Amino acid dipepetide frequency for Phaeodactylibacter luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.044AlaAla: 10.044 ± 0.115	1.015AlaCys: 1.015 ± 0.032	4.887AlaAsp: 4.887 ± 0.065	5.997AlaGlu: 5.997 ± 0.071	4.75AlaPhe: 4.75 ± 0.063	8.036AlaGly: 8.036 ± 0.095	1.817AlaHis: 1.817 ± 0.039	5.118AlaIle: 5.118 ± 0.064	3.503AlaLys: 3.503 ± 0.063	10.303AlaLeu: 10.303 ± 0.108	2.12AlaMet: 2.12 ± 0.035	3.35AlaAsn: 3.35 ± 0.045	4.522AlaPro: 4.522 ± 0.064	4.403AlaGln: 4.403 ± 0.057	4.79AlaArg: 4.79 ± 0.079	5.019AlaSer: 5.019 ± 0.073	4.52AlaThr: 4.52 ± 0.079	6.145AlaVal: 6.145 ± 0.068	1.242AlaTrp: 1.242 ± 0.028	3.735AlaTyr: 3.735 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.775CysAla: 0.775 ± 0.033	0.145CysCys: 0.145 ± 0.01	0.564CysAsp: 0.564 ± 0.026	0.557CysGlu: 0.557 ± 0.025	0.453CysPhe: 0.453 ± 0.021	0.876CysGly: 0.876 ± 0.03	0.234CysHis: 0.234 ± 0.013	0.497CysIle: 0.497 ± 0.019	0.3CysLys: 0.3 ± 0.013	0.858CysLeu: 0.858 ± 0.024	0.175CysMet: 0.175 ± 0.011	0.421CysAsn: 0.421 ± 0.022	0.644CysPro: 0.644 ± 0.033	0.432CysGln: 0.432 ± 0.018	0.487CysArg: 0.487 ± 0.016	0.756CysSer: 0.756 ± 0.03	0.639CysThr: 0.639 ± 0.027	0.423CysVal: 0.423 ± 0.019	0.119CysTrp: 0.119 ± 0.009	0.311CysTyr: 0.311 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.382AspAla: 4.382 ± 0.059	0.645AspCys: 0.645 ± 0.033	2.489AspAsp: 2.489 ± 0.051	3.604AspGlu: 3.604 ± 0.057	2.995AspPhe: 2.995 ± 0.054	4.964AspGly: 4.964 ± 0.099	0.824AspHis: 0.824 ± 0.024	3.394AspIle: 3.394 ± 0.046	2.078AspLys: 2.078 ± 0.045	4.95AspLeu: 4.95 ± 0.056	1.18AspMet: 1.18 ± 0.031	2.305AspAsn: 2.305 ± 0.047	2.463AspPro: 2.463 ± 0.047	1.738AspGln: 1.738 ± 0.03	2.468AspArg: 2.468 ± 0.046	2.765AspSer: 2.765 ± 0.06	2.945AspThr: 2.945 ± 0.063	3.06AspVal: 3.06 ± 0.048	0.902AspTrp: 0.902 ± 0.022	2.352AspTyr: 2.352 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.288GluAla: 7.288 ± 0.085	0.366GluCys: 0.366 ± 0.017	3.53GluAsp: 3.53 ± 0.053	5.348GluGlu: 5.348 ± 0.082	2.048GluPhe: 2.048 ± 0.036	5.393GluGly: 5.393 ± 0.068	1.247GluHis: 1.247 ± 0.036	3.461GluIle: 3.461 ± 0.052	3.263GluLys: 3.263 ± 0.067	6.398GluLeu: 6.398 ± 0.078	1.499GluMet: 1.499 ± 0.032	2.431GluAsn: 2.431 ± 0.041	2.447GluPro: 2.447 ± 0.036	3.515GluGln: 3.515 ± 0.055	3.654GluArg: 3.654 ± 0.055	2.883GluSer: 2.883 ± 0.04	2.638GluThr: 2.638 ± 0.04	5.239GluVal: 5.239 ± 0.065	0.893GluTrp: 0.893 ± 0.025	1.955GluTyr: 1.955 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.747PheAla: 3.747 ± 0.051	0.462PheCys: 0.462 ± 0.02	2.897PheAsp: 2.897 ± 0.047	3.158PheGlu: 3.158 ± 0.049	2.417PhePhe: 2.417 ± 0.042	3.604PheGly: 3.604 ± 0.048	0.824PheHis: 0.824 ± 0.025	2.431PheIle: 2.431 ± 0.039	1.743PheLys: 1.743 ± 0.035	4.442PheLeu: 4.442 ± 0.064	0.903PheMet: 0.903 ± 0.025	2.142PheAsn: 2.142 ± 0.049	1.98PhePro: 1.98 ± 0.038	1.795PheGln: 1.795 ± 0.031	2.515PheArg: 2.515 ± 0.045	3.651PheSer: 3.651 ± 0.062	2.835PheThr: 2.835 ± 0.053	2.593PheVal: 2.593 ± 0.043	0.7PheTrp: 0.7 ± 0.024	1.649PheTyr: 1.649 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.169GlyAla: 7.169 ± 0.104	1.08GlyCys: 1.08 ± 0.049	3.905GlyAsp: 3.905 ± 0.067	4.874GlyGlu: 4.874 ± 0.054	3.65GlyPhe: 3.65 ± 0.05	6.666GlyGly: 6.666 ± 0.154	1.64GlyHis: 1.64 ± 0.035	4.605GlyIle: 4.605 ± 0.059	3.576GlyLys: 3.576 ± 0.062	8.489GlyLeu: 8.489 ± 0.095	1.896GlyMet: 1.896 ± 0.038	3.217GlyAsn: 3.217 ± 0.071	2.722GlyPro: 2.722 ± 0.07	4.665GlyGln: 4.665 ± 0.059	3.952GlyArg: 3.952 ± 0.054	4.956GlySer: 4.956 ± 0.088	4.583GlyThr: 4.583 ± 0.083	4.979GlyVal: 4.979 ± 0.065	1.166GlyTrp: 1.166 ± 0.028	3.109GlyTyr: 3.109 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.366HisAla: 1.366 ± 0.033	0.213HisCys: 0.213 ± 0.012	0.78HisAsp: 0.78 ± 0.022	1.034HisGlu: 1.034 ± 0.029	1.224HisPhe: 1.224 ± 0.03	1.263HisGly: 1.263 ± 0.028	0.562HisHis: 0.562 ± 0.022	1.234HisIle: 1.234 ± 0.033	0.774HisLys: 0.774 ± 0.022	2.257HisLeu: 2.257 ± 0.042	0.328HisMet: 0.328 ± 0.014	0.721HisAsn: 0.721 ± 0.021	1.199HisPro: 1.199 ± 0.03	0.839HisGln: 0.839 ± 0.024	1.082HisArg: 1.082 ± 0.027	0.994HisSer: 0.994 ± 0.024	1.094HisThr: 1.094 ± 0.024	0.851HisVal: 0.851 ± 0.022	0.321HisTrp: 0.321 ± 0.015	0.886HisTyr: 0.886 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.249IleAla: 5.249 ± 0.062	0.561IleCys: 0.561 ± 0.021	3.369IleAsp: 3.369 ± 0.048	3.5IleGlu: 3.5 ± 0.054	2.29IlePhe: 2.29 ± 0.045	4.391IleGly: 4.391 ± 0.058	0.984IleHis: 0.984 ± 0.026	3.074IleIle: 3.074 ± 0.045	2.271IleLys: 2.271 ± 0.046	4.79IleLeu: 4.79 ± 0.059	0.977IleMet: 0.977 ± 0.023	2.571IleAsn: 2.571 ± 0.044	2.561IlePro: 2.561 ± 0.042	2.036IleGln: 2.036 ± 0.038	3.031IleArg: 3.031 ± 0.043	3.765IleSer: 3.765 ± 0.054	3.239IleThr: 3.239 ± 0.058	3.265IleVal: 3.265 ± 0.057	0.655IleTrp: 0.655 ± 0.023	1.8IleTyr: 1.8 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.702LysAla: 4.702 ± 0.086	0.209LysCys: 0.209 ± 0.011	2.195LysAsp: 2.195 ± 0.043	2.969LysGlu: 2.969 ± 0.06	1.281LysPhe: 1.281 ± 0.034	3.552LysGly: 3.552 ± 0.062	0.808LysHis: 0.808 ± 0.026	2.381LysIle: 2.381 ± 0.048	2.431LysLys: 2.431 ± 0.062	3.77LysLeu: 3.77 ± 0.066	1.01LysMet: 1.01 ± 0.027	1.539LysAsn: 1.539 ± 0.034	1.981LysPro: 1.981 ± 0.041	1.704LysGln: 1.704 ± 0.036	2.35LysArg: 2.35 ± 0.052	2.221LysSer: 2.221 ± 0.045	2.113LysThr: 2.113 ± 0.041	2.965LysVal: 2.965 ± 0.059	0.58LysTrp: 0.58 ± 0.022	1.469LysTyr: 1.469 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.334LeuAla: 9.334 ± 0.102	0.944LeuCys: 0.944 ± 0.028	5.138LeuAsp: 5.138 ± 0.065	6.59LeuGlu: 6.59 ± 0.069	4.636LeuPhe: 4.636 ± 0.058	7.382LeuGly: 7.382 ± 0.086	1.978LeuHis: 1.978 ± 0.036	5.128LeuIle: 5.128 ± 0.059	4.714LeuLys: 4.714 ± 0.075	11.235LeuLeu: 11.235 ± 0.152	2.184LeuMet: 2.184 ± 0.04	4.196LeuAsn: 4.196 ± 0.058	5.845LeuPro: 5.845 ± 0.071	5.11LeuGln: 5.11 ± 0.067	5.444LeuArg: 5.444 ± 0.078	8.197LeuSer: 8.197 ± 0.092	5.034LeuThr: 5.034 ± 0.065	5.03LeuVal: 5.03 ± 0.063	1.157LeuTrp: 1.157 ± 0.027	3.338LeuTyr: 3.338 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.343MetAla: 2.343 ± 0.044	0.124MetCys: 0.124 ± 0.008	1.154MetAsp: 1.154 ± 0.03	1.514MetGlu: 1.514 ± 0.033	0.569MetPhe: 0.569 ± 0.023	1.697MetGly: 1.697 ± 0.035	0.386MetHis: 0.386 ± 0.015	0.98MetIle: 0.98 ± 0.024	1.39MetLys: 1.39 ± 0.031	2.077MetLeu: 2.077 ± 0.042	0.531MetMet: 0.531 ± 0.021	0.823MetAsn: 0.823 ± 0.023	1.262MetPro: 1.262 ± 0.026	0.973MetGln: 0.973 ± 0.025	1.097MetArg: 1.097 ± 0.025	1.261MetSer: 1.261 ± 0.026	1.022MetThr: 1.022 ± 0.025	1.322MetVal: 1.322 ± 0.029	0.157MetTrp: 0.157 ± 0.01	0.534MetTyr: 0.534 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.319AsnAla: 3.319 ± 0.045	0.472AsnCys: 0.472 ± 0.024	2.038AsnAsp: 2.038 ± 0.048	2.237AsnGlu: 2.237 ± 0.04	1.885AsnPhe: 1.885 ± 0.041	3.942AsnGly: 3.942 ± 0.089	0.656AsnHis: 0.656 ± 0.021	2.479AsnIle: 2.479 ± 0.047	1.434AsnLys: 1.434 ± 0.035	4.006AsnLeu: 4.006 ± 0.05	0.793AsnMet: 0.793 ± 0.023	1.909AsnAsn: 1.909 ± 0.047	2.454AsnPro: 2.454 ± 0.048	1.538AsnGln: 1.538 ± 0.034	2.157AsnArg: 2.157 ± 0.039	2.214AsnSer: 2.214 ± 0.045	2.35AsnThr: 2.35 ± 0.053	2.132AsnVal: 2.132 ± 0.044	0.62AsnTrp: 0.62 ± 0.022	1.623AsnTyr: 1.623 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.019ProAla: 5.019 ± 0.072	0.444ProCys: 0.444 ± 0.02	3.071ProAsp: 3.071 ± 0.049	3.998ProGlu: 3.998 ± 0.054	2.364ProPhe: 2.364 ± 0.039	4.461ProGly: 4.461 ± 0.072	0.783ProHis: 0.783 ± 0.024	2.293ProIle: 2.293 ± 0.036	1.773ProLys: 1.773 ± 0.036	4.398ProLeu: 4.398 ± 0.05	0.99ProMet: 0.99 ± 0.028	2.163ProAsn: 2.163 ± 0.05	2.147ProPro: 2.147 ± 0.06	1.933ProGln: 1.933 ± 0.049	1.705ProArg: 1.705 ± 0.035	2.753ProSer: 2.753 ± 0.047	2.165ProThr: 2.165 ± 0.034	3.7ProVal: 3.7 ± 0.053	0.553ProTrp: 0.553 ± 0.02	1.753ProTyr: 1.753 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.855GlnAla: 4.855 ± 0.064	0.272GlnCys: 0.272 ± 0.013	2.063GlnAsp: 2.063 ± 0.034	3.214GlnGlu: 3.214 ± 0.056	1.732GlnPhe: 1.732 ± 0.034	3.224GlnGly: 3.224 ± 0.052	0.906GlnHis: 0.906 ± 0.024	2.167GlnIle: 2.167 ± 0.035	1.929GlnLys: 1.929 ± 0.041	5.22GlnLeu: 5.22 ± 0.071	1.027GlnMet: 1.027 ± 0.028	1.516GlnAsn: 1.516 ± 0.034	2.443GlnPro: 2.443 ± 0.04	2.801GlnGln: 2.801 ± 0.059	2.355GlnArg: 2.355 ± 0.043	2.273GlnSer: 2.273 ± 0.036	1.89GlnThr: 1.89 ± 0.038	3.014GlnVal: 3.014 ± 0.04	0.666GlnTrp: 0.666 ± 0.02	1.527GlnTyr: 1.527 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	4.388ArgAla: 4.388 ± 0.061	0.393ArgCys: 0.393 ± 0.016	2.274ArgAsp: 2.274 ± 0.041	3.503ArgGlu: 3.503 ± 0.056	2.674ArgPhe: 2.674 ± 0.048	3.009ArgGly: 3.009 ± 0.054	1.154ArgHis: 1.154 ± 0.03	3.094ArgIle: 3.094 ± 0.048	2.654ArgLys: 2.654 ± 0.054	5.783ArgLeu: 5.783 ± 0.069	1.398ArgMet: 1.398 ± 0.03	1.925ArgAsn: 1.925 ± 0.038	2.32ArgPro: 2.32 ± 0.043	2.654ArgGln: 2.654 ± 0.048	2.74ArgArg: 2.74 ± 0.051	3.018ArgSer: 3.018 ± 0.052	2.243ArgThr: 2.243 ± 0.037	2.936ArgVal: 2.936 ± 0.044	0.707ArgTrp: 0.707 ± 0.022	2.276ArgTyr: 2.276 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.546SerAla: 5.546 ± 0.064	0.779SerCys: 0.779 ± 0.03	2.878SerAsp: 2.878 ± 0.044	3.065SerGlu: 3.065 ± 0.048	3.194SerPhe: 3.194 ± 0.049	5.721SerGly: 5.721 ± 0.09	1.096SerHis: 1.096 ± 0.027	3.482SerIle: 3.482 ± 0.049	2.211SerLys: 2.211 ± 0.043	6.355SerLeu: 6.355 ± 0.078	1.181SerMet: 1.181 ± 0.025	2.436SerAsn: 2.436 ± 0.051	3.501SerPro: 3.501 ± 0.055	2.06SerGln: 2.06 ± 0.033	3.092SerArg: 3.092 ± 0.043	3.855SerSer: 3.855 ± 0.056	3.239SerThr: 3.239 ± 0.056	3.581SerVal: 3.581 ± 0.063	0.972SerTrp: 0.972 ± 0.027	2.354SerTyr: 2.354 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.572ThrAla: 5.572 ± 0.075	0.481ThrCys: 0.481 ± 0.023	3.051ThrAsp: 3.051 ± 0.052	2.762ThrGlu: 2.762 ± 0.044	2.674ThrPhe: 2.674 ± 0.054	4.828ThrGly: 4.828 ± 0.086	0.822ThrHis: 0.822 ± 0.024	2.886ThrIle: 2.886 ± 0.046	1.488ThrLys: 1.488 ± 0.035	5.549ThrLeu: 5.549 ± 0.082	0.82ThrMet: 0.82 ± 0.023	1.885ThrAsn: 1.885 ± 0.045	2.862ThrPro: 2.862 ± 0.047	1.607ThrGln: 1.607 ± 0.034	1.869ThrArg: 1.869 ± 0.036	2.599ThrSer: 2.599 ± 0.05	2.786ThrThr: 2.786 ± 0.053	4.224ThrVal: 4.224 ± 0.087	0.677ThrTrp: 0.677 ± 0.024	2.031ThrTyr: 2.031 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.704ValAla: 5.704 ± 0.071	0.599ValCys: 0.599 ± 0.025	3.387ValAsp: 3.387 ± 0.056	4.134ValGlu: 4.134 ± 0.045	3.143ValPhe: 3.143 ± 0.051	4.219ValGly: 4.219 ± 0.056	1.165ValHis: 1.165 ± 0.028	3.269ValIle: 3.269 ± 0.047	2.698ValLys: 2.698 ± 0.045	6.236ValLeu: 6.236 ± 0.07	1.259ValMet: 1.259 ± 0.033	2.62ValAsn: 2.62 ± 0.041	2.905ValPro: 2.905 ± 0.051	2.674ValGln: 2.674 ± 0.038	3.286ValArg: 3.286 ± 0.043	4.272ValSer: 4.272 ± 0.066	3.371ValThr: 3.371 ± 0.086	4.31ValVal: 4.31 ± 0.066	0.767ValTrp: 0.767 ± 0.024	2.364ValTyr: 2.364 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.443TrpAla: 1.443 ± 0.031	0.124TrpCys: 0.124 ± 0.008	0.742TrpAsp: 0.742 ± 0.026	0.967TrpGlu: 0.967 ± 0.028	0.534TrpPhe: 0.534 ± 0.02	1.088TrpGly: 1.088 ± 0.03	0.321TrpHis: 0.321 ± 0.014	0.591TrpIle: 0.591 ± 0.021	0.575TrpLys: 0.575 ± 0.02	1.554TrpLeu: 1.554 ± 0.035	0.341TrpMet: 0.341 ± 0.014	0.478TrpAsn: 0.478 ± 0.02	0.497TrpPro: 0.497 ± 0.02	0.746TrpGln: 0.746 ± 0.021	0.695TrpArg: 0.695 ± 0.022	0.944TrpSer: 0.944 ± 0.033	0.516TrpThr: 0.516 ± 0.017	0.814TrpVal: 0.814 ± 0.021	0.222TrpTrp: 0.222 ± 0.013	0.463TrpTyr: 0.463 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.072TyrAla: 3.072 ± 0.046	0.338TyrCys: 0.338 ± 0.017	2.092TyrAsp: 2.092 ± 0.042	2.473TyrGlu: 2.473 ± 0.044	1.975TyrPhe: 1.975 ± 0.036	2.584TyrGly: 2.584 ± 0.042	0.815TyrHis: 0.815 ± 0.024	1.812TyrIle: 1.812 ± 0.034	1.423TyrLys: 1.423 ± 0.037	3.942TyrLeu: 3.942 ± 0.055	0.604TyrMet: 0.604 ± 0.02	1.612TyrAsn: 1.612 ± 0.037	1.711TyrPro: 1.711 ± 0.034	1.869TyrGln: 1.869 ± 0.04	2.374TyrArg: 2.374 ± 0.04	2.199TyrSer: 2.199 ± 0.039	2.254TyrThr: 2.254 ± 0.045	1.8TyrVal: 1.8 ± 0.037	0.576TyrTrp: 0.576 ± 0.022	1.582TyrTyr: 1.582 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4366 proteins (1681301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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