Amino acid dipepetide frequency for Subsaximicrobium wynnwilliamsii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.54AlaAla: 4.54 ± 0.087	0.595AlaCys: 0.595 ± 0.026	3.566AlaAsp: 3.566 ± 0.058	4.532AlaGlu: 4.532 ± 0.067	3.63AlaPhe: 3.63 ± 0.051	4.085AlaGly: 4.085 ± 0.069	1.271AlaHis: 1.271 ± 0.034	5.897AlaIle: 5.897 ± 0.074	4.79AlaLys: 4.79 ± 0.072	6.792AlaLeu: 6.792 ± 0.08	1.693AlaMet: 1.693 ± 0.039	3.802AlaAsn: 3.802 ± 0.061	1.899AlaPro: 1.899 ± 0.043	2.663AlaGln: 2.663 ± 0.048	2.098AlaArg: 2.098 ± 0.04	4.638AlaSer: 4.638 ± 0.068	3.87AlaThr: 3.87 ± 0.069	4.076AlaVal: 4.076 ± 0.068	0.633AlaTrp: 0.633 ± 0.024	2.553AlaTyr: 2.553 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.508CysAla: 0.508 ± 0.021	0.13CysCys: 0.13 ± 0.009	0.461CysAsp: 0.461 ± 0.026	0.513CysGlu: 0.513 ± 0.022	0.443CysPhe: 0.443 ± 0.02	0.613CysGly: 0.613 ± 0.028	0.178CysHis: 0.178 ± 0.013	0.554CysIle: 0.554 ± 0.022	0.472CysLys: 0.472 ± 0.019	0.68CysLeu: 0.68 ± 0.027	0.143CysMet: 0.143 ± 0.011	0.386CysAsn: 0.386 ± 0.023	0.311CysPro: 0.311 ± 0.02	0.228CysGln: 0.228 ± 0.014	0.208CysArg: 0.208 ± 0.014	0.561CysSer: 0.561 ± 0.023	0.386CysThr: 0.386 ± 0.02	0.439CysVal: 0.439 ± 0.019	0.063CysTrp: 0.063 ± 0.007	0.297CysTyr: 0.297 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.298AspAla: 4.298 ± 0.06	0.451AspCys: 0.451 ± 0.023	3.298AspAsp: 3.298 ± 0.063	3.838AspGlu: 3.838 ± 0.066	3.824AspPhe: 3.824 ± 0.056	3.897AspGly: 3.897 ± 0.088	0.971AspHis: 0.971 ± 0.029	4.424AspIle: 4.424 ± 0.061	3.99AspLys: 3.99 ± 0.068	5.773AspLeu: 5.773 ± 0.063	1.273AspMet: 1.273 ± 0.027	2.987AspAsn: 2.987 ± 0.052	1.759AspPro: 1.759 ± 0.046	1.721AspGln: 1.721 ± 0.039	1.969AspArg: 1.969 ± 0.042	3.404AspSer: 3.404 ± 0.06	2.861AspThr: 2.861 ± 0.054	3.704AspVal: 3.704 ± 0.056	0.73AspTrp: 0.73 ± 0.022	2.965AspTyr: 2.965 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.096GluAla: 5.096 ± 0.071	0.311GluCys: 0.311 ± 0.018	3.944GluAsp: 3.944 ± 0.066	4.228GluGlu: 4.228 ± 0.078	3.099GluPhe: 3.099 ± 0.048	3.698GluGly: 3.698 ± 0.062	1.361GluHis: 1.361 ± 0.035	5.213GluIle: 5.213 ± 0.067	5.251GluLys: 5.251 ± 0.083	6.234GluLeu: 6.234 ± 0.076	1.58GluMet: 1.58 ± 0.037	4.493GluAsn: 4.493 ± 0.067	1.614GluPro: 1.614 ± 0.037	2.53GluGln: 2.53 ± 0.051	2.688GluArg: 2.688 ± 0.053	3.484GluSer: 3.484 ± 0.058	4.176GluThr: 4.176 ± 0.064	4.137GluVal: 4.137 ± 0.063	0.586GluTrp: 0.586 ± 0.021	2.164GluTyr: 2.164 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.146PheAla: 3.146 ± 0.056	0.453PheCys: 0.453 ± 0.019	3.549PheAsp: 3.549 ± 0.059	3.929PheGlu: 3.929 ± 0.057	2.722PhePhe: 2.722 ± 0.054	3.75PheGly: 3.75 ± 0.066	0.813PheHis: 0.813 ± 0.028	3.704PheIle: 3.704 ± 0.056	3.934PheLys: 3.934 ± 0.065	4.503PheLeu: 4.503 ± 0.07	1.166PheMet: 1.166 ± 0.032	3.204PheAsn: 3.204 ± 0.061	1.703PhePro: 1.703 ± 0.034	1.74PheGln: 1.74 ± 0.044	1.69PheArg: 1.69 ± 0.041	4.092PheSer: 4.092 ± 0.056	3.026PheThr: 3.026 ± 0.058	3.015PheVal: 3.015 ± 0.049	0.582PheTrp: 0.582 ± 0.023	2.214PheTyr: 2.214 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.007GlyAla: 4.007 ± 0.074	0.601GlyCys: 0.601 ± 0.035	3.376GlyAsp: 3.376 ± 0.069	3.31GlyGlu: 3.31 ± 0.058	3.714GlyPhe: 3.714 ± 0.055	4.165GlyGly: 4.165 ± 0.09	1.132GlyHis: 1.132 ± 0.03	5.261GlyIle: 5.261 ± 0.067	4.641GlyLys: 4.641 ± 0.066	5.765GlyLeu: 5.765 ± 0.07	1.548GlyMet: 1.548 ± 0.034	3.767GlyAsn: 3.767 ± 0.073	1.24GlyPro: 1.24 ± 0.035	2.063GlyGln: 2.063 ± 0.045	2.043GlyArg: 2.043 ± 0.043	4.143GlySer: 4.143 ± 0.075	3.906GlyThr: 3.906 ± 0.083	4.031GlyVal: 4.031 ± 0.066	0.711GlyTrp: 0.711 ± 0.027	2.605GlyTyr: 2.605 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	0.991HisAla: 0.991 ± 0.029	0.192HisCys: 0.192 ± 0.014	0.88HisAsp: 0.88 ± 0.024	1.046HisGlu: 1.046 ± 0.027	1.188HisPhe: 1.188 ± 0.03	1.049HisGly: 1.049 ± 0.032	0.462HisHis: 0.462 ± 0.022	1.479HisIle: 1.479 ± 0.034	1.313HisLys: 1.313 ± 0.039	1.879HisLeu: 1.879 ± 0.043	0.323HisMet: 0.323 ± 0.017	0.983HisAsn: 0.983 ± 0.028	0.891HisPro: 0.891 ± 0.031	0.782HisGln: 0.782 ± 0.03	0.653HisArg: 0.653 ± 0.024	1.066HisSer: 1.066 ± 0.026	0.856HisThr: 0.856 ± 0.026	0.901HisVal: 0.901 ± 0.028	0.222HisTrp: 0.222 ± 0.014	0.873HisTyr: 0.873 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.731IleAla: 5.731 ± 0.069	0.639IleCys: 0.639 ± 0.023	4.99IleAsp: 4.99 ± 0.07	5.437IleGlu: 5.437 ± 0.077	3.529IlePhe: 3.529 ± 0.064	4.996IleGly: 4.996 ± 0.073	1.262IleHis: 1.262 ± 0.033	5.631IleIle: 5.631 ± 0.083	5.599IleLys: 5.599 ± 0.074	7.063IleLeu: 7.063 ± 0.074	1.424IleMet: 1.424 ± 0.032	4.601IleAsn: 4.601 ± 0.066	3.082IlePro: 3.082 ± 0.051	2.478IleGln: 2.478 ± 0.048	2.428IleArg: 2.428 ± 0.043	5.661IleSer: 5.661 ± 0.058	4.518IleThr: 4.518 ± 0.07	4.655IleVal: 4.655 ± 0.068	0.671IleTrp: 0.671 ± 0.024	2.787IleTyr: 2.787 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.207LysAla: 5.207 ± 0.076	0.336LysCys: 0.336 ± 0.017	4.572LysAsp: 4.572 ± 0.059	5.01LysGlu: 5.01 ± 0.078	2.855LysPhe: 2.855 ± 0.051	4.076LysGly: 4.076 ± 0.064	1.545LysHis: 1.545 ± 0.04	5.784LysIle: 5.784 ± 0.082	5.891LysLys: 5.891 ± 0.098	6.641LysLeu: 6.641 ± 0.082	1.971LysMet: 1.971 ± 0.043	4.812LysAsn: 4.812 ± 0.067	2.454LysPro: 2.454 ± 0.046	2.983LysGln: 2.983 ± 0.05	3.044LysArg: 3.044 ± 0.051	4.698LysSer: 4.698 ± 0.071	4.989LysThr: 4.989 ± 0.075	4.367LysVal: 4.367 ± 0.062	0.74LysTrp: 0.74 ± 0.022	2.655LysTyr: 2.655 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.957LeuAla: 5.957 ± 0.083	0.733LeuCys: 0.733 ± 0.023	5.338LeuAsp: 5.338 ± 0.073	6.482LeuGlu: 6.482 ± 0.078	4.907LeuPhe: 4.907 ± 0.078	5.747LeuGly: 5.747 ± 0.07	1.541LeuHis: 1.541 ± 0.04	6.99LeuIle: 6.99 ± 0.093	8.133LeuLys: 8.133 ± 0.103	8.749LeuLeu: 8.749 ± 0.1	2.179LeuMet: 2.179 ± 0.042	5.831LeuAsn: 5.831 ± 0.089	3.509LeuPro: 3.509 ± 0.055	3.38LeuGln: 3.38 ± 0.053	3.269LeuArg: 3.269 ± 0.049	6.974LeuSer: 6.974 ± 0.077	5.131LeuThr: 5.131 ± 0.064	5.448LeuVal: 5.448 ± 0.07	0.851LeuTrp: 0.851 ± 0.028	3.192LeuTyr: 3.192 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.846MetAla: 1.846 ± 0.038	0.143MetCys: 0.143 ± 0.01	1.374MetAsp: 1.374 ± 0.037	1.431MetGlu: 1.431 ± 0.041	0.868MetPhe: 0.868 ± 0.025	1.298MetGly: 1.298 ± 0.036	0.425MetHis: 0.425 ± 0.016	1.561MetIle: 1.561 ± 0.033	2.13MetLys: 2.13 ± 0.041	2.078MetLeu: 2.078 ± 0.043	0.59MetMet: 0.59 ± 0.027	1.229MetAsn: 1.229 ± 0.035	0.891MetPro: 0.891 ± 0.024	0.855MetGln: 0.855 ± 0.029	0.893MetArg: 0.893 ± 0.026	1.484MetSer: 1.484 ± 0.036	1.319MetThr: 1.319 ± 0.033	1.363MetVal: 1.363 ± 0.033	0.141MetTrp: 0.141 ± 0.011	0.636MetTyr: 0.636 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	4.345AsnAla: 4.345 ± 0.061	0.485AsnCys: 0.485 ± 0.022	3.426AsnAsp: 3.426 ± 0.056	3.686AsnGlu: 3.686 ± 0.059	3.129AsnPhe: 3.129 ± 0.054	3.966AsnGly: 3.966 ± 0.076	1.039AsnHis: 1.039 ± 0.03	4.355AsnIle: 4.355 ± 0.061	3.926AsnLys: 3.926 ± 0.062	5.438AsnLeu: 5.438 ± 0.073	1.248AsnMet: 1.248 ± 0.026	3.722AsnAsn: 3.722 ± 0.077	2.763AsnPro: 2.763 ± 0.057	2.344AsnGln: 2.344 ± 0.046	2.169AsnArg: 2.169 ± 0.046	4.005AsnSer: 4.005 ± 0.061	3.652AsnThr: 3.652 ± 0.068	3.345AsnVal: 3.345 ± 0.054	0.726AsnTrp: 0.726 ± 0.027	2.851AsnTyr: 2.851 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.853ProAla: 1.853 ± 0.04	0.219ProCys: 0.219 ± 0.012	1.967ProAsp: 1.967 ± 0.038	2.767ProGlu: 2.767 ± 0.049	1.918ProPhe: 1.918 ± 0.041	1.69ProGly: 1.69 ± 0.04	0.526ProHis: 0.526 ± 0.022	2.669ProIle: 2.669 ± 0.037	2.613ProLys: 2.613 ± 0.051	2.881ProLeu: 2.881 ± 0.047	0.74ProMet: 0.74 ± 0.024	2.362ProAsn: 2.362 ± 0.044	0.788ProPro: 0.788 ± 0.029	1.106ProGln: 1.106 ± 0.029	0.951ProArg: 0.951 ± 0.028	2.268ProSer: 2.268 ± 0.047	1.866ProThr: 1.866 ± 0.04	2.089ProVal: 2.089 ± 0.041	0.301ProTrp: 0.301 ± 0.015	1.413ProTyr: 1.413 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.281GlnAla: 2.281 ± 0.047	0.204GlnCys: 0.204 ± 0.011	1.933GlnAsp: 1.933 ± 0.04	2.236GlnGlu: 2.236 ± 0.046	1.892GlnPhe: 1.892 ± 0.039	1.86GlnGly: 1.86 ± 0.042	0.706GlnHis: 0.706 ± 0.023	2.812GlnIle: 2.812 ± 0.04	2.732GlnLys: 2.732 ± 0.049	3.931GlnLeu: 3.931 ± 0.066	0.958GlnMet: 0.958 ± 0.036	2.265GlnAsn: 2.265 ± 0.049	1.192GlnPro: 1.192 ± 0.03	1.632GlnGln: 1.632 ± 0.045	1.395GlnArg: 1.395 ± 0.033	2.107GlnSer: 2.107 ± 0.046	2.096GlnThr: 2.096 ± 0.037	2.018GlnVal: 2.018 ± 0.037	0.376GlnTrp: 0.376 ± 0.018	1.33GlnTyr: 1.33 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.18ArgAla: 2.18 ± 0.047	0.189ArgCys: 0.189 ± 0.012	2.014ArgAsp: 2.014 ± 0.04	2.146ArgGlu: 2.146 ± 0.046	2.082ArgPhe: 2.082 ± 0.045	1.87ArgGly: 1.87 ± 0.04	0.654ArgHis: 0.654 ± 0.024	2.89ArgIle: 2.89 ± 0.05	2.603ArgLys: 2.603 ± 0.054	3.531ArgLeu: 3.531 ± 0.06	0.87ArgMet: 0.87 ± 0.029	2.067ArgAsn: 2.067 ± 0.046	1.107ArgPro: 1.107 ± 0.031	1.22ArgGln: 1.22 ± 0.033	1.323ArgArg: 1.323 ± 0.037	2.077ArgSer: 2.077 ± 0.043	1.861ArgThr: 1.861 ± 0.034	2.053ArgVal: 2.053 ± 0.04	0.381ArgTrp: 0.381 ± 0.016	1.552ArgTyr: 1.552 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.276SerAla: 4.276 ± 0.063	0.604SerCys: 0.604 ± 0.025	3.657SerAsp: 3.657 ± 0.052	4.548SerGlu: 4.548 ± 0.062	3.759SerPhe: 3.759 ± 0.057	4.569SerGly: 4.569 ± 0.071	1.107SerHis: 1.107 ± 0.035	5.303SerIle: 5.303 ± 0.077	5.046SerLys: 5.046 ± 0.066	6.062SerLeu: 6.062 ± 0.08	1.337SerMet: 1.337 ± 0.036	4.165SerAsn: 4.165 ± 0.064	1.969SerPro: 1.969 ± 0.039	2.369SerGln: 2.369 ± 0.042	2.216SerArg: 2.216 ± 0.043	4.509SerSer: 4.509 ± 0.068	3.603SerThr: 3.603 ± 0.069	4.135SerVal: 4.135 ± 0.062	0.669SerTrp: 0.669 ± 0.024	2.798SerTyr: 2.798 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.065ThrAla: 4.065 ± 0.065	0.377ThrCys: 0.377 ± 0.017	3.215ThrAsp: 3.215 ± 0.056	3.771ThrGlu: 3.771 ± 0.057	2.973ThrPhe: 2.973 ± 0.056	3.863ThrGly: 3.863 ± 0.07	1.043ThrHis: 1.043 ± 0.027	4.696ThrIle: 4.696 ± 0.066	3.85ThrLys: 3.85 ± 0.055	5.552ThrLeu: 5.552 ± 0.07	1.038ThrMet: 1.038 ± 0.028	3.365ThrAsn: 3.365 ± 0.055	2.171ThrPro: 2.171 ± 0.047	2.05ThrGln: 2.05 ± 0.05	1.714ThrArg: 1.714 ± 0.037	3.915ThrSer: 3.915 ± 0.068	3.423ThrThr: 3.423 ± 0.063	3.771ThrVal: 3.771 ± 0.066	0.541ThrTrp: 0.541 ± 0.024	2.451ThrTyr: 2.451 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.241ValAla: 4.241 ± 0.062	0.5ValCys: 0.5 ± 0.02	3.502ValAsp: 3.502 ± 0.063	3.884ValGlu: 3.884 ± 0.062	3.459ValPhe: 3.459 ± 0.058	3.708ValGly: 3.708 ± 0.06	0.977ValHis: 0.977 ± 0.028	4.68ValIle: 4.68 ± 0.059	4.048ValLys: 4.048 ± 0.061	5.981ValLeu: 5.981 ± 0.076	1.372ValMet: 1.372 ± 0.031	3.502ValAsn: 3.502 ± 0.051	2.066ValPro: 2.066 ± 0.05	1.82ValGln: 1.82 ± 0.033	1.936ValArg: 1.936 ± 0.034	4.394ValSer: 4.394 ± 0.067	3.448ValThr: 3.448 ± 0.069	4.028ValVal: 4.028 ± 0.058	0.571ValTrp: 0.571 ± 0.023	2.272ValTyr: 2.272 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.55TrpAla: 0.55 ± 0.02	0.085TrpCys: 0.085 ± 0.007	0.611TrpAsp: 0.611 ± 0.025	0.668TrpGlu: 0.668 ± 0.022	0.584TrpPhe: 0.584 ± 0.024	0.568TrpGly: 0.568 ± 0.022	0.22TrpHis: 0.22 ± 0.013	0.701TrpIle: 0.701 ± 0.025	0.731TrpLys: 0.731 ± 0.026	1.017TrpLeu: 1.017 ± 0.028	0.317TrpMet: 0.317 ± 0.016	0.663TrpAsn: 0.663 ± 0.021	0.223TrpPro: 0.223 ± 0.013	0.427TrpGln: 0.427 ± 0.02	0.4TrpArg: 0.4 ± 0.019	0.652TrpSer: 0.652 ± 0.028	0.538TrpThr: 0.538 ± 0.021	0.589TrpVal: 0.589 ± 0.021	0.138TrpTrp: 0.138 ± 0.011	0.43TrpTyr: 0.43 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.505TyrAla: 2.505 ± 0.042	0.326TyrCys: 0.326 ± 0.016	2.468TyrAsp: 2.468 ± 0.043	2.424TyrGlu: 2.424 ± 0.05	2.36TyrPhe: 2.36 ± 0.047	2.56TyrGly: 2.56 ± 0.051	0.798TyrHis: 0.798 ± 0.028	2.577TyrIle: 2.577 ± 0.047	2.938TyrLys: 2.938 ± 0.048	3.788TyrLeu: 3.788 ± 0.065	0.785TyrMet: 0.785 ± 0.024	2.414TyrAsn: 2.414 ± 0.049	1.356TyrPro: 1.356 ± 0.038	1.563TyrGln: 1.563 ± 0.038	1.585TyrArg: 1.585 ± 0.037	2.569TyrSer: 2.569 ± 0.045	2.319TyrThr: 2.319 ± 0.046	2.223TyrVal: 2.223 ± 0.039	0.478TyrTrp: 0.478 ± 0.019	1.775TyrTyr: 1.775 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3955 proteins (1316798 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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