Amino acid dipepetide frequency for Changjiang picorna-like virus 9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.714AlaAla: 5.714 ± 1.224
1.319AlaCys: 1.319 ± 0.615
2.637AlaAsp: 2.637 ± 0.211
1.319AlaGlu: 1.319 ± 0.615
2.198AlaPhe: 2.198 ± 1.136
6.593AlaGly: 6.593 ± 0.194
2.198AlaHis: 2.198 ± 0.305
3.956AlaIle: 3.956 ± 0.404
7.473AlaLys: 7.473 ± 2.764
5.714AlaLeu: 5.714 ± 0.936
2.637AlaMet: 2.637 ± 1.23
3.956AlaAsn: 3.956 ± 0.316
3.956AlaPro: 3.956 ± 1.036
1.758AlaGln: 1.758 ± 0.1
5.275AlaArg: 5.275 ± 0.299
2.637AlaSer: 2.637 ± 0.211
4.396AlaThr: 4.396 ± 1.551
8.352AlaVal: 8.352 ± 1.014
0.0AlaTrp: 0.0 ± 0.0
2.198AlaTyr: 2.198 ± 0.416
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.44CysCys: 0.44 ± 0.205
1.319CysAsp: 1.319 ± 0.105
3.077CysGlu: 3.077 ± 1.435
0.879CysPhe: 0.879 ± 0.41
0.44CysGly: 0.44 ± 0.205
0.0CysHis: 0.0 ± 0.0
1.319CysIle: 1.319 ± 0.825
0.0CysLys: 0.0 ± 0.0
1.758CysLeu: 1.758 ± 0.82
0.0CysMet: 0.0 ± 0.0
0.44CysAsn: 0.44 ± 0.515
0.879CysPro: 0.879 ± 0.31
0.44CysGln: 0.44 ± 0.515
0.44CysArg: 0.44 ± 0.205
0.879CysSer: 0.879 ± 0.41
0.44CysThr: 0.44 ± 0.205
0.879CysVal: 0.879 ± 0.41
0.44CysTrp: 0.44 ± 0.205
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.198AspAla: 2.198 ± 0.305
2.198AspCys: 2.198 ± 0.416
3.516AspAsp: 3.516 ± 0.521
3.956AspGlu: 3.956 ± 0.404
4.396AspPhe: 4.396 ± 0.111
4.396AspGly: 4.396 ± 0.609
1.319AspHis: 1.319 ± 0.615
1.758AspIle: 1.758 ± 0.1
1.758AspLys: 1.758 ± 0.82
7.033AspLeu: 7.033 ± 1.839
0.44AspMet: 0.44 ± 0.515
3.956AspAsn: 3.956 ± 1.036
1.758AspPro: 1.758 ± 0.1
1.758AspGln: 1.758 ± 0.1
3.956AspArg: 3.956 ± 1.845
2.637AspSer: 2.637 ± 0.211
3.516AspThr: 3.516 ± 1.241
6.154AspVal: 6.154 ± 0.709
1.319AspTrp: 1.319 ± 0.615
3.077AspTyr: 3.077 ± 0.715
0.0AspXaa: 0.0 ± 0.0
Glu
3.077GluAla: 3.077 ± 1.435
0.879GluCys: 0.879 ± 0.41
1.758GluAsp: 1.758 ± 0.82
3.516GluGlu: 3.516 ± 1.64
2.198GluPhe: 2.198 ± 0.416
2.198GluGly: 2.198 ± 0.305
1.758GluHis: 1.758 ± 0.82
3.516GluIle: 3.516 ± 0.199
6.154GluLys: 6.154 ± 1.429
3.516GluLeu: 3.516 ± 0.92
1.319GluMet: 1.319 ± 0.105
1.758GluAsn: 1.758 ± 0.1
1.319GluPro: 1.319 ± 0.615
3.077GluGln: 3.077 ± 1.435
1.758GluArg: 1.758 ± 0.82
3.077GluSer: 3.077 ± 0.726
1.758GluThr: 1.758 ± 0.82
3.956GluVal: 3.956 ± 0.316
0.0GluTrp: 0.0 ± 0.0
3.077GluTyr: 3.077 ± 1.435
0.0GluXaa: 0.0 ± 0.0
Phe
5.275PheAla: 5.275 ± 1.141
0.44PheCys: 0.44 ± 0.515
2.637PheAsp: 2.637 ± 0.211
1.319PheGlu: 1.319 ± 0.105
3.516PhePhe: 3.516 ± 0.92
3.956PheGly: 3.956 ± 0.316
1.758PheHis: 1.758 ± 0.1
2.198PheIle: 2.198 ± 0.416
1.758PheLys: 1.758 ± 0.1
7.033PheLeu: 7.033 ± 1.762
2.637PheMet: 2.637 ± 1.23
0.44PheAsn: 0.44 ± 0.205
1.319PhePro: 1.319 ± 0.105
1.319PheGln: 1.319 ± 0.615
3.956PheArg: 3.956 ± 1.756
3.956PheSer: 3.956 ± 0.316
1.758PheThr: 1.758 ± 0.1
3.077PheVal: 3.077 ± 0.726
0.879PheTrp: 0.879 ± 0.31
1.319PheTyr: 1.319 ± 0.105
0.0PheXaa: 0.0 ± 0.0
Gly
4.835GlyAla: 4.835 ± 0.814
0.44GlyCys: 0.44 ± 0.205
4.835GlyAsp: 4.835 ± 0.814
3.077GlyGlu: 3.077 ± 0.006
3.956GlyPhe: 3.956 ± 1.036
5.714GlyGly: 5.714 ± 1.656
0.879GlyHis: 0.879 ± 0.41
3.077GlyIle: 3.077 ± 1.446
4.835GlyLys: 4.835 ± 0.814
6.593GlyLeu: 6.593 ± 1.247
0.879GlyMet: 0.879 ± 0.41
2.198GlyAsn: 2.198 ± 1.136
3.516GlyPro: 3.516 ± 0.521
2.637GlyGln: 2.637 ± 0.51
3.516GlyArg: 3.516 ± 0.92
3.516GlySer: 3.516 ± 1.241
4.396GlyThr: 4.396 ± 0.831
7.473GlyVal: 7.473 ± 0.604
0.0GlyTrp: 0.0 ± 0.0
2.198GlyTyr: 2.198 ± 1.856
0.0GlyXaa: 0.0 ± 0.0
His
0.879HisAla: 0.879 ± 0.31
0.44HisCys: 0.44 ± 0.205
1.758HisAsp: 1.758 ± 0.82
0.44HisGlu: 0.44 ± 0.205
2.198HisPhe: 2.198 ± 0.305
1.319HisGly: 1.319 ± 0.825
0.879HisHis: 0.879 ± 0.31
1.758HisIle: 1.758 ± 0.1
1.758HisLys: 1.758 ± 0.82
2.198HisLeu: 2.198 ± 0.416
1.319HisMet: 1.319 ± 0.105
0.44HisAsn: 0.44 ± 0.205
1.319HisPro: 1.319 ± 0.615
0.0HisGln: 0.0 ± 0.0
1.319HisArg: 1.319 ± 0.105
0.44HisSer: 0.44 ± 0.205
3.516HisThr: 3.516 ± 1.64
0.44HisVal: 0.44 ± 0.515
0.0HisTrp: 0.0 ± 0.0
0.879HisTyr: 0.879 ± 1.03
0.0HisXaa: 0.0 ± 0.0
Ile
2.198IleAla: 2.198 ± 0.305
2.198IleCys: 2.198 ± 0.416
3.516IleAsp: 3.516 ± 0.199
2.198IleGlu: 2.198 ± 0.305
1.319IlePhe: 1.319 ± 0.105
4.396IleGly: 4.396 ± 2.992
1.758IleHis: 1.758 ± 0.1
2.198IleIle: 2.198 ± 0.305
0.44IleLys: 0.44 ± 0.205
6.593IleLeu: 6.593 ± 0.194
0.44IleMet: 0.44 ± 0.515
2.637IleAsn: 2.637 ± 0.51
3.516IlePro: 3.516 ± 1.961
0.44IleGln: 0.44 ± 0.205
1.758IleArg: 1.758 ± 0.1
4.835IleSer: 4.835 ± 0.094
2.198IleThr: 2.198 ± 0.416
2.198IleVal: 2.198 ± 0.416
0.44IleTrp: 0.44 ± 0.205
1.758IleTyr: 1.758 ± 0.1
0.0IleXaa: 0.0 ± 0.0
Lys
4.396LysAla: 4.396 ± 0.609
0.44LysCys: 0.44 ± 0.205
4.396LysAsp: 4.396 ± 2.05
3.077LysGlu: 3.077 ± 0.006
2.637LysPhe: 2.637 ± 0.51
4.396LysGly: 4.396 ± 2.05
2.198LysHis: 2.198 ± 0.305
2.637LysIle: 2.637 ± 0.211
3.077LysLys: 3.077 ± 1.435
7.473LysLeu: 7.473 ± 3.485
1.319LysMet: 1.319 ± 0.105
0.879LysAsn: 0.879 ± 0.41
2.637LysPro: 2.637 ± 0.931
1.758LysGln: 1.758 ± 0.62
3.956LysArg: 3.956 ± 1.125
2.198LysSer: 2.198 ± 1.025
3.077LysThr: 3.077 ± 0.715
2.637LysVal: 2.637 ± 0.51
0.879LysTrp: 0.879 ± 0.41
1.758LysTyr: 1.758 ± 0.62
0.0LysXaa: 0.0 ± 0.0
Leu
6.593LeuAla: 6.593 ± 0.914
1.758LeuCys: 1.758 ± 0.82
5.714LeuAsp: 5.714 ± 1.945
7.473LeuGlu: 7.473 ± 2.044
3.077LeuPhe: 3.077 ± 0.726
7.033LeuGly: 7.033 ± 1.119
2.637LeuHis: 2.637 ± 0.211
5.275LeuIle: 5.275 ± 1.019
5.275LeuLys: 5.275 ± 0.421
6.593LeuLeu: 6.593 ± 0.914
3.077LeuMet: 3.077 ± 0.715
4.396LeuAsn: 4.396 ± 0.609
5.275LeuPro: 5.275 ± 2.582
2.637LeuGln: 2.637 ± 0.51
4.835LeuArg: 4.835 ± 0.814
5.275LeuSer: 5.275 ± 0.299
6.593LeuThr: 6.593 ± 0.914
3.956LeuVal: 3.956 ± 0.404
3.516LeuTrp: 3.516 ± 0.199
2.198LeuTyr: 2.198 ± 0.305
0.0LeuXaa: 0.0 ± 0.0
Met
2.198MetAla: 2.198 ± 0.305
0.0MetCys: 0.0 ± 0.0
1.319MetAsp: 1.319 ± 0.825
2.198MetGlu: 2.198 ± 0.305
1.319MetPhe: 1.319 ± 0.105
0.879MetGly: 0.879 ± 0.41
1.319MetHis: 1.319 ± 0.615
1.319MetIle: 1.319 ± 1.546
0.879MetLys: 0.879 ± 0.41
1.758MetLeu: 1.758 ± 0.82
0.44MetMet: 0.44 ± 0.515
0.879MetAsn: 0.879 ± 0.41
0.879MetPro: 0.879 ± 0.41
1.758MetGln: 1.758 ± 0.1
1.758MetArg: 1.758 ± 0.1
1.758MetSer: 1.758 ± 0.1
0.879MetThr: 0.879 ± 0.41
3.077MetVal: 3.077 ± 0.726
0.44MetTrp: 0.44 ± 0.205
1.758MetTyr: 1.758 ± 0.62
0.0MetXaa: 0.0 ± 0.0
Asn
3.956AsnAla: 3.956 ± 1.125
0.0AsnCys: 0.0 ± 0.0
1.758AsnAsp: 1.758 ± 0.1
0.0AsnGlu: 0.0 ± 0.0
1.758AsnPhe: 1.758 ± 0.1
3.077AsnGly: 3.077 ± 0.006
0.879AsnHis: 0.879 ± 0.31
0.44AsnIle: 0.44 ± 0.205
2.637AsnLys: 2.637 ± 0.51
3.956AsnLeu: 3.956 ± 0.404
0.879AsnMet: 0.879 ± 0.41
2.637AsnAsn: 2.637 ± 1.651
1.758AsnPro: 1.758 ± 1.341
2.637AsnGln: 2.637 ± 1.651
1.319AsnArg: 1.319 ± 0.105
3.956AsnSer: 3.956 ± 1.125
1.758AsnThr: 1.758 ± 0.62
4.835AsnVal: 4.835 ± 1.346
1.319AsnTrp: 1.319 ± 0.825
0.44AsnTyr: 0.44 ± 0.205
0.0AsnXaa: 0.0 ± 0.0
Pro
7.473ProAla: 7.473 ± 2.997
0.879ProCys: 0.879 ± 0.41
2.637ProAsp: 2.637 ± 0.931
1.319ProGlu: 1.319 ± 0.105
1.758ProPhe: 1.758 ± 2.061
1.319ProGly: 1.319 ± 0.615
0.879ProHis: 0.879 ± 0.41
1.758ProIle: 1.758 ± 0.82
0.44ProLys: 0.44 ± 0.205
6.154ProLeu: 6.154 ± 1.451
1.758ProMet: 1.758 ± 0.1
1.319ProAsn: 1.319 ± 0.105
1.758ProPro: 1.758 ± 2.061
0.879ProGln: 0.879 ± 0.31
3.077ProArg: 3.077 ± 0.006
3.956ProSer: 3.956 ± 3.197
1.319ProThr: 1.319 ± 0.825
8.352ProVal: 8.352 ± 1.867
0.879ProTrp: 0.879 ± 0.31
3.956ProTyr: 3.956 ± 1.036
0.0ProXaa: 0.0 ± 0.0
Gln
2.637GlnAla: 2.637 ± 0.51
0.44GlnCys: 0.44 ± 0.205
3.077GlnAsp: 3.077 ± 0.006
1.758GlnGlu: 1.758 ± 0.82
0.879GlnPhe: 0.879 ± 0.41
2.198GlnGly: 2.198 ± 1.136
0.0GlnHis: 0.0 ± 0.0
1.758GlnIle: 1.758 ± 0.62
2.198GlnLys: 2.198 ± 0.305
3.956GlnLeu: 3.956 ± 0.316
0.44GlnMet: 0.44 ± 0.515
0.0GlnAsn: 0.0 ± 0.0
1.758GlnPro: 1.758 ± 1.341
1.319GlnGln: 1.319 ± 0.105
1.758GlnArg: 1.758 ± 0.1
4.396GlnSer: 4.396 ± 0.111
1.758GlnThr: 1.758 ± 0.82
2.637GlnVal: 2.637 ± 0.211
0.44GlnTrp: 0.44 ± 0.205
0.879GlnTyr: 0.879 ± 1.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.077ArgAla: 3.077 ± 1.435
0.0ArgCys: 0.0 ± 0.0
4.396ArgAsp: 4.396 ± 1.33
2.198ArgGlu: 2.198 ± 1.025
3.516ArgPhe: 3.516 ± 0.521
3.077ArgGly: 3.077 ± 1.446
1.319ArgHis: 1.319 ± 0.615
0.879ArgIle: 0.879 ± 0.31
2.198ArgLys: 2.198 ± 0.305
5.714ArgLeu: 5.714 ± 1.224
3.077ArgMet: 3.077 ± 0.726
2.637ArgAsn: 2.637 ± 0.51
2.637ArgPro: 2.637 ± 0.51
1.758ArgGln: 1.758 ± 0.62
4.396ArgArg: 4.396 ± 1.33
4.396ArgSer: 4.396 ± 1.33
3.077ArgThr: 3.077 ± 0.006
3.516ArgVal: 3.516 ± 0.199
0.44ArgTrp: 0.44 ± 0.205
2.198ArgTyr: 2.198 ± 1.136
0.0ArgXaa: 0.0 ± 0.0
Ser
5.714SerAla: 5.714 ± 0.216
0.0SerCys: 0.0 ± 0.0
5.275SerAsp: 5.275 ± 1.141
3.077SerGlu: 3.077 ± 0.715
4.396SerPhe: 4.396 ± 0.609
5.275SerGly: 5.275 ± 0.421
0.879SerHis: 0.879 ± 0.31
3.516SerIle: 3.516 ± 1.961
6.154SerLys: 6.154 ± 2.15
4.835SerLeu: 4.835 ± 0.094
1.319SerMet: 1.319 ± 0.395
2.637SerAsn: 2.637 ± 0.931
3.956SerPro: 3.956 ± 0.316
0.44SerGln: 0.44 ± 0.515
4.396SerArg: 4.396 ± 0.111
5.275SerSer: 5.275 ± 1.141
3.956SerThr: 3.956 ± 1.756
4.396SerVal: 4.396 ± 0.111
0.0SerTrp: 0.0 ± 0.0
3.077SerTyr: 3.077 ± 0.726
0.0SerXaa: 0.0 ± 0.0
Thr
3.956ThrAla: 3.956 ± 0.316
0.0ThrCys: 0.0 ± 0.0
2.637ThrAsp: 2.637 ± 0.931
1.319ThrGlu: 1.319 ± 0.615
4.396ThrPhe: 4.396 ± 0.111
3.956ThrGly: 3.956 ± 0.316
0.0ThrHis: 0.0 ± 0.0
3.516ThrIle: 3.516 ± 0.92
2.637ThrLys: 2.637 ± 0.51
6.154ThrLeu: 6.154 ± 2.87
1.319ThrMet: 1.319 ± 0.105
2.637ThrAsn: 2.637 ± 0.931
5.275ThrPro: 5.275 ± 1.141
2.637ThrGln: 2.637 ± 0.211
0.879ThrArg: 0.879 ± 0.31
6.593ThrSer: 6.593 ± 1.247
2.198ThrThr: 2.198 ± 1.136
3.516ThrVal: 3.516 ± 0.521
0.0ThrTrp: 0.0 ± 0.0
2.198ThrTyr: 2.198 ± 1.136
0.0ThrXaa: 0.0 ± 0.0
Val
7.912ValAla: 7.912 ± 0.632
0.879ValCys: 0.879 ± 0.41
4.835ValAsp: 4.835 ± 0.814
5.714ValGlu: 5.714 ± 1.224
2.637ValPhe: 2.637 ± 0.51
4.835ValGly: 4.835 ± 0.626
1.758ValHis: 1.758 ± 1.341
3.077ValIle: 3.077 ± 0.726
3.516ValLys: 3.516 ± 0.199
3.516ValLeu: 3.516 ± 1.64
1.758ValMet: 1.758 ± 0.1
3.077ValAsn: 3.077 ± 0.715
5.275ValPro: 5.275 ± 2.582
4.835ValGln: 4.835 ± 2.066
3.956ValArg: 3.956 ± 0.404
4.835ValSer: 4.835 ± 2.787
6.154ValThr: 6.154 ± 0.011
5.714ValVal: 5.714 ± 0.504
1.758ValTrp: 1.758 ± 0.82
2.198ValTyr: 2.198 ± 1.025
0.0ValXaa: 0.0 ± 0.0
Trp
0.879TrpAla: 0.879 ± 0.41
0.44TrpCys: 0.44 ± 0.515
1.319TrpAsp: 1.319 ± 0.615
1.758TrpGlu: 1.758 ± 0.82
1.319TrpPhe: 1.319 ± 1.546
0.44TrpGly: 0.44 ± 0.205
0.44TrpHis: 0.44 ± 0.515
1.319TrpIle: 1.319 ± 0.615
0.44TrpLys: 0.44 ± 0.205
0.44TrpLeu: 0.44 ± 0.205
0.0TrpMet: 0.0 ± 0.0
0.879TrpAsn: 0.879 ± 0.41
0.44TrpPro: 0.44 ± 0.515
0.879TrpGln: 0.879 ± 0.41
0.44TrpArg: 0.44 ± 0.515
0.879TrpSer: 0.879 ± 0.41
0.44TrpThr: 0.44 ± 0.205
0.44TrpVal: 0.44 ± 0.515
0.0TrpTrp: 0.0 ± 0.0
1.319TrpTyr: 1.319 ± 0.615
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.319TyrAla: 1.319 ± 0.825
0.879TyrCys: 0.879 ± 0.41
1.758TyrAsp: 1.758 ± 0.1
0.879TyrGlu: 0.879 ± 0.31
2.198TyrPhe: 2.198 ± 0.416
3.077TyrGly: 3.077 ± 1.446
0.44TyrHis: 0.44 ± 0.205
1.758TyrIle: 1.758 ± 0.62
2.198TyrLys: 2.198 ± 0.416
2.198TyrLeu: 2.198 ± 0.305
1.319TyrMet: 1.319 ± 0.265
2.198TyrAsn: 2.198 ± 1.136
2.637TyrPro: 2.637 ± 0.211
1.319TyrGln: 1.319 ± 0.615
1.758TyrArg: 1.758 ± 0.1
3.516TyrSer: 3.516 ± 0.521
2.637TyrThr: 2.637 ± 0.931
2.637TyrVal: 2.637 ± 0.51
1.758TyrTrp: 1.758 ± 0.62
1.319TyrTyr: 1.319 ± 0.615
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski