Amino acid dipepetide frequency for Drechmeria coniospora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.853AlaAla: 11.853 ± 0.102	1.246AlaCys: 1.246 ± 0.022	5.465AlaAsp: 5.465 ± 0.043	5.65AlaGlu: 5.65 ± 0.068	3.057AlaPhe: 3.057 ± 0.034	7.11AlaGly: 7.11 ± 0.065	2.028AlaHis: 2.028 ± 0.025	3.835AlaIle: 3.835 ± 0.036	4.237AlaLys: 4.237 ± 0.043	7.895AlaLeu: 7.895 ± 0.056	2.332AlaMet: 2.332 ± 0.029	2.998AlaAsn: 2.998 ± 0.033	5.609AlaPro: 5.609 ± 0.063	3.37AlaGln: 3.37 ± 0.044	6.153AlaArg: 6.153 ± 0.048	8.471AlaSer: 8.471 ± 0.067	5.818AlaThr: 5.818 ± 0.06	6.434AlaVal: 6.434 ± 0.076	1.19AlaTrp: 1.19 ± 0.019	2.001AlaTyr: 2.001 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.055CysAla: 1.055 ± 0.02	0.261CysCys: 0.261 ± 0.009	0.688CysAsp: 0.688 ± 0.015	0.589CysGlu: 0.589 ± 0.011	0.53CysPhe: 0.53 ± 0.014	0.95CysGly: 0.95 ± 0.019	0.386CysHis: 0.386 ± 0.009	0.693CysIle: 0.693 ± 0.025	0.5CysLys: 0.5 ± 0.012	1.267CysLeu: 1.267 ± 0.02	0.278CysMet: 0.278 ± 0.009	0.394CysAsn: 0.394 ± 0.012	0.882CysPro: 0.882 ± 0.037	0.452CysGln: 0.452 ± 0.012	0.982CysArg: 0.982 ± 0.017	0.981CysSer: 0.981 ± 0.018	0.9CysThr: 0.9 ± 0.046	0.875CysVal: 0.875 ± 0.023	0.197CysTrp: 0.197 ± 0.008	0.333CysTyr: 0.333 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.999AspAla: 5.999 ± 0.044	0.695AspCys: 0.695 ± 0.014	5.534AspAsp: 5.534 ± 0.069	4.915AspGlu: 4.915 ± 0.044	2.035AspPhe: 2.035 ± 0.023	5.414AspGly: 5.414 ± 0.046	1.238AspHis: 1.238 ± 0.023	2.445AspIle: 2.445 ± 0.029	2.396AspLys: 2.396 ± 0.033	4.702AspLeu: 4.702 ± 0.036	1.387AspMet: 1.387 ± 0.018	1.611AspAsn: 1.611 ± 0.024	3.01AspPro: 3.01 ± 0.031	1.72AspGln: 1.72 ± 0.023	3.383AspArg: 3.383 ± 0.037	3.921AspSer: 3.921 ± 0.034	2.592AspThr: 2.592 ± 0.031	4.139AspVal: 4.139 ± 0.052	0.831AspTrp: 0.831 ± 0.015	1.304AspTyr: 1.304 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.926GluAla: 5.926 ± 0.05	0.652GluCys: 0.652 ± 0.013	3.709GluAsp: 3.709 ± 0.042	4.723GluGlu: 4.723 ± 0.069	1.731GluPhe: 1.731 ± 0.023	3.523GluGly: 3.523 ± 0.039	1.399GluHis: 1.399 ± 0.021	2.347GluIle: 2.347 ± 0.027	3.042GluLys: 3.042 ± 0.038	4.976GluLeu: 4.976 ± 0.04	1.534GluMet: 1.534 ± 0.018	1.868GluAsn: 1.868 ± 0.023	3.022GluPro: 3.022 ± 0.039	2.279GluGln: 2.279 ± 0.031	4.115GluArg: 4.115 ± 0.047	4.229GluSer: 4.229 ± 0.044	3.357GluThr: 3.357 ± 0.051	3.348GluVal: 3.348 ± 0.062	0.77GluTrp: 0.77 ± 0.015	1.4GluTyr: 1.4 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.052PheAla: 3.052 ± 0.032	0.532PheCys: 0.532 ± 0.015	2.193PheAsp: 2.193 ± 0.027	1.875PheGlu: 1.875 ± 0.024	1.403PhePhe: 1.403 ± 0.023	2.732PheGly: 2.732 ± 0.043	0.868PheHis: 0.868 ± 0.017	1.412PheIle: 1.412 ± 0.024	1.274PheLys: 1.274 ± 0.021	3.099PheLeu: 3.099 ± 0.034	0.699PheMet: 0.699 ± 0.012	1.15PheAsn: 1.15 ± 0.018	1.823PhePro: 1.823 ± 0.022	1.227PheGln: 1.227 ± 0.019	2.005PheArg: 2.005 ± 0.025	2.626PheSer: 2.626 ± 0.029	1.87PheThr: 1.87 ± 0.03	2.392PheVal: 2.392 ± 0.031	0.531PheTrp: 0.531 ± 0.013	0.894PheTyr: 0.894 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	6.126GlyAla: 6.126 ± 0.055	1.097GlyCys: 1.097 ± 0.051	4.04GlyAsp: 4.04 ± 0.037	3.797GlyGlu: 3.797 ± 0.036	2.527GlyPhe: 2.527 ± 0.034	6.687GlyGly: 6.687 ± 0.109	1.976GlyHis: 1.976 ± 0.024	3.17GlyIle: 3.17 ± 0.041	3.37GlyLys: 3.37 ± 0.037	5.895GlyLeu: 5.895 ± 0.046	1.624GlyMet: 1.624 ± 0.023	2.549GlyAsn: 2.549 ± 0.053	4.019GlyPro: 4.019 ± 0.066	2.789GlyGln: 2.789 ± 0.034	5.255GlyArg: 5.255 ± 0.048	6.09GlySer: 6.09 ± 0.061	4.75GlyThr: 4.75 ± 0.121	4.223GlyVal: 4.223 ± 0.034	1.136GlyTrp: 1.136 ± 0.018	1.885GlyTyr: 1.885 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.265HisAla: 2.265 ± 0.029	0.342HisCys: 0.342 ± 0.009	1.561HisAsp: 1.561 ± 0.027	1.346HisGlu: 1.346 ± 0.021	0.863HisPhe: 0.863 ± 0.015	2.151HisGly: 2.151 ± 0.029	0.983HisHis: 0.983 ± 0.022	0.968HisIle: 0.968 ± 0.014	0.842HisLys: 0.842 ± 0.03	2.303HisLeu: 2.303 ± 0.027	0.5HisMet: 0.5 ± 0.011	0.701HisAsn: 0.701 ± 0.014	1.821HisPro: 1.821 ± 0.028	1.05HisGln: 1.05 ± 0.019	1.859HisArg: 1.859 ± 0.03	1.741HisSer: 1.741 ± 0.024	1.07HisThr: 1.07 ± 0.016	1.664HisVal: 1.664 ± 0.024	0.312HisTrp: 0.312 ± 0.009	0.609HisTyr: 0.609 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.549IleAla: 3.549 ± 0.033	0.62IleCys: 0.62 ± 0.015	2.472IleAsp: 2.472 ± 0.026	2.237IleGlu: 2.237 ± 0.026	1.599IlePhe: 1.599 ± 0.022	2.776IleGly: 2.776 ± 0.032	1.04IleHis: 1.04 ± 0.017	2.137IleIle: 2.137 ± 0.051	1.839IleLys: 1.839 ± 0.025	3.843IleLeu: 3.843 ± 0.041	0.934IleMet: 0.934 ± 0.019	1.407IleAsn: 1.407 ± 0.021	2.662IlePro: 2.662 ± 0.043	1.499IleGln: 1.499 ± 0.021	2.617IleArg: 2.617 ± 0.03	3.1IleSer: 3.1 ± 0.033	2.424IleThr: 2.424 ± 0.067	3.16IleVal: 3.16 ± 0.071	0.564IleTrp: 0.564 ± 0.013	1.065IleTyr: 1.065 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.355LysAla: 4.355 ± 0.046	0.465LysCys: 0.465 ± 0.013	2.45LysAsp: 2.45 ± 0.032	2.776LysGlu: 2.776 ± 0.04	1.278LysPhe: 1.278 ± 0.02	2.825LysGly: 2.825 ± 0.033	1.104LysHis: 1.104 ± 0.032	1.822LysIle: 1.822 ± 0.025	2.828LysLys: 2.828 ± 0.057	3.789LysLeu: 3.789 ± 0.037	1.045LysMet: 1.045 ± 0.016	1.419LysAsn: 1.419 ± 0.021	2.503LysPro: 2.503 ± 0.03	1.752LysGln: 1.752 ± 0.024	3.272LysArg: 3.272 ± 0.038	3.16LysSer: 3.16 ± 0.037	2.477LysThr: 2.477 ± 0.026	2.604LysVal: 2.604 ± 0.029	0.543LysTrp: 0.543 ± 0.012	1.1LysTyr: 1.1 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	8.699LeuAla: 8.699 ± 0.066	1.212LeuCys: 1.212 ± 0.018	5.342LeuAsp: 5.342 ± 0.043	5.004LeuGlu: 5.004 ± 0.04	2.998LeuPhe: 2.998 ± 0.032	5.948LeuGly: 5.948 ± 0.045	2.235LeuHis: 2.235 ± 0.027	3.107LeuIle: 3.107 ± 0.036	3.451LeuLys: 3.451 ± 0.034	8.18LeuLeu: 8.18 ± 0.072	1.712LeuMet: 1.712 ± 0.024	2.532LeuAsn: 2.532 ± 0.029	5.863LeuPro: 5.863 ± 0.051	3.475LeuGln: 3.475 ± 0.038	6.126LeuArg: 6.126 ± 0.043	6.819LeuSer: 6.819 ± 0.047	4.521LeuThr: 4.521 ± 0.034	5.882LeuVal: 5.882 ± 0.061	1.089LeuTrp: 1.089 ± 0.019	1.999LeuTyr: 1.999 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.619MetAla: 2.619 ± 0.031	0.237MetCys: 0.237 ± 0.008	1.371MetAsp: 1.371 ± 0.022	1.29MetGlu: 1.29 ± 0.018	0.652MetPhe: 0.652 ± 0.014	1.441MetGly: 1.441 ± 0.021	0.536MetHis: 0.536 ± 0.014	0.85MetIle: 0.85 ± 0.015	0.958MetLys: 0.958 ± 0.016	1.934MetLeu: 1.934 ± 0.027	0.632MetMet: 0.632 ± 0.015	0.729MetAsn: 0.729 ± 0.014	1.538MetPro: 1.538 ± 0.022	0.906MetGln: 0.906 ± 0.017	1.38MetArg: 1.38 ± 0.018	1.836MetSer: 1.836 ± 0.024	1.479MetThr: 1.479 ± 0.022	1.357MetVal: 1.357 ± 0.022	0.248MetTrp: 0.248 ± 0.008	0.52MetTyr: 0.52 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.92AsnAla: 2.92 ± 0.032	0.522AsnCys: 0.522 ± 0.041	1.831AsnAsp: 1.831 ± 0.025	1.697AsnGlu: 1.697 ± 0.022	1.121AsnPhe: 1.121 ± 0.017	2.818AsnGly: 2.818 ± 0.038	0.737AsnHis: 0.737 ± 0.015	1.529AsnIle: 1.529 ± 0.021	1.295AsnLys: 1.295 ± 0.022	2.87AsnLeu: 2.87 ± 0.031	0.742AsnMet: 0.742 ± 0.013	1.123AsnAsn: 1.123 ± 0.029	2.127AsnPro: 2.127 ± 0.027	1.144AsnGln: 1.144 ± 0.029	1.892AsnArg: 1.892 ± 0.024	2.288AsnSer: 2.288 ± 0.046	1.686AsnThr: 1.686 ± 0.032	2.113AsnVal: 2.113 ± 0.025	0.425AsnTrp: 0.425 ± 0.01	0.863AsnTyr: 0.863 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.542ProAla: 6.542 ± 0.067	0.72ProCys: 0.72 ± 0.017	3.275ProAsp: 3.275 ± 0.032	3.391ProGlu: 3.391 ± 0.054	2.003ProPhe: 2.003 ± 0.023	4.464ProGly: 4.464 ± 0.074	1.451ProHis: 1.451 ± 0.024	2.14ProIle: 2.14 ± 0.024	2.351ProLys: 2.351 ± 0.029	5.002ProLeu: 5.002 ± 0.042	1.219ProMet: 1.219 ± 0.018	1.876ProAsn: 1.876 ± 0.024	6.616ProPro: 6.616 ± 0.099	2.278ProGln: 2.278 ± 0.031	4.231ProArg: 4.231 ± 0.045	6.929ProSer: 6.929 ± 0.083	4.453ProThr: 4.453 ± 0.074	3.852ProVal: 3.852 ± 0.049	0.794ProTrp: 0.794 ± 0.023	1.354ProTyr: 1.354 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.68GlnAla: 3.68 ± 0.038	0.419GlnCys: 0.419 ± 0.01	1.95GlnAsp: 1.95 ± 0.025	2.097GlnGlu: 2.097 ± 0.031	1.168GlnPhe: 1.168 ± 0.023	2.453GlnGly: 2.453 ± 0.03	1.156GlnHis: 1.156 ± 0.021	1.486GlnIle: 1.486 ± 0.021	1.7GlnLys: 1.7 ± 0.03	3.361GlnLeu: 3.361 ± 0.038	0.909GlnMet: 0.909 ± 0.016	1.271GlnAsn: 1.271 ± 0.027	2.658GlnPro: 2.658 ± 0.039	2.652GlnGln: 2.652 ± 0.07	2.786GlnArg: 2.786 ± 0.029	2.819GlnSer: 2.819 ± 0.03	2.068GlnThr: 2.068 ± 0.029	2.192GlnVal: 2.192 ± 0.022	0.493GlnTrp: 0.493 ± 0.011	0.97GlnTyr: 0.97 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.68ArgAla: 5.68 ± 0.051	0.938ArgCys: 0.938 ± 0.015	3.751ArgAsp: 3.751 ± 0.041	3.91ArgGlu: 3.91 ± 0.039	2.205ArgPhe: 2.205 ± 0.025	4.386ArgGly: 4.386 ± 0.045	2.043ArgHis: 2.043 ± 0.027	2.829ArgIle: 2.829 ± 0.03	3.368ArgLys: 3.368 ± 0.035	6.067ArgLeu: 6.067 ± 0.039	1.471ArgMet: 1.471 ± 0.02	2.231ArgAsn: 2.231 ± 0.025	4.528ArgPro: 4.528 ± 0.046	3.017ArgGln: 3.017 ± 0.032	6.902ArgArg: 6.902 ± 0.071	5.394ArgSer: 5.394 ± 0.055	3.703ArgThr: 3.703 ± 0.035	3.668ArgVal: 3.668 ± 0.03	1.018ArgTrp: 1.018 ± 0.017	1.582ArgTyr: 1.582 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.308SerAla: 7.308 ± 0.063	1.0SerCys: 1.0 ± 0.018	4.182SerAsp: 4.182 ± 0.043	3.72SerGlu: 3.72 ± 0.053	2.789SerPhe: 2.789 ± 0.029	5.63SerGly: 5.63 ± 0.078	2.014SerHis: 2.014 ± 0.027	3.552SerIle: 3.552 ± 0.037	3.356SerLys: 3.356 ± 0.037	7.002SerLeu: 7.002 ± 0.044	1.866SerMet: 1.866 ± 0.022	2.685SerAsn: 2.685 ± 0.05	5.871SerPro: 5.871 ± 0.065	2.99SerGln: 2.99 ± 0.03	5.746SerArg: 5.746 ± 0.05	8.953SerSer: 8.953 ± 0.123	5.903SerThr: 5.903 ± 0.112	4.713SerVal: 4.713 ± 0.038	1.078SerTrp: 1.078 ± 0.017	1.8SerTyr: 1.8 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.8ThrAla: 5.8 ± 0.056	0.786ThrCys: 0.786 ± 0.016	2.848ThrAsp: 2.848 ± 0.032	2.886ThrGlu: 2.886 ± 0.042	2.05ThrPhe: 2.05 ± 0.034	4.502ThrGly: 4.502 ± 0.107	1.23ThrHis: 1.23 ± 0.019	2.976ThrIle: 2.976 ± 0.087	2.443ThrLys: 2.443 ± 0.032	4.954ThrLeu: 4.954 ± 0.04	1.33ThrMet: 1.33 ± 0.018	1.801ThrAsn: 1.801 ± 0.036	4.31ThrPro: 4.31 ± 0.064	1.894ThrGln: 1.894 ± 0.031	3.509ThrArg: 3.509 ± 0.034	5.595ThrSer: 5.595 ± 0.127	5.216ThrThr: 5.216 ± 0.255	4.152ThrVal: 4.152 ± 0.082	0.75ThrTrp: 0.75 ± 0.016	1.391ThrTyr: 1.391 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	6.265ValAla: 6.265 ± 0.073	0.87ValCys: 0.87 ± 0.016	4.264ValAsp: 4.264 ± 0.049	3.987ValGlu: 3.987 ± 0.036	2.21ValPhe: 2.21 ± 0.028	4.492ValGly: 4.492 ± 0.045	1.52ValHis: 1.52 ± 0.032	2.622ValIle: 2.622 ± 0.039	2.727ValLys: 2.727 ± 0.027	5.541ValLeu: 5.541 ± 0.059	1.38ValMet: 1.38 ± 0.024	1.984ValAsn: 1.984 ± 0.026	4.146ValPro: 4.146 ± 0.062	2.348ValGln: 2.348 ± 0.028	3.938ValArg: 3.938 ± 0.035	4.511ValSer: 4.511 ± 0.041	3.965ValThr: 3.965 ± 0.112	5.027ValVal: 5.027 ± 0.142	0.808ValTrp: 0.808 ± 0.021	1.471ValTyr: 1.471 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.091TrpAla: 1.091 ± 0.018	0.188TrpCys: 0.188 ± 0.006	0.827TrpAsp: 0.827 ± 0.015	0.758TrpGlu: 0.758 ± 0.015	0.464TrpPhe: 0.464 ± 0.011	0.802TrpGly: 0.802 ± 0.014	0.375TrpHis: 0.375 ± 0.009	0.619TrpIle: 0.619 ± 0.013	0.672TrpLys: 0.672 ± 0.014	1.239TrpLeu: 1.239 ± 0.018	0.361TrpMet: 0.361 ± 0.01	0.544TrpAsn: 0.544 ± 0.018	0.645TrpPro: 0.645 ± 0.014	0.556TrpGln: 0.556 ± 0.011	0.983TrpArg: 0.983 ± 0.016	0.977TrpSer: 0.977 ± 0.014	0.913TrpThr: 0.913 ± 0.029	0.781TrpVal: 0.781 ± 0.02	0.27TrpTrp: 0.27 ± 0.009	0.353TrpTyr: 0.353 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.967TyrAla: 1.967 ± 0.028	0.395TyrCys: 0.395 ± 0.013	1.517TyrAsp: 1.517 ± 0.022	1.301TyrGlu: 1.301 ± 0.018	0.973TyrPhe: 0.973 ± 0.016	1.901TyrGly: 1.901 ± 0.025	0.635TyrHis: 0.635 ± 0.013	1.005TyrIle: 1.005 ± 0.017	0.916TyrLys: 0.916 ± 0.017	2.275TyrLeu: 2.275 ± 0.028	0.555TyrMet: 0.555 ± 0.012	0.869TyrAsn: 0.869 ± 0.021	1.289TyrPro: 1.289 ± 0.026	0.888TyrGln: 0.888 ± 0.019	1.559TyrArg: 1.559 ± 0.021	1.719TyrSer: 1.719 ± 0.035	1.257TyrThr: 1.257 ± 0.023	1.503TyrVal: 1.503 ± 0.025	0.37TyrTrp: 0.37 ± 0.01	0.778TyrTyr: 0.778 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8231 proteins (4273924 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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