Amino acid dipepetide frequency for Halomonas sp. es.049

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.871AlaAla: 10.871 ± 0.143
1.106AlaCys: 1.106 ± 0.039
8.029AlaAsp: 8.029 ± 1.439
6.535AlaGlu: 6.535 ± 0.107
3.933AlaPhe: 3.933 ± 0.087
7.921AlaGly: 7.921 ± 0.127
2.276AlaHis: 2.276 ± 0.049
5.55AlaIle: 5.55 ± 0.08
3.15AlaLys: 3.15 ± 0.062
13.226AlaLeu: 13.226 ± 0.186
3.134AlaMet: 3.134 ± 0.067
3.296AlaAsn: 3.296 ± 0.087
4.352AlaPro: 4.352 ± 0.076
4.617AlaGln: 4.617 ± 0.081
6.294AlaArg: 6.294 ± 0.108
6.658AlaSer: 6.658 ± 0.111
5.43AlaThr: 5.43 ± 0.131
7.04AlaVal: 7.04 ± 0.101
1.617AlaTrp: 1.617 ± 0.046
2.327AlaTyr: 2.327 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.848CysAla: 0.848 ± 0.036
0.13CysCys: 0.13 ± 0.01
0.573CysAsp: 0.573 ± 0.022
0.533CysGlu: 0.533 ± 0.022
0.339CysPhe: 0.339 ± 0.018
0.804CysGly: 0.804 ± 0.029
0.334CysHis: 0.334 ± 0.017
0.4CysIle: 0.4 ± 0.019
0.221CysLys: 0.221 ± 0.017
0.994CysLeu: 0.994 ± 0.033
0.206CysMet: 0.206 ± 0.013
0.219CysAsn: 0.219 ± 0.014
0.465CysPro: 0.465 ± 0.022
0.497CysGln: 0.497 ± 0.026
0.589CysArg: 0.589 ± 0.024
0.465CysSer: 0.465 ± 0.02
0.371CysThr: 0.371 ± 0.018
0.629CysVal: 0.629 ± 0.027
0.148CysTrp: 0.148 ± 0.012
0.256CysTyr: 0.256 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
8.801AspAla: 8.801 ± 1.442
0.432AspCys: 0.432 ± 0.022
3.978AspAsp: 3.978 ± 0.114
3.909AspGlu: 3.909 ± 0.077
2.058AspPhe: 2.058 ± 0.052
4.647AspGly: 4.647 ± 0.222
1.327AspHis: 1.327 ± 0.046
3.583AspIle: 3.583 ± 0.085
1.686AspLys: 1.686 ± 0.043
5.135AspLeu: 5.135 ± 0.101
1.403AspMet: 1.403 ± 0.039
2.116AspAsn: 2.116 ± 0.093
2.581AspPro: 2.581 ± 0.062
2.321AspGln: 2.321 ± 0.075
2.811AspArg: 2.811 ± 0.068
3.069AspSer: 3.069 ± 0.089
3.278AspThr: 3.278 ± 0.073
4.471AspVal: 4.471 ± 0.129
0.944AspTrp: 0.944 ± 0.032
1.724AspTyr: 1.724 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
7.062GluAla: 7.062 ± 0.114
0.481GluCys: 0.481 ± 0.021
3.166GluAsp: 3.166 ± 0.098
3.7GluGlu: 3.7 ± 0.078
1.691GluPhe: 1.691 ± 0.046
4.53GluGly: 4.53 ± 0.067
1.71GluHis: 1.71 ± 0.047
2.952GluIle: 2.952 ± 0.07
2.386GluLys: 2.386 ± 0.058
6.297GluLeu: 6.297 ± 0.108
1.536GluMet: 1.536 ± 0.042
2.025GluAsn: 2.025 ± 0.051
2.548GluPro: 2.548 ± 0.062
3.632GluGln: 3.632 ± 0.072
4.945GluArg: 4.945 ± 0.095
3.448GluSer: 3.448 ± 0.062
3.461GluThr: 3.461 ± 0.07
4.126GluVal: 4.126 ± 0.07
0.868GluTrp: 0.868 ± 0.03
1.278GluTyr: 1.278 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.449PheAla: 3.449 ± 0.066
0.386PheCys: 0.386 ± 0.02
2.502PheAsp: 2.502 ± 0.054
2.158PheGlu: 2.158 ± 0.053
1.376PhePhe: 1.376 ± 0.046
3.053PheGly: 3.053 ± 0.061
0.809PheHis: 0.809 ± 0.028
1.969PheIle: 1.969 ± 0.054
1.059PheLys: 1.059 ± 0.035
3.055PheLeu: 3.055 ± 0.081
0.928PheMet: 0.928 ± 0.034
1.334PheAsn: 1.334 ± 0.048
1.408PhePro: 1.408 ± 0.045
1.258PheGln: 1.258 ± 0.039
1.763PheArg: 1.763 ± 0.049
2.589PheSer: 2.589 ± 0.054
2.109PheThr: 2.109 ± 0.043
2.278PheVal: 2.278 ± 0.056
0.525PheTrp: 0.525 ± 0.024
0.983PheTyr: 0.983 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
6.631GlyAla: 6.631 ± 0.115
0.86GlyCys: 0.86 ± 0.028
4.485GlyAsp: 4.485 ± 0.167
5.137GlyGlu: 5.137 ± 0.088
3.18GlyPhe: 3.18 ± 0.053
5.943GlyGly: 5.943 ± 0.168
1.896GlyHis: 1.896 ± 0.055
4.509GlyIle: 4.509 ± 0.069
2.903GlyLys: 2.903 ± 0.059
8.36GlyLeu: 8.36 ± 0.113
2.277GlyMet: 2.277 ± 0.052
2.714GlyAsn: 2.714 ± 0.139
2.476GlyPro: 2.476 ± 0.06
3.299GlyGln: 3.299 ± 0.064
4.373GlyArg: 4.373 ± 0.074
4.383GlySer: 4.383 ± 0.109
3.778GlyThr: 3.778 ± 0.164
6.041GlyVal: 6.041 ± 0.099
1.376GlyTrp: 1.376 ± 0.041
2.389GlyTyr: 2.389 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.437HisAla: 2.437 ± 0.057
0.272HisCys: 0.272 ± 0.019
1.411HisAsp: 1.411 ± 0.052
1.233HisGlu: 1.233 ± 0.038
1.085HisPhe: 1.085 ± 0.04
1.932HisGly: 1.932 ± 0.048
0.876HisHis: 0.876 ± 0.031
1.051HisIle: 1.051 ± 0.038
0.604HisLys: 0.604 ± 0.024
2.611HisLeu: 2.611 ± 0.064
0.521HisMet: 0.521 ± 0.023
0.677HisAsn: 0.677 ± 0.027
1.483HisPro: 1.483 ± 0.044
1.322HisGln: 1.322 ± 0.04
1.531HisArg: 1.531 ± 0.045
1.311HisSer: 1.311 ± 0.033
1.122HisThr: 1.122 ± 0.035
1.419HisVal: 1.419 ± 0.036
0.467HisTrp: 0.467 ± 0.025
0.867HisTyr: 0.867 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.87IleAla: 5.87 ± 0.08
0.431IleCys: 0.431 ± 0.021
3.709IleAsp: 3.709 ± 0.097
3.651IleGlu: 3.651 ± 0.073
1.55IlePhe: 1.55 ± 0.048
4.383IleGly: 4.383 ± 0.108
1.132IleHis: 1.132 ± 0.037
2.374IleIle: 2.374 ± 0.061
1.675IleLys: 1.675 ± 0.049
3.971IleLeu: 3.971 ± 0.083
1.142IleMet: 1.142 ± 0.038
2.044IleAsn: 2.044 ± 0.058
2.202IlePro: 2.202 ± 0.054
1.728IleGln: 1.728 ± 0.042
2.779IleArg: 2.779 ± 0.065
3.338IleSer: 3.338 ± 0.082
3.207IleThr: 3.207 ± 0.146
3.38IleVal: 3.38 ± 0.074
0.494IleTrp: 0.494 ± 0.026
1.139IleTyr: 1.139 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.67LysAla: 3.67 ± 0.068
0.175LysCys: 0.175 ± 0.014
1.52LysAsp: 1.52 ± 0.043
1.837LysGlu: 1.837 ± 0.047
0.655LysPhe: 0.655 ± 0.03
2.402LysGly: 2.402 ± 0.055
0.73LysHis: 0.73 ± 0.026
1.343LysIle: 1.343 ± 0.04
1.303LysLys: 1.303 ± 0.041
3.093LysLeu: 3.093 ± 0.063
0.774LysMet: 0.774 ± 0.028
0.951LysAsn: 0.951 ± 0.037
1.73LysPro: 1.73 ± 0.047
1.514LysGln: 1.514 ± 0.046
2.673LysArg: 2.673 ± 0.066
1.686LysSer: 1.686 ± 0.041
1.759LysThr: 1.759 ± 0.049
2.264LysVal: 2.264 ± 0.055
0.343LysTrp: 0.343 ± 0.018
0.561LysTyr: 0.561 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
12.87LeuAla: 12.87 ± 0.172
1.058LeuCys: 1.058 ± 0.038
6.613LeuAsp: 6.613 ± 0.111
6.965LeuGlu: 6.965 ± 0.109
3.672LeuPhe: 3.672 ± 0.084
8.276LeuGly: 8.276 ± 0.12
2.268LeuHis: 2.268 ± 0.056
5.51LeuIle: 5.51 ± 0.101
3.836LeuLys: 3.836 ± 0.072
11.632LeuLeu: 11.632 ± 0.225
3.063LeuMet: 3.063 ± 0.073
3.688LeuAsn: 3.688 ± 0.069
5.956LeuPro: 5.956 ± 0.122
3.706LeuGln: 3.706 ± 0.081
6.156LeuArg: 6.156 ± 0.093
7.286LeuSer: 7.286 ± 0.124
6.352LeuThr: 6.352 ± 0.109
7.327LeuVal: 7.327 ± 0.119
1.379LeuTrp: 1.379 ± 0.045
2.386LeuTyr: 2.386 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
3.175MetAla: 3.175 ± 0.068
0.183MetCys: 0.183 ± 0.014
1.163MetAsp: 1.163 ± 0.034
1.234MetGlu: 1.234 ± 0.036
0.756MetPhe: 0.756 ± 0.038
1.971MetGly: 1.971 ± 0.049
0.524MetHis: 0.524 ± 0.025
1.293MetIle: 1.293 ± 0.034
0.899MetLys: 0.899 ± 0.029
2.857MetLeu: 2.857 ± 0.079
0.694MetMet: 0.694 ± 0.03
0.885MetAsn: 0.885 ± 0.027
1.409MetPro: 1.409 ± 0.037
1.205MetGln: 1.205 ± 0.037
1.536MetArg: 1.536 ± 0.039
1.792MetSer: 1.792 ± 0.048
1.769MetThr: 1.769 ± 0.044
1.839MetVal: 1.839 ± 0.049
0.202MetTrp: 0.202 ± 0.013
0.379MetTyr: 0.379 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.863AsnAla: 3.863 ± 0.073
0.238AsnCys: 0.238 ± 0.017
1.991AsnAsp: 1.991 ± 0.103
1.836AsnGlu: 1.836 ± 0.061
1.004AsnPhe: 1.004 ± 0.036
2.814AsnGly: 2.814 ± 0.15
0.747AsnHis: 0.747 ± 0.026
1.744AsnIle: 1.744 ± 0.089
0.834AsnLys: 0.834 ± 0.035
3.091AsnLeu: 3.091 ± 0.068
0.669AsnMet: 0.669 ± 0.03
1.118AsnAsn: 1.118 ± 0.061
1.865AsnPro: 1.865 ± 0.066
1.391AsnGln: 1.391 ± 0.038
1.947AsnArg: 1.947 ± 0.051
1.629AsnSer: 1.629 ± 0.091
1.903AsnThr: 1.903 ± 0.105
2.507AsnVal: 2.507 ± 0.094
0.412AsnTrp: 0.412 ± 0.021
0.775AsnTyr: 0.775 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.61ProAla: 4.61 ± 0.087
0.324ProCys: 0.324 ± 0.016
3.259ProAsp: 3.259 ± 0.059
3.84ProGlu: 3.84 ± 0.082
1.71ProPhe: 1.71 ± 0.045
3.702ProGly: 3.702 ± 0.07
1.051ProHis: 1.051 ± 0.033
1.998ProIle: 1.998 ± 0.046
1.352ProLys: 1.352 ± 0.044
5.327ProLeu: 5.327 ± 0.106
1.191ProMet: 1.191 ± 0.036
1.434ProAsn: 1.434 ± 0.05
2.015ProPro: 2.015 ± 0.051
1.891ProGln: 1.891 ± 0.042
2.384ProArg: 2.384 ± 0.063
2.831ProSer: 2.831 ± 0.06
2.337ProThr: 2.337 ± 0.053
3.581ProVal: 3.581 ± 0.067
0.767ProTrp: 0.767 ± 0.028
1.052ProTyr: 1.052 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
5.602GlnAla: 5.602 ± 0.099
0.348GlnCys: 0.348 ± 0.021
1.931GlnAsp: 1.931 ± 0.05
2.484GlnGlu: 2.484 ± 0.056
1.217GlnPhe: 1.217 ± 0.039
3.4GlnGly: 3.4 ± 0.07
1.301GlnHis: 1.301 ± 0.037
1.826GlnIle: 1.826 ± 0.047
1.235GlnLys: 1.235 ± 0.041
5.166GlnLeu: 5.166 ± 0.09
0.958GlnMet: 0.958 ± 0.028
1.082GlnAsn: 1.082 ± 0.034
2.168GlnPro: 2.168 ± 0.067
3.138GlnGln: 3.138 ± 0.084
3.856GlnArg: 3.856 ± 0.088
2.301GlnSer: 2.301 ± 0.055
2.097GlnThr: 2.097 ± 0.047
3.189GlnVal: 3.189 ± 0.052
0.84GlnTrp: 0.84 ± 0.038
0.822GlnTyr: 0.822 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
5.097ArgAla: 5.097 ± 0.09
0.589ArgCys: 0.589 ± 0.026
3.545ArgAsp: 3.545 ± 0.054
4.348ArgGlu: 4.348 ± 0.083
2.782ArgPhe: 2.782 ± 0.06
3.657ArgGly: 3.657 ± 0.071
2.032ArgHis: 2.032 ± 0.055
3.163ArgIle: 3.163 ± 0.061
1.92ArgLys: 1.92 ± 0.05
7.979ArgLeu: 7.979 ± 0.153
1.563ArgMet: 1.563 ± 0.046
1.762ArgAsn: 1.762 ± 0.052
2.421ArgPro: 2.421 ± 0.061
3.555ArgGln: 3.555 ± 0.07
4.264ArgArg: 4.264 ± 0.09
3.06ArgSer: 3.06 ± 0.061
2.578ArgThr: 2.578 ± 0.056
4.16ArgVal: 4.16 ± 0.081
1.088ArgTrp: 1.088 ± 0.036
2.083ArgTyr: 2.083 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
6.152SerAla: 6.152 ± 0.089
0.439SerCys: 0.439 ± 0.023
3.432SerAsp: 3.432 ± 0.073
3.491SerGlu: 3.491 ± 0.059
2.038SerPhe: 2.038 ± 0.046
5.32SerGly: 5.32 ± 0.106
1.44SerHis: 1.44 ± 0.038
2.706SerIle: 2.706 ± 0.056
1.521SerLys: 1.521 ± 0.042
6.84SerLeu: 6.84 ± 0.114
1.572SerMet: 1.572 ± 0.045
1.774SerAsn: 1.774 ± 0.091
2.885SerPro: 2.885 ± 0.052
2.744SerGln: 2.744 ± 0.055
3.705SerArg: 3.705 ± 0.068
3.667SerSer: 3.667 ± 0.066
3.1SerThr: 3.1 ± 0.079
4.524SerVal: 4.524 ± 0.153
0.77SerTrp: 0.77 ± 0.029
1.334SerTyr: 1.334 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
5.39ThrAla: 5.39 ± 0.134
0.46ThrCys: 0.46 ± 0.022
2.928ThrAsp: 2.928 ± 0.136
2.528ThrGlu: 2.528 ± 0.057
2.006ThrPhe: 2.006 ± 0.045
4.44ThrGly: 4.44 ± 0.19
1.321ThrHis: 1.321 ± 0.04
2.437ThrIle: 2.437 ± 0.135
1.09ThrLys: 1.09 ± 0.03
7.799ThrLeu: 7.799 ± 0.116
1.086ThrMet: 1.086 ± 0.036
1.408ThrAsn: 1.408 ± 0.083
3.625ThrPro: 3.625 ± 0.065
2.459ThrGln: 2.459 ± 0.053
3.253ThrArg: 3.253 ± 0.061
3.201ThrSer: 3.201 ± 0.104
2.974ThrThr: 2.974 ± 0.102
3.609ThrVal: 3.609 ± 0.107
0.67ThrTrp: 0.67 ± 0.029
1.267ThrTyr: 1.267 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
7.565ValAla: 7.565 ± 0.134
0.652ValCys: 0.652 ± 0.023
4.186ValAsp: 4.186 ± 0.082
4.532ValGlu: 4.532 ± 0.072
2.483ValPhe: 2.483 ± 0.056
5.075ValGly: 5.075 ± 0.092
1.347ValHis: 1.347 ± 0.04
4.145ValIle: 4.145 ± 0.077
2.294ValLys: 2.294 ± 0.052
7.331ValLeu: 7.331 ± 0.129
2.141ValMet: 2.141 ± 0.057
2.738ValAsn: 2.738 ± 0.182
3.094ValPro: 3.094 ± 0.054
2.144ValGln: 2.144 ± 0.053
3.822ValArg: 3.822 ± 0.073
4.654ValSer: 4.654 ± 0.07
4.426ValThr: 4.426 ± 0.144
5.556ValVal: 5.556 ± 0.098
0.838ValTrp: 0.838 ± 0.029
1.554ValTyr: 1.554 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.039TrpAla: 1.039 ± 0.034
0.182TrpCys: 0.182 ± 0.012
0.565TrpAsp: 0.565 ± 0.026
0.719TrpGlu: 0.719 ± 0.028
0.541TrpPhe: 0.541 ± 0.024
0.859TrpGly: 0.859 ± 0.034
0.424TrpHis: 0.424 ± 0.023
0.637TrpIle: 0.637 ± 0.025
0.441TrpLys: 0.441 ± 0.022
2.424TrpLeu: 2.424 ± 0.07
0.402TrpMet: 0.402 ± 0.022
0.442TrpAsn: 0.442 ± 0.035
0.73TrpPro: 0.73 ± 0.028
1.131TrpGln: 1.131 ± 0.043
1.035TrpArg: 1.035 ± 0.036
0.701TrpSer: 0.701 ± 0.026
0.529TrpThr: 0.529 ± 0.023
1.033TrpVal: 1.033 ± 0.03
0.279TrpTrp: 0.279 ± 0.015
0.335TrpTyr: 0.335 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.36TyrAla: 2.36 ± 0.049
0.275TyrCys: 0.275 ± 0.015
1.289TyrAsp: 1.289 ± 0.036
1.173TyrGlu: 1.173 ± 0.038
0.915TyrPhe: 0.915 ± 0.033
1.88TyrGly: 1.88 ± 0.045
0.685TyrHis: 0.685 ± 0.026
1.007TyrIle: 1.007 ± 0.034
0.572TyrLys: 0.572 ± 0.023
2.813TyrLeu: 2.813 ± 0.064
0.504TyrMet: 0.504 ± 0.023
0.673TyrAsn: 0.673 ± 0.027
1.243TyrPro: 1.243 ± 0.038
1.409TyrGln: 1.409 ± 0.042
1.928TyrArg: 1.928 ± 0.051
1.385TyrSer: 1.385 ± 0.039
1.372TyrThr: 1.372 ± 0.078
1.604TyrVal: 1.604 ± 0.051
0.423TyrTrp: 0.423 ± 0.018
0.744TyrTyr: 0.744 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3282 proteins (1130750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski