Amino acid dipepetide frequency for Schaedlerella arabinosiphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.244AlaAla: 8.244 ± 0.118	1.197AlaCys: 1.197 ± 0.03	4.62AlaAsp: 4.62 ± 0.065	6.274AlaGlu: 6.274 ± 0.083	3.115AlaPhe: 3.115 ± 0.051	6.585AlaGly: 6.585 ± 0.085	1.077AlaHis: 1.077 ± 0.025	4.219AlaIle: 4.219 ± 0.056	4.471AlaLys: 4.471 ± 0.055	6.808AlaLeu: 6.808 ± 0.073	2.33AlaMet: 2.33 ± 0.036	2.348AlaAsn: 2.348 ± 0.037	2.036AlaPro: 2.036 ± 0.038	2.377AlaGln: 2.377 ± 0.042	3.274AlaArg: 3.274 ± 0.047	3.829AlaSer: 3.829 ± 0.055	2.476AlaThr: 2.476 ± 0.058	6.571AlaVal: 6.571 ± 0.076	0.697AlaTrp: 0.697 ± 0.02	2.828AlaTyr: 2.828 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.024	0.305CysCys: 0.305 ± 0.014	0.827CysAsp: 0.827 ± 0.023	0.941CysGlu: 0.941 ± 0.022	0.693CysPhe: 0.693 ± 0.018	1.58CysGly: 1.58 ± 0.027	0.287CysHis: 0.287 ± 0.013	1.121CysIle: 1.121 ± 0.027	0.732CysLys: 0.732 ± 0.022	1.286CysLeu: 1.286 ± 0.028	0.506CysMet: 0.506 ± 0.016	0.524CysAsn: 0.524 ± 0.017	0.669CysPro: 0.669 ± 0.019	0.424CysGln: 0.424 ± 0.017	1.043CysArg: 1.043 ± 0.029	0.965CysSer: 0.965 ± 0.02	0.796CysThr: 0.796 ± 0.022	1.015CysVal: 1.015 ± 0.026	0.136CysTrp: 0.136 ± 0.008	0.584CysTyr: 0.584 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.16AspAla: 4.16 ± 0.053	0.856AspCys: 0.856 ± 0.023	2.618AspAsp: 2.618 ± 0.047	4.342AspGlu: 4.342 ± 0.057	2.74AspPhe: 2.74 ± 0.041	4.32AspGly: 4.32 ± 0.063	0.895AspHis: 0.895 ± 0.023	4.309AspIle: 4.309 ± 0.044	3.062AspLys: 3.062 ± 0.048	4.671AspLeu: 4.671 ± 0.053	1.844AspMet: 1.844 ± 0.031	1.97AspAsn: 1.97 ± 0.037	1.761AspPro: 1.761 ± 0.036	1.465AspGln: 1.465 ± 0.027	2.772AspArg: 2.772 ± 0.045	3.232AspSer: 3.232 ± 0.041	3.041AspThr: 3.041 ± 0.037	3.451AspVal: 3.451 ± 0.051	0.64AspTrp: 0.64 ± 0.018	2.713AspTyr: 2.713 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.89GluAla: 5.89 ± 0.076	0.911GluCys: 0.911 ± 0.023	4.368GluAsp: 4.368 ± 0.06	7.864GluGlu: 7.864 ± 0.102	2.614GluPhe: 2.614 ± 0.04	4.727GluGly: 4.727 ± 0.058	1.527GluHis: 1.527 ± 0.029	5.762GluIle: 5.762 ± 0.058	6.898GluLys: 6.898 ± 0.068	7.099GluLeu: 7.099 ± 0.075	2.633GluMet: 2.633 ± 0.041	4.111GluAsn: 4.111 ± 0.052	2.113GluPro: 2.113 ± 0.044	3.376GluGln: 3.376 ± 0.05	4.039GluArg: 4.039 ± 0.052	3.698GluSer: 3.698 ± 0.059	3.939GluThr: 3.939 ± 0.055	4.357GluVal: 4.357 ± 0.056	0.799GluTrp: 0.799 ± 0.021	3.537GluTyr: 3.537 ± 0.048	0.001GluXaa: 0.001 ± 0.001
Phe	2.948PheAla: 2.948 ± 0.05	0.831PheCys: 0.831 ± 0.023	2.49PheAsp: 2.49 ± 0.037	2.785PheGlu: 2.785 ± 0.044	1.986PhePhe: 1.986 ± 0.042	3.026PheGly: 3.026 ± 0.043	0.901PheHis: 0.901 ± 0.022	2.713PheIle: 2.713 ± 0.046	1.797PheLys: 1.797 ± 0.032	4.313PheLeu: 4.313 ± 0.067	1.153PheMet: 1.153 ± 0.025	1.334PheAsn: 1.334 ± 0.028	1.481PhePro: 1.481 ± 0.032	1.568PheGln: 1.568 ± 0.029	2.135PheArg: 2.135 ± 0.039	3.021PheSer: 3.021 ± 0.046	2.261PheThr: 2.261 ± 0.037	2.624PheVal: 2.624 ± 0.036	0.477PheTrp: 0.477 ± 0.015	1.808PheTyr: 1.808 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.103GlyAla: 5.103 ± 0.079	1.259GlyCys: 1.259 ± 0.032	3.383GlyAsp: 3.383 ± 0.049	5.115GlyGlu: 5.115 ± 0.062	3.194GlyPhe: 3.194 ± 0.045	4.925GlyGly: 4.925 ± 0.071	1.23GlyHis: 1.23 ± 0.03	6.09GlyIle: 6.09 ± 0.06	5.353GlyLys: 5.353 ± 0.056	5.845GlyLeu: 5.845 ± 0.066	2.625GlyMet: 2.625 ± 0.047	3.199GlyAsn: 3.199 ± 0.047	1.261GlyPro: 1.261 ± 0.05	2.334GlyGln: 2.334 ± 0.038	3.755GlyArg: 3.755 ± 0.052	4.148GlySer: 4.148 ± 0.059	4.19GlyThr: 4.19 ± 0.059	4.439GlyVal: 4.439 ± 0.05	0.729GlyTrp: 0.729 ± 0.019	3.346GlyTyr: 3.346 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.183HisAla: 1.183 ± 0.028	0.348HisCys: 0.348 ± 0.014	0.906HisAsp: 0.906 ± 0.022	1.147HisGlu: 1.147 ± 0.026	0.9HisPhe: 0.9 ± 0.023	1.307HisGly: 1.307 ± 0.03	0.413HisHis: 0.413 ± 0.022	1.45HisIle: 1.45 ± 0.028	0.924HisLys: 0.924 ± 0.021	1.62HisLeu: 1.62 ± 0.032	0.603HisMet: 0.603 ± 0.019	0.699HisAsn: 0.699 ± 0.02	0.881HisPro: 0.881 ± 0.025	0.571HisGln: 0.571 ± 0.018	0.906HisArg: 0.906 ± 0.024	1.018HisSer: 1.018 ± 0.022	0.988HisThr: 0.988 ± 0.024	1.15HisVal: 1.15 ± 0.029	0.189HisTrp: 0.189 ± 0.009	0.841HisTyr: 0.841 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.193IleAla: 5.193 ± 0.057	1.296IleCys: 1.296 ± 0.029	3.794IleAsp: 3.794 ± 0.052	4.656IleGlu: 4.656 ± 0.059	2.941IlePhe: 2.941 ± 0.052	4.735IleGly: 4.735 ± 0.059	1.409IleHis: 1.409 ± 0.026	4.349IleIle: 4.349 ± 0.067	3.634IleLys: 3.634 ± 0.052	7.203IleLeu: 7.203 ± 0.079	1.823IleMet: 1.823 ± 0.035	2.547IleAsn: 2.547 ± 0.043	3.144IlePro: 3.144 ± 0.042	2.503IleGln: 2.503 ± 0.043	4.366IleArg: 4.366 ± 0.048	4.866IleSer: 4.866 ± 0.061	3.672IleThr: 3.672 ± 0.045	4.277IleVal: 4.277 ± 0.058	0.654IleTrp: 0.654 ± 0.022	2.72IleTyr: 2.72 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.802LysAla: 4.802 ± 0.067	0.702LysCys: 0.702 ± 0.022	3.506LysAsp: 3.506 ± 0.047	6.407LysGlu: 6.407 ± 0.08	1.759LysPhe: 1.759 ± 0.034	3.961LysGly: 3.961 ± 0.046	1.085LysHis: 1.085 ± 0.024	4.455LysIle: 4.455 ± 0.053	5.91LysLys: 5.91 ± 0.078	5.218LysLeu: 5.218 ± 0.054	1.958LysMet: 1.958 ± 0.029	3.391LysAsn: 3.391 ± 0.048	1.994LysPro: 1.994 ± 0.039	2.408LysGln: 2.408 ± 0.043	3.455LysArg: 3.455 ± 0.046	3.288LysSer: 3.288 ± 0.049	3.477LysThr: 3.477 ± 0.046	3.589LysVal: 3.589 ± 0.048	0.621LysTrp: 0.621 ± 0.018	2.781LysTyr: 2.781 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	6.779LeuAla: 6.779 ± 0.072	1.682LeuCys: 1.682 ± 0.028	5.132LeuAsp: 5.132 ± 0.056	6.965LeuGlu: 6.965 ± 0.066	4.081LeuPhe: 4.081 ± 0.064	5.791LeuGly: 5.791 ± 0.074	1.641LeuHis: 1.641 ± 0.031	5.748LeuIle: 5.748 ± 0.068	6.067LeuLys: 6.067 ± 0.058	9.176LeuLeu: 9.176 ± 0.1	2.644LeuMet: 2.644 ± 0.034	3.75LeuAsn: 3.75 ± 0.046	3.609LeuPro: 3.609 ± 0.046	3.011LeuGln: 3.011 ± 0.042	4.36LeuArg: 4.36 ± 0.055	6.434LeuSer: 6.434 ± 0.075	4.905LeuThr: 4.905 ± 0.048	5.251LeuVal: 5.251 ± 0.063	0.848LeuTrp: 0.848 ± 0.024	3.624LeuTyr: 3.624 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.346MetAla: 2.346 ± 0.038	0.385MetCys: 0.385 ± 0.015	1.928MetAsp: 1.928 ± 0.034	2.89MetGlu: 2.89 ± 0.041	1.062MetPhe: 1.062 ± 0.024	2.057MetGly: 2.057 ± 0.041	0.49MetHis: 0.49 ± 0.014	2.086MetIle: 2.086 ± 0.04	2.423MetLys: 2.423 ± 0.036	2.982MetLeu: 2.982 ± 0.036	0.957MetMet: 0.957 ± 0.024	1.482MetAsn: 1.482 ± 0.028	1.158MetPro: 1.158 ± 0.029	1.137MetGln: 1.137 ± 0.026	1.37MetArg: 1.37 ± 0.027	1.858MetSer: 1.858 ± 0.033	1.679MetThr: 1.679 ± 0.031	1.808MetVal: 1.808 ± 0.034	0.225MetTrp: 0.225 ± 0.012	0.93MetTyr: 0.93 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.016AsnAla: 3.016 ± 0.044	0.595AsnCys: 0.595 ± 0.019	1.886AsnAsp: 1.886 ± 0.034	2.668AsnGlu: 2.668 ± 0.046	1.515AsnPhe: 1.515 ± 0.032	3.366AsnGly: 3.366 ± 0.046	0.888AsnHis: 0.888 ± 0.024	3.135AsnIle: 3.135 ± 0.045	2.125AsnLys: 2.125 ± 0.039	3.802AsnLeu: 3.802 ± 0.047	1.3AsnMet: 1.3 ± 0.025	1.574AsnAsn: 1.574 ± 0.04	2.024AsnPro: 2.024 ± 0.034	1.561AsnGln: 1.561 ± 0.03	2.317AsnArg: 2.317 ± 0.036	2.196AsnSer: 2.196 ± 0.038	2.216AsnThr: 2.216 ± 0.038	2.498AsnVal: 2.498 ± 0.038	0.442AsnTrp: 0.442 ± 0.015	1.767AsnTyr: 1.767 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.659ProAla: 2.659 ± 0.039	0.454ProCys: 0.454 ± 0.018	2.402ProAsp: 2.402 ± 0.043	3.674ProGlu: 3.674 ± 0.056	1.551ProPhe: 1.551 ± 0.029	2.561ProGly: 2.561 ± 0.044	0.578ProHis: 0.578 ± 0.019	1.941ProIle: 1.941 ± 0.037	1.898ProLys: 1.898 ± 0.033	2.751ProLeu: 2.751 ± 0.036	0.937ProMet: 0.937 ± 0.024	1.175ProAsn: 1.175 ± 0.027	0.888ProPro: 0.888 ± 0.025	1.102ProGln: 1.102 ± 0.028	1.239ProArg: 1.239 ± 0.03	1.762ProSer: 1.762 ± 0.034	1.41ProThr: 1.41 ± 0.035	2.883ProVal: 2.883 ± 0.041	0.369ProTrp: 0.369 ± 0.014	1.463ProTyr: 1.463 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.74GlnAla: 2.74 ± 0.044	0.379GlnCys: 0.379 ± 0.014	1.761GlnAsp: 1.761 ± 0.031	3.273GlnGlu: 3.273 ± 0.047	1.244GlnPhe: 1.244 ± 0.024	2.181GlnGly: 2.181 ± 0.042	0.478GlnHis: 0.478 ± 0.017	2.765GlnIle: 2.765 ± 0.042	2.855GlnLys: 2.855 ± 0.044	2.652GlnLeu: 2.652 ± 0.04	1.264GlnMet: 1.264 ± 0.03	1.684GlnAsn: 1.684 ± 0.028	1.018GlnPro: 1.018 ± 0.024	1.235GlnGln: 1.235 ± 0.029	1.613GlnArg: 1.613 ± 0.03	1.779GlnSer: 1.779 ± 0.037	1.773GlnThr: 1.773 ± 0.034	2.067GlnVal: 2.067 ± 0.037	0.327GlnTrp: 0.327 ± 0.014	1.449GlnTyr: 1.449 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	3.132ArgAla: 3.132 ± 0.043	0.684ArgCys: 0.684 ± 0.018	2.512ArgAsp: 2.512 ± 0.039	4.763ArgGlu: 4.763 ± 0.062	2.212ArgPhe: 2.212 ± 0.038	2.862ArgGly: 2.862 ± 0.042	0.998ArgHis: 0.998 ± 0.028	4.022ArgIle: 4.022 ± 0.048	3.976ArgLys: 3.976 ± 0.046	4.794ArgLeu: 4.794 ± 0.058	1.818ArgMet: 1.818 ± 0.033	2.287ArgAsn: 2.287 ± 0.042	1.593ArgPro: 1.593 ± 0.033	2.153ArgGln: 2.153 ± 0.042	3.025ArgArg: 3.025 ± 0.054	2.477ArgSer: 2.477 ± 0.041	2.479ArgThr: 2.479 ± 0.038	2.825ArgVal: 2.825 ± 0.048	0.465ArgTrp: 0.465 ± 0.016	2.187ArgTyr: 2.187 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.451SerAla: 4.451 ± 0.064	0.903SerCys: 0.903 ± 0.024	3.176SerAsp: 3.176 ± 0.053	4.223SerGlu: 4.223 ± 0.059	2.614SerPhe: 2.614 ± 0.04	5.34SerGly: 5.34 ± 0.06	1.071SerHis: 1.071 ± 0.023	4.01SerIle: 4.01 ± 0.055	2.998SerLys: 2.998 ± 0.049	5.257SerLeu: 5.257 ± 0.076	1.896SerMet: 1.896 ± 0.032	2.073SerAsn: 2.073 ± 0.041	1.874SerPro: 1.874 ± 0.031	1.882SerGln: 1.882 ± 0.038	3.242SerArg: 3.242 ± 0.048	3.452SerSer: 3.452 ± 0.053	2.613SerThr: 2.613 ± 0.04	4.117SerVal: 4.117 ± 0.05	0.594SerTrp: 0.594 ± 0.019	2.397SerTyr: 2.397 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.509ThrAla: 4.509 ± 0.058	0.647ThrCys: 0.647 ± 0.019	3.091ThrAsp: 3.091 ± 0.035	3.938ThrGlu: 3.938 ± 0.051	2.064ThrPhe: 2.064 ± 0.032	4.558ThrGly: 4.558 ± 0.068	0.835ThrHis: 0.835 ± 0.025	3.358ThrIle: 3.358 ± 0.046	2.692ThrLys: 2.692 ± 0.048	4.546ThrLeu: 4.546 ± 0.051	1.421ThrMet: 1.421 ± 0.029	1.819ThrAsn: 1.819 ± 0.031	2.011ThrPro: 2.011 ± 0.035	1.438ThrGln: 1.438 ± 0.031	2.154ThrArg: 2.154 ± 0.041	2.67ThrSer: 2.67 ± 0.045	2.347ThrThr: 2.347 ± 0.043	4.079ThrVal: 4.079 ± 0.052	0.495ThrTrp: 0.495 ± 0.017	1.963ThrTyr: 1.963 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	3.777ValAla: 3.777 ± 0.056	1.234ValCys: 1.234 ± 0.026	3.372ValAsp: 3.372 ± 0.049	4.396ValGlu: 4.396 ± 0.055	3.035ValPhe: 3.035 ± 0.043	3.776ValGly: 3.776 ± 0.057	1.081ValHis: 1.081 ± 0.025	4.663ValIle: 4.663 ± 0.056	4.046ValLys: 4.046 ± 0.054	6.56ValLeu: 6.56 ± 0.066	2.011ValMet: 2.011 ± 0.034	2.653ValAsn: 2.653 ± 0.038	2.506ValPro: 2.506 ± 0.043	1.983ValGln: 1.983 ± 0.035	3.37ValArg: 3.37 ± 0.046	4.583ValSer: 4.583 ± 0.051	3.635ValThr: 3.635 ± 0.045	4.186ValVal: 4.186 ± 0.053	0.716ValTrp: 0.716 ± 0.021	2.706ValTyr: 2.706 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.584TrpAla: 0.584 ± 0.018	0.175TrpCys: 0.175 ± 0.01	0.607TrpAsp: 0.607 ± 0.019	0.785TrpGlu: 0.785 ± 0.022	0.411TrpPhe: 0.411 ± 0.015	0.705TrpGly: 0.705 ± 0.02	0.196TrpHis: 0.196 ± 0.012	0.721TrpIle: 0.721 ± 0.02	0.796TrpLys: 0.796 ± 0.02	0.932TrpLeu: 0.932 ± 0.023	0.353TrpMet: 0.353 ± 0.013	0.601TrpAsn: 0.601 ± 0.019	0.205TrpPro: 0.205 ± 0.012	0.386TrpGln: 0.386 ± 0.016	0.446TrpArg: 0.446 ± 0.015	0.53TrpSer: 0.53 ± 0.019	0.463TrpThr: 0.463 ± 0.015	0.543TrpVal: 0.543 ± 0.017	0.111TrpTrp: 0.111 ± 0.008	0.429TrpTyr: 0.429 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.761TyrAla: 2.761 ± 0.04	0.689TyrCys: 0.689 ± 0.019	2.482TyrAsp: 2.482 ± 0.039	3.156TyrGlu: 3.156 ± 0.05	1.922TyrPhe: 1.922 ± 0.038	3.161TyrGly: 3.161 ± 0.043	0.965TyrHis: 0.965 ± 0.025	2.864TyrIle: 2.864 ± 0.047	2.112TyrLys: 2.112 ± 0.04	3.988TyrLeu: 3.988 ± 0.054	1.179TyrMet: 1.179 ± 0.028	1.666TyrAsn: 1.666 ± 0.03	1.47TyrPro: 1.47 ± 0.027	1.625TyrGln: 1.625 ± 0.03	2.384TyrArg: 2.384 ± 0.04	2.379TyrSer: 2.379 ± 0.036	2.272TyrThr: 2.272 ± 0.039	2.559TyrVal: 2.559 ± 0.034	0.442TyrTrp: 0.442 ± 0.016	1.894TyrTyr: 1.894 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5980 proteins (1817401 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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