Amino acid dipepetide frequency for Powellomyces hirtus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.06AlaAla: 11.06 ± 0.104	1.008AlaCys: 1.008 ± 0.019	4.843AlaAsp: 4.843 ± 0.04	5.538AlaGlu: 5.538 ± 0.047	3.186AlaPhe: 3.186 ± 0.03	5.931AlaGly: 5.931 ± 0.051	2.079AlaHis: 2.079 ± 0.026	4.181AlaIle: 4.181 ± 0.036	4.724AlaLys: 4.724 ± 0.043	8.227AlaLeu: 8.227 ± 0.063	2.089AlaMet: 2.089 ± 0.025	3.085AlaAsn: 3.085 ± 0.029	5.2AlaPro: 5.2 ± 0.054	3.472AlaGln: 3.472 ± 0.035	4.939AlaArg: 4.939 ± 0.04	7.19AlaSer: 7.19 ± 0.056	6.034AlaThr: 6.034 ± 0.05	6.129AlaVal: 6.129 ± 0.046	0.953AlaTrp: 0.953 ± 0.015	2.14AlaTyr: 2.14 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.953CysAla: 0.953 ± 0.017	0.234CysCys: 0.234 ± 0.009	0.615CysAsp: 0.615 ± 0.014	0.629CysGlu: 0.629 ± 0.013	0.5CysPhe: 0.5 ± 0.013	0.92CysGly: 0.92 ± 0.021	0.318CysHis: 0.318 ± 0.009	0.68CysIle: 0.68 ± 0.015	0.606CysLys: 0.606 ± 0.013	1.186CysLeu: 1.186 ± 0.021	0.29CysMet: 0.29 ± 0.008	0.422CysAsn: 0.422 ± 0.012	0.626CysPro: 0.626 ± 0.018	0.409CysGln: 0.409 ± 0.011	0.69CysArg: 0.69 ± 0.012	0.829CysSer: 0.829 ± 0.018	0.72CysThr: 0.72 ± 0.015	0.862CysVal: 0.862 ± 0.016	0.157CysTrp: 0.157 ± 0.006	0.35CysTyr: 0.35 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.284AspAla: 5.284 ± 0.044	0.593AspCys: 0.593 ± 0.014	4.336AspAsp: 4.336 ± 0.059	4.38AspGlu: 4.38 ± 0.047	2.125AspPhe: 2.125 ± 0.025	3.839AspGly: 3.839 ± 0.037	1.321AspHis: 1.321 ± 0.022	2.989AspIle: 2.989 ± 0.026	2.561AspLys: 2.561 ± 0.024	5.201AspLeu: 5.201 ± 0.044	1.442AspMet: 1.442 ± 0.02	1.95AspAsn: 1.95 ± 0.025	3.201AspPro: 3.201 ± 0.031	1.844AspGln: 1.844 ± 0.021	3.057AspArg: 3.057 ± 0.035	3.798AspSer: 3.798 ± 0.036	3.026AspThr: 3.026 ± 0.027	4.206AspVal: 4.206 ± 0.038	0.755AspTrp: 0.755 ± 0.017	1.515AspTyr: 1.515 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.242GluAla: 5.242 ± 0.051	0.656GluCys: 0.656 ± 0.015	4.071GluAsp: 4.071 ± 0.045	5.304GluGlu: 5.304 ± 0.057	2.037GluPhe: 2.037 ± 0.023	3.467GluGly: 3.467 ± 0.036	1.456GluHis: 1.456 ± 0.023	3.1GluIle: 3.1 ± 0.035	3.824GluLys: 3.824 ± 0.044	5.486GluLeu: 5.486 ± 0.061	1.596GluMet: 1.596 ± 0.024	2.319GluAsn: 2.319 ± 0.028	2.503GluPro: 2.503 ± 0.031	2.601GluGln: 2.601 ± 0.031	3.809GluArg: 3.809 ± 0.043	3.94GluSer: 3.94 ± 0.037	3.555GluThr: 3.555 ± 0.035	3.679GluVal: 3.679 ± 0.044	0.792GluTrp: 0.792 ± 0.015	1.649GluTyr: 1.649 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.119PheAla: 3.119 ± 0.03	0.538PheCys: 0.538 ± 0.012	2.247PheAsp: 2.247 ± 0.026	2.144PheGlu: 2.144 ± 0.026	1.481PhePhe: 1.481 ± 0.024	2.634PheGly: 2.634 ± 0.042	0.92PheHis: 0.92 ± 0.02	1.665PheIle: 1.665 ± 0.022	1.66PheLys: 1.66 ± 0.025	3.343PheLeu: 3.343 ± 0.031	0.796PheMet: 0.796 ± 0.015	1.34PheAsn: 1.34 ± 0.022	1.784PhePro: 1.784 ± 0.024	1.334PheGln: 1.334 ± 0.02	1.913PheArg: 1.913 ± 0.025	2.667PheSer: 2.667 ± 0.031	2.107PheThr: 2.107 ± 0.029	2.578PheVal: 2.578 ± 0.031	0.497PheTrp: 0.497 ± 0.013	1.077PheTyr: 1.077 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.395GlyAla: 5.395 ± 0.044	0.792GlyCys: 0.792 ± 0.017	3.578GlyAsp: 3.578 ± 0.035	3.408GlyGlu: 3.408 ± 0.036	2.462GlyPhe: 2.462 ± 0.034	5.654GlyGly: 5.654 ± 0.065	1.598GlyHis: 1.598 ± 0.026	3.141GlyIle: 3.141 ± 0.033	3.674GlyLys: 3.674 ± 0.037	5.344GlyLeu: 5.344 ± 0.049	1.57GlyMet: 1.57 ± 0.024	2.372GlyAsn: 2.372 ± 0.027	2.929GlyPro: 2.929 ± 0.034	2.301GlyGln: 2.301 ± 0.028	3.7GlyArg: 3.7 ± 0.041	5.171GlySer: 5.171 ± 0.052	3.961GlyThr: 3.961 ± 0.036	4.182GlyVal: 4.182 ± 0.042	0.858GlyTrp: 0.858 ± 0.016	1.85GlyTyr: 1.85 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.086HisAla: 2.086 ± 0.03	0.315HisCys: 0.315 ± 0.01	1.337HisAsp: 1.337 ± 0.022	1.287HisGlu: 1.287 ± 0.02	0.949HisPhe: 0.949 ± 0.017	1.524HisGly: 1.524 ± 0.023	1.197HisHis: 1.197 ± 0.028	1.292HisIle: 1.292 ± 0.022	1.067HisLys: 1.067 ± 0.018	2.456HisLeu: 2.456 ± 0.028	0.558HisMet: 0.558 ± 0.014	0.919HisAsn: 0.919 ± 0.016	1.8HisPro: 1.8 ± 0.026	1.205HisGln: 1.205 ± 0.027	1.537HisArg: 1.537 ± 0.022	1.831HisSer: 1.831 ± 0.025	1.389HisThr: 1.389 ± 0.022	1.655HisVal: 1.655 ± 0.023	0.28HisTrp: 0.28 ± 0.008	0.736HisTyr: 0.736 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.348IleAla: 4.348 ± 0.035	0.713IleCys: 0.713 ± 0.015	2.866IleAsp: 2.866 ± 0.027	2.803IleGlu: 2.803 ± 0.034	1.736IlePhe: 1.736 ± 0.025	2.959IleGly: 2.959 ± 0.034	1.198IleHis: 1.198 ± 0.02	2.285IleIle: 2.285 ± 0.028	2.488IleLys: 2.488 ± 0.027	4.486IleLeu: 4.486 ± 0.045	1.095IleMet: 1.095 ± 0.02	1.787IleAsn: 1.787 ± 0.024	2.98IlePro: 2.98 ± 0.032	1.762IleGln: 1.762 ± 0.025	2.825IleArg: 2.825 ± 0.029	3.523IleSer: 3.523 ± 0.033	2.869IleThr: 2.869 ± 0.028	3.424IleVal: 3.424 ± 0.031	0.562IleTrp: 0.562 ± 0.014	1.292IleTyr: 1.292 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.618LysAla: 4.618 ± 0.044	0.589LysCys: 0.589 ± 0.014	2.918LysAsp: 2.918 ± 0.03	3.69LysGlu: 3.69 ± 0.043	1.614LysPhe: 1.614 ± 0.02	3.054LysGly: 3.054 ± 0.029	1.3LysHis: 1.3 ± 0.021	2.506LysIle: 2.506 ± 0.031	3.804LysLys: 3.804 ± 0.057	4.676LysLeu: 4.676 ± 0.04	1.248LysMet: 1.248 ± 0.02	1.928LysAsn: 1.928 ± 0.025	2.714LysPro: 2.714 ± 0.033	2.189LysGln: 2.189 ± 0.026	3.618LysArg: 3.618 ± 0.038	3.538LysSer: 3.538 ± 0.035	3.154LysThr: 3.154 ± 0.031	3.183LysVal: 3.183 ± 0.031	0.662LysTrp: 0.662 ± 0.015	1.429LysTyr: 1.429 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	8.235LeuAla: 8.235 ± 0.057	1.268LeuCys: 1.268 ± 0.023	5.2LeuAsp: 5.2 ± 0.038	5.561LeuGlu: 5.561 ± 0.063	3.307LeuPhe: 3.307 ± 0.038	5.367LeuGly: 5.367 ± 0.047	2.37LeuHis: 2.37 ± 0.028	3.964LeuIle: 3.964 ± 0.034	4.895LeuLys: 4.895 ± 0.04	8.667LeuLeu: 8.667 ± 0.067	1.977LeuMet: 1.977 ± 0.026	3.276LeuAsn: 3.276 ± 0.033	5.274LeuPro: 5.274 ± 0.044	3.988LeuGln: 3.988 ± 0.047	5.742LeuArg: 5.742 ± 0.05	6.889LeuSer: 6.889 ± 0.048	5.247LeuThr: 5.247 ± 0.044	5.753LeuVal: 5.753 ± 0.047	1.007LeuTrp: 1.007 ± 0.019	2.398LeuTyr: 2.398 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.111MetAla: 2.111 ± 0.026	0.269MetCys: 0.269 ± 0.01	1.491MetAsp: 1.491 ± 0.019	1.517MetGlu: 1.517 ± 0.027	0.805MetPhe: 0.805 ± 0.016	1.426MetGly: 1.426 ± 0.021	0.557MetHis: 0.557 ± 0.014	1.051MetIle: 1.051 ± 0.019	1.166MetLys: 1.166 ± 0.017	2.045MetLeu: 2.045 ± 0.028	0.627MetMet: 0.627 ± 0.016	0.903MetAsn: 0.903 ± 0.015	1.171MetPro: 1.171 ± 0.018	1.011MetGln: 1.011 ± 0.02	1.359MetArg: 1.359 ± 0.019	1.906MetSer: 1.906 ± 0.023	1.409MetThr: 1.409 ± 0.021	1.458MetVal: 1.458 ± 0.022	0.266MetTrp: 0.266 ± 0.009	0.623MetTyr: 0.623 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.375AsnAla: 3.375 ± 0.03	0.433AsnCys: 0.433 ± 0.011	2.035AsnAsp: 2.035 ± 0.025	2.066AsnGlu: 2.066 ± 0.029	1.268AsnPhe: 1.268 ± 0.018	2.661AsnGly: 2.661 ± 0.033	0.856AsnHis: 0.856 ± 0.014	1.954AsnIle: 1.954 ± 0.024	1.73AsnLys: 1.73 ± 0.026	3.335AsnLeu: 3.335 ± 0.032	0.912AsnMet: 0.912 ± 0.016	1.665AsnAsn: 1.665 ± 0.029	2.364AsnPro: 2.364 ± 0.027	1.282AsnGln: 1.282 ± 0.021	1.967AsnArg: 1.967 ± 0.025	2.481AsnSer: 2.481 ± 0.031	2.146AsnThr: 2.146 ± 0.029	2.678AsnVal: 2.678 ± 0.028	0.446AsnTrp: 0.446 ± 0.012	0.997AsnTyr: 0.997 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.856ProAla: 5.856 ± 0.055	0.495ProCys: 0.495 ± 0.013	2.999ProAsp: 2.999 ± 0.033	3.297ProGlu: 3.297 ± 0.032	1.916ProPhe: 1.916 ± 0.022	3.312ProGly: 3.312 ± 0.035	1.498ProHis: 1.498 ± 0.024	2.529ProIle: 2.529 ± 0.029	2.544ProLys: 2.544 ± 0.032	4.712ProLeu: 4.712 ± 0.042	1.121ProMet: 1.121 ± 0.019	2.007ProAsn: 2.007 ± 0.024	5.574ProPro: 5.574 ± 0.092	2.397ProGln: 2.397 ± 0.036	2.998ProArg: 2.998 ± 0.031	5.403ProSer: 5.403 ± 0.046	4.421ProThr: 4.421 ± 0.044	3.768ProVal: 3.768 ± 0.035	0.536ProTrp: 0.536 ± 0.014	1.409ProTyr: 1.409 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.207GlnAla: 3.207 ± 0.035	0.463GlnCys: 0.463 ± 0.013	1.857GlnAsp: 1.857 ± 0.026	2.339GlnGlu: 2.339 ± 0.031	1.317GlnPhe: 1.317 ± 0.018	2.002GlnGly: 2.002 ± 0.029	1.323GlnHis: 1.323 ± 0.025	1.93GlnIle: 1.93 ± 0.025	2.17GlnLys: 2.17 ± 0.028	3.866GlnLeu: 3.866 ± 0.041	1.019GlnMet: 1.019 ± 0.019	1.478GlnAsn: 1.478 ± 0.02	2.507GlnPro: 2.507 ± 0.033	3.7GlnGln: 3.7 ± 0.1	2.655GlnArg: 2.655 ± 0.032	2.848GlnSer: 2.848 ± 0.032	2.354GlnThr: 2.354 ± 0.024	2.164GlnVal: 2.164 ± 0.026	0.494GlnTrp: 0.494 ± 0.012	1.197GlnTyr: 1.197 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	4.846ArgAla: 4.846 ± 0.044	0.681ArgCys: 0.681 ± 0.015	3.303ArgAsp: 3.303 ± 0.037	3.656ArgGlu: 3.656 ± 0.04	2.125ArgPhe: 2.125 ± 0.023	3.428ArgGly: 3.428 ± 0.034	1.513ArgHis: 1.513 ± 0.024	3.004ArgIle: 3.004 ± 0.029	3.679ArgLys: 3.679 ± 0.039	5.242ArgLeu: 5.242 ± 0.044	1.436ArgMet: 1.436 ± 0.023	2.285ArgAsn: 2.285 ± 0.024	3.133ArgPro: 3.133 ± 0.034	2.384ArgGln: 2.384 ± 0.03	4.509ArgArg: 4.509 ± 0.054	4.258ArgSer: 4.258 ± 0.045	3.547ArgThr: 3.547 ± 0.036	3.55ArgVal: 3.55 ± 0.03	0.682ArgTrp: 0.682 ± 0.016	1.615ArgTyr: 1.615 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	7.059SerAla: 7.059 ± 0.054	0.78SerCys: 0.78 ± 0.017	4.117SerAsp: 4.117 ± 0.038	3.796SerGlu: 3.796 ± 0.04	2.702SerPhe: 2.702 ± 0.031	5.116SerGly: 5.116 ± 0.048	1.834SerHis: 1.834 ± 0.022	3.543SerIle: 3.543 ± 0.034	3.497SerLys: 3.497 ± 0.036	6.733SerLeu: 6.733 ± 0.047	1.643SerMet: 1.643 ± 0.023	2.714SerAsn: 2.714 ± 0.025	5.037SerPro: 5.037 ± 0.054	2.875SerGln: 2.875 ± 0.032	4.341SerArg: 4.341 ± 0.042	7.973SerSer: 7.973 ± 0.075	5.416SerThr: 5.416 ± 0.05	4.704SerVal: 4.704 ± 0.04	0.812SerTrp: 0.812 ± 0.017	1.811SerTyr: 1.811 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.038ThrAla: 6.038 ± 0.05	0.75ThrCys: 0.75 ± 0.018	3.102ThrAsp: 3.102 ± 0.03	3.172ThrGlu: 3.172 ± 0.031	2.288ThrPhe: 2.288 ± 0.026	4.078ThrGly: 4.078 ± 0.039	1.502ThrHis: 1.502 ± 0.023	3.107ThrIle: 3.107 ± 0.03	2.853ThrLys: 2.853 ± 0.03	5.708ThrLeu: 5.708 ± 0.046	1.245ThrMet: 1.245 ± 0.02	2.148ThrAsn: 2.148 ± 0.029	4.473ThrPro: 4.473 ± 0.046	2.141ThrGln: 2.141 ± 0.026	3.228ThrArg: 3.228 ± 0.033	5.272ThrSer: 5.272 ± 0.047	5.033ThrThr: 5.033 ± 0.068	4.164ThrVal: 4.164 ± 0.041	0.714ThrTrp: 0.714 ± 0.015	1.624ThrTyr: 1.624 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	6.087ValAla: 6.087 ± 0.05	0.832ValCys: 0.832 ± 0.014	4.086ValAsp: 4.086 ± 0.034	4.244ValGlu: 4.244 ± 0.038	2.448ValPhe: 2.448 ± 0.033	4.037ValGly: 4.037 ± 0.04	1.566ValHis: 1.566 ± 0.023	3.063ValIle: 3.063 ± 0.032	3.477ValLys: 3.477 ± 0.032	6.042ValLeu: 6.042 ± 0.053	1.507ValMet: 1.507 ± 0.022	2.393ValAsn: 2.393 ± 0.029	3.767ValPro: 3.767 ± 0.037	2.513ValGln: 2.513 ± 0.03	3.697ValArg: 3.697 ± 0.038	4.433ValSer: 4.433 ± 0.043	3.927ValThr: 3.927 ± 0.042	4.981ValVal: 4.981 ± 0.051	0.755ValTrp: 0.755 ± 0.014	1.713ValTyr: 1.713 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.92TrpAla: 0.92 ± 0.013	0.184TrpCys: 0.184 ± 0.007	0.791TrpAsp: 0.791 ± 0.016	0.71TrpGlu: 0.71 ± 0.015	0.471TrpPhe: 0.471 ± 0.012	0.695TrpGly: 0.695 ± 0.017	0.277TrpHis: 0.277 ± 0.008	0.618TrpIle: 0.618 ± 0.014	0.732TrpLys: 0.732 ± 0.015	1.008TrpLeu: 1.008 ± 0.017	0.336TrpMet: 0.336 ± 0.01	0.573TrpAsn: 0.573 ± 0.014	0.437TrpPro: 0.437 ± 0.012	0.418TrpGln: 0.418 ± 0.011	0.727TrpArg: 0.727 ± 0.014	0.811TrpSer: 0.811 ± 0.018	0.796TrpThr: 0.796 ± 0.016	0.728TrpVal: 0.728 ± 0.014	0.211TrpTrp: 0.211 ± 0.008	0.327TrpTyr: 0.327 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.168TyrAla: 2.168 ± 0.026	0.402TyrCys: 0.402 ± 0.011	1.631TyrAsp: 1.631 ± 0.02	1.545TyrGlu: 1.545 ± 0.023	1.104TyrPhe: 1.104 ± 0.019	1.838TyrGly: 1.838 ± 0.031	0.738TyrHis: 0.738 ± 0.015	1.397TyrIle: 1.397 ± 0.021	1.282TyrLys: 1.282 ± 0.02	2.619TyrLeu: 2.619 ± 0.031	0.665TyrMet: 0.665 ± 0.014	1.089TyrAsn: 1.089 ± 0.018	1.316TyrPro: 1.316 ± 0.022	1.063TyrGln: 1.063 ± 0.02	1.566TyrArg: 1.566 ± 0.019	1.743TyrSer: 1.743 ± 0.028	1.531TyrThr: 1.531 ± 0.022	1.724TyrVal: 1.724 ± 0.022	0.328TyrTrp: 0.328 ± 0.011	0.856TyrTyr: 0.856 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6533 proteins (3660536 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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