Amino acid dipepetide frequency for Streptococcus phage Javan78

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.814AlaAla: 4.814 ± 1.301
0.535AlaCys: 0.535 ± 0.195
4.547AlaAsp: 4.547 ± 0.707
5.616AlaGlu: 5.616 ± 0.725
3.209AlaPhe: 3.209 ± 0.808
5.616AlaGly: 5.616 ± 1.369
0.624AlaHis: 0.624 ± 0.252
6.508AlaIle: 6.508 ± 1.118
5.171AlaLys: 5.171 ± 0.7
7.132AlaLeu: 7.132 ± 1.035
2.05AlaMet: 2.05 ± 0.622
3.655AlaAsn: 3.655 ± 0.601
1.694AlaPro: 1.694 ± 0.328
3.833AlaGln: 3.833 ± 0.684
2.496AlaArg: 2.496 ± 0.449
4.458AlaSer: 4.458 ± 1.138
3.477AlaThr: 3.477 ± 0.471
4.19AlaVal: 4.19 ± 0.876
0.624AlaTrp: 0.624 ± 0.246
2.229AlaTyr: 2.229 ± 0.301
0.0AlaXaa: 0.0 ± 0.0
Cys
0.267CysAla: 0.267 ± 0.142
0.089CysCys: 0.089 ± 0.084
0.178CysAsp: 0.178 ± 0.13
0.535CysGlu: 0.535 ± 0.247
0.357CysPhe: 0.357 ± 0.208
0.535CysGly: 0.535 ± 0.269
0.178CysHis: 0.178 ± 0.121
0.089CysIle: 0.089 ± 0.09
0.267CysLys: 0.267 ± 0.221
0.892CysLeu: 0.892 ± 0.334
0.089CysMet: 0.089 ± 0.103
0.178CysAsn: 0.178 ± 0.129
0.178CysPro: 0.178 ± 0.195
0.267CysGln: 0.267 ± 0.131
0.089CysArg: 0.089 ± 0.081
0.267CysSer: 0.267 ± 0.152
0.089CysThr: 0.089 ± 0.089
0.446CysVal: 0.446 ± 0.179
0.089CysTrp: 0.089 ± 0.09
0.178CysTyr: 0.178 ± 0.125
0.0CysXaa: 0.0 ± 0.0
Asp
5.082AspAla: 5.082 ± 0.854
0.267AspCys: 0.267 ± 0.199
4.992AspAsp: 4.992 ± 0.763
4.368AspGlu: 4.368 ± 0.666
2.942AspPhe: 2.942 ± 0.61
5.082AspGly: 5.082 ± 0.626
0.713AspHis: 0.713 ± 0.221
4.725AspIle: 4.725 ± 0.503
5.438AspLys: 5.438 ± 0.831
5.26AspLeu: 5.26 ± 0.839
1.426AspMet: 1.426 ± 0.335
3.12AspAsn: 3.12 ± 0.576
1.159AspPro: 1.159 ± 0.362
0.892AspGln: 0.892 ± 0.261
1.783AspArg: 1.783 ± 0.382
3.031AspSer: 3.031 ± 0.528
5.26AspThr: 5.26 ± 0.668
3.299AspVal: 3.299 ± 0.545
0.357AspTrp: 0.357 ± 0.158
3.566AspTyr: 3.566 ± 0.674
0.0AspXaa: 0.0 ± 0.0
Glu
3.655GluAla: 3.655 ± 0.556
0.357GluCys: 0.357 ± 0.205
3.299GluAsp: 3.299 ± 0.627
5.171GluGlu: 5.171 ± 0.837
3.299GluPhe: 3.299 ± 0.518
2.585GluGly: 2.585 ± 0.411
1.159GluHis: 1.159 ± 0.341
6.241GluIle: 6.241 ± 1.111
4.725GluLys: 4.725 ± 0.909
7.399GluLeu: 7.399 ± 1.169
1.605GluMet: 1.605 ± 0.366
5.616GluAsn: 5.616 ± 0.804
1.605GluPro: 1.605 ± 0.512
4.19GluGln: 4.19 ± 0.585
3.833GluArg: 3.833 ± 0.767
2.496GluSer: 2.496 ± 0.454
3.031GluThr: 3.031 ± 0.537
5.082GluVal: 5.082 ± 0.717
0.802GluTrp: 0.802 ± 0.214
2.496GluTyr: 2.496 ± 0.628
0.0GluXaa: 0.0 ± 0.0
Phe
2.853PheAla: 2.853 ± 0.448
0.267PheCys: 0.267 ± 0.164
4.903PheAsp: 4.903 ± 0.67
3.477PheGlu: 3.477 ± 0.646
0.981PhePhe: 0.981 ± 0.346
2.764PheGly: 2.764 ± 0.424
0.624PheHis: 0.624 ± 0.233
2.585PheIle: 2.585 ± 0.436
3.031PheLys: 3.031 ± 0.723
3.031PheLeu: 3.031 ± 0.522
0.624PheMet: 0.624 ± 0.215
2.585PheAsn: 2.585 ± 0.408
0.981PhePro: 0.981 ± 0.34
1.516PheGln: 1.516 ± 0.409
1.694PheArg: 1.694 ± 0.399
2.764PheSer: 2.764 ± 0.647
2.318PheThr: 2.318 ± 0.456
3.209PheVal: 3.209 ± 0.704
0.089PheTrp: 0.089 ± 0.084
1.426PheTyr: 1.426 ± 0.433
0.0PheXaa: 0.0 ± 0.0
Gly
4.636GlyAla: 4.636 ± 1.404
0.178GlyCys: 0.178 ± 0.122
3.299GlyAsp: 3.299 ± 0.598
3.566GlyGlu: 3.566 ± 0.464
3.388GlyPhe: 3.388 ± 0.644
3.655GlyGly: 3.655 ± 0.755
1.605GlyHis: 1.605 ± 0.443
5.884GlyIle: 5.884 ± 0.926
5.349GlyLys: 5.349 ± 0.517
5.884GlyLeu: 5.884 ± 0.891
1.961GlyMet: 1.961 ± 0.384
4.903GlyAsn: 4.903 ± 0.757
0.267GlyPro: 0.267 ± 0.121
3.209GlyGln: 3.209 ± 0.598
2.675GlyArg: 2.675 ± 0.453
3.388GlySer: 3.388 ± 0.571
3.566GlyThr: 3.566 ± 0.674
4.368GlyVal: 4.368 ± 0.693
0.446GlyTrp: 0.446 ± 0.181
3.833GlyTyr: 3.833 ± 0.819
0.0GlyXaa: 0.0 ± 0.0
His
0.535HisAla: 0.535 ± 0.285
0.178HisCys: 0.178 ± 0.137
1.337HisAsp: 1.337 ± 0.46
1.159HisGlu: 1.159 ± 0.281
0.535HisPhe: 0.535 ± 0.199
0.713HisGly: 0.713 ± 0.246
0.357HisHis: 0.357 ± 0.153
1.337HisIle: 1.337 ± 0.382
1.516HisLys: 1.516 ± 0.373
0.624HisLeu: 0.624 ± 0.225
0.178HisMet: 0.178 ± 0.101
0.535HisAsn: 0.535 ± 0.208
0.624HisPro: 0.624 ± 0.29
0.713HisGln: 0.713 ± 0.225
0.535HisArg: 0.535 ± 0.208
0.802HisSer: 0.802 ± 0.247
0.535HisThr: 0.535 ± 0.294
0.624HisVal: 0.624 ± 0.23
0.089HisTrp: 0.089 ± 0.081
0.802HisTyr: 0.802 ± 0.344
0.0HisXaa: 0.0 ± 0.0
Ile
6.597IleAla: 6.597 ± 0.668
0.267IleCys: 0.267 ± 0.154
5.26IleAsp: 5.26 ± 0.583
5.349IleGlu: 5.349 ± 0.71
1.961IlePhe: 1.961 ± 0.43
4.903IleGly: 4.903 ± 0.856
1.159IleHis: 1.159 ± 0.363
4.012IleIle: 4.012 ± 0.76
6.419IleLys: 6.419 ± 0.892
5.171IleLeu: 5.171 ± 0.793
1.337IleMet: 1.337 ± 0.372
5.349IleAsn: 5.349 ± 0.742
1.605IlePro: 1.605 ± 0.353
2.853IleGln: 2.853 ± 0.515
2.585IleArg: 2.585 ± 0.545
5.438IleSer: 5.438 ± 0.769
4.19IleThr: 4.19 ± 0.59
4.636IleVal: 4.636 ± 0.613
0.802IleTrp: 0.802 ± 0.291
3.209IleTyr: 3.209 ± 0.52
0.0IleXaa: 0.0 ± 0.0
Lys
4.903LysAla: 4.903 ± 0.753
0.357LysCys: 0.357 ± 0.213
4.814LysAsp: 4.814 ± 0.495
5.706LysGlu: 5.706 ± 1.044
2.764LysPhe: 2.764 ± 0.539
4.547LysGly: 4.547 ± 0.754
1.07LysHis: 1.07 ± 0.311
5.616LysIle: 5.616 ± 0.688
6.954LysLys: 6.954 ± 0.868
5.616LysLeu: 5.616 ± 0.601
2.318LysMet: 2.318 ± 0.464
4.636LysAsn: 4.636 ± 0.619
2.853LysPro: 2.853 ± 0.459
3.833LysGln: 3.833 ± 0.704
3.209LysArg: 3.209 ± 0.67
5.616LysSer: 5.616 ± 0.793
5.616LysThr: 5.616 ± 0.719
6.865LysVal: 6.865 ± 0.673
0.892LysTrp: 0.892 ± 0.279
3.031LysTyr: 3.031 ± 0.644
0.0LysXaa: 0.0 ± 0.0
Leu
6.508LeuAla: 6.508 ± 0.729
0.624LeuCys: 0.624 ± 0.221
5.973LeuAsp: 5.973 ± 0.775
6.775LeuGlu: 6.775 ± 0.966
3.031LeuPhe: 3.031 ± 0.447
6.241LeuGly: 6.241 ± 1.095
0.981LeuHis: 0.981 ± 0.312
4.992LeuIle: 4.992 ± 0.658
8.113LeuLys: 8.113 ± 1.013
6.597LeuLeu: 6.597 ± 0.749
1.605LeuMet: 1.605 ± 0.37
5.527LeuAsn: 5.527 ± 0.87
2.496LeuPro: 2.496 ± 0.501
3.299LeuGln: 3.299 ± 0.518
2.14LeuArg: 2.14 ± 0.426
6.775LeuSer: 6.775 ± 0.727
5.082LeuThr: 5.082 ± 0.522
3.744LeuVal: 3.744 ± 0.584
0.713LeuTrp: 0.713 ± 0.442
2.675LeuTyr: 2.675 ± 0.605
0.0LeuXaa: 0.0 ± 0.0
Met
1.516MetAla: 1.516 ± 0.44
0.178MetCys: 0.178 ± 0.108
1.426MetAsp: 1.426 ± 0.405
1.516MetGlu: 1.516 ± 0.46
0.802MetPhe: 0.802 ± 0.202
1.248MetGly: 1.248 ± 0.352
0.0MetHis: 0.0 ± 0.0
1.337MetIle: 1.337 ± 0.268
1.961MetLys: 1.961 ± 0.442
1.516MetLeu: 1.516 ± 0.324
1.07MetMet: 1.07 ± 0.305
1.426MetAsn: 1.426 ± 0.337
0.178MetPro: 0.178 ± 0.102
2.229MetGln: 2.229 ± 0.513
1.426MetArg: 1.426 ± 0.29
1.783MetSer: 1.783 ± 0.391
2.05MetThr: 2.05 ± 0.648
1.961MetVal: 1.961 ± 0.521
0.267MetTrp: 0.267 ± 0.145
0.802MetTyr: 0.802 ± 0.23
0.0MetXaa: 0.0 ± 0.0
Asn
4.725AsnAla: 4.725 ± 1.069
0.089AsnCys: 0.089 ± 0.085
2.764AsnAsp: 2.764 ± 0.71
3.744AsnGlu: 3.744 ± 0.61
2.14AsnPhe: 2.14 ± 0.395
4.547AsnGly: 4.547 ± 0.721
0.713AsnHis: 0.713 ± 0.248
4.992AsnIle: 4.992 ± 0.814
4.279AsnLys: 4.279 ± 0.62
5.26AsnLeu: 5.26 ± 0.655
1.159AsnMet: 1.159 ± 0.289
4.101AsnAsn: 4.101 ± 0.731
2.764AsnPro: 2.764 ± 0.535
2.496AsnGln: 2.496 ± 0.469
2.318AsnArg: 2.318 ± 0.571
4.458AsnSer: 4.458 ± 0.755
3.477AsnThr: 3.477 ± 0.542
3.566AsnVal: 3.566 ± 0.434
0.802AsnTrp: 0.802 ± 0.227
2.675AsnTyr: 2.675 ± 0.454
0.0AsnXaa: 0.0 ± 0.0
Pro
1.248ProAla: 1.248 ± 0.383
0.178ProCys: 0.178 ± 0.125
1.783ProAsp: 1.783 ± 0.463
1.783ProGlu: 1.783 ± 0.346
1.872ProPhe: 1.872 ± 0.438
0.892ProGly: 0.892 ± 0.241
0.267ProHis: 0.267 ± 0.138
1.694ProIle: 1.694 ± 0.354
2.496ProLys: 2.496 ± 0.56
1.961ProLeu: 1.961 ± 0.352
0.802ProMet: 0.802 ± 0.269
1.783ProAsn: 1.783 ± 0.367
0.535ProPro: 0.535 ± 0.186
1.516ProGln: 1.516 ± 0.392
0.446ProArg: 0.446 ± 0.236
1.516ProSer: 1.516 ± 0.281
1.605ProThr: 1.605 ± 0.528
1.872ProVal: 1.872 ± 0.432
0.267ProTrp: 0.267 ± 0.158
0.981ProTyr: 0.981 ± 0.297
0.0ProXaa: 0.0 ± 0.0
Gln
4.012GlnAla: 4.012 ± 0.68
0.267GlnCys: 0.267 ± 0.18
2.407GlnAsp: 2.407 ± 0.517
3.209GlnGlu: 3.209 ± 0.726
1.248GlnPhe: 1.248 ± 0.321
4.279GlnGly: 4.279 ± 0.802
0.446GlnHis: 0.446 ± 0.169
2.764GlnIle: 2.764 ± 0.578
4.814GlnLys: 4.814 ± 0.766
3.566GlnLeu: 3.566 ± 0.424
1.694GlnMet: 1.694 ± 0.358
1.783GlnAsn: 1.783 ± 0.441
0.713GlnPro: 0.713 ± 0.277
2.229GlnGln: 2.229 ± 0.664
1.248GlnArg: 1.248 ± 0.315
3.566GlnSer: 3.566 ± 0.579
1.783GlnThr: 1.783 ± 0.36
3.299GlnVal: 3.299 ± 0.569
0.535GlnTrp: 0.535 ± 0.206
1.248GlnTyr: 1.248 ± 0.287
0.0GlnXaa: 0.0 ± 0.0
Arg
2.764ArgAla: 2.764 ± 0.857
0.178ArgCys: 0.178 ± 0.152
2.05ArgAsp: 2.05 ± 0.427
2.318ArgGlu: 2.318 ± 0.477
2.318ArgPhe: 2.318 ± 0.55
2.496ArgGly: 2.496 ± 0.619
0.624ArgHis: 0.624 ± 0.224
1.961ArgIle: 1.961 ± 0.427
3.209ArgLys: 3.209 ± 0.557
3.744ArgLeu: 3.744 ± 0.589
0.802ArgMet: 0.802 ± 0.23
1.961ArgAsn: 1.961 ± 0.485
1.07ArgPro: 1.07 ± 0.314
0.892ArgGln: 0.892 ± 0.275
1.337ArgArg: 1.337 ± 0.361
1.248ArgSer: 1.248 ± 0.269
1.961ArgThr: 1.961 ± 0.408
2.942ArgVal: 2.942 ± 0.442
0.446ArgTrp: 0.446 ± 0.205
1.694ArgTyr: 1.694 ± 0.343
0.0ArgXaa: 0.0 ± 0.0
Ser
4.368SerAla: 4.368 ± 0.716
0.446SerCys: 0.446 ± 0.195
3.12SerAsp: 3.12 ± 0.486
3.477SerGlu: 3.477 ± 0.695
3.12SerPhe: 3.12 ± 0.57
4.458SerGly: 4.458 ± 0.886
1.07SerHis: 1.07 ± 0.291
4.814SerIle: 4.814 ± 0.666
4.903SerLys: 4.903 ± 0.581
5.616SerLeu: 5.616 ± 0.59
2.407SerMet: 2.407 ± 0.594
3.477SerAsn: 3.477 ± 0.658
1.961SerPro: 1.961 ± 0.391
3.12SerGln: 3.12 ± 0.54
1.961SerArg: 1.961 ± 0.4
5.26SerSer: 5.26 ± 0.742
4.012SerThr: 4.012 ± 0.634
3.477SerVal: 3.477 ± 0.668
0.981SerTrp: 0.981 ± 0.269
1.961SerTyr: 1.961 ± 0.366
0.0SerXaa: 0.0 ± 0.0
Thr
4.903ThrAla: 4.903 ± 1.407
0.357ThrCys: 0.357 ± 0.166
3.031ThrAsp: 3.031 ± 0.515
2.942ThrGlu: 2.942 ± 0.715
2.764ThrPhe: 2.764 ± 0.545
3.655ThrGly: 3.655 ± 0.539
0.624ThrHis: 0.624 ± 0.229
5.706ThrIle: 5.706 ± 0.715
4.992ThrLys: 4.992 ± 0.757
4.547ThrLeu: 4.547 ± 0.705
1.516ThrMet: 1.516 ± 0.338
2.853ThrAsn: 2.853 ± 0.596
2.229ThrPro: 2.229 ± 0.405
3.031ThrGln: 3.031 ± 0.522
2.496ThrArg: 2.496 ± 0.449
3.299ThrSer: 3.299 ± 0.579
3.744ThrThr: 3.744 ± 0.476
4.814ThrVal: 4.814 ± 0.747
0.535ThrTrp: 0.535 ± 0.236
1.961ThrTyr: 1.961 ± 0.373
0.0ThrXaa: 0.0 ± 0.0
Val
5.527ValAla: 5.527 ± 0.743
0.089ValCys: 0.089 ± 0.087
3.923ValAsp: 3.923 ± 0.661
5.082ValGlu: 5.082 ± 0.8
2.318ValPhe: 2.318 ± 0.473
4.725ValGly: 4.725 ± 0.78
0.713ValHis: 0.713 ± 0.263
4.368ValIle: 4.368 ± 0.682
4.458ValLys: 4.458 ± 0.621
5.082ValLeu: 5.082 ± 0.615
0.981ValMet: 0.981 ± 0.321
4.19ValAsn: 4.19 ± 0.517
1.961ValPro: 1.961 ± 0.447
1.516ValGln: 1.516 ± 0.472
1.605ValArg: 1.605 ± 0.405
4.725ValSer: 4.725 ± 0.667
5.349ValThr: 5.349 ± 0.791
4.101ValVal: 4.101 ± 0.586
0.802ValTrp: 0.802 ± 0.288
3.031ValTyr: 3.031 ± 0.549
0.0ValXaa: 0.0 ± 0.0
Trp
1.07TrpAla: 1.07 ± 0.348
0.0TrpCys: 0.0 ± 0.0
0.713TrpAsp: 0.713 ± 0.265
0.267TrpGlu: 0.267 ± 0.157
0.446TrpPhe: 0.446 ± 0.172
0.981TrpGly: 0.981 ± 0.332
0.178TrpHis: 0.178 ± 0.109
0.535TrpIle: 0.535 ± 0.172
0.802TrpLys: 0.802 ± 0.259
1.07TrpLeu: 1.07 ± 0.237
0.089TrpMet: 0.089 ± 0.081
0.624TrpAsn: 0.624 ± 0.265
0.0TrpPro: 0.0 ± 0.0
0.624TrpGln: 0.624 ± 0.267
0.446TrpArg: 0.446 ± 0.19
0.535TrpSer: 0.535 ± 0.256
0.357TrpThr: 0.357 ± 0.245
0.178TrpVal: 0.178 ± 0.109
0.178TrpTrp: 0.178 ± 0.108
0.981TrpTyr: 0.981 ± 0.418
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.496TyrAla: 2.496 ± 0.473
0.357TyrCys: 0.357 ± 0.244
2.942TyrAsp: 2.942 ± 0.654
2.585TyrGlu: 2.585 ± 0.525
2.229TyrPhe: 2.229 ± 0.565
2.14TyrGly: 2.14 ± 0.453
0.624TyrHis: 0.624 ± 0.198
2.942TyrIle: 2.942 ± 0.595
2.318TyrLys: 2.318 ± 0.593
3.923TyrLeu: 3.923 ± 0.797
0.892TyrMet: 0.892 ± 0.308
2.764TyrAsn: 2.764 ± 0.638
0.624TyrPro: 0.624 ± 0.218
2.853TyrGln: 2.853 ± 0.421
1.694TyrArg: 1.694 ± 0.357
2.585TyrSer: 2.585 ± 0.434
2.496TyrThr: 2.496 ± 0.288
1.961TyrVal: 1.961 ± 0.411
0.357TyrTrp: 0.357 ± 0.202
1.337TyrTyr: 1.337 ± 0.353
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (11218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski