Amino acid dipepetide frequency for Sugiyamaella lignohabitans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.774AlaAla: 7.774 ± 0.193	0.71AlaCys: 0.71 ± 0.017	3.884AlaAsp: 3.884 ± 0.054	4.366AlaGlu: 4.366 ± 0.084	2.579AlaPhe: 2.579 ± 0.036	5.021AlaGly: 5.021 ± 0.077	1.381AlaHis: 1.381 ± 0.023	4.295AlaIle: 4.295 ± 0.05	4.321AlaLys: 4.321 ± 0.056	6.513AlaLeu: 6.513 ± 0.078	1.366AlaMet: 1.366 ± 0.025	3.439AlaAsn: 3.439 ± 0.047	3.814AlaPro: 3.814 ± 0.096	2.64AlaGln: 2.64 ± 0.051	3.47AlaArg: 3.47 ± 0.039	7.49AlaSer: 7.49 ± 0.207	4.863AlaThr: 4.863 ± 0.067	4.883AlaVal: 4.883 ± 0.06	0.667AlaTrp: 0.667 ± 0.015	1.976AlaTyr: 1.976 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.593CysAla: 0.593 ± 0.016	0.169CysCys: 0.169 ± 0.009	0.537CysAsp: 0.537 ± 0.015	0.496CysGlu: 0.496 ± 0.014	0.454CysPhe: 0.454 ± 0.013	0.746CysGly: 0.746 ± 0.027	0.272CysHis: 0.272 ± 0.012	0.627CysIle: 0.627 ± 0.017	0.459CysLys: 0.459 ± 0.014	0.956CysLeu: 0.956 ± 0.021	0.221CysMet: 0.221 ± 0.008	0.375CysAsn: 0.375 ± 0.011	0.464CysPro: 0.464 ± 0.012	0.361CysGln: 0.361 ± 0.013	0.507CysArg: 0.507 ± 0.015	0.786CysSer: 0.786 ± 0.02	0.51CysThr: 0.51 ± 0.015	0.621CysVal: 0.621 ± 0.015	0.115CysTrp: 0.115 ± 0.007	0.32CysTyr: 0.32 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.637AspAla: 3.637 ± 0.041	0.489AspCys: 0.489 ± 0.015	4.898AspAsp: 4.898 ± 0.087	5.067AspGlu: 5.067 ± 0.095	2.261AspPhe: 2.261 ± 0.028	3.584AspGly: 3.584 ± 0.043	1.195AspHis: 1.195 ± 0.022	3.813AspIle: 3.813 ± 0.039	2.986AspLys: 2.986 ± 0.04	5.266AspLeu: 5.266 ± 0.052	1.075AspMet: 1.075 ± 0.021	2.588AspAsn: 2.588 ± 0.037	2.855AspPro: 2.855 ± 0.038	1.924AspGln: 1.924 ± 0.03	2.771AspArg: 2.771 ± 0.046	5.219AspSer: 5.219 ± 0.062	2.991AspThr: 2.991 ± 0.036	3.597AspVal: 3.597 ± 0.035	0.652AspTrp: 0.652 ± 0.017	1.907AspTyr: 1.907 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	4.92GluAla: 4.92 ± 0.114	0.525GluCys: 0.525 ± 0.016	4.304GluAsp: 4.304 ± 0.069	5.761GluGlu: 5.761 ± 0.118	2.269GluPhe: 2.269 ± 0.031	3.056GluGly: 3.056 ± 0.035	1.284GluHis: 1.284 ± 0.022	3.539GluIle: 3.539 ± 0.043	4.131GluLys: 4.131 ± 0.055	5.796GluLeu: 5.796 ± 0.072	1.158GluMet: 1.158 ± 0.024	2.951GluAsn: 2.951 ± 0.037	2.606GluPro: 2.606 ± 0.061	2.595GluGln: 2.595 ± 0.039	3.089GluArg: 3.089 ± 0.043	5.192GluSer: 5.192 ± 0.055	3.503GluThr: 3.503 ± 0.043	3.691GluVal: 3.691 ± 0.04	0.709GluTrp: 0.709 ± 0.017	1.937GluTyr: 1.937 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	2.629PheAla: 2.629 ± 0.035	0.461PheCys: 0.461 ± 0.012	2.396PheAsp: 2.396 ± 0.03	2.268PheGlu: 2.268 ± 0.032	1.587PhePhe: 1.587 ± 0.03	2.78PheGly: 2.78 ± 0.045	0.783PheHis: 0.783 ± 0.018	2.088PheIle: 2.088 ± 0.035	1.925PheLys: 1.925 ± 0.03	3.42PheLeu: 3.42 ± 0.04	0.727PheMet: 0.727 ± 0.018	1.733PheAsn: 1.733 ± 0.027	1.674PhePro: 1.674 ± 0.027	1.38PheGln: 1.38 ± 0.024	1.694PheArg: 1.694 ± 0.025	3.318PheSer: 3.318 ± 0.043	2.152PheThr: 2.152 ± 0.03	2.556PheVal: 2.556 ± 0.035	0.508PheTrp: 0.508 ± 0.015	1.261PheTyr: 1.261 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	4.904GlyAla: 4.904 ± 0.16	0.625GlyCys: 0.625 ± 0.018	3.366GlyAsp: 3.366 ± 0.038	3.178GlyGlu: 3.178 ± 0.039	2.576GlyPhe: 2.576 ± 0.038	5.149GlyGly: 5.149 ± 0.086	1.554GlyHis: 1.554 ± 0.027	3.733GlyIle: 3.733 ± 0.04	3.385GlyLys: 3.385 ± 0.041	5.678GlyLeu: 5.678 ± 0.056	1.119GlyMet: 1.119 ± 0.024	2.889GlyAsn: 2.889 ± 0.043	2.922GlyPro: 2.922 ± 0.043	2.297GlyGln: 2.297 ± 0.041	3.064GlyArg: 3.064 ± 0.043	6.933GlySer: 6.933 ± 0.113	3.879GlyThr: 3.879 ± 0.048	4.117GlyVal: 4.117 ± 0.046	0.768GlyTrp: 0.768 ± 0.019	2.114GlyTyr: 2.114 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	1.263HisAla: 1.263 ± 0.025	0.226HisCys: 0.226 ± 0.009	1.235HisAsp: 1.235 ± 0.027	1.235HisGlu: 1.235 ± 0.02	0.842HisPhe: 0.842 ± 0.018	1.455HisGly: 1.455 ± 0.031	0.89HisHis: 0.89 ± 0.053	1.291HisIle: 1.291 ± 0.021	1.076HisLys: 1.076 ± 0.02	1.919HisLeu: 1.919 ± 0.032	0.414HisMet: 0.414 ± 0.012	1.041HisAsn: 1.041 ± 0.022	1.324HisPro: 1.324 ± 0.024	1.025HisGln: 1.025 ± 0.027	1.225HisArg: 1.225 ± 0.022	1.998HisSer: 1.998 ± 0.035	1.201HisThr: 1.201 ± 0.076	1.302HisVal: 1.302 ± 0.022	0.229HisTrp: 0.229 ± 0.009	0.689HisTyr: 0.689 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.214IleAla: 4.214 ± 0.046	0.689IleCys: 0.689 ± 0.017	3.66IleAsp: 3.66 ± 0.042	3.454IleGlu: 3.454 ± 0.039	2.146IlePhe: 2.146 ± 0.031	3.367IleGly: 3.367 ± 0.041	1.225IleHis: 1.225 ± 0.023	3.193IleIle: 3.193 ± 0.045	3.108IleLys: 3.108 ± 0.039	5.037IleLeu: 5.037 ± 0.056	1.01IleMet: 1.01 ± 0.02	2.513IleAsn: 2.513 ± 0.03	3.126IlePro: 3.126 ± 0.038	2.096IleGln: 2.096 ± 0.029	2.83IleArg: 2.83 ± 0.039	5.205IleSer: 5.205 ± 0.05	3.144IleThr: 3.144 ± 0.034	3.731IleVal: 3.731 ± 0.047	0.646IleTrp: 0.646 ± 0.017	1.744IleTyr: 1.744 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.975LysAla: 3.975 ± 0.054	0.48LysCys: 0.48 ± 0.014	3.15LysAsp: 3.15 ± 0.041	3.901LysGlu: 3.901 ± 0.055	2.083LysPhe: 2.083 ± 0.032	2.804LysGly: 2.804 ± 0.036	1.3LysHis: 1.3 ± 0.08	3.092LysIle: 3.092 ± 0.038	4.178LysLys: 4.178 ± 0.06	5.239LysLeu: 5.239 ± 0.055	1.021LysMet: 1.021 ± 0.021	2.395LysAsn: 2.395 ± 0.036	2.672LysPro: 2.672 ± 0.039	2.213LysGln: 2.213 ± 0.029	3.363LysArg: 3.363 ± 0.045	4.837LysSer: 4.837 ± 0.048	3.265LysThr: 3.265 ± 0.052	3.464LysVal: 3.464 ± 0.043	0.65LysTrp: 0.65 ± 0.017	2.004LysTyr: 2.004 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	7.068LeuAla: 7.068 ± 0.066	0.973LeuCys: 0.973 ± 0.022	5.374LeuAsp: 5.374 ± 0.057	5.814LeuGlu: 5.814 ± 0.059	3.426LeuPhe: 3.426 ± 0.045	5.296LeuGly: 5.296 ± 0.054	1.872LeuHis: 1.872 ± 0.027	4.571LeuIle: 4.571 ± 0.059	5.063LeuLys: 5.063 ± 0.052	8.249LeuLeu: 8.249 ± 0.09	1.61LeuMet: 1.61 ± 0.025	3.926LeuAsn: 3.926 ± 0.044	4.646LeuPro: 4.646 ± 0.047	3.633LeuGln: 3.633 ± 0.042	4.718LeuArg: 4.718 ± 0.048	8.078LeuSer: 8.078 ± 0.061	4.937LeuThr: 4.937 ± 0.045	5.798LeuVal: 5.798 ± 0.056	0.952LeuTrp: 0.952 ± 0.021	2.656LeuTyr: 2.656 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.589MetAla: 1.589 ± 0.027	0.184MetCys: 0.184 ± 0.008	1.049MetAsp: 1.049 ± 0.023	1.009MetGlu: 1.009 ± 0.019	0.762MetPhe: 0.762 ± 0.019	1.151MetGly: 1.151 ± 0.027	0.294MetHis: 0.294 ± 0.011	1.035MetIle: 1.035 ± 0.02	0.991MetLys: 0.991 ± 0.02	1.555MetLeu: 1.555 ± 0.025	0.435MetMet: 0.435 ± 0.016	0.833MetAsn: 0.833 ± 0.018	0.86MetPro: 0.86 ± 0.02	0.558MetGln: 0.558 ± 0.016	0.776MetArg: 0.776 ± 0.018	1.946MetSer: 1.946 ± 0.031	1.181MetThr: 1.181 ± 0.024	1.16MetVal: 1.16 ± 0.021	0.197MetTrp: 0.197 ± 0.008	0.52MetTyr: 0.52 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.082AsnAla: 3.082 ± 0.043	0.433AsnCys: 0.433 ± 0.014	2.688AsnAsp: 2.688 ± 0.037	2.779AsnGlu: 2.779 ± 0.04	1.637AsnPhe: 1.637 ± 0.024	3.664AsnGly: 3.664 ± 0.049	1.008AsnHis: 1.008 ± 0.019	2.839AsnIle: 2.839 ± 0.033	2.282AsnLys: 2.282 ± 0.034	3.709AsnLeu: 3.709 ± 0.038	0.887AsnMet: 0.887 ± 0.019	2.64AsnAsn: 2.64 ± 0.048	2.411AsnPro: 2.411 ± 0.033	1.74AsnGln: 1.74 ± 0.031	2.155AsnArg: 2.155 ± 0.031	4.71AsnSer: 4.71 ± 0.056	2.687AsnThr: 2.687 ± 0.036	2.736AsnVal: 2.736 ± 0.036	0.546AsnTrp: 0.546 ± 0.018	1.369AsnTyr: 1.369 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.966ProAla: 3.966 ± 0.066	0.367ProCys: 0.367 ± 0.017	2.783ProAsp: 2.783 ± 0.044	3.501ProGlu: 3.501 ± 0.086	1.872ProPhe: 1.872 ± 0.03	3.322ProGly: 3.322 ± 0.054	1.073ProHis: 1.073 ± 0.025	2.727ProIle: 2.727 ± 0.032	2.619ProLys: 2.619 ± 0.032	4.379ProLeu: 4.379 ± 0.048	0.782ProMet: 0.782 ± 0.021	2.229ProAsn: 2.229 ± 0.033	3.994ProPro: 3.994 ± 0.109	2.104ProGln: 2.104 ± 0.041	2.339ProArg: 2.339 ± 0.04	5.53ProSer: 5.53 ± 0.077	3.333ProThr: 3.333 ± 0.045	3.693ProVal: 3.693 ± 0.051	0.477ProTrp: 0.477 ± 0.014	1.439ProTyr: 1.439 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.942GlnAla: 2.942 ± 0.051	0.329GlnCys: 0.329 ± 0.011	1.852GlnAsp: 1.852 ± 0.033	2.385GlnGlu: 2.385 ± 0.033	1.475GlnPhe: 1.475 ± 0.025	2.043GlnGly: 2.043 ± 0.029	0.992GlnHis: 0.992 ± 0.028	2.065GlnIle: 2.065 ± 0.031	2.147GlnLys: 2.147 ± 0.033	3.833GlnLeu: 3.833 ± 0.041	0.758GlnMet: 0.758 ± 0.017	1.743GlnAsn: 1.743 ± 0.035	2.133GlnPro: 2.133 ± 0.046	3.519GlnGln: 3.519 ± 0.138	2.002GlnArg: 2.002 ± 0.033	3.325GlnSer: 3.325 ± 0.045	2.186GlnThr: 2.186 ± 0.029	2.3GlnVal: 2.3 ± 0.029	0.43GlnTrp: 0.43 ± 0.013	1.237GlnTyr: 1.237 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.446ArgAla: 3.446 ± 0.034	0.464ArgCys: 0.464 ± 0.014	2.818ArgAsp: 2.818 ± 0.054	3.043ArgGlu: 3.043 ± 0.043	1.821ArgPhe: 1.821 ± 0.027	2.813ArgGly: 2.813 ± 0.039	1.185ArgHis: 1.185 ± 0.026	2.772ArgIle: 2.772 ± 0.036	3.3ArgLys: 3.3 ± 0.042	4.647ArgLeu: 4.647 ± 0.048	0.981ArgMet: 0.981 ± 0.021	2.315ArgAsn: 2.315 ± 0.031	2.543ArgPro: 2.543 ± 0.035	2.24ArgGln: 2.24 ± 0.031	3.589ArgArg: 3.589 ± 0.053	4.388ArgSer: 4.388 ± 0.056	2.678ArgThr: 2.678 ± 0.038	2.93ArgVal: 2.93 ± 0.038	0.542ArgTrp: 0.542 ± 0.014	1.612ArgTyr: 1.612 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	7.017SerAla: 7.017 ± 0.14	0.701SerCys: 0.701 ± 0.017	5.136SerAsp: 5.136 ± 0.059	5.15SerGlu: 5.15 ± 0.054	3.273SerPhe: 3.273 ± 0.041	7.03SerGly: 7.03 ± 0.232	2.097SerHis: 2.097 ± 0.036	5.134SerIle: 5.134 ± 0.05	5.164SerLys: 5.164 ± 0.093	8.094SerLeu: 8.094 ± 0.075	1.625SerMet: 1.625 ± 0.026	4.666SerAsn: 4.666 ± 0.059	5.366SerPro: 5.366 ± 0.084	3.736SerGln: 3.736 ± 0.046	4.786SerArg: 4.786 ± 0.057	12.937SerSer: 12.937 ± 0.313	7.036SerThr: 7.036 ± 0.185	5.749SerVal: 5.749 ± 0.051	0.91SerTrp: 0.91 ± 0.02	2.474SerTyr: 2.474 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.886ThrAla: 4.886 ± 0.053	0.549ThrCys: 0.549 ± 0.017	2.966ThrAsp: 2.966 ± 0.037	3.191ThrGlu: 3.191 ± 0.044	2.067ThrPhe: 2.067 ± 0.025	4.349ThrGly: 4.349 ± 0.056	1.15ThrHis: 1.15 ± 0.022	3.327ThrIle: 3.327 ± 0.042	3.173ThrLys: 3.173 ± 0.057	4.908ThrLeu: 4.908 ± 0.051	0.923ThrMet: 0.923 ± 0.022	2.821ThrAsn: 2.821 ± 0.036	3.861ThrPro: 3.861 ± 0.052	1.83ThrGln: 1.83 ± 0.028	2.63ThrArg: 2.63 ± 0.033	6.724ThrSer: 6.724 ± 0.247	4.637ThrThr: 4.637 ± 0.136	3.988ThrVal: 3.988 ± 0.049	0.597ThrTrp: 0.597 ± 0.018	1.532ThrTyr: 1.532 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	4.886ValAla: 4.886 ± 0.058	0.676ValCys: 0.676 ± 0.017	4.03ValAsp: 4.03 ± 0.043	4.006ValGlu: 4.006 ± 0.046	2.452ValPhe: 2.452 ± 0.034	3.868ValGly: 3.868 ± 0.055	1.365ValHis: 1.365 ± 0.029	3.569ValIle: 3.569 ± 0.039	3.464ValLys: 3.464 ± 0.043	5.614ValLeu: 5.614 ± 0.053	1.106ValMet: 1.106 ± 0.021	2.851ValAsn: 2.851 ± 0.034	3.486ValPro: 3.486 ± 0.049	2.197ValGln: 2.197 ± 0.028	2.977ValArg: 2.977 ± 0.039	5.925ValSer: 5.925 ± 0.056	3.649ValThr: 3.649 ± 0.048	4.465ValVal: 4.465 ± 0.057	0.696ValTrp: 0.696 ± 0.019	1.896ValTyr: 1.896 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.776TrpAla: 0.776 ± 0.019	0.138TrpCys: 0.138 ± 0.007	0.69TrpAsp: 0.69 ± 0.017	0.602TrpGlu: 0.602 ± 0.015	0.405TrpPhe: 0.405 ± 0.015	0.655TrpGly: 0.655 ± 0.019	0.236TrpHis: 0.236 ± 0.011	0.669TrpIle: 0.669 ± 0.017	0.726TrpLys: 0.726 ± 0.017	0.954TrpLeu: 0.954 ± 0.022	0.271TrpMet: 0.271 ± 0.01	0.564TrpAsn: 0.564 ± 0.016	0.37TrpPro: 0.37 ± 0.012	0.399TrpGln: 0.399 ± 0.014	0.598TrpArg: 0.598 ± 0.016	0.912TrpSer: 0.912 ± 0.02	0.687TrpThr: 0.687 ± 0.016	0.639TrpVal: 0.639 ± 0.016	0.173TrpTrp: 0.173 ± 0.009	0.357TrpTyr: 0.357 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.888TyrAla: 1.888 ± 0.029	0.4TyrCys: 0.4 ± 0.012	1.958TyrAsp: 1.958 ± 0.031	1.807TyrGlu: 1.807 ± 0.024	1.352TyrPhe: 1.352 ± 0.024	2.099TyrGly: 2.099 ± 0.034	0.724TyrHis: 0.724 ± 0.017	1.76TyrIle: 1.76 ± 0.03	1.586TyrLys: 1.586 ± 0.027	2.894TyrLeu: 2.894 ± 0.041	0.595TyrMet: 0.595 ± 0.015	1.489TyrAsn: 1.489 ± 0.025	1.401TyrPro: 1.401 ± 0.026	1.211TyrGln: 1.211 ± 0.025	1.546TyrArg: 1.546 ± 0.024	2.627TyrSer: 2.627 ± 0.037	1.593TyrThr: 1.593 ± 0.025	1.757TyrVal: 1.757 ± 0.028	0.357TyrTrp: 0.357 ± 0.012	1.138TyrTyr: 1.138 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5131 proteins (2635212 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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