Amino acid dipepetide frequency for Leptobacterium flavescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.438AlaAla: 4.438 ± 0.073	0.542AlaCys: 0.542 ± 0.023	3.614AlaAsp: 3.614 ± 0.064	4.329AlaGlu: 4.329 ± 0.064	3.616AlaPhe: 3.616 ± 0.054	4.41AlaGly: 4.41 ± 0.074	1.1AlaHis: 1.1 ± 0.028	5.055AlaIle: 5.055 ± 0.069	4.009AlaLys: 4.009 ± 0.063	6.178AlaLeu: 6.178 ± 0.074	1.454AlaMet: 1.454 ± 0.039	3.131AlaAsn: 3.131 ± 0.054	1.964AlaPro: 1.964 ± 0.053	2.227AlaGln: 2.227 ± 0.048	2.549AlaArg: 2.549 ± 0.053	4.362AlaSer: 4.362 ± 0.064	3.332AlaThr: 3.332 ± 0.064	4.512AlaVal: 4.512 ± 0.062	0.61AlaTrp: 0.61 ± 0.023	2.656AlaTyr: 2.656 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.398CysAla: 0.398 ± 0.019	0.089CysCys: 0.089 ± 0.008	0.408CysAsp: 0.408 ± 0.021	0.427CysGlu: 0.427 ± 0.019	0.412CysPhe: 0.412 ± 0.02	0.588CysGly: 0.588 ± 0.02	0.185CysHis: 0.185 ± 0.015	0.562CysIle: 0.562 ± 0.024	0.392CysLys: 0.392 ± 0.017	0.607CysLeu: 0.607 ± 0.023	0.15CysMet: 0.15 ± 0.011	0.408CysAsn: 0.408 ± 0.021	0.33CysPro: 0.33 ± 0.022	0.19CysGln: 0.19 ± 0.012	0.269CysArg: 0.269 ± 0.015	0.519CysSer: 0.519 ± 0.022	0.424CysThr: 0.424 ± 0.024	0.4CysVal: 0.4 ± 0.02	0.07CysTrp: 0.07 ± 0.01	0.273CysTyr: 0.273 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.731AspAla: 3.731 ± 0.075	0.414AspCys: 0.414 ± 0.02	2.953AspAsp: 2.953 ± 0.086	3.915AspGlu: 3.915 ± 0.062	3.66AspPhe: 3.66 ± 0.059	4.139AspGly: 4.139 ± 0.113	1.171AspHis: 1.171 ± 0.033	4.72AspIle: 4.72 ± 0.066	4.103AspLys: 4.103 ± 0.067	5.287AspLeu: 5.287 ± 0.061	1.052AspMet: 1.052 ± 0.03	2.996AspAsn: 2.996 ± 0.065	2.311AspPro: 2.311 ± 0.064	1.749AspGln: 1.749 ± 0.035	2.414AspArg: 2.414 ± 0.041	3.291AspSer: 3.291 ± 0.059	2.878AspThr: 2.878 ± 0.053	3.335AspVal: 3.335 ± 0.065	0.711AspTrp: 0.711 ± 0.025	2.663AspTyr: 2.663 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.772GluAla: 4.772 ± 0.073	0.358GluCys: 0.358 ± 0.016	4.128GluAsp: 4.128 ± 0.064	6.265GluGlu: 6.265 ± 0.087	2.998GluPhe: 2.998 ± 0.054	4.247GluGly: 4.247 ± 0.058	1.278GluHis: 1.278 ± 0.038	5.57GluIle: 5.57 ± 0.061	6.332GluLys: 6.332 ± 0.092	6.89GluLeu: 6.89 ± 0.076	1.549GluMet: 1.549 ± 0.042	4.569GluAsn: 4.569 ± 0.066	1.593GluPro: 1.593 ± 0.033	2.466GluGln: 2.466 ± 0.048	2.898GluArg: 2.898 ± 0.054	3.41GluSer: 3.41 ± 0.05	3.371GluThr: 3.371 ± 0.054	4.696GluVal: 4.696 ± 0.064	0.713GluTrp: 0.713 ± 0.025	2.616GluTyr: 2.616 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.043PheAla: 3.043 ± 0.051	0.396PheCys: 0.396 ± 0.016	3.27PheAsp: 3.27 ± 0.055	3.382PheGlu: 3.382 ± 0.053	2.938PhePhe: 2.938 ± 0.062	3.754PheGly: 3.754 ± 0.07	0.847PheHis: 0.847 ± 0.027	3.883PheIle: 3.883 ± 0.066	3.661PheLys: 3.661 ± 0.053	5.082PheLeu: 5.082 ± 0.081	1.126PheMet: 1.126 ± 0.031	3.213PheAsn: 3.213 ± 0.067	1.765PhePro: 1.765 ± 0.043	1.448PheGln: 1.448 ± 0.033	2.13PheArg: 2.13 ± 0.045	4.139PheSer: 4.139 ± 0.064	3.031PheThr: 3.031 ± 0.064	3.039PheVal: 3.039 ± 0.059	0.587PheTrp: 0.587 ± 0.022	2.357PheTyr: 2.357 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.208GlyAla: 4.208 ± 0.068	0.593GlyCys: 0.593 ± 0.03	3.744GlyAsp: 3.744 ± 0.078	3.983GlyGlu: 3.983 ± 0.059	3.895GlyPhe: 3.895 ± 0.064	4.873GlyGly: 4.873 ± 0.101	1.187GlyHis: 1.187 ± 0.033	5.532GlyIle: 5.532 ± 0.065	5.104GlyLys: 5.104 ± 0.066	5.958GlyLeu: 5.958 ± 0.081	1.587GlyMet: 1.587 ± 0.043	3.929GlyAsn: 3.929 ± 0.067	1.529GlyPro: 1.529 ± 0.041	1.952GlyGln: 1.952 ± 0.04	2.579GlyArg: 2.579 ± 0.044	4.263GlySer: 4.263 ± 0.072	3.947GlyThr: 3.947 ± 0.08	4.353GlyVal: 4.353 ± 0.067	0.842GlyTrp: 0.842 ± 0.026	2.802GlyTyr: 2.802 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.943HisAla: 0.943 ± 0.028	0.171HisCys: 0.171 ± 0.011	0.807HisAsp: 0.807 ± 0.026	0.98HisGlu: 0.98 ± 0.027	1.2HisPhe: 1.2 ± 0.034	1.093HisGly: 1.093 ± 0.031	0.492HisHis: 0.492 ± 0.025	1.448HisIle: 1.448 ± 0.037	1.224HisLys: 1.224 ± 0.032	1.815HisLeu: 1.815 ± 0.041	0.362HisMet: 0.362 ± 0.015	0.871HisAsn: 0.871 ± 0.024	0.914HisPro: 0.914 ± 0.03	0.717HisGln: 0.717 ± 0.026	0.781HisArg: 0.781 ± 0.025	1.101HisSer: 1.101 ± 0.029	0.954HisThr: 0.954 ± 0.028	0.847HisVal: 0.847 ± 0.029	0.244HisTrp: 0.244 ± 0.012	0.863HisTyr: 0.863 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.311IleAla: 5.311 ± 0.066	0.576IleCys: 0.576 ± 0.021	4.851IleAsp: 4.851 ± 0.063	5.321IleGlu: 5.321 ± 0.068	3.528IlePhe: 3.528 ± 0.057	5.125IleGly: 5.125 ± 0.073	1.35IleHis: 1.35 ± 0.032	5.449IleIle: 5.449 ± 0.084	5.177IleLys: 5.177 ± 0.068	6.852IleLeu: 6.852 ± 0.082	1.305IleMet: 1.305 ± 0.033	4.426IleAsn: 4.426 ± 0.054	3.176IlePro: 3.176 ± 0.053	2.305IleGln: 2.305 ± 0.043	3.355IleArg: 3.355 ± 0.052	5.911IleSer: 5.911 ± 0.083	4.326IleThr: 4.326 ± 0.083	4.477IleVal: 4.477 ± 0.068	0.712IleTrp: 0.712 ± 0.028	2.796IleTyr: 2.796 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.929LysAla: 4.929 ± 0.081	0.312LysCys: 0.312 ± 0.017	4.474LysAsp: 4.474 ± 0.073	6.716LysGlu: 6.716 ± 0.096	2.624LysPhe: 2.624 ± 0.051	4.579LysGly: 4.579 ± 0.06	1.274LysHis: 1.274 ± 0.032	5.428LysIle: 5.428 ± 0.081	6.892LysLys: 6.892 ± 0.096	6.471LysLeu: 6.471 ± 0.078	1.84LysMet: 1.84 ± 0.046	4.437LysAsn: 4.437 ± 0.066	2.207LysPro: 2.207 ± 0.043	2.445LysGln: 2.445 ± 0.046	3.194LysArg: 3.194 ± 0.049	3.945LysSer: 3.945 ± 0.067	3.958LysThr: 3.958 ± 0.061	4.318LysVal: 4.318 ± 0.06	0.872LysTrp: 0.872 ± 0.025	2.898LysTyr: 2.898 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.782LeuAla: 5.782 ± 0.073	0.683LeuCys: 0.683 ± 0.024	5.137LeuAsp: 5.137 ± 0.067	6.232LeuGlu: 6.232 ± 0.079	5.16LeuPhe: 5.16 ± 0.076	5.945LeuGly: 5.945 ± 0.067	1.56LeuHis: 1.56 ± 0.036	7.386LeuIle: 7.386 ± 0.088	7.789LeuLys: 7.789 ± 0.101	9.154LeuLeu: 9.154 ± 0.097	2.107LeuMet: 2.107 ± 0.044	5.588LeuAsn: 5.588 ± 0.079	3.55LeuPro: 3.55 ± 0.061	3.096LeuGln: 3.096 ± 0.057	3.898LeuArg: 3.898 ± 0.056	7.171LeuSer: 7.171 ± 0.07	4.765LeuThr: 4.765 ± 0.074	5.105LeuVal: 5.105 ± 0.064	0.885LeuTrp: 0.885 ± 0.025	3.193LeuTyr: 3.193 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.501MetAla: 1.501 ± 0.034	0.141MetCys: 0.141 ± 0.01	1.104MetAsp: 1.104 ± 0.032	1.594MetGlu: 1.594 ± 0.039	0.817MetPhe: 0.817 ± 0.029	1.406MetGly: 1.406 ± 0.038	0.37MetHis: 0.37 ± 0.016	1.535MetIle: 1.535 ± 0.036	2.075MetLys: 2.075 ± 0.042	1.899MetLeu: 1.899 ± 0.043	0.523MetMet: 0.523 ± 0.022	1.21MetAsn: 1.21 ± 0.035	0.715MetPro: 0.715 ± 0.026	0.749MetGln: 0.749 ± 0.029	0.952MetArg: 0.952 ± 0.031	1.345MetSer: 1.345 ± 0.034	0.988MetThr: 0.988 ± 0.029	1.294MetVal: 1.294 ± 0.03	0.162MetTrp: 0.162 ± 0.013	0.658MetTyr: 0.658 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.672AsnAla: 3.672 ± 0.063	0.427AsnCys: 0.427 ± 0.024	3.218AsnAsp: 3.218 ± 0.066	3.613AsnGlu: 3.613 ± 0.061	2.909AsnPhe: 2.909 ± 0.054	4.135AsnGly: 4.135 ± 0.077	0.908AsnHis: 0.908 ± 0.025	4.388AsnIle: 4.388 ± 0.066	3.819AsnLys: 3.819 ± 0.059	4.671AsnLeu: 4.671 ± 0.061	1.153AsnMet: 1.153 ± 0.027	3.334AsnAsn: 3.334 ± 0.068	2.514AsnPro: 2.514 ± 0.054	1.747AsnGln: 1.747 ± 0.043	2.581AsnArg: 2.581 ± 0.055	3.698AsnSer: 3.698 ± 0.066	3.526AsnThr: 3.526 ± 0.059	3.203AsnVal: 3.203 ± 0.058	0.8AsnTrp: 0.8 ± 0.027	2.625AsnTyr: 2.625 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	2.167ProAla: 2.167 ± 0.05	0.198ProCys: 0.198 ± 0.014	2.456ProAsp: 2.456 ± 0.052	3.232ProGlu: 3.232 ± 0.057	1.944ProPhe: 1.944 ± 0.035	2.343ProGly: 2.343 ± 0.054	0.621ProHis: 0.621 ± 0.025	2.156ProIle: 2.156 ± 0.046	2.118ProLys: 2.118 ± 0.042	3.138ProLeu: 3.138 ± 0.052	0.689ProMet: 0.689 ± 0.029	1.86ProAsn: 1.86 ± 0.047	0.969ProPro: 0.969 ± 0.03	1.217ProGln: 1.217 ± 0.037	1.112ProArg: 1.112 ± 0.03	2.232ProSer: 2.232 ± 0.041	1.744ProThr: 1.744 ± 0.046	2.664ProVal: 2.664 ± 0.052	0.324ProTrp: 0.324 ± 0.018	1.327ProTyr: 1.327 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.167GlnAla: 2.167 ± 0.047	0.187GlnCys: 0.187 ± 0.012	1.609GlnAsp: 1.609 ± 0.038	2.315GlnGlu: 2.315 ± 0.05	1.62GlnPhe: 1.62 ± 0.037	1.832GlnGly: 1.832 ± 0.043	0.532GlnHis: 0.532 ± 0.024	2.385GlnIle: 2.385 ± 0.046	2.65GlnLys: 2.65 ± 0.052	3.641GlnLeu: 3.641 ± 0.053	0.775GlnMet: 0.775 ± 0.028	1.859GlnAsn: 1.859 ± 0.038	1.086GlnPro: 1.086 ± 0.03	1.454GlnGln: 1.454 ± 0.045	1.414GlnArg: 1.414 ± 0.035	1.812GlnSer: 1.812 ± 0.044	1.674GlnThr: 1.674 ± 0.041	1.753GlnVal: 1.753 ± 0.041	0.371GlnTrp: 0.371 ± 0.019	1.223GlnTyr: 1.223 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.419ArgAla: 2.419 ± 0.047	0.181ArgCys: 0.181 ± 0.012	2.101ArgAsp: 2.101 ± 0.045	3.089ArgGlu: 3.089 ± 0.053	2.235ArgPhe: 2.235 ± 0.049	2.381ArgGly: 2.381 ± 0.049	0.721ArgHis: 0.721 ± 0.025	3.586ArgIle: 3.586 ± 0.047	3.434ArgLys: 3.434 ± 0.058	3.942ArgLeu: 3.942 ± 0.06	0.977ArgMet: 0.977 ± 0.031	2.535ArgAsn: 2.535 ± 0.048	1.288ArgPro: 1.288 ± 0.037	1.364ArgGln: 1.364 ± 0.038	1.784ArgArg: 1.784 ± 0.042	2.599ArgSer: 2.599 ± 0.048	2.176ArgThr: 2.176 ± 0.043	2.495ArgVal: 2.495 ± 0.048	0.48ArgTrp: 0.48 ± 0.018	1.736ArgTyr: 1.736 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.831SerAla: 3.831 ± 0.058	0.649SerCys: 0.649 ± 0.026	3.582SerAsp: 3.582 ± 0.059	4.23SerGlu: 4.23 ± 0.061	4.228SerPhe: 4.228 ± 0.066	5.016SerGly: 5.016 ± 0.078	1.08SerHis: 1.08 ± 0.03	4.745SerIle: 4.745 ± 0.067	4.166SerLys: 4.166 ± 0.064	6.507SerLeu: 6.507 ± 0.081	1.31SerMet: 1.31 ± 0.032	3.337SerAsn: 3.337 ± 0.065	2.333SerPro: 2.333 ± 0.042	1.988SerGln: 1.988 ± 0.037	2.814SerArg: 2.814 ± 0.05	4.429SerSer: 4.429 ± 0.077	3.31SerThr: 3.31 ± 0.054	4.297SerVal: 4.297 ± 0.064	0.81SerTrp: 0.81 ± 0.03	2.922SerTyr: 2.922 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	3.888ThrAla: 3.888 ± 0.086	0.283ThrCys: 0.283 ± 0.018	3.498ThrAsp: 3.498 ± 0.076	3.621ThrGlu: 3.621 ± 0.059	2.667ThrPhe: 2.667 ± 0.056	4.048ThrGly: 4.048 ± 0.066	1.023ThrHis: 1.023 ± 0.03	4.2ThrIle: 4.2 ± 0.07	2.976ThrLys: 2.976 ± 0.051	5.01ThrLeu: 5.01 ± 0.067	0.789ThrMet: 0.789 ± 0.025	2.712ThrAsn: 2.712 ± 0.061	2.264ThrPro: 2.264 ± 0.049	1.651ThrGln: 1.651 ± 0.041	1.95ThrArg: 1.95 ± 0.04	3.611ThrSer: 3.611 ± 0.073	3.085ThrThr: 3.085 ± 0.072	3.813ThrVal: 3.813 ± 0.083	0.48ThrTrp: 0.48 ± 0.021	2.155ThrTyr: 2.155 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	3.872ValAla: 3.872 ± 0.077	0.48ValCys: 0.48 ± 0.021	3.55ValAsp: 3.55 ± 0.067	4.128ValGlu: 4.128 ± 0.059	3.601ValPhe: 3.601 ± 0.057	3.578ValGly: 3.578 ± 0.063	1.063ValHis: 1.063 ± 0.031	4.791ValIle: 4.791 ± 0.064	4.254ValLys: 4.254 ± 0.059	6.101ValLeu: 6.101 ± 0.077	1.263ValMet: 1.263 ± 0.032	3.587ValAsn: 3.587 ± 0.054	2.226ValPro: 2.226 ± 0.049	1.783ValGln: 1.783 ± 0.037	2.325ValArg: 2.325 ± 0.051	4.496ValSer: 4.496 ± 0.061	3.315ValThr: 3.315 ± 0.091	4.075ValVal: 4.075 ± 0.077	0.585ValTrp: 0.585 ± 0.022	2.392ValTyr: 2.392 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.634TrpAla: 0.634 ± 0.022	0.099TrpCys: 0.099 ± 0.008	0.63TrpAsp: 0.63 ± 0.021	0.744TrpGlu: 0.744 ± 0.023	0.6TrpPhe: 0.6 ± 0.026	0.717TrpGly: 0.717 ± 0.026	0.231TrpHis: 0.231 ± 0.014	0.791TrpIle: 0.791 ± 0.029	0.882TrpLys: 0.882 ± 0.03	1.017TrpLeu: 1.017 ± 0.031	0.314TrpMet: 0.314 ± 0.015	0.684TrpAsn: 0.684 ± 0.025	0.258TrpPro: 0.258 ± 0.014	0.404TrpGln: 0.404 ± 0.019	0.456TrpArg: 0.456 ± 0.021	0.651TrpSer: 0.651 ± 0.025	0.547TrpThr: 0.547 ± 0.025	0.652TrpVal: 0.652 ± 0.022	0.165TrpTrp: 0.165 ± 0.013	0.462TrpTyr: 0.462 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.382TyrAla: 2.382 ± 0.044	0.321TyrCys: 0.321 ± 0.018	2.362TyrAsp: 2.362 ± 0.056	2.6TyrGlu: 2.6 ± 0.054	2.438TyrPhe: 2.438 ± 0.05	2.653TyrGly: 2.653 ± 0.05	0.834TyrHis: 0.834 ± 0.027	2.72TyrIle: 2.72 ± 0.056	2.754TyrLys: 2.754 ± 0.051	3.966TyrLeu: 3.966 ± 0.061	0.713TyrMet: 0.713 ± 0.026	2.253TyrAsn: 2.253 ± 0.051	1.518TyrPro: 1.518 ± 0.04	1.41TyrGln: 1.41 ± 0.041	2.069TyrArg: 2.069 ± 0.036	2.599TyrSer: 2.599 ± 0.052	2.374TyrThr: 2.374 ± 0.064	2.138TyrVal: 2.138 ± 0.047	0.512TyrTrp: 0.512 ± 0.021	1.793TyrTyr: 1.793 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3760 proteins (1265630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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