Amino acid dipepetide frequency for Pseudomonas virus phiCTX

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.812AlaAla: 12.812 ± 1.401
0.915AlaCys: 0.915 ± 0.25
7.504AlaAsp: 7.504 ± 0.74
6.04AlaGlu: 6.04 ± 0.777
2.654AlaPhe: 2.654 ± 0.508
10.616AlaGly: 10.616 ± 1.618
2.288AlaHis: 2.288 ± 0.502
5.216AlaIle: 5.216 ± 0.711
3.478AlaLys: 3.478 ± 0.704
11.897AlaLeu: 11.897 ± 1.061
2.562AlaMet: 2.562 ± 0.608
4.759AlaAsn: 4.759 ± 0.818
3.661AlaPro: 3.661 ± 0.579
6.223AlaGln: 6.223 ± 0.743
7.779AlaArg: 7.779 ± 0.778
5.766AlaSer: 5.766 ± 1.073
7.504AlaThr: 7.504 ± 1.048
7.138AlaVal: 7.138 ± 0.876
1.739AlaTrp: 1.739 ± 0.453
3.112AlaTyr: 3.112 ± 0.496
0.0AlaXaa: 0.0 ± 0.0
Cys
0.732CysAla: 0.732 ± 0.255
0.275CysCys: 0.275 ± 0.151
0.549CysAsp: 0.549 ± 0.23
0.549CysGlu: 0.549 ± 0.23
0.549CysPhe: 0.549 ± 0.276
1.281CysGly: 1.281 ± 0.384
0.275CysHis: 0.275 ± 0.148
0.366CysIle: 0.366 ± 0.213
0.641CysLys: 0.641 ± 0.262
0.915CysLeu: 0.915 ± 0.301
0.366CysMet: 0.366 ± 0.172
0.366CysAsn: 0.366 ± 0.182
0.732CysPro: 0.732 ± 0.246
0.275CysGln: 0.275 ± 0.18
0.458CysArg: 0.458 ± 0.251
0.641CysSer: 0.641 ± 0.223
0.366CysThr: 0.366 ± 0.185
0.549CysVal: 0.549 ± 0.232
0.458CysTrp: 0.458 ± 0.188
0.183CysTyr: 0.183 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
6.589AspAla: 6.589 ± 0.732
0.366AspCys: 0.366 ± 0.186
2.929AspAsp: 2.929 ± 0.481
2.379AspGlu: 2.379 ± 0.557
1.739AspPhe: 1.739 ± 0.313
4.942AspGly: 4.942 ± 0.752
1.007AspHis: 1.007 ± 0.248
3.203AspIle: 3.203 ± 0.451
2.105AspLys: 2.105 ± 0.501
8.328AspLeu: 8.328 ± 0.879
1.281AspMet: 1.281 ± 0.33
2.013AspAsn: 2.013 ± 0.387
3.386AspPro: 3.386 ± 0.819
3.112AspGln: 3.112 ± 0.577
3.661AspArg: 3.661 ± 0.581
3.661AspSer: 3.661 ± 0.445
3.112AspThr: 3.112 ± 0.509
2.471AspVal: 2.471 ± 0.429
1.83AspTrp: 1.83 ± 0.497
2.471AspTyr: 2.471 ± 0.566
0.0AspXaa: 0.0 ± 0.0
Glu
6.132GluAla: 6.132 ± 0.772
1.19GluCys: 1.19 ± 0.289
2.837GluAsp: 2.837 ± 0.442
2.013GluGlu: 2.013 ± 0.309
2.471GluPhe: 2.471 ± 0.619
2.562GluGly: 2.562 ± 0.458
1.098GluHis: 1.098 ± 0.282
3.203GluIle: 3.203 ± 0.555
2.837GluLys: 2.837 ± 0.716
6.132GluLeu: 6.132 ± 0.827
0.824GluMet: 0.824 ± 0.29
1.647GluAsn: 1.647 ± 0.322
2.471GluPro: 2.471 ± 0.492
2.562GluGln: 2.562 ± 0.483
3.935GluArg: 3.935 ± 0.636
2.837GluSer: 2.837 ± 0.661
2.379GluThr: 2.379 ± 0.38
3.752GluVal: 3.752 ± 0.651
1.19GluTrp: 1.19 ± 0.33
1.373GluTyr: 1.373 ± 0.289
0.0GluXaa: 0.0 ± 0.0
Phe
3.203PheAla: 3.203 ± 0.447
0.366PheCys: 0.366 ± 0.17
2.654PheAsp: 2.654 ± 0.5
1.647PheGlu: 1.647 ± 0.4
0.641PhePhe: 0.641 ± 0.249
1.922PheGly: 1.922 ± 0.432
0.824PheHis: 0.824 ± 0.282
1.373PheIle: 1.373 ± 0.392
1.556PheLys: 1.556 ± 0.423
2.471PheLeu: 2.471 ± 0.567
0.183PheMet: 0.183 ± 0.106
1.007PheAsn: 1.007 ± 0.228
1.556PhePro: 1.556 ± 0.365
1.464PheGln: 1.464 ± 0.329
2.196PheArg: 2.196 ± 0.525
2.471PheSer: 2.471 ± 0.615
1.739PheThr: 1.739 ± 0.378
1.464PheVal: 1.464 ± 0.387
1.007PheTrp: 1.007 ± 0.294
0.915PheTyr: 0.915 ± 0.28
0.0PheXaa: 0.0 ± 0.0
Gly
7.779GlyAla: 7.779 ± 0.846
0.915GlyCys: 0.915 ± 0.288
4.667GlyAsp: 4.667 ± 0.637
3.844GlyGlu: 3.844 ± 0.573
1.83GlyPhe: 1.83 ± 0.339
7.504GlyGly: 7.504 ± 1.146
1.373GlyHis: 1.373 ± 0.423
3.935GlyIle: 3.935 ± 0.791
3.295GlyLys: 3.295 ± 0.573
8.511GlyLeu: 8.511 ± 0.942
1.83GlyMet: 1.83 ± 0.487
3.02GlyAsn: 3.02 ± 0.461
2.471GlyPro: 2.471 ± 0.56
3.295GlyGln: 3.295 ± 0.659
5.033GlyArg: 5.033 ± 0.737
3.844GlySer: 3.844 ± 0.685
4.942GlyThr: 4.942 ± 0.67
5.857GlyVal: 5.857 ± 0.659
1.556GlyTrp: 1.556 ± 0.329
2.745GlyTyr: 2.745 ± 0.475
0.0GlyXaa: 0.0 ± 0.0
His
2.562HisAla: 2.562 ± 0.448
0.0HisCys: 0.0 ± 0.0
1.19HisAsp: 1.19 ± 0.346
0.915HisGlu: 0.915 ± 0.247
1.19HisPhe: 1.19 ± 0.342
1.464HisGly: 1.464 ± 0.364
0.641HisHis: 0.641 ± 0.259
1.007HisIle: 1.007 ± 0.319
0.458HisLys: 0.458 ± 0.168
1.739HisLeu: 1.739 ± 0.402
0.458HisMet: 0.458 ± 0.208
0.641HisAsn: 0.641 ± 0.274
0.915HisPro: 0.915 ± 0.341
1.464HisGln: 1.464 ± 0.315
1.739HisArg: 1.739 ± 0.425
1.464HisSer: 1.464 ± 0.367
0.824HisThr: 0.824 ± 0.255
0.641HisVal: 0.641 ± 0.307
0.275HisTrp: 0.275 ± 0.165
0.458HisTyr: 0.458 ± 0.245
0.0HisXaa: 0.0 ± 0.0
Ile
6.132IleAla: 6.132 ± 0.693
0.732IleCys: 0.732 ± 0.355
4.85IleAsp: 4.85 ± 0.401
2.471IleGlu: 2.471 ± 0.566
1.647IlePhe: 1.647 ± 0.435
3.661IleGly: 3.661 ± 0.724
0.549IleHis: 0.549 ± 0.221
1.739IleIle: 1.739 ± 0.444
1.556IleLys: 1.556 ± 0.443
3.935IleLeu: 3.935 ± 0.616
0.824IleMet: 0.824 ± 0.246
1.556IleAsn: 1.556 ± 0.33
2.288IlePro: 2.288 ± 0.536
1.739IleGln: 1.739 ± 0.392
3.752IleArg: 3.752 ± 0.514
2.654IleSer: 2.654 ± 0.474
3.661IleThr: 3.661 ± 0.528
2.288IleVal: 2.288 ± 0.411
1.007IleTrp: 1.007 ± 0.31
1.007IleTyr: 1.007 ± 0.288
0.0IleXaa: 0.0 ± 0.0
Lys
4.576LysAla: 4.576 ± 0.631
0.275LysCys: 0.275 ± 0.168
2.471LysAsp: 2.471 ± 0.562
1.83LysGlu: 1.83 ± 0.511
1.739LysPhe: 1.739 ± 0.376
2.929LysGly: 2.929 ± 0.478
0.732LysHis: 0.732 ± 0.263
1.464LysIle: 1.464 ± 0.399
1.83LysLys: 1.83 ± 0.518
3.661LysLeu: 3.661 ± 0.691
0.732LysMet: 0.732 ± 0.216
1.464LysAsn: 1.464 ± 0.379
1.83LysPro: 1.83 ± 0.422
1.556LysGln: 1.556 ± 0.361
3.844LysArg: 3.844 ± 0.567
1.739LysSer: 1.739 ± 0.464
3.02LysThr: 3.02 ± 0.601
2.929LysVal: 2.929 ± 0.642
0.458LysTrp: 0.458 ± 0.23
1.281LysTyr: 1.281 ± 0.423
0.0LysXaa: 0.0 ± 0.0
Leu
12.08LeuAla: 12.08 ± 1.126
1.007LeuCys: 1.007 ± 0.331
6.04LeuAsp: 6.04 ± 0.554
6.681LeuGlu: 6.681 ± 0.95
2.471LeuPhe: 2.471 ± 0.412
8.236LeuGly: 8.236 ± 1.468
2.013LeuHis: 2.013 ± 0.384
4.393LeuIle: 4.393 ± 0.537
5.949LeuLys: 5.949 ± 0.832
10.433LeuLeu: 10.433 ± 1.101
2.471LeuMet: 2.471 ± 0.492
2.745LeuAsn: 2.745 ± 0.417
4.942LeuPro: 4.942 ± 0.68
4.85LeuGln: 4.85 ± 0.802
7.321LeuArg: 7.321 ± 0.986
6.681LeuSer: 6.681 ± 0.689
5.857LeuThr: 5.857 ± 0.775
6.406LeuVal: 6.406 ± 0.748
1.83LeuTrp: 1.83 ± 0.37
2.562LeuTyr: 2.562 ± 0.483
0.0LeuXaa: 0.0 ± 0.0
Met
2.929MetAla: 2.929 ± 0.568
0.092MetCys: 0.092 ± 0.09
1.098MetAsp: 1.098 ± 0.414
0.915MetGlu: 0.915 ± 0.294
0.641MetPhe: 0.641 ± 0.236
1.556MetGly: 1.556 ± 0.389
0.366MetHis: 0.366 ± 0.192
1.098MetIle: 1.098 ± 0.302
0.641MetLys: 0.641 ± 0.219
2.837MetLeu: 2.837 ± 0.564
0.183MetMet: 0.183 ± 0.127
0.915MetAsn: 0.915 ± 0.324
1.373MetPro: 1.373 ± 0.347
0.915MetGln: 0.915 ± 0.246
1.373MetArg: 1.373 ± 0.417
1.19MetSer: 1.19 ± 0.295
0.915MetThr: 0.915 ± 0.263
0.824MetVal: 0.824 ± 0.257
0.275MetTrp: 0.275 ± 0.159
0.641MetTyr: 0.641 ± 0.209
0.0MetXaa: 0.0 ± 0.0
Asn
3.752AsnAla: 3.752 ± 0.723
0.549AsnCys: 0.549 ± 0.198
1.922AsnAsp: 1.922 ± 0.367
2.471AsnGlu: 2.471 ± 0.496
1.098AsnPhe: 1.098 ± 0.311
4.393AsnGly: 4.393 ± 0.758
0.641AsnHis: 0.641 ± 0.302
1.464AsnIle: 1.464 ± 0.397
1.373AsnLys: 1.373 ± 0.329
3.478AsnLeu: 3.478 ± 0.48
0.732AsnMet: 0.732 ± 0.224
1.19AsnAsn: 1.19 ± 0.335
1.739AsnPro: 1.739 ± 0.441
1.739AsnGln: 1.739 ± 0.409
1.647AsnArg: 1.647 ± 0.36
1.647AsnSer: 1.647 ± 0.362
1.007AsnThr: 1.007 ± 0.26
1.83AsnVal: 1.83 ± 0.427
0.275AsnTrp: 0.275 ± 0.153
0.915AsnTyr: 0.915 ± 0.328
0.0AsnXaa: 0.0 ± 0.0
Pro
6.132ProAla: 6.132 ± 0.877
0.458ProCys: 0.458 ± 0.209
3.295ProAsp: 3.295 ± 0.735
3.569ProGlu: 3.569 ± 0.573
1.373ProPhe: 1.373 ± 0.342
3.478ProGly: 3.478 ± 0.493
0.824ProHis: 0.824 ± 0.249
1.739ProIle: 1.739 ± 0.416
1.83ProLys: 1.83 ± 0.359
4.393ProLeu: 4.393 ± 0.589
1.098ProMet: 1.098 ± 0.286
1.098ProAsn: 1.098 ± 0.335
2.562ProPro: 2.562 ± 0.455
1.464ProGln: 1.464 ± 0.379
3.112ProArg: 3.112 ± 0.623
3.02ProSer: 3.02 ± 0.579
2.196ProThr: 2.196 ± 0.58
3.203ProVal: 3.203 ± 0.52
0.732ProTrp: 0.732 ± 0.2
0.641ProTyr: 0.641 ± 0.253
0.0ProXaa: 0.0 ± 0.0
Gln
6.589GlnAla: 6.589 ± 1.041
0.275GlnCys: 0.275 ± 0.149
1.647GlnAsp: 1.647 ± 0.32
1.739GlnGlu: 1.739 ± 0.409
1.19GlnPhe: 1.19 ± 0.427
3.295GlnGly: 3.295 ± 0.571
1.007GlnHis: 1.007 ± 0.374
2.562GlnIle: 2.562 ± 0.459
1.739GlnLys: 1.739 ± 0.482
5.766GlnLeu: 5.766 ± 0.597
1.739GlnMet: 1.739 ± 0.357
1.281GlnAsn: 1.281 ± 0.285
2.196GlnPro: 2.196 ± 0.48
3.295GlnGln: 3.295 ± 0.764
3.935GlnArg: 3.935 ± 0.646
2.562GlnSer: 2.562 ± 0.511
2.288GlnThr: 2.288 ± 0.447
2.471GlnVal: 2.471 ± 0.471
0.458GlnTrp: 0.458 ± 0.265
1.556GlnTyr: 1.556 ± 0.45
0.0GlnXaa: 0.0 ± 0.0
Arg
6.223ArgAla: 6.223 ± 0.87
0.732ArgCys: 0.732 ± 0.238
3.935ArgAsp: 3.935 ± 0.67
3.844ArgGlu: 3.844 ± 0.539
1.83ArgPhe: 1.83 ± 0.322
4.21ArgGly: 4.21 ± 0.69
1.922ArgHis: 1.922 ± 0.458
4.21ArgIle: 4.21 ± 0.723
2.654ArgLys: 2.654 ± 0.42
8.053ArgLeu: 8.053 ± 0.834
1.373ArgMet: 1.373 ± 0.31
2.745ArgAsn: 2.745 ± 0.537
3.478ArgPro: 3.478 ± 0.526
4.484ArgGln: 4.484 ± 0.955
4.85ArgArg: 4.85 ± 0.817
3.844ArgSer: 3.844 ± 0.707
3.661ArgThr: 3.661 ± 0.536
4.393ArgVal: 4.393 ± 0.574
1.373ArgTrp: 1.373 ± 0.345
2.013ArgTyr: 2.013 ± 0.494
0.0ArgXaa: 0.0 ± 0.0
Ser
8.236SerAla: 8.236 ± 0.801
0.366SerCys: 0.366 ± 0.196
3.295SerAsp: 3.295 ± 0.527
3.112SerGlu: 3.112 ± 0.541
1.373SerPhe: 1.373 ± 0.283
4.393SerGly: 4.393 ± 0.909
1.373SerHis: 1.373 ± 0.329
2.105SerIle: 2.105 ± 0.387
2.471SerLys: 2.471 ± 0.383
5.857SerLeu: 5.857 ± 0.898
1.281SerMet: 1.281 ± 0.365
1.464SerAsn: 1.464 ± 0.372
3.02SerPro: 3.02 ± 0.402
2.105SerGln: 2.105 ± 0.428
3.569SerArg: 3.569 ± 0.559
3.661SerSer: 3.661 ± 0.967
3.478SerThr: 3.478 ± 0.74
3.844SerVal: 3.844 ± 0.521
1.007SerTrp: 1.007 ± 0.28
1.556SerTyr: 1.556 ± 0.388
0.0SerXaa: 0.0 ± 0.0
Thr
6.406ThrAla: 6.406 ± 1.025
0.824ThrCys: 0.824 ± 0.249
3.02ThrAsp: 3.02 ± 0.477
2.837ThrGlu: 2.837 ± 0.597
2.562ThrPhe: 2.562 ± 0.555
5.583ThrGly: 5.583 ± 0.855
0.732ThrHis: 0.732 ± 0.265
3.295ThrIle: 3.295 ± 0.473
1.83ThrLys: 1.83 ± 0.387
6.406ThrLeu: 6.406 ± 0.705
0.824ThrMet: 0.824 ± 0.315
1.83ThrAsn: 1.83 ± 0.429
2.196ThrPro: 2.196 ± 0.419
2.105ThrGln: 2.105 ± 0.435
4.027ThrArg: 4.027 ± 0.732
2.929ThrSer: 2.929 ± 0.56
3.478ThrThr: 3.478 ± 0.738
3.844ThrVal: 3.844 ± 0.724
0.824ThrTrp: 0.824 ± 0.251
1.739ThrTyr: 1.739 ± 0.363
0.0ThrXaa: 0.0 ± 0.0
Val
6.406ValAla: 6.406 ± 0.814
0.732ValCys: 0.732 ± 0.287
4.118ValAsp: 4.118 ± 0.68
4.21ValGlu: 4.21 ± 0.668
1.464ValPhe: 1.464 ± 0.357
3.203ValGly: 3.203 ± 0.648
1.19ValHis: 1.19 ± 0.388
3.386ValIle: 3.386 ± 0.523
2.471ValLys: 2.471 ± 0.45
4.942ValLeu: 4.942 ± 0.604
1.007ValMet: 1.007 ± 0.258
2.654ValAsn: 2.654 ± 0.688
3.386ValPro: 3.386 ± 0.799
3.112ValGln: 3.112 ± 0.524
4.027ValArg: 4.027 ± 0.532
4.027ValSer: 4.027 ± 0.556
4.667ValThr: 4.667 ± 0.835
4.21ValVal: 4.21 ± 0.65
0.275ValTrp: 0.275 ± 0.131
1.19ValTyr: 1.19 ± 0.378
0.0ValXaa: 0.0 ± 0.0
Trp
1.922TrpAla: 1.922 ± 0.374
0.183TrpCys: 0.183 ± 0.113
1.098TrpAsp: 1.098 ± 0.276
0.732TrpGlu: 0.732 ± 0.262
1.007TrpPhe: 1.007 ± 0.404
0.732TrpGly: 0.732 ± 0.295
0.641TrpHis: 0.641 ± 0.192
0.641TrpIle: 0.641 ± 0.236
0.641TrpLys: 0.641 ± 0.189
1.647TrpLeu: 1.647 ± 0.357
0.275TrpMet: 0.275 ± 0.14
0.641TrpAsn: 0.641 ± 0.209
0.824TrpPro: 0.824 ± 0.307
0.458TrpGln: 0.458 ± 0.186
1.281TrpArg: 1.281 ± 0.385
1.373TrpSer: 1.373 ± 0.32
0.824TrpThr: 0.824 ± 0.327
1.281TrpVal: 1.281 ± 0.333
0.366TrpTrp: 0.366 ± 0.149
1.007TrpTyr: 1.007 ± 0.253
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.471TyrAla: 2.471 ± 0.597
0.275TyrCys: 0.275 ± 0.16
1.464TyrAsp: 1.464 ± 0.383
1.647TyrGlu: 1.647 ± 0.423
1.19TyrPhe: 1.19 ± 0.359
2.288TyrGly: 2.288 ± 0.505
0.549TyrHis: 0.549 ± 0.205
1.647TyrIle: 1.647 ± 0.347
1.007TyrLys: 1.007 ± 0.285
3.661TyrLeu: 3.661 ± 0.495
0.641TyrMet: 0.641 ± 0.239
0.824TyrAsn: 0.824 ± 0.23
1.19TyrPro: 1.19 ± 0.335
1.373TyrGln: 1.373 ± 0.338
2.288TyrArg: 2.288 ± 0.404
1.556TyrSer: 1.556 ± 0.351
1.373TyrThr: 1.373 ± 0.448
1.281TyrVal: 1.281 ± 0.386
0.641TyrTrp: 0.641 ± 0.259
0.732TyrTyr: 0.732 ± 0.209
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (10928 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski