Amino acid dipepetide frequency for Thermodesulfobacterium geofontis (strain OPF15)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.14AlaAla: 2.14 ± 0.085	0.829AlaCys: 0.829 ± 0.052	1.976AlaAsp: 1.976 ± 0.075	4.322AlaGlu: 4.322 ± 0.103	2.9AlaPhe: 2.9 ± 0.084	3.874AlaGly: 3.874 ± 0.112	0.979AlaHis: 0.979 ± 0.045	5.26AlaIle: 5.26 ± 0.121	5.657AlaLys: 5.657 ± 0.122	7.321AlaLeu: 7.321 ± 0.121	1.027AlaMet: 1.027 ± 0.055	1.82AlaAsn: 1.82 ± 0.063	1.688AlaPro: 1.688 ± 0.057	1.696AlaGln: 1.696 ± 0.058	2.073AlaArg: 2.073 ± 0.071	2.677AlaSer: 2.677 ± 0.084	2.496AlaThr: 2.496 ± 0.094	3.137AlaVal: 3.137 ± 0.082	0.48AlaTrp: 0.48 ± 0.031	2.49AlaTyr: 2.49 ± 0.071	0.0AlaXaa: 0.0 ± 0.0
Cys	0.634CysAla: 0.634 ± 0.039	0.126CysCys: 0.126 ± 0.016	0.385CysAsp: 0.385 ± 0.028	0.851CysGlu: 0.851 ± 0.041	0.555CysPhe: 0.555 ± 0.031	1.033CysGly: 1.033 ± 0.053	0.316CysHis: 0.316 ± 0.072	0.746CysIle: 0.746 ± 0.035	0.932CysLys: 0.932 ± 0.059	0.875CysLeu: 0.875 ± 0.047	0.154CysMet: 0.154 ± 0.018	0.344CysAsn: 0.344 ± 0.031	0.727CysPro: 0.727 ± 0.047	0.251CysGln: 0.251 ± 0.023	0.324CysArg: 0.324 ± 0.025	0.6CysSer: 0.6 ± 0.035	0.353CysThr: 0.353 ± 0.032	0.533CysVal: 0.533 ± 0.036	0.103CysTrp: 0.103 ± 0.014	0.409CysTyr: 0.409 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	1.876AspAla: 1.876 ± 0.073	0.413AspCys: 0.413 ± 0.033	1.281AspAsp: 1.281 ± 0.053	3.426AspGlu: 3.426 ± 0.094	3.167AspPhe: 3.167 ± 0.079	2.184AspGly: 2.184 ± 0.072	0.551AspHis: 0.551 ± 0.031	4.061AspIle: 4.061 ± 0.089	3.69AspLys: 3.69 ± 0.082	5.998AspLeu: 5.998 ± 0.106	0.628AspMet: 0.628 ± 0.04	1.216AspAsn: 1.216 ± 0.047	2.413AspPro: 2.413 ± 0.086	0.74AspGln: 0.74 ± 0.043	1.449AspArg: 1.449 ± 0.062	1.69AspSer: 1.69 ± 0.055	1.579AspThr: 1.579 ± 0.061	2.231AspVal: 2.231 ± 0.075	0.622AspTrp: 0.622 ± 0.034	2.059AspTyr: 2.059 ± 0.071	0.0AspXaa: 0.0 ± 0.0
Glu	4.598GluAla: 4.598 ± 0.1	0.533GluCys: 0.533 ± 0.036	4.028GluAsp: 4.028 ± 0.104	10.044GluGlu: 10.044 ± 0.184	3.83GluPhe: 3.83 ± 0.089	4.95GluGly: 4.95 ± 0.123	0.837GluHis: 0.837 ± 0.042	10.423GluIle: 10.423 ± 0.164	12.095GluLys: 12.095 ± 0.2	8.342GluLeu: 8.342 ± 0.165	1.56GluMet: 1.56 ± 0.065	4.942GluAsn: 4.942 ± 0.11	2.269GluPro: 2.269 ± 0.069	1.046GluGln: 1.046 ± 0.054	4.158GluArg: 4.158 ± 0.113	2.861GluSer: 2.861 ± 0.077	3.666GluThr: 3.666 ± 0.082	5.974GluVal: 5.974 ± 0.109	0.638GluTrp: 0.638 ± 0.044	2.675GluTyr: 2.675 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	2.454PheAla: 2.454 ± 0.083	0.709PheCys: 0.709 ± 0.039	2.298PheAsp: 2.298 ± 0.075	4.045PheGlu: 4.045 ± 0.105	3.333PhePhe: 3.333 ± 0.119	3.145PheGly: 3.145 ± 0.083	0.819PheHis: 0.819 ± 0.046	5.236PheIle: 5.236 ± 0.129	5.313PheLys: 5.313 ± 0.102	7.747PheLeu: 7.747 ± 0.194	0.938PheMet: 0.938 ± 0.046	2.231PheAsn: 2.231 ± 0.062	2.346PhePro: 2.346 ± 0.065	1.37PheGln: 1.37 ± 0.051	1.85PheArg: 1.85 ± 0.065	4.166PheSer: 4.166 ± 0.101	2.312PheThr: 2.312 ± 0.091	2.758PheVal: 2.758 ± 0.087	0.699PheTrp: 0.699 ± 0.042	2.869PheTyr: 2.869 ± 0.087	0.0PheXaa: 0.0 ± 0.0
Gly	3.856GlyAla: 3.856 ± 0.111	0.738GlyCys: 0.738 ± 0.049	2.598GlyAsp: 2.598 ± 0.087	4.74GlyGlu: 4.74 ± 0.098	3.625GlyPhe: 3.625 ± 0.088	4.111GlyGly: 4.111 ± 0.119	0.987GlyHis: 0.987 ± 0.049	6.427GlyIle: 6.427 ± 0.116	6.03GlyLys: 6.03 ± 0.112	6.095GlyLeu: 6.095 ± 0.108	1.108GlyMet: 1.108 ± 0.055	2.259GlyAsn: 2.259 ± 0.127	1.816GlyPro: 1.816 ± 0.059	1.11GlyGln: 1.11 ± 0.048	2.393GlyArg: 2.393 ± 0.083	2.924GlySer: 2.924 ± 0.089	2.916GlyThr: 2.916 ± 0.09	4.049GlyVal: 4.049 ± 0.106	0.681GlyTrp: 0.681 ± 0.04	2.764GlyTyr: 2.764 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	0.677HisAla: 0.677 ± 0.037	0.178HisCys: 0.178 ± 0.021	0.432HisAsp: 0.432 ± 0.031	0.725HisGlu: 0.725 ± 0.037	0.867HisPhe: 0.867 ± 0.042	0.837HisGly: 0.837 ± 0.047	0.355HisHis: 0.355 ± 0.027	1.268HisIle: 1.268 ± 0.055	1.189HisLys: 1.189 ± 0.058	1.718HisLeu: 1.718 ± 0.062	0.249HisMet: 0.249 ± 0.022	0.547HisAsn: 0.547 ± 0.034	1.094HisPro: 1.094 ± 0.052	0.428HisGln: 0.428 ± 0.032	0.521HisArg: 0.521 ± 0.032	0.689HisSer: 0.689 ± 0.039	0.691HisThr: 0.691 ± 0.036	0.663HisVal: 0.663 ± 0.039	0.148HisTrp: 0.148 ± 0.017	0.636HisTyr: 0.636 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.481IleAla: 5.481 ± 0.122	0.932IleCys: 0.932 ± 0.048	4.251IleAsp: 4.251 ± 0.099	7.972IleGlu: 7.972 ± 0.147	5.597IlePhe: 5.597 ± 0.134	5.471IleGly: 5.471 ± 0.128	1.191IleHis: 1.191 ± 0.047	8.225IleIle: 8.225 ± 0.159	9.951IleLys: 9.951 ± 0.157	10.979IleLeu: 10.979 ± 0.166	1.4IleMet: 1.4 ± 0.054	4.075IleAsn: 4.075 ± 0.1	4.661IlePro: 4.661 ± 0.105	1.797IleGln: 1.797 ± 0.065	3.394IleArg: 3.394 ± 0.087	6.079IleSer: 6.079 ± 0.114	4.087IleThr: 4.087 ± 0.098	5.088IleVal: 5.088 ± 0.113	0.776IleTrp: 0.776 ± 0.039	3.84IleTyr: 3.84 ± 0.085	0.0IleXaa: 0.0 ± 0.0
Lys	5.901LysAla: 5.901 ± 0.125	0.709LysCys: 0.709 ± 0.05	5.279LysAsp: 5.279 ± 0.11	12.825LysGlu: 12.825 ± 0.234	4.217LysPhe: 4.217 ± 0.088	6.02LysGly: 6.02 ± 0.118	1.009LysHis: 1.009 ± 0.051	11.216LysIle: 11.216 ± 0.181	10.563LysLys: 10.563 ± 0.186	9.102LysLeu: 9.102 ± 0.147	1.686LysMet: 1.686 ± 0.054	5.797LysAsn: 5.797 ± 0.14	3.461LysPro: 3.461 ± 0.08	1.467LysGln: 1.467 ± 0.06	4.288LysArg: 4.288 ± 0.106	4.038LysSer: 4.038 ± 0.096	4.344LysThr: 4.344 ± 0.11	6.472LysVal: 6.472 ± 0.125	0.794LysTrp: 0.794 ± 0.042	3.615LysTyr: 3.615 ± 0.081	0.0LysXaa: 0.0 ± 0.0
Leu	6.646LeuAla: 6.646 ± 0.119	1.056LeuCys: 1.056 ± 0.046	4.375LeuAsp: 4.375 ± 0.1	10.241LeuGlu: 10.241 ± 0.196	5.651LeuPhe: 5.651 ± 0.141	6.851LeuGly: 6.851 ± 0.123	1.26LeuHis: 1.26 ± 0.051	10.014LeuIle: 10.014 ± 0.171	13.392LeuLys: 13.392 ± 0.235	10.5LeuLeu: 10.5 ± 0.217	1.759LeuMet: 1.759 ± 0.065	5.108LeuAsn: 5.108 ± 0.112	4.699LeuPro: 4.699 ± 0.113	2.436LeuGln: 2.436 ± 0.064	4.391LeuArg: 4.391 ± 0.111	7.368LeuSer: 7.368 ± 0.131	4.679LeuThr: 4.679 ± 0.093	5.736LeuVal: 5.736 ± 0.126	1.019LeuTrp: 1.019 ± 0.048	4.004LeuTyr: 4.004 ± 0.103	0.0LeuXaa: 0.0 ± 0.0
Met	1.193MetAla: 1.193 ± 0.054	0.156MetCys: 0.156 ± 0.019	0.756MetAsp: 0.756 ± 0.04	1.42MetGlu: 1.42 ± 0.059	0.659MetPhe: 0.659 ± 0.04	1.305MetGly: 1.305 ± 0.044	0.223MetHis: 0.223 ± 0.023	1.238MetIle: 1.238 ± 0.051	1.921MetLys: 1.921 ± 0.068	1.453MetLeu: 1.453 ± 0.055	0.251MetMet: 0.251 ± 0.022	0.65MetAsn: 0.65 ± 0.038	0.725MetPro: 0.725 ± 0.04	0.397MetGln: 0.397 ± 0.029	0.756MetArg: 0.756 ± 0.04	0.845MetSer: 0.845 ± 0.04	0.614MetThr: 0.614 ± 0.036	1.076MetVal: 1.076 ± 0.051	0.152MetTrp: 0.152 ± 0.016	0.462MetTyr: 0.462 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	1.856AsnAla: 1.856 ± 0.088	0.458AsnCys: 0.458 ± 0.03	1.015AsnAsp: 1.015 ± 0.046	2.654AsnGlu: 2.654 ± 0.071	3.435AsnPhe: 3.435 ± 0.106	1.797AsnGly: 1.797 ± 0.102	0.537AsnHis: 0.537 ± 0.032	4.089AsnIle: 4.089 ± 0.089	3.633AsnLys: 3.633 ± 0.103	6.768AsnLeu: 6.768 ± 0.168	0.707AsnMet: 0.707 ± 0.035	1.601AsnAsn: 1.601 ± 0.077	2.719AsnPro: 2.719 ± 0.066	1.046AsnGln: 1.046 ± 0.052	1.422AsnArg: 1.422 ± 0.054	1.99AsnSer: 1.99 ± 0.077	1.692AsnThr: 1.692 ± 0.055	2.01AsnVal: 2.01 ± 0.072	0.61AsnTrp: 0.61 ± 0.035	2.168AsnTyr: 2.168 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.757ProAla: 1.757 ± 0.063	0.401ProCys: 0.401 ± 0.027	1.88ProAsp: 1.88 ± 0.063	4.658ProGlu: 4.658 ± 0.116	2.798ProPhe: 2.798 ± 0.079	2.509ProGly: 2.509 ± 0.081	0.792ProHis: 0.792 ± 0.037	3.313ProIle: 3.313 ± 0.082	3.682ProLys: 3.682 ± 0.096	4.44ProLeu: 4.44 ± 0.091	0.584ProMet: 0.584 ± 0.038	1.451ProAsn: 1.451 ± 0.057	1.927ProPro: 1.927 ± 0.081	1.414ProGln: 1.414 ± 0.051	1.175ProArg: 1.175 ± 0.056	2.494ProSer: 2.494 ± 0.072	1.755ProThr: 1.755 ± 0.059	2.677ProVal: 2.677 ± 0.084	0.462ProTrp: 0.462 ± 0.036	2.19ProTyr: 2.19 ± 0.073	0.0ProXaa: 0.0 ± 0.0
Gln	1.587GlnAla: 1.587 ± 0.051	0.162GlnCys: 0.162 ± 0.016	0.831GlnAsp: 0.831 ± 0.039	1.963GlnGlu: 1.963 ± 0.068	1.013GlnPhe: 1.013 ± 0.041	1.315GlnGly: 1.315 ± 0.058	0.251GlnHis: 0.251 ± 0.022	2.549GlnIle: 2.549 ± 0.077	2.715GlnLys: 2.715 ± 0.092	1.82GlnLeu: 1.82 ± 0.062	0.424GlnMet: 0.424 ± 0.029	1.052GlnAsn: 1.052 ± 0.051	0.748GlnPro: 0.748 ± 0.039	0.48GlnGln: 0.48 ± 0.036	0.989GlnArg: 0.989 ± 0.048	0.871GlnSer: 0.871 ± 0.041	1.025GlnThr: 1.025 ± 0.046	1.433GlnVal: 1.433 ± 0.055	0.18GlnTrp: 0.18 ± 0.021	0.691GlnTyr: 0.691 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.399ArgAla: 2.399 ± 0.078	0.468ArgCys: 0.468 ± 0.033	1.714ArgAsp: 1.714 ± 0.069	3.641ArgGlu: 3.641 ± 0.095	2.041ArgPhe: 2.041 ± 0.059	2.334ArgGly: 2.334 ± 0.071	0.488ArgHis: 0.488 ± 0.03	3.765ArgIle: 3.765 ± 0.084	3.846ArgLys: 3.846 ± 0.088	3.826ArgLeu: 3.826 ± 0.098	0.642ArgMet: 0.642 ± 0.036	1.552ArgAsn: 1.552 ± 0.053	1.404ArgPro: 1.404 ± 0.062	0.772ArgGln: 0.772 ± 0.043	1.643ArgArg: 1.643 ± 0.062	1.427ArgSer: 1.427 ± 0.063	1.518ArgThr: 1.518 ± 0.056	2.391ArgVal: 2.391 ± 0.072	0.397ArgTrp: 0.397 ± 0.028	1.487ArgTyr: 1.487 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	3.508SerAla: 3.508 ± 0.096	0.541SerCys: 0.541 ± 0.035	1.884SerAsp: 1.884 ± 0.057	4.03SerGlu: 4.03 ± 0.091	3.781SerPhe: 3.781 ± 0.092	3.291SerGly: 3.291 ± 0.093	0.877SerHis: 0.877 ± 0.039	4.377SerIle: 4.377 ± 0.102	4.428SerLys: 4.428 ± 0.102	6.49SerLeu: 6.49 ± 0.119	0.813SerMet: 0.813 ± 0.042	1.781SerAsn: 1.781 ± 0.061	2.545SerPro: 2.545 ± 0.067	1.86SerGln: 1.86 ± 0.058	1.479SerArg: 1.479 ± 0.053	3.24SerSer: 3.24 ± 0.104	2.073SerThr: 2.073 ± 0.065	2.351SerVal: 2.351 ± 0.069	0.521SerTrp: 0.521 ± 0.034	2.375SerTyr: 2.375 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	2.389ThrAla: 2.389 ± 0.076	0.545ThrCys: 0.545 ± 0.036	1.552ThrAsp: 1.552 ± 0.062	2.839ThrGlu: 2.839 ± 0.079	2.533ThrPhe: 2.533 ± 0.073	3.408ThrGly: 3.408 ± 0.111	0.798ThrHis: 0.798 ± 0.036	3.481ThrIle: 3.481 ± 0.084	3.236ThrLys: 3.236 ± 0.074	5.321ThrLeu: 5.321 ± 0.11	0.638ThrMet: 0.638 ± 0.04	1.526ThrAsn: 1.526 ± 0.091	2.456ThrPro: 2.456 ± 0.083	1.179ThrGln: 1.179 ± 0.053	1.268ThrArg: 1.268 ± 0.051	2.413ThrSer: 2.413 ± 0.078	1.929ThrThr: 1.929 ± 0.079	2.29ThrVal: 2.29 ± 0.071	0.347ThrTrp: 0.347 ± 0.027	1.86ThrTyr: 1.86 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	3.404ValAla: 3.404 ± 0.09	0.817ValCys: 0.817 ± 0.044	2.723ValAsp: 2.723 ± 0.068	4.808ValGlu: 4.808 ± 0.098	3.179ValPhe: 3.179 ± 0.082	3.568ValGly: 3.568 ± 0.099	0.748ValHis: 0.748 ± 0.043	5.489ValIle: 5.489 ± 0.122	5.692ValLys: 5.692 ± 0.111	5.949ValLeu: 5.949 ± 0.124	0.965ValMet: 0.965 ± 0.045	2.197ValAsn: 2.197 ± 0.075	2.344ValPro: 2.344 ± 0.074	0.956ValGln: 0.956 ± 0.04	2.166ValArg: 2.166 ± 0.073	3.349ValSer: 3.349 ± 0.082	2.274ValThr: 2.274 ± 0.073	3.82ValVal: 3.82 ± 0.109	0.531ValTrp: 0.531 ± 0.031	2.288ValTyr: 2.288 ± 0.072	0.0ValXaa: 0.0 ± 0.0
Trp	0.571TrpAla: 0.571 ± 0.035	0.111TrpCys: 0.111 ± 0.017	0.541TrpAsp: 0.541 ± 0.035	1.056TrpGlu: 1.056 ± 0.042	0.486TrpPhe: 0.486 ± 0.028	0.738TrpGly: 0.738 ± 0.04	0.182TrpHis: 0.182 ± 0.018	0.92TrpIle: 0.92 ± 0.047	0.875TrpLys: 0.875 ± 0.042	0.981TrpLeu: 0.981 ± 0.047	0.158TrpMet: 0.158 ± 0.019	0.375TrpAsn: 0.375 ± 0.027	0.197TrpPro: 0.197 ± 0.028	0.294TrpGln: 0.294 ± 0.026	0.419TrpArg: 0.419 ± 0.028	0.34TrpSer: 0.34 ± 0.027	0.28TrpThr: 0.28 ± 0.026	0.59TrpVal: 0.59 ± 0.032	0.13TrpTrp: 0.13 ± 0.015	0.411TrpTyr: 0.411 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.917TyrAla: 1.917 ± 0.077	0.367TyrCys: 0.367 ± 0.028	1.475TyrAsp: 1.475 ± 0.054	3.21TyrGlu: 3.21 ± 0.087	2.971TyrPhe: 2.971 ± 0.084	2.488TyrGly: 2.488 ± 0.075	0.713TyrHis: 0.713 ± 0.041	3.151TyrIle: 3.151 ± 0.082	3.965TyrLys: 3.965 ± 0.102	5.459TyrLeu: 5.459 ± 0.124	0.559TyrMet: 0.559 ± 0.037	1.682TyrAsn: 1.682 ± 0.067	2.12TyrPro: 2.12 ± 0.065	1.36TyrGln: 1.36 ± 0.051	1.597TyrArg: 1.597 ± 0.053	2.186TyrSer: 2.186 ± 0.064	1.722TyrThr: 1.722 ± 0.056	1.984TyrVal: 1.984 ± 0.064	0.365TyrTrp: 0.365 ± 0.027	2.024TyrTyr: 2.024 ± 0.07	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1594 proteins (506494 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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