Amino acid dipepetide frequency for Thalassobacillus cyri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.343AlaAla: 6.343 ± 0.092
0.602AlaCys: 0.602 ± 0.025
3.864AlaAsp: 3.864 ± 0.058
5.094AlaGlu: 5.094 ± 0.066
3.472AlaPhe: 3.472 ± 0.063
5.972AlaGly: 5.972 ± 0.083
1.285AlaHis: 1.285 ± 0.031
5.89AlaIle: 5.89 ± 0.079
4.503AlaLys: 4.503 ± 0.078
7.069AlaLeu: 7.069 ± 0.096
2.263AlaMet: 2.263 ± 0.046
2.659AlaAsn: 2.659 ± 0.048
2.319AlaPro: 2.319 ± 0.046
2.31AlaGln: 2.31 ± 0.05
2.746AlaArg: 2.746 ± 0.048
4.27AlaSer: 4.27 ± 0.072
3.525AlaThr: 3.525 ± 0.055
5.69AlaVal: 5.69 ± 0.079
0.726AlaTrp: 0.726 ± 0.026
2.491AlaTyr: 2.491 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.381CysAla: 0.381 ± 0.021
0.083CysCys: 0.083 ± 0.009
0.355CysAsp: 0.355 ± 0.019
0.409CysGlu: 0.409 ± 0.017
0.263CysPhe: 0.263 ± 0.013
0.632CysGly: 0.632 ± 0.025
0.199CysHis: 0.199 ± 0.01
0.397CysIle: 0.397 ± 0.019
0.322CysLys: 0.322 ± 0.017
0.53CysLeu: 0.53 ± 0.022
0.176CysMet: 0.176 ± 0.011
0.245CysAsn: 0.245 ± 0.015
0.363CysPro: 0.363 ± 0.02
0.231CysGln: 0.231 ± 0.013
0.266CysArg: 0.266 ± 0.015
0.419CysSer: 0.419 ± 0.019
0.35CysThr: 0.35 ± 0.019
0.337CysVal: 0.337 ± 0.019
0.056CysTrp: 0.056 ± 0.006
0.213CysTyr: 0.213 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.485AspAla: 3.485 ± 0.052
0.332AspCys: 0.332 ± 0.018
2.751AspAsp: 2.751 ± 0.064
4.552AspGlu: 4.552 ± 0.075
2.447AspPhe: 2.447 ± 0.045
3.661AspGly: 3.661 ± 0.056
1.387AspHis: 1.387 ± 0.034
4.123AspIle: 4.123 ± 0.055
3.379AspLys: 3.379 ± 0.055
4.995AspLeu: 4.995 ± 0.075
1.592AspMet: 1.592 ± 0.034
1.999AspAsn: 1.999 ± 0.046
2.277AspPro: 2.277 ± 0.046
2.257AspGln: 2.257 ± 0.044
2.526AspArg: 2.526 ± 0.046
2.65AspSer: 2.65 ± 0.054
2.681AspThr: 2.681 ± 0.045
3.875AspVal: 3.875 ± 0.064
0.694AspTrp: 0.694 ± 0.023
2.344AspTyr: 2.344 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
6.119GluAla: 6.119 ± 0.089
0.322GluCys: 0.322 ± 0.017
4.329GluAsp: 4.329 ± 0.069
7.996GluGlu: 7.996 ± 0.111
2.426GluPhe: 2.426 ± 0.047
5.068GluGly: 5.068 ± 0.077
1.651GluHis: 1.651 ± 0.042
5.165GluIle: 5.165 ± 0.068
6.545GluLys: 6.545 ± 0.087
7.0GluLeu: 7.0 ± 0.093
2.363GluMet: 2.363 ± 0.047
3.753GluAsn: 3.753 ± 0.06
2.173GluPro: 2.173 ± 0.044
3.738GluGln: 3.738 ± 0.064
3.698GluArg: 3.698 ± 0.066
3.651GluSer: 3.651 ± 0.05
4.108GluThr: 4.108 ± 0.055
5.597GluVal: 5.597 ± 0.081
0.928GluTrp: 0.928 ± 0.027
2.179GluTyr: 2.179 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
2.98PheAla: 2.98 ± 0.052
0.305PheCys: 0.305 ± 0.015
2.405PheAsp: 2.405 ± 0.045
2.865PheGlu: 2.865 ± 0.048
2.343PhePhe: 2.343 ± 0.064
3.361PheGly: 3.361 ± 0.054
1.116PheHis: 1.116 ± 0.034
3.491PheIle: 3.491 ± 0.066
2.134PheLys: 2.134 ± 0.045
4.431PheLeu: 4.431 ± 0.089
1.214PheMet: 1.214 ± 0.035
1.67PheAsn: 1.67 ± 0.034
1.725PhePro: 1.725 ± 0.04
1.622PheGln: 1.622 ± 0.033
1.589PheArg: 1.589 ± 0.038
2.941PheSer: 2.941 ± 0.052
2.574PheThr: 2.574 ± 0.042
2.948PheVal: 2.948 ± 0.056
0.509PheTrp: 0.509 ± 0.024
1.702PheTyr: 1.702 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
5.293GlyAla: 5.293 ± 0.083
0.589GlyCys: 0.589 ± 0.025
3.646GlyAsp: 3.646 ± 0.055
5.228GlyGlu: 5.228 ± 0.065
3.476GlyPhe: 3.476 ± 0.061
5.348GlyGly: 5.348 ± 0.085
1.437GlyHis: 1.437 ± 0.031
5.822GlyIle: 5.822 ± 0.085
5.029GlyLys: 5.029 ± 0.066
6.743GlyLeu: 6.743 ± 0.089
2.426GlyMet: 2.426 ± 0.055
2.826GlyAsn: 2.826 ± 0.049
1.955GlyPro: 1.955 ± 0.044
2.197GlyGln: 2.197 ± 0.046
2.817GlyArg: 2.817 ± 0.053
4.162GlySer: 4.162 ± 0.06
4.192GlyThr: 4.192 ± 0.062
5.518GlyVal: 5.518 ± 0.08
0.918GlyTrp: 0.918 ± 0.033
2.933GlyTyr: 2.933 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.535HisAla: 1.535 ± 0.037
0.183HisCys: 0.183 ± 0.012
1.13HisAsp: 1.13 ± 0.03
1.511HisGlu: 1.511 ± 0.037
1.056HisPhe: 1.056 ± 0.031
1.582HisGly: 1.582 ± 0.038
0.767HisHis: 0.767 ± 0.03
1.455HisIle: 1.455 ± 0.031
1.029HisLys: 1.029 ± 0.028
2.234HisLeu: 2.234 ± 0.052
0.606HisMet: 0.606 ± 0.021
0.785HisAsn: 0.785 ± 0.025
1.282HisPro: 1.282 ± 0.028
1.019HisGln: 1.019 ± 0.028
0.949HisArg: 0.949 ± 0.028
1.192HisSer: 1.192 ± 0.03
1.129HisThr: 1.129 ± 0.029
1.474HisVal: 1.474 ± 0.036
0.25HisTrp: 0.25 ± 0.014
0.903HisTyr: 0.903 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.984IleAla: 5.984 ± 0.078
0.492IleCys: 0.492 ± 0.019
4.211IleAsp: 4.211 ± 0.062
5.331IleGlu: 5.331 ± 0.066
3.078IlePhe: 3.078 ± 0.071
5.93IleGly: 5.93 ± 0.092
1.663IleHis: 1.663 ± 0.043
5.349IleIle: 5.349 ± 0.091
4.004IleLys: 4.004 ± 0.062
6.487IleLeu: 6.487 ± 0.094
1.767IleMet: 1.767 ± 0.045
3.022IleAsn: 3.022 ± 0.052
3.303IlePro: 3.303 ± 0.054
2.741IleGln: 2.741 ± 0.049
2.919IleArg: 2.919 ± 0.047
4.431IleSer: 4.431 ± 0.07
4.289IleThr: 4.289 ± 0.066
4.981IleVal: 4.981 ± 0.07
0.625IleTrp: 0.625 ± 0.025
2.318IleTyr: 2.318 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.542LysAla: 4.542 ± 0.075
0.28LysCys: 0.28 ± 0.016
3.672LysAsp: 3.672 ± 0.058
6.81LysGlu: 6.81 ± 0.087
1.752LysPhe: 1.752 ± 0.039
4.441LysGly: 4.441 ± 0.064
1.435LysHis: 1.435 ± 0.035
3.855LysIle: 3.855 ± 0.05
5.408LysLys: 5.408 ± 0.077
5.362LysLeu: 5.362 ± 0.064
2.095LysMet: 2.095 ± 0.042
3.011LysAsn: 3.011 ± 0.059
2.192LysPro: 2.192 ± 0.042
3.375LysGln: 3.375 ± 0.055
3.244LysArg: 3.244 ± 0.047
3.208LysSer: 3.208 ± 0.054
3.198LysThr: 3.198 ± 0.055
4.579LysVal: 4.579 ± 0.057
0.797LysTrp: 0.797 ± 0.026
1.856LysTyr: 1.856 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
7.456LeuAla: 7.456 ± 0.097
0.522LeuCys: 0.522 ± 0.023
4.901LeuAsp: 4.901 ± 0.066
6.805LeuGlu: 6.805 ± 0.088
4.659LeuPhe: 4.659 ± 0.076
6.6LeuGly: 6.6 ± 0.088
1.984LeuHis: 1.984 ± 0.047
6.613LeuIle: 6.613 ± 0.091
5.959LeuLys: 5.959 ± 0.077
9.596LeuLeu: 9.596 ± 0.124
2.656LeuMet: 2.656 ± 0.053
3.864LeuAsn: 3.864 ± 0.057
3.986LeuPro: 3.986 ± 0.056
3.466LeuGln: 3.466 ± 0.055
3.436LeuArg: 3.436 ± 0.065
6.236LeuSer: 6.236 ± 0.08
5.449LeuThr: 5.449 ± 0.07
6.361LeuVal: 6.361 ± 0.081
0.915LeuTrp: 0.915 ± 0.031
3.044LeuTyr: 3.044 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.292MetAla: 2.292 ± 0.043
0.121MetCys: 0.121 ± 0.009
1.694MetAsp: 1.694 ± 0.04
2.379MetGlu: 2.379 ± 0.041
1.114MetPhe: 1.114 ± 0.031
1.985MetGly: 1.985 ± 0.043
0.481MetHis: 0.481 ± 0.018
2.241MetIle: 2.241 ± 0.048
2.594MetLys: 2.594 ± 0.039
2.66MetLeu: 2.66 ± 0.047
1.021MetMet: 1.021 ± 0.034
1.572MetAsn: 1.572 ± 0.034
1.097MetPro: 1.097 ± 0.04
1.002MetGln: 1.002 ± 0.033
1.128MetArg: 1.128 ± 0.031
1.669MetSer: 1.669 ± 0.034
1.791MetThr: 1.791 ± 0.039
2.048MetVal: 2.048 ± 0.039
0.2MetTrp: 0.2 ± 0.013
0.737MetTyr: 0.737 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.586AsnAla: 2.586 ± 0.046
0.26AsnCys: 0.26 ± 0.016
2.325AsnAsp: 2.325 ± 0.044
3.31AsnGlu: 3.31 ± 0.066
1.581AsnPhe: 1.581 ± 0.038
3.144AsnGly: 3.144 ± 0.06
1.125AsnHis: 1.125 ± 0.034
3.052AsnIle: 3.052 ± 0.049
2.632AsnLys: 2.632 ± 0.052
3.521AsnLeu: 3.521 ± 0.057
1.232AsnMet: 1.232 ± 0.035
1.894AsnAsn: 1.894 ± 0.049
2.137AsnPro: 2.137 ± 0.043
1.939AsnGln: 1.939 ± 0.048
1.998AsnArg: 1.998 ± 0.043
1.992AsnSer: 1.992 ± 0.046
2.056AsnThr: 2.056 ± 0.043
2.821AsnVal: 2.821 ± 0.056
0.491AsnTrp: 0.491 ± 0.023
1.551AsnTyr: 1.551 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
2.751ProAla: 2.751 ± 0.048
0.203ProCys: 0.203 ± 0.011
2.45ProAsp: 2.45 ± 0.044
3.474ProGlu: 3.474 ± 0.053
1.989ProPhe: 1.989 ± 0.041
2.797ProGly: 2.797 ± 0.057
0.823ProHis: 0.823 ± 0.025
2.613ProIle: 2.613 ± 0.055
2.059ProLys: 2.059 ± 0.041
3.502ProLeu: 3.502 ± 0.049
1.028ProMet: 1.028 ± 0.032
1.471ProAsn: 1.471 ± 0.032
1.138ProPro: 1.138 ± 0.032
1.089ProGln: 1.089 ± 0.026
1.216ProArg: 1.216 ± 0.031
2.246ProSer: 2.246 ± 0.046
1.912ProThr: 1.912 ± 0.038
3.204ProVal: 3.204 ± 0.054
0.428ProTrp: 0.428 ± 0.02
1.522ProTyr: 1.522 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.232GlnAla: 3.232 ± 0.05
0.181GlnCys: 0.181 ± 0.013
1.804GlnAsp: 1.804 ± 0.04
3.408GlnGlu: 3.408 ± 0.056
1.492GlnPhe: 1.492 ± 0.035
2.457GlnGly: 2.457 ± 0.046
0.804GlnHis: 0.804 ± 0.025
2.279GlnIle: 2.279 ± 0.044
2.587GlnLys: 2.587 ± 0.053
4.049GlnLeu: 4.049 ± 0.07
1.294GlnMet: 1.294 ± 0.032
1.505GlnAsn: 1.505 ± 0.039
1.409GlnPro: 1.409 ± 0.039
2.053GlnGln: 2.053 ± 0.056
1.617GlnArg: 1.617 ± 0.041
2.201GlnSer: 2.201 ± 0.046
2.001GlnThr: 2.001 ± 0.047
2.632GlnVal: 2.632 ± 0.049
0.484GlnTrp: 0.484 ± 0.021
1.212GlnTyr: 1.212 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.468ArgAla: 2.468 ± 0.049
0.241ArgCys: 0.241 ± 0.013
2.106ArgAsp: 2.106 ± 0.045
3.352ArgGlu: 3.352 ± 0.061
1.809ArgPhe: 1.809 ± 0.037
2.418ArgGly: 2.418 ± 0.045
0.886ArgHis: 0.886 ± 0.029
3.019ArgIle: 3.019 ± 0.051
3.192ArgLys: 3.192 ± 0.053
4.014ArgLeu: 4.014 ± 0.061
1.383ArgMet: 1.383 ± 0.035
1.881ArgAsn: 1.881 ± 0.04
1.413ArgPro: 1.413 ± 0.035
1.677ArgGln: 1.677 ± 0.036
1.836ArgArg: 1.836 ± 0.043
2.278ArgSer: 2.278 ± 0.043
2.119ArgThr: 2.119 ± 0.044
2.741ArgVal: 2.741 ± 0.05
0.436ArgTrp: 0.436 ± 0.018
1.644ArgTyr: 1.644 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.601SerAla: 3.601 ± 0.054
0.355SerCys: 0.355 ± 0.017
2.89SerAsp: 2.89 ± 0.047
3.916SerGlu: 3.916 ± 0.064
3.06SerPhe: 3.06 ± 0.051
4.535SerGly: 4.535 ± 0.063
1.279SerHis: 1.279 ± 0.034
4.304SerIle: 4.304 ± 0.06
3.424SerLys: 3.424 ± 0.051
5.827SerLeu: 5.827 ± 0.088
1.81SerMet: 1.81 ± 0.039
2.341SerAsn: 2.341 ± 0.047
2.172SerPro: 2.172 ± 0.045
1.878SerGln: 1.878 ± 0.043
2.33SerArg: 2.33 ± 0.052
3.607SerSer: 3.607 ± 0.07
2.938SerThr: 2.938 ± 0.048
3.845SerVal: 3.845 ± 0.051
0.653SerTrp: 0.653 ± 0.023
2.312SerTyr: 2.312 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.136ThrAla: 4.136 ± 0.063
0.328ThrCys: 0.328 ± 0.017
2.849ThrAsp: 2.849 ± 0.054
3.719ThrGlu: 3.719 ± 0.057
2.536ThrPhe: 2.536 ± 0.049
4.51ThrGly: 4.51 ± 0.066
1.105ThrHis: 1.105 ± 0.029
4.366ThrIle: 4.366 ± 0.06
3.076ThrLys: 3.076 ± 0.049
5.108ThrLeu: 5.108 ± 0.068
1.445ThrMet: 1.445 ± 0.034
2.29ThrAsn: 2.29 ± 0.048
2.362ThrPro: 2.362 ± 0.041
1.502ThrGln: 1.502 ± 0.041
1.88ThrArg: 1.88 ± 0.039
3.169ThrSer: 3.169 ± 0.052
2.967ThrThr: 2.967 ± 0.055
4.052ThrVal: 4.052 ± 0.065
0.579ThrTrp: 0.579 ± 0.021
1.951ThrTyr: 1.951 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
5.137ValAla: 5.137 ± 0.077
0.502ValCys: 0.502 ± 0.022
4.052ValAsp: 4.052 ± 0.056
5.231ValGlu: 5.231 ± 0.075
3.105ValPhe: 3.105 ± 0.052
4.73ValGly: 4.73 ± 0.08
1.439ValHis: 1.439 ± 0.034
5.701ValIle: 5.701 ± 0.063
4.449ValLys: 4.449 ± 0.06
6.777ValLeu: 6.777 ± 0.08
2.084ValMet: 2.084 ± 0.045
2.895ValAsn: 2.895 ± 0.047
2.787ValPro: 2.787 ± 0.049
2.335ValGln: 2.335 ± 0.048
2.666ValArg: 2.666 ± 0.046
4.346ValSer: 4.346 ± 0.063
4.31ValThr: 4.31 ± 0.064
5.185ValVal: 5.185 ± 0.068
0.693ValTrp: 0.693 ± 0.024
2.313ValTyr: 2.313 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.666TrpAla: 0.666 ± 0.023
0.064TrpCys: 0.064 ± 0.007
0.539TrpAsp: 0.539 ± 0.023
0.801TrpGlu: 0.801 ± 0.028
0.553TrpPhe: 0.553 ± 0.023
0.741TrpGly: 0.741 ± 0.027
0.22TrpHis: 0.22 ± 0.013
0.836TrpIle: 0.836 ± 0.027
0.865TrpLys: 0.865 ± 0.024
1.235TrpLeu: 1.235 ± 0.037
0.444TrpMet: 0.444 ± 0.021
0.575TrpAsn: 0.575 ± 0.025
0.292TrpPro: 0.292 ± 0.016
0.383TrpGln: 0.383 ± 0.02
0.393TrpArg: 0.393 ± 0.018
0.589TrpSer: 0.589 ± 0.026
0.531TrpThr: 0.531 ± 0.02
0.723TrpVal: 0.723 ± 0.024
0.156TrpTrp: 0.156 ± 0.012
0.364TrpTyr: 0.364 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.11TyrAla: 2.11 ± 0.039
0.263TyrCys: 0.263 ± 0.016
2.032TyrAsp: 2.032 ± 0.042
2.618TyrGlu: 2.618 ± 0.045
1.713TyrPhe: 1.713 ± 0.037
2.643TyrGly: 2.643 ± 0.043
0.984TyrHis: 0.984 ± 0.032
2.355TyrIle: 2.355 ± 0.047
1.921TyrLys: 1.921 ± 0.04
3.365TyrLeu: 3.365 ± 0.059
0.925TyrMet: 0.925 ± 0.032
1.39TyrAsn: 1.39 ± 0.038
1.533TyrPro: 1.533 ± 0.038
1.887TyrGln: 1.887 ± 0.047
1.66TyrArg: 1.66 ± 0.037
1.821TyrSer: 1.821 ± 0.042
1.811TyrThr: 1.811 ± 0.038
2.125TyrVal: 2.125 ± 0.046
0.434TyrTrp: 0.434 ± 0.019
1.465TyrTyr: 1.465 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4309 proteins (1218288 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski