Amino acid dipepetide frequency for Streptomyces sp. A7024

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.223AlaAla: 24.223 ± 0.148	1.031AlaCys: 1.031 ± 0.022	8.786AlaAsp: 8.786 ± 0.076	9.393AlaGlu: 9.393 ± 0.081	3.517AlaPhe: 3.517 ± 0.042	14.182AlaGly: 14.182 ± 0.088	2.645AlaHis: 2.645 ± 0.034	4.029AlaIle: 4.029 ± 0.042	3.349AlaLys: 3.349 ± 0.052	14.501AlaLeu: 14.501 ± 0.104	2.657AlaMet: 2.657 ± 0.032	1.984AlaAsn: 1.984 ± 0.03	6.997AlaPro: 6.997 ± 0.057	3.697AlaGln: 3.697 ± 0.04	9.788AlaArg: 9.788 ± 0.083	5.48AlaSer: 5.48 ± 0.049	7.008AlaThr: 7.008 ± 0.055	12.032AlaVal: 12.032 ± 0.08	1.864AlaTrp: 1.864 ± 0.032	3.021AlaTyr: 3.021 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.02	0.087CysCys: 0.087 ± 0.006	0.455CysAsp: 0.455 ± 0.015	0.379CysGlu: 0.379 ± 0.012	0.222CysPhe: 0.222 ± 0.01	0.953CysGly: 0.953 ± 0.02	0.192CysHis: 0.192 ± 0.008	0.187CysIle: 0.187 ± 0.009	0.125CysLys: 0.125 ± 0.007	0.691CysLeu: 0.691 ± 0.018	0.119CysMet: 0.119 ± 0.006	0.125CysAsn: 0.125 ± 0.007	0.447CysPro: 0.447 ± 0.014	0.147CysGln: 0.147 ± 0.007	0.557CysArg: 0.557 ± 0.014	0.384CysSer: 0.384 ± 0.013	0.504CysThr: 0.504 ± 0.013	0.568CysVal: 0.568 ± 0.015	0.123CysTrp: 0.123 ± 0.006	0.166CysTyr: 0.166 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.959AspAla: 7.959 ± 0.062	0.424AspCys: 0.424 ± 0.012	3.786AspAsp: 3.786 ± 0.046	3.942AspGlu: 3.942 ± 0.04	1.785AspPhe: 1.785 ± 0.027	6.591AspGly: 6.591 ± 0.064	1.359AspHis: 1.359 ± 0.025	1.977AspIle: 1.977 ± 0.028	1.445AspLys: 1.445 ± 0.026	6.036AspLeu: 6.036 ± 0.051	0.841AspMet: 0.841 ± 0.018	0.934AspAsn: 0.934 ± 0.021	4.462AspPro: 4.462 ± 0.044	1.581AspGln: 1.581 ± 0.027	4.755AspArg: 4.755 ± 0.055	2.446AspSer: 2.446 ± 0.029	3.075AspThr: 3.075 ± 0.041	4.549AspVal: 4.549 ± 0.045	1.06AspTrp: 1.06 ± 0.023	1.253AspTyr: 1.253 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.551GluAla: 7.551 ± 0.072	0.334GluCys: 0.334 ± 0.011	2.815GluAsp: 2.815 ± 0.035	3.411GluGlu: 3.411 ± 0.04	1.43GluPhe: 1.43 ± 0.024	4.371GluGly: 4.371 ± 0.038	1.53GluHis: 1.53 ± 0.024	2.168GluIle: 2.168 ± 0.032	1.593GluLys: 1.593 ± 0.031	7.359GluLeu: 7.359 ± 0.061	0.901GluMet: 0.901 ± 0.019	0.989GluAsn: 0.989 ± 0.022	3.494GluPro: 3.494 ± 0.04	2.339GluGln: 2.339 ± 0.033	5.481GluArg: 5.481 ± 0.05	2.611GluSer: 2.611 ± 0.033	2.805GluThr: 2.805 ± 0.035	4.467GluVal: 4.467 ± 0.049	0.818GluTrp: 0.818 ± 0.019	1.144GluTyr: 1.144 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.934PheAla: 3.934 ± 0.035	0.262PheCys: 0.262 ± 0.01	1.874PheAsp: 1.874 ± 0.028	1.406PheGlu: 1.406 ± 0.022	0.941PhePhe: 0.941 ± 0.021	3.096PheGly: 3.096 ± 0.043	0.603PheHis: 0.603 ± 0.017	0.855PheIle: 0.855 ± 0.022	0.61PheLys: 0.61 ± 0.017	2.557PheLeu: 2.557 ± 0.031	0.432PheMet: 0.432 ± 0.012	0.634PheAsn: 0.634 ± 0.017	1.384PhePro: 1.384 ± 0.02	0.654PheGln: 0.654 ± 0.015	1.825PheArg: 1.825 ± 0.025	1.453PheSer: 1.453 ± 0.023	2.112PheThr: 2.112 ± 0.03	2.033PheVal: 2.033 ± 0.031	0.435PheTrp: 0.435 ± 0.012	0.635PheTyr: 0.635 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.585GlyAla: 11.585 ± 0.078	0.838GlyCys: 0.838 ± 0.02	5.428GlyAsp: 5.428 ± 0.057	5.475GlyGlu: 5.475 ± 0.05	2.978GlyPhe: 2.978 ± 0.039	9.38GlyGly: 9.38 ± 0.095	2.129GlyHis: 2.129 ± 0.028	3.662GlyIle: 3.662 ± 0.04	2.924GlyLys: 2.924 ± 0.039	9.593GlyLeu: 9.593 ± 0.063	2.132GlyMet: 2.132 ± 0.034	1.801GlyAsn: 1.801 ± 0.027	5.119GlyPro: 5.119 ± 0.051	2.737GlyGln: 2.737 ± 0.038	7.572GlyArg: 7.572 ± 0.053	5.348GlySer: 5.348 ± 0.057	5.906GlyThr: 5.906 ± 0.057	7.448GlyVal: 7.448 ± 0.061	1.784GlyTrp: 1.784 ± 0.031	2.538GlyTyr: 2.538 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.624HisAla: 2.624 ± 0.034	0.204HisCys: 0.204 ± 0.009	1.321HisAsp: 1.321 ± 0.025	1.178HisGlu: 1.178 ± 0.022	0.659HisPhe: 0.659 ± 0.016	2.257HisGly: 2.257 ± 0.029	0.666HisHis: 0.666 ± 0.018	0.69HisIle: 0.69 ± 0.017	0.355HisLys: 0.355 ± 0.013	2.338HisLeu: 2.338 ± 0.031	0.3HisMet: 0.3 ± 0.011	0.398HisAsn: 0.398 ± 0.012	1.75HisPro: 1.75 ± 0.023	0.619HisGln: 0.619 ± 0.015	1.964HisArg: 1.964 ± 0.028	0.897HisSer: 0.897 ± 0.018	1.236HisThr: 1.236 ± 0.022	1.52HisVal: 1.52 ± 0.024	0.386HisTrp: 0.386 ± 0.012	0.507HisTyr: 0.507 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.319IleAla: 5.319 ± 0.054	0.303IleCys: 0.303 ± 0.01	2.274IleAsp: 2.274 ± 0.029	2.032IleGlu: 2.032 ± 0.029	0.861IlePhe: 0.861 ± 0.02	3.805IleGly: 3.805 ± 0.045	0.641IleHis: 0.641 ± 0.013	0.983IleIle: 0.983 ± 0.023	0.894IleLys: 0.894 ± 0.018	2.512IleLeu: 2.512 ± 0.032	0.492IleMet: 0.492 ± 0.016	0.725IleAsn: 0.725 ± 0.018	1.94IlePro: 1.94 ± 0.03	0.731IleGln: 0.731 ± 0.017	2.336IleArg: 2.336 ± 0.028	1.784IleSer: 1.784 ± 0.03	2.298IleThr: 2.298 ± 0.028	2.715IleVal: 2.715 ± 0.029	0.438IleTrp: 0.438 ± 0.013	0.613IleTyr: 0.613 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.318LysAla: 3.318 ± 0.043	0.123LysCys: 0.123 ± 0.007	1.591LysAsp: 1.591 ± 0.035	1.352LysGlu: 1.352 ± 0.026	0.532LysPhe: 0.532 ± 0.016	2.058LysGly: 2.058 ± 0.038	0.502LysHis: 0.502 ± 0.015	0.948LysIle: 0.948 ± 0.024	1.095LysLys: 1.095 ± 0.035	2.373LysLeu: 2.373 ± 0.035	0.434LysMet: 0.434 ± 0.014	0.568LysAsn: 0.568 ± 0.019	1.637LysPro: 1.637 ± 0.029	0.883LysGln: 0.883 ± 0.019	1.606LysArg: 1.606 ± 0.03	1.314LysSer: 1.314 ± 0.026	1.443LysThr: 1.443 ± 0.029	2.12LysVal: 2.12 ± 0.036	0.343LysTrp: 0.343 ± 0.013	0.537LysTyr: 0.537 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.581LeuAla: 15.581 ± 0.092	0.789LeuCys: 0.789 ± 0.017	6.55LeuAsp: 6.55 ± 0.052	4.706LeuGlu: 4.706 ± 0.048	2.699LeuPhe: 2.699 ± 0.038	9.451LeuGly: 9.451 ± 0.079	2.267LeuHis: 2.267 ± 0.032	3.605LeuIle: 3.605 ± 0.048	2.29LeuLys: 2.29 ± 0.035	11.444LeuLeu: 11.444 ± 0.095	1.649LeuMet: 1.649 ± 0.028	1.771LeuAsn: 1.771 ± 0.032	6.533LeuPro: 6.533 ± 0.053	2.403LeuGln: 2.403 ± 0.029	8.533LeuArg: 8.533 ± 0.077	5.138LeuSer: 5.138 ± 0.051	6.808LeuThr: 6.808 ± 0.056	8.12LeuVal: 8.12 ± 0.062	1.293LeuTrp: 1.293 ± 0.025	1.894LeuTyr: 1.894 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.375MetAla: 2.375 ± 0.032	0.132MetCys: 0.132 ± 0.007	0.916MetAsp: 0.916 ± 0.02	0.753MetGlu: 0.753 ± 0.017	0.458MetPhe: 0.458 ± 0.014	1.375MetGly: 1.375 ± 0.023	0.367MetHis: 0.367 ± 0.01	0.71MetIle: 0.71 ± 0.016	0.463MetLys: 0.463 ± 0.014	1.806MetLeu: 1.806 ± 0.029	0.336MetMet: 0.336 ± 0.012	0.409MetAsn: 0.409 ± 0.014	1.161MetPro: 1.161 ± 0.022	0.471MetGln: 0.471 ± 0.013	1.42MetArg: 1.42 ± 0.023	1.254MetSer: 1.254 ± 0.021	1.568MetThr: 1.568 ± 0.024	1.283MetVal: 1.283 ± 0.021	0.233MetTrp: 0.233 ± 0.009	0.357MetTyr: 0.357 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.192AsnAla: 2.192 ± 0.032	0.16AsnCys: 0.16 ± 0.009	1.012AsnAsp: 1.012 ± 0.018	0.835AsnGlu: 0.835 ± 0.018	0.526AsnPhe: 0.526 ± 0.016	1.925AsnGly: 1.925 ± 0.029	0.393AsnHis: 0.393 ± 0.013	0.678AsnIle: 0.678 ± 0.017	0.485AsnLys: 0.485 ± 0.016	1.649AsnLeu: 1.649 ± 0.025	0.299AsnMet: 0.299 ± 0.011	0.459AsnAsn: 0.459 ± 0.015	1.403AsnPro: 1.403 ± 0.024	0.476AsnGln: 0.476 ± 0.016	1.234AsnArg: 1.234 ± 0.022	0.916AsnSer: 0.916 ± 0.021	1.089AsnThr: 1.089 ± 0.024	1.358AsnVal: 1.358 ± 0.024	0.303AsnTrp: 0.303 ± 0.011	0.446AsnTyr: 0.446 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.728ProAla: 8.728 ± 0.074	0.288ProCys: 0.288 ± 0.011	4.56ProAsp: 4.56 ± 0.043	4.486ProGlu: 4.486 ± 0.048	1.484ProPhe: 1.484 ± 0.022	6.6ProGly: 6.6 ± 0.05	1.302ProHis: 1.302 ± 0.022	1.315ProIle: 1.315 ± 0.021	1.452ProLys: 1.452 ± 0.027	5.279ProLeu: 5.279 ± 0.046	1.041ProMet: 1.041 ± 0.02	0.925ProAsn: 0.925 ± 0.019	3.568ProPro: 3.568 ± 0.049	1.763ProGln: 1.763 ± 0.027	3.784ProArg: 3.784 ± 0.042	2.825ProSer: 2.825 ± 0.038	2.865ProThr: 2.865 ± 0.031	5.227ProVal: 5.227 ± 0.042	0.901ProTrp: 0.901 ± 0.019	1.518ProTyr: 1.518 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.76GlnAla: 3.76 ± 0.044	0.171GlnCys: 0.171 ± 0.007	1.389GlnAsp: 1.389 ± 0.022	1.484GlnGlu: 1.484 ± 0.024	0.689GlnPhe: 0.689 ± 0.016	2.232GlnGly: 2.232 ± 0.036	0.676GlnHis: 0.676 ± 0.017	1.072GlnIle: 1.072 ± 0.02	0.659GlnLys: 0.659 ± 0.02	3.335GlnLeu: 3.335 ± 0.038	0.488GlnMet: 0.488 ± 0.015	0.502GlnAsn: 0.502 ± 0.013	1.843GlnPro: 1.843 ± 0.031	1.352GlnGln: 1.352 ± 0.026	2.419GlnArg: 2.419 ± 0.032	1.247GlnSer: 1.247 ± 0.022	1.286GlnThr: 1.286 ± 0.023	2.353GlnVal: 2.353 ± 0.031	0.457GlnTrp: 0.457 ± 0.012	0.602GlnTyr: 0.602 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.564ArgAla: 9.564 ± 0.087	0.547ArgCys: 0.547 ± 0.016	4.267ArgAsp: 4.267 ± 0.043	4.731ArgGlu: 4.731 ± 0.042	2.184ArgPhe: 2.184 ± 0.031	5.839ArgGly: 5.839 ± 0.05	1.951ArgHis: 1.951 ± 0.027	3.359ArgIle: 3.359 ± 0.038	1.861ArgLys: 1.861 ± 0.03	8.61ArgLeu: 8.61 ± 0.093	1.733ArgMet: 1.733 ± 0.022	1.356ArgAsn: 1.356 ± 0.022	4.589ArgPro: 4.589 ± 0.049	2.304ArgGln: 2.304 ± 0.031	7.408ArgArg: 7.408 ± 0.077	3.707ArgSer: 3.707 ± 0.036	5.136ArgThr: 5.136 ± 0.053	5.322ArgVal: 5.322 ± 0.049	1.372ArgTrp: 1.372 ± 0.026	1.858ArgTyr: 1.858 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.499SerAla: 6.499 ± 0.06	0.36SerCys: 0.36 ± 0.012	2.618SerAsp: 2.618 ± 0.035	2.304SerGlu: 2.304 ± 0.032	1.534SerPhe: 1.534 ± 0.023	5.897SerGly: 5.897 ± 0.054	0.927SerHis: 0.927 ± 0.021	1.462SerIle: 1.462 ± 0.025	1.158SerLys: 1.158 ± 0.025	4.566SerLeu: 4.566 ± 0.044	1.055SerMet: 1.055 ± 0.018	0.853SerAsn: 0.853 ± 0.018	2.907SerPro: 2.907 ± 0.034	1.187SerGln: 1.187 ± 0.021	3.455SerArg: 3.455 ± 0.035	2.569SerSer: 2.569 ± 0.037	2.736SerThr: 2.736 ± 0.033	3.918SerVal: 3.918 ± 0.038	0.895SerTrp: 0.895 ± 0.019	1.282SerTyr: 1.282 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.689ThrAla: 8.689 ± 0.072	0.385ThrCys: 0.385 ± 0.013	3.567ThrAsp: 3.567 ± 0.036	3.17ThrGlu: 3.17 ± 0.038	1.617ThrPhe: 1.617 ± 0.025	6.58ThrGly: 6.58 ± 0.053	1.141ThrHis: 1.141 ± 0.021	1.822ThrIle: 1.822 ± 0.028	1.32ThrLys: 1.32 ± 0.026	5.517ThrLeu: 5.517 ± 0.045	0.962ThrMet: 0.962 ± 0.019	0.994ThrAsn: 0.994 ± 0.022	3.85ThrPro: 3.85 ± 0.045	1.348ThrGln: 1.348 ± 0.027	3.663ThrArg: 3.663 ± 0.033	2.934ThrSer: 2.934 ± 0.036	3.578ThrThr: 3.578 ± 0.044	5.446ThrVal: 5.446 ± 0.047	0.906ThrTrp: 0.906 ± 0.02	1.367ThrTyr: 1.367 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	10.532ValAla: 10.532 ± 0.08	0.711ValCys: 0.711 ± 0.016	4.546ValAsp: 4.546 ± 0.039	4.355ValGlu: 4.355 ± 0.048	2.393ValPhe: 2.393 ± 0.035	6.184ValGly: 6.184 ± 0.057	1.776ValHis: 1.776 ± 0.029	3.086ValIle: 3.086 ± 0.038	1.874ValLys: 1.874 ± 0.033	9.31ValLeu: 9.31 ± 0.077	1.384ValMet: 1.384 ± 0.021	1.589ValAsn: 1.589 ± 0.025	4.883ValPro: 4.883 ± 0.046	2.036ValGln: 2.036 ± 0.032	6.652ValArg: 6.652 ± 0.06	4.035ValSer: 4.035 ± 0.04	5.208ValThr: 5.208 ± 0.044	7.236ValVal: 7.236 ± 0.078	1.118ValTrp: 1.118 ± 0.022	1.59ValTyr: 1.59 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.67TrpAla: 1.67 ± 0.028	0.148TrpCys: 0.148 ± 0.007	0.871TrpAsp: 0.871 ± 0.019	0.774TrpGlu: 0.774 ± 0.017	0.517TrpPhe: 0.517 ± 0.015	1.092TrpGly: 1.092 ± 0.021	0.387TrpHis: 0.387 ± 0.013	0.581TrpIle: 0.581 ± 0.015	0.396TrpLys: 0.396 ± 0.012	1.876TrpLeu: 1.876 ± 0.029	0.311TrpMet: 0.311 ± 0.011	0.395TrpAsn: 0.395 ± 0.014	0.811TrpPro: 0.811 ± 0.017	0.671TrpGln: 0.671 ± 0.017	1.34TrpArg: 1.34 ± 0.025	0.921TrpSer: 0.921 ± 0.022	0.995TrpThr: 0.995 ± 0.018	0.99TrpVal: 0.99 ± 0.02	0.353TrpTrp: 0.353 ± 0.012	0.362TrpTyr: 0.362 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.038TyrAla: 3.038 ± 0.035	0.177TyrCys: 0.177 ± 0.008	1.631TyrAsp: 1.631 ± 0.028	1.446TyrGlu: 1.446 ± 0.024	0.711TyrPhe: 0.711 ± 0.017	2.51TyrGly: 2.51 ± 0.034	0.413TyrHis: 0.413 ± 0.013	0.506TyrIle: 0.506 ± 0.014	0.43TyrLys: 0.43 ± 0.015	2.171TyrLeu: 2.171 ± 0.031	0.279TyrMet: 0.279 ± 0.009	0.427TyrAsn: 0.427 ± 0.014	1.133TyrPro: 1.133 ± 0.02	0.618TyrGln: 0.618 ± 0.015	1.904TyrArg: 1.904 ± 0.028	0.918TyrSer: 0.918 ± 0.02	1.199TyrThr: 1.199 ± 0.024	1.794TyrVal: 1.794 ± 0.027	0.381TyrTrp: 0.381 ± 0.013	0.498TyrTyr: 0.498 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8226 proteins (2696956 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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