Amino acid dipepetide frequency for Prevotella oralis ATCC 33269

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.878AlaAla: 5.878 ± 0.125
1.034AlaCys: 1.034 ± 0.038
4.741AlaAsp: 4.741 ± 0.078
4.568AlaGlu: 4.568 ± 0.085
3.247AlaPhe: 3.247 ± 0.059
5.147AlaGly: 5.147 ± 0.094
1.414AlaHis: 1.414 ± 0.041
4.885AlaIle: 4.885 ± 0.085
4.595AlaLys: 4.595 ± 0.081
6.561AlaLeu: 6.561 ± 0.097
2.052AlaMet: 2.052 ± 0.052
3.225AlaAsn: 3.225 ± 0.072
2.227AlaPro: 2.227 ± 0.054
2.851AlaGln: 2.851 ± 0.063
3.213AlaArg: 3.213 ± 0.069
4.141AlaSer: 4.141 ± 0.074
3.959AlaThr: 3.959 ± 0.078
5.093AlaVal: 5.093 ± 0.09
0.851AlaTrp: 0.851 ± 0.035
3.164AlaTyr: 3.164 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.808CysAla: 0.808 ± 0.032
0.232CysCys: 0.232 ± 0.018
0.65CysAsp: 0.65 ± 0.026
0.641CysGlu: 0.641 ± 0.029
0.606CysPhe: 0.606 ± 0.025
1.03CysGly: 1.03 ± 0.042
0.367CysHis: 0.367 ± 0.023
0.921CysIle: 0.921 ± 0.035
0.762CysLys: 0.762 ± 0.037
1.145CysLeu: 1.145 ± 0.041
0.363CysMet: 0.363 ± 0.023
0.675CysAsn: 0.675 ± 0.027
0.485CysPro: 0.485 ± 0.025
0.284CysGln: 0.284 ± 0.02
0.743CysArg: 0.743 ± 0.031
0.813CysSer: 0.813 ± 0.032
0.703CysThr: 0.703 ± 0.03
0.807CysVal: 0.807 ± 0.035
0.169CysTrp: 0.169 ± 0.013
0.59CysTyr: 0.59 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.217AspAla: 4.217 ± 0.08
0.694AspCys: 0.694 ± 0.031
2.999AspAsp: 2.999 ± 0.076
3.745AspGlu: 3.745 ± 0.083
2.961AspPhe: 2.961 ± 0.062
4.402AspGly: 4.402 ± 0.085
0.975AspHis: 0.975 ± 0.036
4.503AspIle: 4.503 ± 0.079
4.14AspLys: 4.14 ± 0.078
4.238AspLeu: 4.238 ± 0.065
1.789AspMet: 1.789 ± 0.051
3.091AspAsn: 3.091 ± 0.063
1.65AspPro: 1.65 ± 0.048
1.183AspGln: 1.183 ± 0.041
2.991AspArg: 2.991 ± 0.061
3.005AspSer: 3.005 ± 0.066
3.185AspThr: 3.185 ± 0.068
3.777AspVal: 3.777 ± 0.065
0.788AspTrp: 0.788 ± 0.033
2.87AspTyr: 2.87 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
4.317GluAla: 4.317 ± 0.084
0.646GluCys: 0.646 ± 0.03
3.02GluAsp: 3.02 ± 0.07
4.105GluGlu: 4.105 ± 0.082
2.191GluPhe: 2.191 ± 0.052
3.558GluGly: 3.558 ± 0.07
1.468GluHis: 1.468 ± 0.043
4.165GluIle: 4.165 ± 0.083
4.257GluLys: 4.257 ± 0.088
5.255GluLeu: 5.255 ± 0.092
1.858GluMet: 1.858 ± 0.048
3.193GluAsn: 3.193 ± 0.068
1.746GluPro: 1.746 ± 0.045
2.601GluGln: 2.601 ± 0.063
3.391GluArg: 3.391 ± 0.065
2.532GluSer: 2.532 ± 0.057
3.09GluThr: 3.09 ± 0.065
3.584GluVal: 3.584 ± 0.073
0.807GluTrp: 0.807 ± 0.029
2.626GluTyr: 2.626 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.158PheAla: 3.158 ± 0.071
0.776PheCys: 0.776 ± 0.032
2.813PheAsp: 2.813 ± 0.051
2.199PheGlu: 2.199 ± 0.052
2.171PhePhe: 2.171 ± 0.056
3.369PheGly: 3.369 ± 0.068
0.923PheHis: 0.923 ± 0.032
3.236PheIle: 3.236 ± 0.077
2.523PheLys: 2.523 ± 0.048
3.704PheLeu: 3.704 ± 0.078
1.365PheMet: 1.365 ± 0.043
2.394PheAsn: 2.394 ± 0.061
1.547PhePro: 1.547 ± 0.043
1.056PheGln: 1.056 ± 0.034
2.152PheArg: 2.152 ± 0.046
3.198PheSer: 3.198 ± 0.068
2.818PheThr: 2.818 ± 0.063
3.035PheVal: 3.035 ± 0.07
0.534PheTrp: 0.534 ± 0.028
1.94PheTyr: 1.94 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.538GlyAla: 4.538 ± 0.088
0.862GlyCys: 0.862 ± 0.037
3.596GlyAsp: 3.596 ± 0.072
3.719GlyGlu: 3.719 ± 0.075
3.103GlyPhe: 3.103 ± 0.061
4.936GlyGly: 4.936 ± 0.09
1.415GlyHis: 1.415 ± 0.046
5.526GlyIle: 5.526 ± 0.09
5.162GlyLys: 5.162 ± 0.079
5.58GlyLeu: 5.58 ± 0.093
2.13GlyMet: 2.13 ± 0.056
3.782GlyAsn: 3.782 ± 0.079
1.26GlyPro: 1.26 ± 0.047
2.076GlyGln: 2.076 ± 0.054
3.335GlyArg: 3.335 ± 0.068
4.087GlySer: 4.087 ± 0.079
4.619GlyThr: 4.619 ± 0.09
4.652GlyVal: 4.652 ± 0.085
0.948GlyTrp: 0.948 ± 0.037
3.414GlyTyr: 3.414 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.492HisAla: 1.492 ± 0.05
0.328HisCys: 0.328 ± 0.022
1.158HisAsp: 1.158 ± 0.039
1.095HisGlu: 1.095 ± 0.037
1.025HisPhe: 1.025 ± 0.039
1.462HisGly: 1.462 ± 0.045
0.568HisHis: 0.568 ± 0.029
1.655HisIle: 1.655 ± 0.046
1.144HisLys: 1.144 ± 0.036
1.847HisLeu: 1.847 ± 0.052
0.379HisMet: 0.379 ± 0.021
1.079HisAsn: 1.079 ± 0.035
1.056HisPro: 1.056 ± 0.037
0.641HisGln: 0.641 ± 0.026
1.233HisArg: 1.233 ± 0.039
1.192HisSer: 1.192 ± 0.039
1.177HisThr: 1.177 ± 0.035
1.285HisVal: 1.285 ± 0.042
0.279HisTrp: 0.279 ± 0.016
0.957HisTyr: 0.957 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.456IleAla: 5.456 ± 0.094
1.009IleCys: 1.009 ± 0.04
4.913IleAsp: 4.913 ± 0.07
4.319IleGlu: 4.319 ± 0.09
2.915IlePhe: 2.915 ± 0.073
4.99IleGly: 4.99 ± 0.087
1.367IleHis: 1.367 ± 0.04
4.774IleIle: 4.774 ± 0.098
4.187IleLys: 4.187 ± 0.075
5.651IleLeu: 5.651 ± 0.097
1.718IleMet: 1.718 ± 0.045
3.473IleAsn: 3.473 ± 0.072
2.992IlePro: 2.992 ± 0.064
1.933IleGln: 1.933 ± 0.042
3.568IleArg: 3.568 ± 0.064
4.638IleSer: 4.638 ± 0.08
4.222IleThr: 4.222 ± 0.072
4.72IleVal: 4.72 ± 0.089
0.656IleTrp: 0.656 ± 0.03
2.795IleTyr: 2.795 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.957LysAla: 4.957 ± 0.082
0.531LysCys: 0.531 ± 0.023
3.955LysAsp: 3.955 ± 0.07
4.889LysGlu: 4.889 ± 0.084
2.189LysPhe: 2.189 ± 0.049
4.472LysGly: 4.472 ± 0.085
1.443LysHis: 1.443 ± 0.049
4.413LysIle: 4.413 ± 0.068
4.709LysLys: 4.709 ± 0.1
5.189LysLeu: 5.189 ± 0.09
2.116LysMet: 2.116 ± 0.052
3.557LysAsn: 3.557 ± 0.073
2.134LysPro: 2.134 ± 0.055
2.646LysGln: 2.646 ± 0.058
3.457LysArg: 3.457 ± 0.071
3.375LysSer: 3.375 ± 0.064
3.854LysThr: 3.854 ± 0.07
4.15LysVal: 4.15 ± 0.075
0.817LysTrp: 0.817 ± 0.032
3.055LysTyr: 3.055 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
6.068LeuAla: 6.068 ± 0.103
1.408LeuCys: 1.408 ± 0.044
4.475LeuAsp: 4.475 ± 0.07
4.022LeuGlu: 4.022 ± 0.075
4.225LeuPhe: 4.225 ± 0.084
5.445LeuGly: 5.445 ± 0.089
2.104LeuHis: 2.104 ± 0.04
5.273LeuIle: 5.273 ± 0.099
5.904LeuLys: 5.904 ± 0.088
8.314LeuLeu: 8.314 ± 0.125
2.474LeuMet: 2.474 ± 0.06
4.619LeuAsn: 4.619 ± 0.082
3.849LeuPro: 3.849 ± 0.06
3.43LeuGln: 3.43 ± 0.065
4.634LeuArg: 4.634 ± 0.09
6.408LeuSer: 6.408 ± 0.102
5.16LeuThr: 5.16 ± 0.08
4.741LeuVal: 4.741 ± 0.079
1.038LeuTrp: 1.038 ± 0.037
3.733LeuTyr: 3.733 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.235MetAla: 2.235 ± 0.052
0.275MetCys: 0.275 ± 0.021
1.337MetAsp: 1.337 ± 0.04
1.612MetGlu: 1.612 ± 0.043
1.115MetPhe: 1.115 ± 0.037
1.859MetGly: 1.859 ± 0.049
0.588MetHis: 0.588 ± 0.029
1.759MetIle: 1.759 ± 0.048
2.549MetLys: 2.549 ± 0.054
2.755MetLeu: 2.755 ± 0.055
0.93MetMet: 0.93 ± 0.036
1.641MetAsn: 1.641 ± 0.043
1.336MetPro: 1.336 ± 0.04
1.252MetGln: 1.252 ± 0.035
1.584MetArg: 1.584 ± 0.045
1.666MetSer: 1.666 ± 0.048
1.528MetThr: 1.528 ± 0.037
1.626MetVal: 1.626 ± 0.046
0.266MetTrp: 0.266 ± 0.02
0.934MetTyr: 0.934 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.781AsnAla: 3.781 ± 0.078
0.571AsnCys: 0.571 ± 0.028
2.974AsnAsp: 2.974 ± 0.056
2.935AsnGlu: 2.935 ± 0.056
2.085AsnPhe: 2.085 ± 0.052
4.212AsnGly: 4.212 ± 0.082
0.988AsnHis: 0.988 ± 0.042
4.212AsnIle: 4.212 ± 0.086
3.399AsnLys: 3.399 ± 0.067
4.166AsnLeu: 4.166 ± 0.071
1.497AsnMet: 1.497 ± 0.041
2.86AsnAsn: 2.86 ± 0.079
2.164AsnPro: 2.164 ± 0.05
1.37AsnGln: 1.37 ± 0.046
2.64AsnArg: 2.64 ± 0.067
2.9AsnSer: 2.9 ± 0.058
2.923AsnThr: 2.923 ± 0.07
3.421AsnVal: 3.421 ± 0.074
0.586AsnTrp: 0.586 ± 0.03
2.347AsnTyr: 2.347 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
2.605ProAla: 2.605 ± 0.056
0.376ProCys: 0.376 ± 0.021
2.467ProAsp: 2.467 ± 0.058
2.7ProGlu: 2.7 ± 0.068
1.77ProPhe: 1.77 ± 0.044
1.79ProGly: 1.79 ± 0.049
0.768ProHis: 0.768 ± 0.034
2.411ProIle: 2.411 ± 0.058
2.054ProLys: 2.054 ± 0.049
3.167ProLeu: 3.167 ± 0.058
1.006ProMet: 1.006 ± 0.036
1.724ProAsn: 1.724 ± 0.042
0.805ProPro: 0.805 ± 0.034
1.447ProGln: 1.447 ± 0.039
1.322ProArg: 1.322 ± 0.041
2.17ProSer: 2.17 ± 0.056
2.008ProThr: 2.008 ± 0.054
2.682ProVal: 2.682 ± 0.057
0.437ProTrp: 0.437 ± 0.023
1.758ProTyr: 1.758 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
2.404GlnAla: 2.404 ± 0.053
0.353GlnCys: 0.353 ± 0.02
1.579GlnAsp: 1.579 ± 0.045
2.077GlnGlu: 2.077 ± 0.053
1.393GlnPhe: 1.393 ± 0.047
2.204GlnGly: 2.204 ± 0.057
0.741GlnHis: 0.741 ± 0.031
2.386GlnIle: 2.386 ± 0.057
2.38GlnLys: 2.38 ± 0.064
3.254GlnLeu: 3.254 ± 0.066
1.065GlnMet: 1.065 ± 0.04
1.807GlnAsn: 1.807 ± 0.044
1.16GlnPro: 1.16 ± 0.039
1.689GlnGln: 1.689 ± 0.054
1.805GlnArg: 1.805 ± 0.046
1.884GlnSer: 1.884 ± 0.046
2.133GlnThr: 2.133 ± 0.054
1.99GlnVal: 1.99 ± 0.05
0.459GlnTrp: 0.459 ± 0.023
1.498GlnTyr: 1.498 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
3.108ArgAla: 3.108 ± 0.061
0.518ArgCys: 0.518 ± 0.024
2.353ArgAsp: 2.353 ± 0.055
2.866ArgGlu: 2.866 ± 0.06
2.385ArgPhe: 2.385 ± 0.046
2.737ArgGly: 2.737 ± 0.057
1.222ArgHis: 1.222 ± 0.042
3.813ArgIle: 3.813 ± 0.068
3.583ArgLys: 3.583 ± 0.074
4.899ArgLeu: 4.899 ± 0.091
1.754ArgMet: 1.754 ± 0.048
2.837ArgAsn: 2.837 ± 0.069
1.7ArgPro: 1.7 ± 0.046
2.167ArgGln: 2.167 ± 0.051
2.896ArgArg: 2.896 ± 0.064
2.692ArgSer: 2.692 ± 0.055
2.705ArgThr: 2.705 ± 0.054
2.658ArgVal: 2.658 ± 0.056
0.704ArgTrp: 0.704 ± 0.03
2.531ArgTyr: 2.531 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.405SerAla: 4.405 ± 0.077
0.781SerCys: 0.781 ± 0.033
3.162SerAsp: 3.162 ± 0.058
3.168SerGlu: 3.168 ± 0.052
3.084SerPhe: 3.084 ± 0.071
4.428SerGly: 4.428 ± 0.082
1.228SerHis: 1.228 ± 0.038
4.231SerIle: 4.231 ± 0.085
3.501SerLys: 3.501 ± 0.065
5.494SerLeu: 5.494 ± 0.081
1.68SerMet: 1.68 ± 0.045
2.846SerAsn: 2.846 ± 0.063
2.127SerPro: 2.127 ± 0.054
1.788SerGln: 1.788 ± 0.046
2.686SerArg: 2.686 ± 0.054
3.778SerSer: 3.778 ± 0.08
3.387SerThr: 3.387 ± 0.073
4.32SerVal: 4.32 ± 0.079
0.743SerTrp: 0.743 ± 0.03
2.804SerTyr: 2.804 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.666ThrAla: 4.666 ± 0.077
0.654ThrCys: 0.654 ± 0.029
3.965ThrAsp: 3.965 ± 0.073
3.229ThrGlu: 3.229 ± 0.056
2.782ThrPhe: 2.782 ± 0.065
4.437ThrGly: 4.437 ± 0.065
1.059ThrHis: 1.059 ± 0.036
3.986ThrIle: 3.986 ± 0.079
3.263ThrLys: 3.263 ± 0.071
5.271ThrLeu: 5.271 ± 0.078
1.356ThrMet: 1.356 ± 0.038
2.576ThrAsn: 2.576 ± 0.064
2.614ThrPro: 2.614 ± 0.057
1.775ThrGln: 1.775 ± 0.054
2.094ThrArg: 2.094 ± 0.055
3.259ThrSer: 3.259 ± 0.061
3.373ThrThr: 3.373 ± 0.078
4.39ThrVal: 4.39 ± 0.069
0.651ThrTrp: 0.651 ± 0.033
2.605ThrTyr: 2.605 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
4.679ValAla: 4.679 ± 0.091
1.011ValCys: 1.011 ± 0.036
3.757ValAsp: 3.757 ± 0.068
3.609ValGlu: 3.609 ± 0.068
2.938ValPhe: 2.938 ± 0.069
4.181ValGly: 4.181 ± 0.086
1.133ValHis: 1.133 ± 0.04
4.28ValIle: 4.28 ± 0.074
4.312ValLys: 4.312 ± 0.077
5.822ValLeu: 5.822 ± 0.102
1.751ValMet: 1.751 ± 0.051
3.274ValAsn: 3.274 ± 0.068
2.567ValPro: 2.567 ± 0.063
2.01ValGln: 2.01 ± 0.056
3.127ValArg: 3.127 ± 0.068
4.494ValSer: 4.494 ± 0.079
3.771ValThr: 3.771 ± 0.077
4.578ValVal: 4.578 ± 0.086
0.781ValTrp: 0.781 ± 0.029
2.717ValTyr: 2.717 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.808TrpAla: 0.808 ± 0.03
0.156TrpCys: 0.156 ± 0.014
0.641TrpAsp: 0.641 ± 0.027
0.661TrpGlu: 0.661 ± 0.03
0.516TrpPhe: 0.516 ± 0.026
0.926TrpGly: 0.926 ± 0.036
0.307TrpHis: 0.307 ± 0.018
0.831TrpIle: 0.831 ± 0.033
0.829TrpLys: 0.829 ± 0.037
1.177TrpLeu: 1.177 ± 0.043
0.38TrpMet: 0.38 ± 0.021
0.797TrpAsn: 0.797 ± 0.037
0.248TrpPro: 0.248 ± 0.017
0.604TrpGln: 0.604 ± 0.025
0.599TrpArg: 0.599 ± 0.025
0.718TrpSer: 0.718 ± 0.03
0.678TrpThr: 0.678 ± 0.031
0.667TrpVal: 0.667 ± 0.03
0.176TrpTrp: 0.176 ± 0.015
0.536TrpTyr: 0.536 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.266TyrAla: 3.266 ± 0.06
0.58TyrCys: 0.58 ± 0.026
2.649TyrAsp: 2.649 ± 0.055
2.253TyrGlu: 2.253 ± 0.057
2.209TyrPhe: 2.209 ± 0.053
3.153TyrGly: 3.153 ± 0.077
0.975TyrHis: 0.975 ± 0.037
3.035TyrIle: 3.035 ± 0.057
2.658TyrLys: 2.658 ± 0.06
3.833TyrLeu: 3.833 ± 0.079
1.183TyrMet: 1.183 ± 0.034
2.581TyrAsn: 2.581 ± 0.066
1.799TyrPro: 1.799 ± 0.048
1.459TyrGln: 1.459 ± 0.043
2.658TyrArg: 2.658 ± 0.063
2.693TyrSer: 2.693 ± 0.065
2.717TyrThr: 2.717 ± 0.063
2.612TyrVal: 2.612 ± 0.057
0.564TyrTrp: 0.564 ± 0.028
2.215TyrTyr: 2.215 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2479 proteins (841153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski