Amino acid dipepetide frequency for Archangium gephyra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.407AlaAla: 13.407 ± 0.099	1.259AlaCys: 1.259 ± 0.023	4.701AlaAsp: 4.701 ± 0.038	7.624AlaGlu: 7.624 ± 0.076	3.756AlaPhe: 3.756 ± 0.032	9.412AlaGly: 9.412 ± 0.066	2.403AlaHis: 2.403 ± 0.03	3.197AlaIle: 3.197 ± 0.035	2.871AlaLys: 2.871 ± 0.046	14.281AlaLeu: 14.281 ± 0.104	2.282AlaMet: 2.282 ± 0.031	2.221AlaAsn: 2.221 ± 0.028	7.012AlaPro: 7.012 ± 0.063	4.163AlaGln: 4.163 ± 0.04	10.444AlaArg: 10.444 ± 0.076	6.928AlaSer: 6.928 ± 0.055	5.798AlaThr: 5.798 ± 0.054	8.277AlaVal: 8.277 ± 0.055	1.751AlaTrp: 1.751 ± 0.026	2.274AlaTyr: 2.274 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.097CysAla: 1.097 ± 0.019	0.106CysCys: 0.106 ± 0.006	0.514CysAsp: 0.514 ± 0.017	0.572CysGlu: 0.572 ± 0.014	0.332CysPhe: 0.332 ± 0.01	1.014CysGly: 1.014 ± 0.024	0.257CysHis: 0.257 ± 0.011	0.294CysIle: 0.294 ± 0.009	0.194CysLys: 0.194 ± 0.008	0.871CysLeu: 0.871 ± 0.015	0.155CysMet: 0.155 ± 0.007	0.247CysAsn: 0.247 ± 0.011	0.585CysPro: 0.585 ± 0.018	0.335CysGln: 0.335 ± 0.01	0.663CysArg: 0.663 ± 0.017	0.579CysSer: 0.579 ± 0.017	0.591CysThr: 0.591 ± 0.015	0.69CysVal: 0.69 ± 0.016	0.118CysTrp: 0.118 ± 0.006	0.206CysTyr: 0.206 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.851AspAla: 5.851 ± 0.052	0.475AspCys: 0.475 ± 0.015	2.142AspAsp: 2.142 ± 0.033	3.374AspGlu: 3.374 ± 0.033	1.998AspPhe: 1.998 ± 0.026	4.995AspGly: 4.995 ± 0.069	0.81AspHis: 0.81 ± 0.014	1.716AspIle: 1.716 ± 0.026	1.445AspLys: 1.445 ± 0.022	4.696AspLeu: 4.696 ± 0.041	0.851AspMet: 0.851 ± 0.015	1.027AspAsn: 1.027 ± 0.022	3.013AspPro: 3.013 ± 0.038	1.168AspGln: 1.168 ± 0.021	2.912AspArg: 2.912 ± 0.034	2.465AspSer: 2.465 ± 0.035	2.634AspThr: 2.634 ± 0.035	4.159AspVal: 4.159 ± 0.034	0.774AspTrp: 0.774 ± 0.015	1.143AspTyr: 1.143 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	8.752GluAla: 8.752 ± 0.082	0.451GluCys: 0.451 ± 0.012	3.227GluAsp: 3.227 ± 0.032	4.789GluGlu: 4.789 ± 0.066	1.537GluPhe: 1.537 ± 0.025	5.688GluGly: 5.688 ± 0.049	1.574GluHis: 1.574 ± 0.025	1.482GluIle: 1.482 ± 0.026	2.321GluLys: 2.321 ± 0.036	8.527GluLeu: 8.527 ± 0.08	1.206GluMet: 1.206 ± 0.021	1.189GluAsn: 1.189 ± 0.016	3.978GluPro: 3.978 ± 0.04	3.058GluGln: 3.058 ± 0.035	6.726GluArg: 6.726 ± 0.073	3.232GluSer: 3.232 ± 0.028	2.899GluThr: 2.899 ± 0.034	5.43GluVal: 5.43 ± 0.047	0.825GluTrp: 0.825 ± 0.019	1.141GluTyr: 1.141 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.225PheAla: 3.225 ± 0.035	0.312PheCys: 0.312 ± 0.009	1.963PheAsp: 1.963 ± 0.026	2.291PheGlu: 2.291 ± 0.029	1.424PhePhe: 1.424 ± 0.028	2.82PheGly: 2.82 ± 0.033	0.822PheHis: 0.822 ± 0.018	1.204PheIle: 1.204 ± 0.021	0.861PheLys: 0.861 ± 0.017	3.533PheLeu: 3.533 ± 0.034	0.61PheMet: 0.61 ± 0.013	0.912PheAsn: 0.912 ± 0.018	1.648PhePro: 1.648 ± 0.021	1.268PheGln: 1.268 ± 0.019	2.328PheArg: 2.328 ± 0.024	2.354PheSer: 2.354 ± 0.026	2.152PheThr: 2.152 ± 0.027	2.437PheVal: 2.437 ± 0.031	0.452PheTrp: 0.452 ± 0.011	0.778PheTyr: 0.778 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	9.036GlyAla: 9.036 ± 0.065	1.034GlyCys: 1.034 ± 0.021	4.043GlyAsp: 4.043 ± 0.045	5.629GlyGlu: 5.629 ± 0.054	3.135GlyPhe: 3.135 ± 0.031	8.034GlyGly: 8.034 ± 0.08	1.944GlyHis: 1.944 ± 0.026	2.807GlyIle: 2.807 ± 0.033	3.09GlyLys: 3.09 ± 0.037	9.358GlyLeu: 9.358 ± 0.06	1.991GlyMet: 1.991 ± 0.026	2.19GlyAsn: 2.19 ± 0.028	4.417GlyPro: 4.417 ± 0.044	3.382GlyGln: 3.382 ± 0.038	6.793GlyArg: 6.793 ± 0.055	5.323GlySer: 5.323 ± 0.059	5.943GlyThr: 5.943 ± 0.073	6.7GlyVal: 6.7 ± 0.051	1.403GlyTrp: 1.403 ± 0.024	2.093GlyTyr: 2.093 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.327HisAla: 2.327 ± 0.028	0.205HisCys: 0.205 ± 0.008	0.922HisAsp: 0.922 ± 0.016	1.432HisGlu: 1.432 ± 0.022	0.84HisPhe: 0.84 ± 0.015	2.058HisGly: 2.058 ± 0.028	0.664HisHis: 0.664 ± 0.02	0.635HisIle: 0.635 ± 0.014	0.44HisLys: 0.44 ± 0.012	2.478HisLeu: 2.478 ± 0.031	0.345HisMet: 0.345 ± 0.011	0.379HisAsn: 0.379 ± 0.01	1.688HisPro: 1.688 ± 0.026	0.75HisGln: 0.75 ± 0.014	1.67HisArg: 1.67 ± 0.022	1.076HisSer: 1.076 ± 0.018	1.074HisThr: 1.074 ± 0.021	1.689HisVal: 1.689 ± 0.025	0.329HisTrp: 0.329 ± 0.009	0.543HisTyr: 0.543 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.251IleAla: 3.251 ± 0.039	0.263IleCys: 0.263 ± 0.009	1.636IleAsp: 1.636 ± 0.025	1.862IleGlu: 1.862 ± 0.025	0.955IlePhe: 0.955 ± 0.018	2.414IleGly: 2.414 ± 0.026	0.796IleHis: 0.796 ± 0.016	1.133IleIle: 1.133 ± 0.023	0.727IleLys: 0.727 ± 0.016	2.67IleLeu: 2.67 ± 0.032	0.335IleMet: 0.335 ± 0.011	0.839IleAsn: 0.839 ± 0.017	1.87IlePro: 1.87 ± 0.029	1.105IleGln: 1.105 ± 0.018	2.143IleArg: 2.143 ± 0.026	1.869IleSer: 1.869 ± 0.025	1.724IleThr: 1.724 ± 0.025	2.061IleVal: 2.061 ± 0.027	0.324IleTrp: 0.324 ± 0.009	0.643IleTyr: 0.643 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.514LysAla: 3.514 ± 0.046	0.182LysCys: 0.182 ± 0.007	1.734LysAsp: 1.734 ± 0.029	1.802LysGlu: 1.802 ± 0.028	0.624LysPhe: 0.624 ± 0.015	2.508LysGly: 2.508 ± 0.028	0.567LysHis: 0.567 ± 0.013	0.727LysIle: 0.727 ± 0.017	1.335LysLys: 1.335 ± 0.03	3.295LysLeu: 3.295 ± 0.039	0.604LysMet: 0.604 ± 0.015	0.704LysAsn: 0.704 ± 0.016	1.974LysPro: 1.974 ± 0.028	1.121LysGln: 1.121 ± 0.021	2.1LysArg: 2.1 ± 0.03	1.423LysSer: 1.423 ± 0.021	1.555LysThr: 1.555 ± 0.02	2.539LysVal: 2.539 ± 0.032	0.327LysTrp: 0.327 ± 0.01	0.579LysTyr: 0.579 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.738LeuAla: 13.738 ± 0.087	1.02LeuCys: 1.02 ± 0.018	5.454LeuAsp: 5.454 ± 0.049	8.41LeuGlu: 8.41 ± 0.077	3.61LeuPhe: 3.61 ± 0.04	9.833LeuGly: 9.833 ± 0.069	2.419LeuHis: 2.419 ± 0.03	2.848LeuIle: 2.848 ± 0.031	3.47LeuLys: 3.47 ± 0.038	12.568LeuLeu: 12.568 ± 0.102	1.941LeuMet: 1.941 ± 0.023	2.188LeuAsn: 2.188 ± 0.025	6.965LeuPro: 6.965 ± 0.069	3.647LeuGln: 3.647 ± 0.04	9.259LeuArg: 9.259 ± 0.077	7.228LeuSer: 7.228 ± 0.055	6.039LeuThr: 6.039 ± 0.047	8.889LeuVal: 8.889 ± 0.062	1.494LeuTrp: 1.494 ± 0.031	2.414LeuTyr: 2.414 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.349MetAla: 2.349 ± 0.027	0.122MetCys: 0.122 ± 0.005	0.981MetAsp: 0.981 ± 0.017	1.235MetGlu: 1.235 ± 0.02	0.446MetPhe: 0.446 ± 0.011	1.713MetGly: 1.713 ± 0.025	0.379MetHis: 0.379 ± 0.009	0.448MetIle: 0.448 ± 0.012	0.832MetLys: 0.832 ± 0.018	2.062MetLeu: 2.062 ± 0.026	0.481MetMet: 0.481 ± 0.012	0.583MetAsn: 0.583 ± 0.013	1.196MetPro: 1.196 ± 0.017	0.606MetGln: 0.606 ± 0.012	1.632MetArg: 1.632 ± 0.018	1.351MetSer: 1.351 ± 0.02	1.075MetThr: 1.075 ± 0.017	1.392MetVal: 1.392 ± 0.022	0.19MetTrp: 0.19 ± 0.008	0.295MetTyr: 0.295 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.451AsnAla: 2.451 ± 0.031	0.234AsnCys: 0.234 ± 0.009	1.0AsnAsp: 1.0 ± 0.02	1.17AsnGlu: 1.17 ± 0.02	0.696AsnPhe: 0.696 ± 0.014	2.13AsnGly: 2.13 ± 0.029	0.462AsnHis: 0.462 ± 0.01	0.778AsnIle: 0.778 ± 0.017	0.585AsnLys: 0.585 ± 0.014	2.353AsnLeu: 2.353 ± 0.028	0.35AsnMet: 0.35 ± 0.009	0.642AsnAsn: 0.642 ± 0.018	1.732AsnPro: 1.732 ± 0.024	0.724AsnGln: 0.724 ± 0.016	1.433AsnArg: 1.433 ± 0.021	1.034AsnSer: 1.034 ± 0.023	1.334AsnThr: 1.334 ± 0.023	1.758AsnVal: 1.758 ± 0.024	0.288AsnTrp: 0.288 ± 0.01	0.529AsnTyr: 0.529 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.229ProAla: 7.229 ± 0.064	0.397ProCys: 0.397 ± 0.012	3.205ProAsp: 3.205 ± 0.033	5.377ProGlu: 5.377 ± 0.049	1.975ProPhe: 1.975 ± 0.029	6.138ProGly: 6.138 ± 0.049	1.178ProHis: 1.178 ± 0.02	1.502ProIle: 1.502 ± 0.023	1.494ProLys: 1.494 ± 0.027	6.191ProLeu: 6.191 ± 0.059	1.253ProMet: 1.253 ± 0.019	1.132ProAsn: 1.132 ± 0.02	4.501ProPro: 4.501 ± 0.056	1.819ProGln: 1.819 ± 0.024	4.401ProArg: 4.401 ± 0.038	3.84ProSer: 3.84 ± 0.038	3.047ProThr: 3.047 ± 0.034	4.971ProVal: 4.971 ± 0.043	0.815ProTrp: 0.815 ± 0.017	1.178ProTyr: 1.178 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	4.334GlnAla: 4.334 ± 0.038	0.283GlnCys: 0.283 ± 0.01	1.549GlnAsp: 1.549 ± 0.021	2.31GlnGlu: 2.31 ± 0.031	0.867GlnPhe: 0.867 ± 0.017	3.176GlnGly: 3.176 ± 0.032	0.745GlnHis: 0.745 ± 0.018	0.769GlnIle: 0.769 ± 0.017	1.115GlnLys: 1.115 ± 0.021	3.987GlnLeu: 3.987 ± 0.044	0.652GlnMet: 0.652 ± 0.015	0.657GlnAsn: 0.657 ± 0.015	2.218GlnPro: 2.218 ± 0.031	1.556GlnGln: 1.556 ± 0.028	3.13GlnArg: 3.13 ± 0.038	1.683GlnSer: 1.683 ± 0.023	1.53GlnThr: 1.53 ± 0.025	3.295GlnVal: 3.295 ± 0.039	0.524GlnTrp: 0.524 ± 0.014	0.68GlnTyr: 0.68 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	8.908ArgAla: 8.908 ± 0.071	0.741ArgCys: 0.741 ± 0.016	3.546ArgAsp: 3.546 ± 0.036	6.164ArgGlu: 6.164 ± 0.067	3.166ArgPhe: 3.166 ± 0.035	5.894ArgGly: 5.894 ± 0.045	1.791ArgHis: 1.791 ± 0.023	2.856ArgIle: 2.856 ± 0.031	2.323ArgLys: 2.323 ± 0.029	9.509ArgLeu: 9.509 ± 0.079	2.059ArgMet: 2.059 ± 0.023	1.606ArgAsn: 1.606 ± 0.022	4.347ArgPro: 4.347 ± 0.046	2.892ArgGln: 2.892 ± 0.031	6.346ArgArg: 6.346 ± 0.056	3.97ArgSer: 3.97 ± 0.034	4.177ArgThr: 4.177 ± 0.037	6.514ArgVal: 6.514 ± 0.05	1.332ArgTrp: 1.332 ± 0.019	2.11ArgTyr: 2.11 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.49SerAla: 6.49 ± 0.049	0.615SerCys: 0.615 ± 0.016	2.517SerAsp: 2.517 ± 0.033	3.341SerGlu: 3.341 ± 0.034	2.251SerPhe: 2.251 ± 0.032	5.975SerGly: 5.975 ± 0.061	1.189SerHis: 1.189 ± 0.022	1.804SerIle: 1.804 ± 0.022	1.387SerLys: 1.387 ± 0.024	6.573SerLeu: 6.573 ± 0.058	1.147SerMet: 1.147 ± 0.019	1.359SerAsn: 1.359 ± 0.025	3.902SerPro: 3.902 ± 0.037	1.832SerGln: 1.832 ± 0.02	4.414SerArg: 4.414 ± 0.035	3.816SerSer: 3.816 ± 0.049	3.385SerThr: 3.385 ± 0.039	4.272SerVal: 4.272 ± 0.039	0.906SerTrp: 0.906 ± 0.018	1.277SerTyr: 1.277 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.929ThrAla: 5.929 ± 0.062	0.589ThrCys: 0.589 ± 0.016	2.395ThrAsp: 2.395 ± 0.034	2.872ThrGlu: 2.872 ± 0.029	2.034ThrPhe: 2.034 ± 0.026	5.39ThrGly: 5.39 ± 0.051	1.155ThrHis: 1.155 ± 0.017	1.324ThrIle: 1.324 ± 0.022	1.155ThrLys: 1.155 ± 0.02	6.781ThrLeu: 6.781 ± 0.046	0.759ThrMet: 0.759 ± 0.015	1.133ThrAsn: 1.133 ± 0.023	4.144ThrPro: 4.144 ± 0.043	1.819ThrGln: 1.819 ± 0.026	4.084ThrArg: 4.084 ± 0.037	3.201ThrSer: 3.201 ± 0.041	2.961ThrThr: 2.961 ± 0.043	4.609ThrVal: 4.609 ± 0.058	0.924ThrTrp: 0.924 ± 0.018	1.332ThrTyr: 1.332 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	8.544ValAla: 8.544 ± 0.048	0.762ValCys: 0.762 ± 0.017	4.226ValAsp: 4.226 ± 0.038	5.597ValGlu: 5.597 ± 0.051	2.381ValPhe: 2.381 ± 0.028	6.164ValGly: 6.164 ± 0.052	1.644ValHis: 1.644 ± 0.024	2.208ValIle: 2.208 ± 0.027	2.474ValLys: 2.474 ± 0.027	9.57ValLeu: 9.57 ± 0.07	1.564ValMet: 1.564 ± 0.022	1.679ValAsn: 1.679 ± 0.027	4.645ValPro: 4.645 ± 0.042	2.528ValGln: 2.528 ± 0.027	6.608ValArg: 6.608 ± 0.044	4.802ValSer: 4.802 ± 0.043	4.534ValThr: 4.534 ± 0.051	6.567ValVal: 6.567 ± 0.047	1.039ValTrp: 1.039 ± 0.024	1.604ValTyr: 1.604 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.308TrpAla: 1.308 ± 0.021	0.154TrpCys: 0.154 ± 0.007	0.658TrpAsp: 0.658 ± 0.015	0.8TrpGlu: 0.8 ± 0.016	0.482TrpPhe: 0.482 ± 0.013	1.075TrpGly: 1.075 ± 0.027	0.296TrpHis: 0.296 ± 0.009	0.347TrpIle: 0.347 ± 0.01	0.57TrpLys: 0.57 ± 0.015	1.761TrpLeu: 1.761 ± 0.026	0.41TrpMet: 0.41 ± 0.011	0.437TrpAsn: 0.437 ± 0.012	0.697TrpPro: 0.697 ± 0.014	0.491TrpGln: 0.491 ± 0.012	1.331TrpArg: 1.331 ± 0.022	1.043TrpSer: 1.043 ± 0.025	0.88TrpThr: 0.88 ± 0.017	1.118TrpVal: 1.118 ± 0.021	0.26TrpTrp: 0.26 ± 0.01	0.291TrpTyr: 0.291 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.323TyrAla: 2.323 ± 0.026	0.215TyrCys: 0.215 ± 0.008	1.236TyrAsp: 1.236 ± 0.025	1.38TyrGlu: 1.38 ± 0.021	0.887TyrPhe: 0.887 ± 0.017	1.914TyrGly: 1.914 ± 0.029	0.447TyrHis: 0.447 ± 0.011	0.541TyrIle: 0.541 ± 0.014	0.527TyrLys: 0.527 ± 0.012	2.367TyrLeu: 2.367 ± 0.027	0.374TyrMet: 0.374 ± 0.009	0.56TyrAsn: 0.56 ± 0.015	1.112TyrPro: 1.112 ± 0.02	0.795TyrGln: 0.795 ± 0.017	1.831TyrArg: 1.831 ± 0.023	1.236TyrSer: 1.236 ± 0.023	1.258TyrThr: 1.258 ± 0.022	1.772TyrVal: 1.772 ± 0.027	0.335TyrTrp: 0.335 ± 0.01	0.575TyrTyr: 0.575 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10110 proteins (3715422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---