Amino acid dipepetide frequency for Flavobacterium noncentrifugens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.048AlaAla: 6.048 ± 0.125	0.591AlaCys: 0.591 ± 0.027	3.84AlaAsp: 3.84 ± 0.06	4.271AlaGlu: 4.271 ± 0.07	3.847AlaPhe: 3.847 ± 0.055	4.886AlaGly: 4.886 ± 0.103	1.11AlaHis: 1.11 ± 0.03	5.625AlaIle: 5.625 ± 0.079	4.86AlaLys: 4.86 ± 0.079	6.627AlaLeu: 6.627 ± 0.086	1.673AlaMet: 1.673 ± 0.041	4.179AlaAsn: 4.179 ± 0.074	2.307AlaPro: 2.307 ± 0.06	2.645AlaGln: 2.645 ± 0.043	1.937AlaArg: 1.937 ± 0.042	4.658AlaSer: 4.658 ± 0.087	4.829AlaThr: 4.829 ± 0.149	4.998AlaVal: 4.998 ± 0.084	0.621AlaTrp: 0.621 ± 0.025	2.465AlaTyr: 2.465 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.587CysAla: 0.587 ± 0.035	0.118CysCys: 0.118 ± 0.01	0.412CysAsp: 0.412 ± 0.021	0.458CysGlu: 0.458 ± 0.024	0.417CysPhe: 0.417 ± 0.018	0.665CysGly: 0.665 ± 0.027	0.182CysHis: 0.182 ± 0.013	0.583CysIle: 0.583 ± 0.025	0.477CysLys: 0.477 ± 0.024	0.631CysLeu: 0.631 ± 0.022	0.148CysMet: 0.148 ± 0.012	0.467CysAsn: 0.467 ± 0.026	0.333CysPro: 0.333 ± 0.022	0.222CysGln: 0.222 ± 0.015	0.237CysArg: 0.237 ± 0.014	0.698CysSer: 0.698 ± 0.035	0.53CysThr: 0.53 ± 0.034	0.456CysVal: 0.456 ± 0.021	0.063CysTrp: 0.063 ± 0.008	0.325CysTyr: 0.325 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.073AspAla: 4.073 ± 0.065	0.455AspCys: 0.455 ± 0.022	2.785AspAsp: 2.785 ± 0.057	3.409AspGlu: 3.409 ± 0.062	3.728AspPhe: 3.728 ± 0.065	3.863AspGly: 3.863 ± 0.075	0.935AspHis: 0.935 ± 0.03	4.013AspIle: 4.013 ± 0.057	4.015AspLys: 4.015 ± 0.076	5.017AspLeu: 5.017 ± 0.068	1.109AspMet: 1.109 ± 0.033	2.995AspAsn: 2.995 ± 0.056	1.718AspPro: 1.718 ± 0.035	1.554AspGln: 1.554 ± 0.037	1.83AspArg: 1.83 ± 0.041	2.977AspSer: 2.977 ± 0.055	2.386AspThr: 2.386 ± 0.045	3.433AspVal: 3.433 ± 0.064	0.736AspTrp: 0.736 ± 0.029	2.707AspTyr: 2.707 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.178GluAla: 4.178 ± 0.077	0.316GluCys: 0.316 ± 0.016	2.848GluAsp: 2.848 ± 0.055	3.651GluGlu: 3.651 ± 0.075	2.824GluPhe: 2.824 ± 0.06	3.048GluGly: 3.048 ± 0.052	0.953GluHis: 0.953 ± 0.03	5.435GluIle: 5.435 ± 0.078	5.797GluLys: 5.797 ± 0.102	5.307GluLeu: 5.307 ± 0.089	1.569GluMet: 1.569 ± 0.039	4.891GluAsn: 4.891 ± 0.075	1.517GluPro: 1.517 ± 0.035	2.042GluGln: 2.042 ± 0.048	2.132GluArg: 2.132 ± 0.054	3.397GluSer: 3.397 ± 0.062	3.763GluThr: 3.763 ± 0.059	3.595GluVal: 3.595 ± 0.057	0.552GluTrp: 0.552 ± 0.023	2.036GluTyr: 2.036 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.711PheAla: 3.711 ± 0.063	0.508PheCys: 0.508 ± 0.021	3.409PheAsp: 3.409 ± 0.051	3.524PheGlu: 3.524 ± 0.061	2.873PhePhe: 2.873 ± 0.059	3.808PheGly: 3.808 ± 0.062	0.914PheHis: 0.914 ± 0.027	3.773PheIle: 3.773 ± 0.07	3.46PheLys: 3.46 ± 0.064	4.75PheLeu: 4.75 ± 0.074	1.16PheMet: 1.16 ± 0.031	3.092PheAsn: 3.092 ± 0.064	1.94PhePro: 1.94 ± 0.038	1.595PheGln: 1.595 ± 0.039	1.849PheArg: 1.849 ± 0.041	4.165PheSer: 4.165 ± 0.065	3.526PheThr: 3.526 ± 0.065	3.185PheVal: 3.185 ± 0.057	0.576PheTrp: 0.576 ± 0.025	2.329PheTyr: 2.329 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.257GlyAla: 4.257 ± 0.107	0.679GlyCys: 0.679 ± 0.037	3.131GlyAsp: 3.131 ± 0.062	3.259GlyGlu: 3.259 ± 0.055	3.876GlyPhe: 3.876 ± 0.064	4.53GlyGly: 4.53 ± 0.114	1.059GlyHis: 1.059 ± 0.034	5.664GlyIle: 5.664 ± 0.071	5.199GlyLys: 5.199 ± 0.084	5.55GlyLeu: 5.55 ± 0.081	1.564GlyMet: 1.564 ± 0.037	4.153GlyAsn: 4.153 ± 0.077	1.329GlyPro: 1.329 ± 0.039	2.048GlyGln: 2.048 ± 0.051	1.925GlyArg: 1.925 ± 0.049	4.398GlySer: 4.398 ± 0.094	4.883GlyThr: 4.883 ± 0.148	3.949GlyVal: 3.949 ± 0.071	0.744GlyTrp: 0.744 ± 0.026	2.81GlyTyr: 2.81 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.997HisAla: 0.997 ± 0.027	0.188HisCys: 0.188 ± 0.012	0.884HisAsp: 0.884 ± 0.026	0.956HisGlu: 0.956 ± 0.031	1.245HisPhe: 1.245 ± 0.037	1.015HisGly: 1.015 ± 0.03	0.46HisHis: 0.46 ± 0.021	1.269HisIle: 1.269 ± 0.038	1.083HisLys: 1.083 ± 0.032	1.689HisLeu: 1.689 ± 0.038	0.296HisMet: 0.296 ± 0.016	0.933HisAsn: 0.933 ± 0.028	0.863HisPro: 0.863 ± 0.03	0.688HisGln: 0.688 ± 0.021	0.576HisArg: 0.576 ± 0.022	1.121HisSer: 1.121 ± 0.038	0.888HisThr: 0.888 ± 0.028	0.894HisVal: 0.894 ± 0.028	0.222HisTrp: 0.222 ± 0.015	0.811HisTyr: 0.811 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.077IleAla: 6.077 ± 0.073	0.729IleCys: 0.729 ± 0.028	4.626IleAsp: 4.626 ± 0.069	4.859IleGlu: 4.859 ± 0.082	3.823IlePhe: 3.823 ± 0.063	5.176IleGly: 5.176 ± 0.077	1.333IleHis: 1.333 ± 0.036	5.661IleIle: 5.661 ± 0.096	5.314IleLys: 5.314 ± 0.078	6.87IleLeu: 6.87 ± 0.092	1.424IleMet: 1.424 ± 0.032	4.383IleAsn: 4.383 ± 0.074	3.27IlePro: 3.27 ± 0.055	2.497IleGln: 2.497 ± 0.047	2.824IleArg: 2.824 ± 0.054	5.868IleSer: 5.868 ± 0.075	4.851IleThr: 4.851 ± 0.089	4.931IleVal: 4.931 ± 0.087	0.72IleTrp: 0.72 ± 0.025	2.736IleTyr: 2.736 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.951LysAla: 4.951 ± 0.083	0.361LysCys: 0.361 ± 0.019	4.07LysAsp: 4.07 ± 0.078	4.786LysGlu: 4.786 ± 0.1	3.258LysPhe: 3.258 ± 0.058	4.093LysGly: 4.093 ± 0.068	1.21LysHis: 1.21 ± 0.034	6.699LysIle: 6.699 ± 0.087	6.42LysLys: 6.42 ± 0.096	6.196LysLeu: 6.196 ± 0.084	2.221LysMet: 2.221 ± 0.043	5.258LysAsn: 5.258 ± 0.086	2.597LysPro: 2.597 ± 0.051	2.532LysGln: 2.532 ± 0.052	2.477LysArg: 2.477 ± 0.054	4.762LysSer: 4.762 ± 0.073	4.843LysThr: 4.843 ± 0.069	4.321LysVal: 4.321 ± 0.065	0.715LysTrp: 0.715 ± 0.025	2.934LysTyr: 2.934 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.211LeuAla: 6.211 ± 0.088	0.671LeuCys: 0.671 ± 0.026	4.629LeuAsp: 4.629 ± 0.076	5.353LeuGlu: 5.353 ± 0.084	4.879LeuPhe: 4.879 ± 0.083	5.536LeuGly: 5.536 ± 0.082	1.623LeuHis: 1.623 ± 0.04	6.386LeuIle: 6.386 ± 0.104	7.159LeuLys: 7.159 ± 0.094	8.638LeuLeu: 8.638 ± 0.113	2.053LeuMet: 2.053 ± 0.049	5.272LeuAsn: 5.272 ± 0.087	3.704LeuPro: 3.704 ± 0.067	3.459LeuGln: 3.459 ± 0.058	3.061LeuArg: 3.061 ± 0.055	6.741LeuSer: 6.741 ± 0.083	5.277LeuThr: 5.277 ± 0.108	5.017LeuVal: 5.017 ± 0.067	0.796LeuTrp: 0.796 ± 0.032	3.059LeuTyr: 3.059 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.751MetAla: 1.751 ± 0.043	0.134MetCys: 0.134 ± 0.01	1.106MetAsp: 1.106 ± 0.031	1.336MetGlu: 1.336 ± 0.037	0.875MetPhe: 0.875 ± 0.028	1.274MetGly: 1.274 ± 0.037	0.422MetHis: 0.422 ± 0.021	1.619MetIle: 1.619 ± 0.04	2.327MetLys: 2.327 ± 0.049	2.064MetLeu: 2.064 ± 0.044	0.625MetMet: 0.625 ± 0.027	1.313MetAsn: 1.313 ± 0.033	0.927MetPro: 0.927 ± 0.028	0.897MetGln: 0.897 ± 0.03	0.809MetArg: 0.809 ± 0.028	1.386MetSer: 1.386 ± 0.035	1.297MetThr: 1.297 ± 0.033	1.375MetVal: 1.375 ± 0.04	0.158MetTrp: 0.158 ± 0.012	0.694MetTyr: 0.694 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.632AsnAla: 4.632 ± 0.076	0.502AsnCys: 0.502 ± 0.031	3.313AsnAsp: 3.313 ± 0.061	3.426AsnGlu: 3.426 ± 0.064	3.265AsnPhe: 3.265 ± 0.053	4.508AsnGly: 4.508 ± 0.096	1.099AsnHis: 1.099 ± 0.032	4.794AsnIle: 4.794 ± 0.074	3.771AsnLys: 3.771 ± 0.058	5.606AsnLeu: 5.606 ± 0.099	1.269AsnMet: 1.269 ± 0.034	3.759AsnAsn: 3.759 ± 0.076	3.074AsnPro: 3.074 ± 0.057	2.124AsnGln: 2.124 ± 0.047	2.077AsnArg: 2.077 ± 0.039	3.97AsnSer: 3.97 ± 0.071	3.673AsnThr: 3.673 ± 0.081	3.748AsnVal: 3.748 ± 0.058	0.821AsnTrp: 0.821 ± 0.028	2.839AsnTyr: 2.839 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.619ProAla: 2.619 ± 0.072	0.211ProCys: 0.211 ± 0.016	2.218ProAsp: 2.218 ± 0.045	2.956ProGlu: 2.956 ± 0.056	2.005ProPhe: 2.005 ± 0.038	2.168ProGly: 2.168 ± 0.046	0.529ProHis: 0.529 ± 0.021	2.588ProIle: 2.588 ± 0.052	2.571ProLys: 2.571 ± 0.057	2.992ProLeu: 2.992 ± 0.059	0.819ProMet: 0.819 ± 0.028	2.297ProAsn: 2.297 ± 0.046	0.884ProPro: 0.884 ± 0.034	1.171ProGln: 1.171 ± 0.034	0.857ProArg: 0.857 ± 0.031	2.125ProSer: 2.125 ± 0.049	2.268ProThr: 2.268 ± 0.072	2.781ProVal: 2.781 ± 0.056	0.324ProTrp: 0.324 ± 0.024	1.313ProTyr: 1.313 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.127GlnAla: 2.127 ± 0.044	0.236GlnCys: 0.236 ± 0.018	1.459GlnAsp: 1.459 ± 0.038	1.897GlnGlu: 1.897 ± 0.042	1.762GlnPhe: 1.762 ± 0.043	1.619GlnGly: 1.619 ± 0.038	0.631GlnHis: 0.631 ± 0.024	2.835GlnIle: 2.835 ± 0.052	3.086GlnLys: 3.086 ± 0.062	3.339GlnLeu: 3.339 ± 0.053	0.885GlnMet: 0.885 ± 0.029	2.463GlnAsn: 2.463 ± 0.045	1.172GlnPro: 1.172 ± 0.04	1.64GlnGln: 1.64 ± 0.047	1.155GlnArg: 1.155 ± 0.029	2.198GlnSer: 2.198 ± 0.043	2.142GlnThr: 2.142 ± 0.048	1.821GlnVal: 1.821 ± 0.037	0.403GlnTrp: 0.403 ± 0.025	1.386GlnTyr: 1.386 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.938ArgAla: 1.938 ± 0.044	0.198ArgCys: 0.198 ± 0.013	1.625ArgAsp: 1.625 ± 0.041	2.065ArgGlu: 2.065 ± 0.052	1.918ArgPhe: 1.918 ± 0.037	1.684ArgGly: 1.684 ± 0.044	0.593ArgHis: 0.593 ± 0.022	2.858ArgIle: 2.858 ± 0.049	2.807ArgLys: 2.807 ± 0.058	2.978ArgLeu: 2.978 ± 0.058	0.92ArgMet: 0.92 ± 0.028	2.212ArgAsn: 2.212 ± 0.046	1.043ArgPro: 1.043 ± 0.033	1.109ArgGln: 1.109 ± 0.03	1.213ArgArg: 1.213 ± 0.036	1.884ArgSer: 1.884 ± 0.042	1.819ArgThr: 1.819 ± 0.045	1.908ArgVal: 1.908 ± 0.039	0.328ArgTrp: 0.328 ± 0.017	1.402ArgTyr: 1.402 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.74SerAla: 4.74 ± 0.085	0.664SerCys: 0.664 ± 0.031	3.977SerAsp: 3.977 ± 0.06	4.209SerGlu: 4.209 ± 0.073	3.686SerPhe: 3.686 ± 0.054	5.649SerGly: 5.649 ± 0.107	1.156SerHis: 1.156 ± 0.031	4.862SerIle: 4.862 ± 0.06	4.657SerLys: 4.657 ± 0.093	5.655SerLeu: 5.655 ± 0.093	1.338SerMet: 1.338 ± 0.035	4.021SerAsn: 4.021 ± 0.075	2.287SerPro: 2.287 ± 0.048	2.252SerGln: 2.252 ± 0.055	2.065SerArg: 2.065 ± 0.044	4.052SerSer: 4.052 ± 0.071	3.578SerThr: 3.578 ± 0.068	4.271SerVal: 4.271 ± 0.065	0.739SerTrp: 0.739 ± 0.033	2.675SerTyr: 2.675 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.258ThrAla: 5.258 ± 0.15	0.405ThrCys: 0.405 ± 0.023	3.354ThrAsp: 3.354 ± 0.063	3.359ThrGlu: 3.359 ± 0.06	3.352ThrPhe: 3.352 ± 0.063	4.787ThrGly: 4.787 ± 0.13	0.923ThrHis: 0.923 ± 0.027	5.113ThrIle: 5.113 ± 0.093	3.648ThrLys: 3.648 ± 0.063	5.431ThrLeu: 5.431 ± 0.088	0.986ThrMet: 0.986 ± 0.025	3.558ThrAsn: 3.558 ± 0.083	2.693ThrPro: 2.693 ± 0.085	1.957ThrGln: 1.957 ± 0.051	1.635ThrArg: 1.635 ± 0.04	3.978ThrSer: 3.978 ± 0.085	4.335ThrThr: 4.335 ± 0.15	4.433ThrVal: 4.433 ± 0.111	0.567ThrTrp: 0.567 ± 0.027	2.408ThrTyr: 2.408 ± 0.075	0.0ThrXaa: 0.0 ± 0.0
Val	4.708ValAla: 4.708 ± 0.084	0.571ValCys: 0.571 ± 0.028	3.17ValAsp: 3.17 ± 0.055	3.339ValGlu: 3.339 ± 0.059	3.402ValPhe: 3.402 ± 0.064	3.632ValGly: 3.632 ± 0.07	0.968ValHis: 0.968 ± 0.032	4.737ValIle: 4.737 ± 0.074	4.448ValLys: 4.448 ± 0.072	5.768ValLeu: 5.768 ± 0.074	1.364ValMet: 1.364 ± 0.035	3.689ValAsn: 3.689 ± 0.059	2.297ValPro: 2.297 ± 0.047	1.812ValGln: 1.812 ± 0.039	2.031ValArg: 2.031 ± 0.046	4.834ValSer: 4.834 ± 0.07	4.191ValThr: 4.191 ± 0.104	4.357ValVal: 4.357 ± 0.07	0.55ValTrp: 0.55 ± 0.025	2.416ValTyr: 2.416 ± 0.05	0.001ValXaa: 0.001 ± 0.001
Trp	0.675TrpAla: 0.675 ± 0.026	0.095TrpCys: 0.095 ± 0.009	0.532TrpAsp: 0.532 ± 0.023	0.603TrpGlu: 0.603 ± 0.021	0.549TrpPhe: 0.549 ± 0.02	0.625TrpGly: 0.625 ± 0.028	0.225TrpHis: 0.225 ± 0.015	0.772TrpIle: 0.772 ± 0.031	0.841TrpLys: 0.841 ± 0.025	0.893TrpLeu: 0.893 ± 0.028	0.271TrpMet: 0.271 ± 0.015	0.734TrpAsn: 0.734 ± 0.026	0.241TrpPro: 0.241 ± 0.014	0.446TrpGln: 0.446 ± 0.023	0.343TrpArg: 0.343 ± 0.016	0.623TrpSer: 0.623 ± 0.029	0.632TrpThr: 0.632 ± 0.028	0.576TrpVal: 0.576 ± 0.028	0.133TrpTrp: 0.133 ± 0.01	0.419TrpTyr: 0.419 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.48TyrAla: 2.48 ± 0.044	0.381TyrCys: 0.381 ± 0.022	2.349TyrAsp: 2.349 ± 0.051	2.134TyrGlu: 2.134 ± 0.045	2.562TyrPhe: 2.562 ± 0.048	2.44TyrGly: 2.44 ± 0.057	0.754TyrHis: 0.754 ± 0.029	2.685TyrIle: 2.685 ± 0.049	2.765TyrLys: 2.765 ± 0.061	3.521TyrLeu: 3.521 ± 0.059	0.694TyrMet: 0.694 ± 0.025	2.599TyrAsn: 2.599 ± 0.06	1.502TyrPro: 1.502 ± 0.037	1.565TyrGln: 1.565 ± 0.038	1.469TyrArg: 1.469 ± 0.04	2.697TyrSer: 2.697 ± 0.057	2.47TyrThr: 2.47 ± 0.076	2.236TyrVal: 2.236 ± 0.049	0.462TyrTrp: 0.462 ± 0.023	1.844TyrTyr: 1.844 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3558 proteins (1205208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---