPhe: 1.069 ± 0.033	2.267GlnGly: 2.267 ± 0.036	0.534GlnHis: 0.534 ± 0.024	1.612GlnIle: 1.612 ± 0.039	0.869GlnLys: 0.869 ± 0.032	3.064GlnLeu: 3.064 ± 0.052	0.818GlnMet: 0.818 ± 0.03	0.658GlnAsn: 0.658 ± 0.029	1.728GlnPro: 1.728 ± 0.037	1.076GlnGln: 1.076 ± 0.04	2.481GlnArg: 2.481 ± 0.054	1.596GlnSer: 1.596 ± 0.041	1.36GlnThr: 1.36 ± 0.037	2.032GlnVal: 2.032 ± 0.043	0.441GlnTrp: 0.441 ± 0.021	0.613GlnTyr: 0.613 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.781ArgAla: 9.781 ± 0.111	0.536ArgCys: 0.536 ± 0.027	4.629ArgAsp: 4.629 ± 0.072	4.005ArgGlu: 4.005 ± 0.067	3.301ArgPhe: 3.301 ± 0.054	5.537ArgGly: 5.537 ± 0.082	1.901ArgHis: 1.901 ± 0.05	4.45ArgIle: 4.45 ± 0.066	2.081ArgLys: 2.081 ± 0.05	8.413ArgLeu: 8.413 ± 0.103	1.961ArgMet: 1.961 ± 0.033	1.759ArgAsn: 1.759 ± 0.041	3.965ArgPro: 3.965 ± 0.07	2.531ArgGln: 2.531 ± 0.047	6.329ArgArg: 6.329 ± 0.119	3.732ArgSer: 3.732 ± 0.072	3.572ArgThr: 3.572 ± 0.065	4.858ArgVal: 4.858 ± 0.08	1.296ArgTrp: 1.296 ± 0.041	1.847ArgTyr: 1.847 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.294SerAla: 6.294 ± 0.093	0.407SerCys: 0.407 ± 0.019	3.125SerAsp: 3.125 ± 0.055	2.605SerGlu: 2.605 ± 0.051	2.126SerPhe: 2.126 ± 0.047	5.151SerGly: 5.151 ± 0.072	0.987SerHis: 0.987 ± 0.034	2.552SerIle: 2.552 ± 0.052	1.302SerLys: 1.302 ± 0.041	4.998SerLeu: 4.998 ± 0.073	1.081SerMet: 1.081 ± 0.028	1.285SerAsn: 1.285 ± 0.039	2.73SerPro: 2.73 ± 0.06	1.385SerGln: 1.385 ± 0.036	3.439SerArg: 3.439 ± 0.067	2.512SerSer: 2.512 ± 0.104	2.282SerThr: 2.282 ± 0.059	3.484SerVal: 3.484 ± 0.062	0.75SerTrp: 0.75 ± 0.034	1.196SerTyr: 1.196 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.39ThrAla: 6.39 ± 0.075	0.391ThrCys: 0.391 ± 0.018	2.978ThrAsp: 2.978 ± 0.057	2.21ThrGlu: 2.21 ± 0.047	1.569ThrPhe: 1.569 ± 0.045	5.2ThrGly: 5.2 ± 0.086	0.972ThrHis: 0.972 ± 0.032	2.935ThrIle: 2.935 ± 0.057	1.126ThrLys: 1.126 ± 0.04	5.554ThrLeu: 5.554 ± 0.076	1.272ThrMet: 1.272 ± 0.038	1.236ThrAsn: 1.236 ± 0.039	3.29ThrPro: 3.29 ± 0.054	1.275ThrGln: 1.275 ± 0.033	3.517ThrArg: 3.517 ± 0.073	2.524ThrSer: 2.524 ± 0.053	2.492ThrThr: 2.492 ± 0.048	3.75ThrVal: 3.75 ± 0.069	0.564ThrTrp: 0.564 ± 0.024	0.962ThrTyr: 0.962 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.176ValAla: 10.176 ± 0.106	0.507ValCys: 0.507 ± 0.025	4.433ValAsp: 4.433 ± 0.061	4.488ValGlu: 4.488 ± 0.065	1.984ValPhe: 1.984 ± 0.049	5.799ValGly: 5.799 ± 0.073	1.321ValHis: 1.321 ± 0.037	3.682ValIle: 3.682 ± 0.065	2.079ValLys: 2.079 ± 0.047	5.773ValLeu: 5.773 ± 0.077	1.627ValMet: 1.627 ± 0.039	1.827ValAsn: 1.827 ± 0.051	3.994ValPro: 3.994 ± 0.064	2.063ValGln: 2.063 ± 0.045	5.355ValArg: 5.355 ± 0.075	3.637ValSer: 3.637 ± 0.07	4.302ValThr: 4.302 ± 0.071	5.063ValVal: 5.063 ± 0.085	0.817ValTrp: 0.817 ± 0.031	1.288ValTyr: 1.288 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.455TrpAla: 1.455 ± 0.041	0.16TrpCys: 0.16 ± 0.013	0.747TrpAsp: 0.747 ± 0.028	0.588TrpGlu: 0.588 ± 0.026	0.572TrpPhe: 0.572 ± 0.025	0.997TrpGly: 0.997 ± 0.033	0.334TrpHis: 0.334 ± 0.016	0.739TrpIle: 0.739 ± 0.028	0.465TrpLys: 0.465 ± 0.024	1.883TrpLeu: 1.883 ± 0.05	0.362TrpMet: 0.362 ± 0.019	0.432TrpAsn: 0.432 ± 0.023	0.789TrpPro: 0.789 ± 0.03	0.615TrpGln: 0.615 ± 0.024	1.367TrpArg: 1.367 ± 0.04	0.838TrpSer: 0.838 ± 0.031	0.869TrpThr: 0.869 ± 0.031	0.855TrpVal: 0.855 ± 0.029	0.249TrpTrp: 0.249 ± 0.016	0.304TrpTyr: 0.304 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.608TyrAla: 2.608 ± 0.051	0.213TyrCys: 0.213 ± 0.015	1.552TyrAsp: 1.552 ± 0.042	1.081TyrGlu: 1.081 ± 0.037	0.811TyrPhe: 0.811 ± 0.029	2.036TyrGly: 2.036 ± 0.045	0.497TyrHis: 0.497 ± 0.025	0.829TyrIle: 0.829 ± 0.03	0.524TyrLys: 0.524 ± 0.022	1.986TyrLeu: 1.986 ± 0.057	0.391TyrMet: 0.391 ± 0.02	0.545TyrAsn: 0.545 ± 0.023	1.041TyrPro: 1.041 ± 0.03	0.652TyrGln: 0.652 ± 0.027	1.972TyrArg: 1.972 ± 0.05	1.109TyrSer: 1.109 ± 0.04	0.877TyrThr: 0.877 ± 0.035	1.437TyrVal: 1.437 ± 0.037	0.357TyrTrp: 0.357 ± 0.023	0.588TyrTyr: 0.588 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3184 proteins (1011156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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