Amino acid dipepetide frequency for Amycolatopsis acidiphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.514AlaAla: 19.514 ± 0.152	1.053AlaCys: 1.053 ± 0.023	7.92AlaAsp: 7.92 ± 0.061	8.875AlaGlu: 8.875 ± 0.079	3.564AlaPhe: 3.564 ± 0.037	13.297AlaGly: 13.297 ± 0.092	2.555AlaHis: 2.555 ± 0.036	4.376AlaIle: 4.376 ± 0.053	3.184AlaLys: 3.184 ± 0.038	13.612AlaLeu: 13.612 ± 0.101	2.545AlaMet: 2.545 ± 0.033	2.325AlaAsn: 2.325 ± 0.034	5.965AlaPro: 5.965 ± 0.055	3.923AlaGln: 3.923 ± 0.041	9.74AlaArg: 9.74 ± 0.079	5.742AlaSer: 5.742 ± 0.054	6.893AlaThr: 6.893 ± 0.063	11.695AlaVal: 11.695 ± 0.086	1.679AlaTrp: 1.679 ± 0.027	2.305AlaTyr: 2.305 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.058CysAla: 1.058 ± 0.023	0.115CysCys: 0.115 ± 0.007	0.447CysAsp: 0.447 ± 0.016	0.435CysGlu: 0.435 ± 0.016	0.256CysPhe: 0.256 ± 0.01	0.958CysGly: 0.958 ± 0.021	0.211CysHis: 0.211 ± 0.008	0.18CysIle: 0.18 ± 0.009	0.102CysLys: 0.102 ± 0.006	0.769CysLeu: 0.769 ± 0.019	0.105CysMet: 0.105 ± 0.007	0.123CysAsn: 0.123 ± 0.008	0.483CysPro: 0.483 ± 0.014	0.199CysGln: 0.199 ± 0.01	0.597CysArg: 0.597 ± 0.018	0.455CysSer: 0.455 ± 0.014	0.503CysThr: 0.503 ± 0.016	0.669CysVal: 0.669 ± 0.016	0.144CysTrp: 0.144 ± 0.008	0.203CysTyr: 0.203 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.127AspAla: 7.127 ± 0.06	0.401AspCys: 0.401 ± 0.012	3.349AspAsp: 3.349 ± 0.04	4.188AspGlu: 4.188 ± 0.045	1.605AspPhe: 1.605 ± 0.025	5.706AspGly: 5.706 ± 0.059	1.272AspHis: 1.272 ± 0.024	1.96AspIle: 1.96 ± 0.03	1.155AspLys: 1.155 ± 0.023	6.302AspLeu: 6.302 ± 0.054	0.78AspMet: 0.78 ± 0.017	1.042AspAsn: 1.042 ± 0.021	4.279AspPro: 4.279 ± 0.042	1.729AspGln: 1.729 ± 0.029	4.485AspArg: 4.485 ± 0.044	2.495AspSer: 2.495 ± 0.034	2.908AspThr: 2.908 ± 0.038	5.192AspVal: 5.192 ± 0.055	0.948AspTrp: 0.948 ± 0.022	1.228AspTyr: 1.228 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.675GluAla: 6.675 ± 0.068	0.357GluCys: 0.357 ± 0.013	2.817GluAsp: 2.817 ± 0.036	3.143GluGlu: 3.143 ± 0.051	1.805GluPhe: 1.805 ± 0.028	3.803GluGly: 3.803 ± 0.043	1.808GluHis: 1.808 ± 0.029	2.57GluIle: 2.57 ± 0.039	1.339GluLys: 1.339 ± 0.028	7.745GluLeu: 7.745 ± 0.055	0.908GluMet: 0.908 ± 0.019	1.131GluAsn: 1.131 ± 0.023	3.458GluPro: 3.458 ± 0.043	2.54GluGln: 2.54 ± 0.035	5.273GluArg: 5.273 ± 0.059	2.586GluSer: 2.586 ± 0.038	2.841GluThr: 2.841 ± 0.034	5.097GluVal: 5.097 ± 0.054	0.802GluTrp: 0.802 ± 0.018	1.181GluTyr: 1.181 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.081PheAla: 4.081 ± 0.041	0.319PheCys: 0.319 ± 0.011	2.184PheAsp: 2.184 ± 0.032	1.578PheGlu: 1.578 ± 0.027	0.982PhePhe: 0.982 ± 0.022	3.527PheGly: 3.527 ± 0.043	0.653PheHis: 0.653 ± 0.018	0.772PheIle: 0.772 ± 0.019	0.461PheLys: 0.461 ± 0.014	2.784PheLeu: 2.784 ± 0.04	0.368PheMet: 0.368 ± 0.014	0.58PheAsn: 0.58 ± 0.016	1.496PhePro: 1.496 ± 0.025	0.694PheGln: 0.694 ± 0.018	1.902PheArg: 1.902 ± 0.024	1.609PheSer: 1.609 ± 0.029	2.001PheThr: 2.001 ± 0.029	2.63PheVal: 2.63 ± 0.037	0.423PheTrp: 0.423 ± 0.016	0.648PheTyr: 0.648 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.446GlyAla: 10.446 ± 0.077	0.802GlyCys: 0.802 ± 0.019	4.792GlyAsp: 4.792 ± 0.052	5.467GlyGlu: 5.467 ± 0.049	3.158GlyPhe: 3.158 ± 0.04	8.439GlyGly: 8.439 ± 0.071	2.154GlyHis: 2.154 ± 0.031	3.834GlyIle: 3.834 ± 0.041	2.551GlyLys: 2.551 ± 0.03	9.546GlyLeu: 9.546 ± 0.068	2.094GlyMet: 2.094 ± 0.029	1.873GlyAsn: 1.873 ± 0.03	4.61GlyPro: 4.61 ± 0.048	2.944GlyGln: 2.944 ± 0.035	7.181GlyArg: 7.181 ± 0.062	5.216GlySer: 5.216 ± 0.052	5.676GlyThr: 5.676 ± 0.051	8.053GlyVal: 8.053 ± 0.059	1.76GlyTrp: 1.76 ± 0.031	2.449GlyTyr: 2.449 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.671HisAla: 2.671 ± 0.035	0.206HisCys: 0.206 ± 0.01	1.359HisAsp: 1.359 ± 0.025	1.31HisGlu: 1.31 ± 0.027	0.661HisPhe: 0.661 ± 0.017	2.33HisGly: 2.33 ± 0.034	0.646HisHis: 0.646 ± 0.018	0.662HisIle: 0.662 ± 0.018	0.351HisLys: 0.351 ± 0.012	2.345HisLeu: 2.345 ± 0.035	0.286HisMet: 0.286 ± 0.011	0.428HisAsn: 0.428 ± 0.014	1.65HisPro: 1.65 ± 0.025	0.661HisGln: 0.661 ± 0.015	1.917HisArg: 1.917 ± 0.031	0.976HisSer: 0.976 ± 0.02	1.17HisThr: 1.17 ± 0.024	1.784HisVal: 1.784 ± 0.031	0.364HisTrp: 0.364 ± 0.014	0.528HisTyr: 0.528 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.305IleAla: 5.305 ± 0.052	0.34IleCys: 0.34 ± 0.012	2.43IleAsp: 2.43 ± 0.038	2.236IleGlu: 2.236 ± 0.034	0.844IlePhe: 0.844 ± 0.02	3.933IleGly: 3.933 ± 0.047	0.601IleHis: 0.601 ± 0.016	1.042IleIle: 1.042 ± 0.024	0.721IleLys: 0.721 ± 0.02	2.732IleLeu: 2.732 ± 0.035	0.505IleMet: 0.505 ± 0.015	0.804IleAsn: 0.804 ± 0.02	1.979IlePro: 1.979 ± 0.032	0.808IleGln: 0.808 ± 0.019	2.432IleArg: 2.432 ± 0.029	1.959IleSer: 1.959 ± 0.033	2.391IleThr: 2.391 ± 0.032	3.275IleVal: 3.275 ± 0.044	0.395IleTrp: 0.395 ± 0.012	0.633IleTyr: 0.633 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.745LysAla: 2.745 ± 0.038	0.105LysCys: 0.105 ± 0.007	1.096LysAsp: 1.096 ± 0.025	1.013LysGlu: 1.013 ± 0.025	0.555LysPhe: 0.555 ± 0.017	1.559LysGly: 1.559 ± 0.029	0.497LysHis: 0.497 ± 0.015	0.997LysIle: 0.997 ± 0.022	0.601LysLys: 0.601 ± 0.018	2.391LysLeu: 2.391 ± 0.037	0.413LysMet: 0.413 ± 0.013	0.448LysAsn: 0.448 ± 0.016	1.472LysPro: 1.472 ± 0.027	0.782LysGln: 0.782 ± 0.021	1.568LysArg: 1.568 ± 0.029	1.035LysSer: 1.035 ± 0.022	1.276LysThr: 1.276 ± 0.026	1.983LysVal: 1.983 ± 0.03	0.28LysTrp: 0.28 ± 0.01	0.441LysTyr: 0.441 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.833LeuAla: 15.833 ± 0.115	0.859LeuCys: 0.859 ± 0.017	6.895LeuAsp: 6.895 ± 0.06	4.999LeuGlu: 4.999 ± 0.057	2.793LeuPhe: 2.793 ± 0.038	9.852LeuGly: 9.852 ± 0.08	2.258LeuHis: 2.258 ± 0.037	3.497LeuIle: 3.497 ± 0.045	1.805LeuLys: 1.805 ± 0.03	11.09LeuLeu: 11.09 ± 0.093	1.496LeuMet: 1.496 ± 0.027	1.818LeuAsn: 1.818 ± 0.03	6.432LeuPro: 6.432 ± 0.062	2.338LeuGln: 2.338 ± 0.03	8.923LeuArg: 8.923 ± 0.081	5.817LeuSer: 5.817 ± 0.055	6.462LeuThr: 6.462 ± 0.05	9.712LeuVal: 9.712 ± 0.08	1.223LeuTrp: 1.223 ± 0.025	1.742LeuTyr: 1.742 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.121MetAla: 2.121 ± 0.031	0.138MetCys: 0.138 ± 0.008	0.808MetAsp: 0.808 ± 0.018	0.634MetGlu: 0.634 ± 0.016	0.518MetPhe: 0.518 ± 0.015	1.283MetGly: 1.283 ± 0.027	0.341MetHis: 0.341 ± 0.012	0.728MetIle: 0.728 ± 0.019	0.425MetLys: 0.425 ± 0.014	1.798MetLeu: 1.798 ± 0.03	0.282MetMet: 0.282 ± 0.01	0.426MetAsn: 0.426 ± 0.014	1.094MetPro: 1.094 ± 0.021	0.442MetGln: 0.442 ± 0.014	1.497MetArg: 1.497 ± 0.027	1.327MetSer: 1.327 ± 0.022	1.59MetThr: 1.59 ± 0.025	1.336MetVal: 1.336 ± 0.026	0.205MetTrp: 0.205 ± 0.009	0.282MetTyr: 0.282 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.454AsnAla: 2.454 ± 0.032	0.174AsnCys: 0.174 ± 0.008	0.993AsnAsp: 0.993 ± 0.021	0.929AsnGlu: 0.929 ± 0.022	0.561AsnPhe: 0.561 ± 0.018	1.902AsnGly: 1.902 ± 0.031	0.394AsnHis: 0.394 ± 0.013	0.729AsnIle: 0.729 ± 0.018	0.365AsnLys: 0.365 ± 0.012	2.002AsnLeu: 2.002 ± 0.029	0.315AsnMet: 0.315 ± 0.012	0.466AsnAsn: 0.466 ± 0.018	1.535AsnPro: 1.535 ± 0.028	0.603AsnGln: 0.603 ± 0.017	1.339AsnArg: 1.339 ± 0.025	1.017AsnSer: 1.017 ± 0.023	1.142AsnThr: 1.142 ± 0.023	1.553AsnVal: 1.553 ± 0.025	0.318AsnTrp: 0.318 ± 0.012	0.486AsnTyr: 0.486 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.988ProAla: 7.988 ± 0.07	0.35ProCys: 0.35 ± 0.013	4.144ProAsp: 4.144 ± 0.048	4.165ProGlu: 4.165 ± 0.049	1.622ProPhe: 1.622 ± 0.023	6.442ProGly: 6.442 ± 0.06	1.194ProHis: 1.194 ± 0.026	1.655ProIle: 1.655 ± 0.03	1.252ProLys: 1.252 ± 0.023	5.19ProLeu: 5.19 ± 0.045	1.001ProMet: 1.001 ± 0.021	1.05ProAsn: 1.05 ± 0.024	3.313ProPro: 3.313 ± 0.055	1.665ProGln: 1.665 ± 0.028	3.818ProArg: 3.818 ± 0.042	2.958ProSer: 2.958 ± 0.037	2.92ProThr: 2.92 ± 0.043	5.509ProVal: 5.509 ± 0.051	0.837ProTrp: 0.837 ± 0.021	1.173ProTyr: 1.173 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.917GlnAla: 3.917 ± 0.043	0.195GlnCys: 0.195 ± 0.009	1.357GlnAsp: 1.357 ± 0.025	1.321GlnGlu: 1.321 ± 0.025	0.832GlnPhe: 0.832 ± 0.021	2.163GlnGly: 2.163 ± 0.032	0.716GlnHis: 0.716 ± 0.019	1.194GlnIle: 1.194 ± 0.026	0.597GlnLys: 0.597 ± 0.018	3.693GlnLeu: 3.693 ± 0.044	0.485GlnMet: 0.485 ± 0.016	0.621GlnAsn: 0.621 ± 0.017	1.831GlnPro: 1.831 ± 0.034	1.42GlnGln: 1.42 ± 0.033	2.569GlnArg: 2.569 ± 0.034	1.283GlnSer: 1.283 ± 0.021	1.404GlnThr: 1.404 ± 0.026	2.797GlnVal: 2.797 ± 0.031	0.468GlnTrp: 0.468 ± 0.013	0.617GlnTyr: 0.617 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.347ArgAla: 9.347 ± 0.083	0.602ArgCys: 0.602 ± 0.017	4.19ArgAsp: 4.19 ± 0.049	4.904ArgGlu: 4.904 ± 0.048	2.532ArgPhe: 2.532 ± 0.032	5.803ArgGly: 5.803 ± 0.053	1.975ArgHis: 1.975 ± 0.03	3.187ArgIle: 3.187 ± 0.036	1.883ArgLys: 1.883 ± 0.033	8.539ArgLeu: 8.539 ± 0.068	1.786ArgMet: 1.786 ± 0.026	1.482ArgAsn: 1.482 ± 0.026	4.564ArgPro: 4.564 ± 0.047	2.435ArgGln: 2.435 ± 0.037	7.706ArgArg: 7.706 ± 0.072	3.883ArgSer: 3.883 ± 0.04	4.665ArgThr: 4.665 ± 0.038	6.119ArgVal: 6.119 ± 0.057	1.348ArgTrp: 1.348 ± 0.023	1.919ArgTyr: 1.919 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.511SerAla: 6.511 ± 0.054	0.441SerCys: 0.441 ± 0.015	2.662SerAsp: 2.662 ± 0.033	2.478SerGlu: 2.478 ± 0.033	1.679SerPhe: 1.679 ± 0.032	5.714SerGly: 5.714 ± 0.055	0.915SerHis: 0.915 ± 0.018	1.764SerIle: 1.764 ± 0.031	0.996SerLys: 0.996 ± 0.025	4.946SerLeu: 4.946 ± 0.054	1.186SerMet: 1.186 ± 0.023	0.941SerAsn: 0.941 ± 0.021	3.076SerPro: 3.076 ± 0.039	1.31SerGln: 1.31 ± 0.027	3.676SerArg: 3.676 ± 0.04	3.011SerSer: 3.011 ± 0.045	3.291SerThr: 3.291 ± 0.042	4.44SerVal: 4.44 ± 0.053	0.973SerTrp: 0.973 ± 0.023	1.237SerTyr: 1.237 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	7.631ThrAla: 7.631 ± 0.059	0.447ThrCys: 0.447 ± 0.014	3.331ThrAsp: 3.331 ± 0.037	3.385ThrGlu: 3.385 ± 0.041	1.703ThrPhe: 1.703 ± 0.027	6.272ThrGly: 6.272 ± 0.056	1.123ThrHis: 1.123 ± 0.022	2.112ThrIle: 2.112 ± 0.033	1.258ThrLys: 1.258 ± 0.023	5.517ThrLeu: 5.517 ± 0.048	1.017ThrMet: 1.017 ± 0.024	1.089ThrAsn: 1.089 ± 0.023	3.688ThrPro: 3.688 ± 0.048	1.412ThrGln: 1.412 ± 0.023	3.801ThrArg: 3.801 ± 0.042	3.241ThrSer: 3.241 ± 0.044	3.808ThrThr: 3.808 ± 0.049	5.749ThrVal: 5.749 ± 0.053	0.836ThrTrp: 0.836 ± 0.02	1.179ThrTyr: 1.179 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.383ValAla: 11.383 ± 0.076	0.754ValCys: 0.754 ± 0.016	5.336ValAsp: 5.336 ± 0.052	5.077ValGlu: 5.077 ± 0.054	2.734ValPhe: 2.734 ± 0.039	6.98ValGly: 6.98 ± 0.06	2.079ValHis: 2.079 ± 0.033	3.074ValIle: 3.074 ± 0.038	1.622ValLys: 1.622 ± 0.03	10.538ValLeu: 10.538 ± 0.077	1.229ValMet: 1.229 ± 0.025	1.866ValAsn: 1.866 ± 0.031	5.33ValPro: 5.33 ± 0.055	2.252ValGln: 2.252 ± 0.031	7.189ValArg: 7.189 ± 0.057	4.675ValSer: 4.675 ± 0.05	5.566ValThr: 5.566 ± 0.05	8.991ValVal: 8.991 ± 0.083	1.075ValTrp: 1.075 ± 0.022	1.55ValTyr: 1.55 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.582TrpAla: 1.582 ± 0.027	0.16TrpCys: 0.16 ± 0.009	0.711TrpAsp: 0.711 ± 0.02	0.626TrpGlu: 0.626 ± 0.019	0.564TrpPhe: 0.564 ± 0.016	1.007TrpGly: 1.007 ± 0.022	0.401TrpHis: 0.401 ± 0.013	0.554TrpIle: 0.554 ± 0.016	0.279TrpLys: 0.279 ± 0.012	1.909TrpLeu: 1.909 ± 0.034	0.266TrpMet: 0.266 ± 0.01	0.333TrpAsn: 0.333 ± 0.012	0.815TrpPro: 0.815 ± 0.019	0.641TrpGln: 0.641 ± 0.019	1.354TrpArg: 1.354 ± 0.022	0.89TrpSer: 0.89 ± 0.02	0.937TrpThr: 0.937 ± 0.022	1.039TrpVal: 1.039 ± 0.022	0.334TrpTrp: 0.334 ± 0.013	0.333TrpTyr: 0.333 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.372TyrAla: 2.372 ± 0.035	0.195TyrCys: 0.195 ± 0.01	1.329TyrAsp: 1.329 ± 0.031	1.117TyrGlu: 1.117 ± 0.023	0.721TyrPhe: 0.721 ± 0.015	2.073TyrGly: 2.073 ± 0.031	0.513TyrHis: 0.513 ± 0.014	0.475TyrIle: 0.475 ± 0.016	0.311TyrLys: 0.311 ± 0.013	2.394TyrLeu: 2.394 ± 0.033	0.21TyrMet: 0.21 ± 0.009	0.431TyrAsn: 0.431 ± 0.014	1.177TyrPro: 1.177 ± 0.023	0.683TyrGln: 0.683 ± 0.016	1.903TyrArg: 1.903 ± 0.029	1.073TyrSer: 1.073 ± 0.019	1.155TyrThr: 1.155 ± 0.022	1.68TyrVal: 1.68 ± 0.029	0.323TyrTrp: 0.323 ± 0.012	0.512TyrTyr: 0.512 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7527 proteins (2361779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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