Amino acid dipepetide frequency for Salinigranum rubrum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.713AlaAla: 12.713 ± 0.134
0.787AlaCys: 0.787 ± 0.027
8.568AlaAsp: 8.568 ± 0.106
7.847AlaGlu: 7.847 ± 0.093
4.116AlaPhe: 4.116 ± 0.067
9.436AlaGly: 9.436 ± 0.108
1.926AlaHis: 1.926 ± 0.039
3.889AlaIle: 3.889 ± 0.061
1.783AlaLys: 1.783 ± 0.038
10.78AlaLeu: 10.78 ± 0.127
2.0AlaMet: 2.0 ± 0.042
2.277AlaAsn: 2.277 ± 0.041
4.1AlaPro: 4.1 ± 0.065
2.129AlaGln: 2.129 ± 0.038
6.86AlaArg: 6.86 ± 0.095
6.024AlaSer: 6.024 ± 0.082
6.983AlaThr: 6.983 ± 0.093
10.846AlaVal: 10.846 ± 0.123
1.216AlaTrp: 1.216 ± 0.036
2.732AlaTyr: 2.732 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.653CysAla: 0.653 ± 0.022
0.093CysCys: 0.093 ± 0.009
0.59CysAsp: 0.59 ± 0.023
0.585CysGlu: 0.585 ± 0.026
0.204CysPhe: 0.204 ± 0.013
0.874CysGly: 0.874 ± 0.034
0.183CysHis: 0.183 ± 0.012
0.244CysIle: 0.244 ± 0.015
0.113CysLys: 0.113 ± 0.01
0.616CysLeu: 0.616 ± 0.02
0.107CysMet: 0.107 ± 0.01
0.172CysAsn: 0.172 ± 0.012
0.518CysPro: 0.518 ± 0.023
0.161CysGln: 0.161 ± 0.011
0.548CysArg: 0.548 ± 0.022
0.424CysSer: 0.424 ± 0.019
0.452CysThr: 0.452 ± 0.02
0.562CysVal: 0.562 ± 0.021
0.089CysTrp: 0.089 ± 0.007
0.182CysTyr: 0.182 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
9.583AspAla: 9.583 ± 0.112
0.608AspCys: 0.608 ± 0.024
7.185AspAsp: 7.185 ± 0.099
7.461AspGlu: 7.461 ± 0.09
2.021AspPhe: 2.021 ± 0.042
7.591AspGly: 7.591 ± 0.097
1.848AspHis: 1.848 ± 0.039
2.867AspIle: 2.867 ± 0.053
0.839AspLys: 0.839 ± 0.031
6.818AspLeu: 6.818 ± 0.07
1.164AspMet: 1.164 ± 0.03
1.17AspAsn: 1.17 ± 0.039
4.253AspPro: 4.253 ± 0.066
1.471AspGln: 1.471 ± 0.035
5.969AspArg: 5.969 ± 0.08
3.949AspSer: 3.949 ± 0.065
4.096AspThr: 4.096 ± 0.07
7.731AspVal: 7.731 ± 0.092
0.913AspTrp: 0.913 ± 0.028
1.783AspTyr: 1.783 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
8.342GluAla: 8.342 ± 0.1
0.483GluCys: 0.483 ± 0.021
4.545GluAsp: 4.545 ± 0.069
6.571GluGlu: 6.571 ± 0.09
2.776GluPhe: 2.776 ± 0.054
5.685GluGly: 5.685 ± 0.074
1.923GluHis: 1.923 ± 0.042
2.816GluIle: 2.816 ± 0.061
1.675GluLys: 1.675 ± 0.043
6.955GluLeu: 6.955 ± 0.083
1.789GluMet: 1.789 ± 0.038
2.138GluAsn: 2.138 ± 0.045
3.576GluPro: 3.576 ± 0.063
2.282GluGln: 2.282 ± 0.044
7.765GluArg: 7.765 ± 0.088
5.096GluSer: 5.096 ± 0.069
6.299GluThr: 6.299 ± 0.09
5.854GluVal: 5.854 ± 0.063
1.061GluTrp: 1.061 ± 0.027
2.43GluTyr: 2.43 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.687PheAla: 3.687 ± 0.065
0.297PheCys: 0.297 ± 0.016
3.289PheAsp: 3.289 ± 0.053
3.252PheGlu: 3.252 ± 0.063
1.128PhePhe: 1.128 ± 0.028
3.351PheGly: 3.351 ± 0.056
0.647PheHis: 0.647 ± 0.024
1.067PheIle: 1.067 ± 0.033
0.498PheLys: 0.498 ± 0.022
2.977PheLeu: 2.977 ± 0.058
0.47PheMet: 0.47 ± 0.02
0.658PheAsn: 0.658 ± 0.022
1.399PhePro: 1.399 ± 0.037
0.777PheGln: 0.777 ± 0.025
1.875PheArg: 1.875 ± 0.035
1.856PheSer: 1.856 ± 0.038
1.995PheThr: 1.995 ± 0.044
3.606PheVal: 3.606 ± 0.063
0.392PheTrp: 0.392 ± 0.015
0.854PheTyr: 0.854 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.038GlyAla: 8.038 ± 0.089
0.762GlyCys: 0.762 ± 0.028
6.555GlyAsp: 6.555 ± 0.08
6.698GlyGlu: 6.698 ± 0.074
3.387GlyPhe: 3.387 ± 0.066
7.911GlyGly: 7.911 ± 0.118
1.714GlyHis: 1.714 ± 0.041
3.742GlyIle: 3.742 ± 0.067
1.714GlyLys: 1.714 ± 0.042
7.653GlyLeu: 7.653 ± 0.092
1.732GlyMet: 1.732 ± 0.044
1.906GlyAsn: 1.906 ± 0.041
3.488GlyPro: 3.488 ± 0.055
1.957GlyGln: 1.957 ± 0.049
5.505GlyArg: 5.505 ± 0.069
5.468GlySer: 5.468 ± 0.081
5.909GlyThr: 5.909 ± 0.077
8.662GlyVal: 8.662 ± 0.111
1.207GlyTrp: 1.207 ± 0.036
2.591GlyTyr: 2.591 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.182HisAla: 2.182 ± 0.04
0.199HisCys: 0.199 ± 0.01
1.791HisAsp: 1.791 ± 0.041
1.648HisGlu: 1.648 ± 0.033
0.521HisPhe: 0.521 ± 0.02
2.011HisGly: 2.011 ± 0.047
0.536HisHis: 0.536 ± 0.018
0.7HisIle: 0.7 ± 0.024
0.283HisLys: 0.283 ± 0.017
1.891HisLeu: 1.891 ± 0.042
0.267HisMet: 0.267 ± 0.014
0.421HisAsn: 0.421 ± 0.019
1.311HisPro: 1.311 ± 0.037
0.453HisGln: 0.453 ± 0.019
1.414HisArg: 1.414 ± 0.033
0.906HisSer: 0.906 ± 0.028
1.14HisThr: 1.14 ± 0.032
2.041HisVal: 2.041 ± 0.043
0.221HisTrp: 0.221 ± 0.014
0.542HisTyr: 0.542 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
3.887IleAla: 3.887 ± 0.074
0.226IleCys: 0.226 ± 0.013
3.335IleAsp: 3.335 ± 0.06
3.45IleGlu: 3.45 ± 0.055
0.785IlePhe: 0.785 ± 0.028
3.325IleGly: 3.325 ± 0.061
0.774IleHis: 0.774 ± 0.022
1.236IleIle: 1.236 ± 0.036
0.657IleLys: 0.657 ± 0.022
2.567IleLeu: 2.567 ± 0.062
0.421IleMet: 0.421 ± 0.023
0.889IleAsn: 0.889 ± 0.029
1.926IlePro: 1.926 ± 0.041
0.974IleGln: 0.974 ± 0.027
2.391IleArg: 2.391 ± 0.043
1.962IleSer: 1.962 ± 0.047
2.19IleThr: 2.19 ± 0.05
3.348IleVal: 3.348 ± 0.064
0.297IleTrp: 0.297 ± 0.017
0.804IleTyr: 0.804 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
1.678LysAla: 1.678 ± 0.043
0.125LysCys: 0.125 ± 0.009
0.89LysAsp: 0.89 ± 0.027
1.315LysGlu: 1.315 ± 0.04
0.508LysPhe: 0.508 ± 0.025
1.346LysGly: 1.346 ± 0.038
0.459LysHis: 0.459 ± 0.02
0.669LysIle: 0.669 ± 0.024
0.501LysLys: 0.501 ± 0.024
1.61LysLeu: 1.61 ± 0.04
0.336LysMet: 0.336 ± 0.017
0.567LysAsn: 0.567 ± 0.023
0.922LysPro: 0.922 ± 0.024
0.705LysGln: 0.705 ± 0.028
1.606LysArg: 1.606 ± 0.04
1.081LysSer: 1.081 ± 0.032
1.271LysThr: 1.271 ± 0.039
1.158LysVal: 1.158 ± 0.036
0.222LysTrp: 0.222 ± 0.015
0.523LysTyr: 0.523 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
10.939LeuAla: 10.939 ± 0.121
0.614LeuCys: 0.614 ± 0.02
7.778LeuAsp: 7.778 ± 0.089
5.733LeuGlu: 5.733 ± 0.076
3.309LeuPhe: 3.309 ± 0.057
7.932LeuGly: 7.932 ± 0.109
1.604LeuHis: 1.604 ± 0.038
2.67LeuIle: 2.67 ± 0.061
1.565LeuLys: 1.565 ± 0.038
8.733LeuLeu: 8.733 ± 0.11
1.296LeuMet: 1.296 ± 0.033
1.828LeuAsn: 1.828 ± 0.035
4.371LeuPro: 4.371 ± 0.064
2.035LeuGln: 2.035 ± 0.044
5.831LeuArg: 5.831 ± 0.081
6.24LeuSer: 6.24 ± 0.085
5.7LeuThr: 5.7 ± 0.068
9.732LeuVal: 9.732 ± 0.111
0.902LeuTrp: 0.902 ± 0.03
2.156LeuTyr: 2.156 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.69MetAla: 1.69 ± 0.038
0.129MetCys: 0.129 ± 0.01
1.164MetAsp: 1.164 ± 0.036
1.063MetGlu: 1.063 ± 0.034
0.545MetPhe: 0.545 ± 0.02
1.429MetGly: 1.429 ± 0.038
0.343MetHis: 0.343 ± 0.017
0.606MetIle: 0.606 ± 0.022
0.428MetLys: 0.428 ± 0.017
1.437MetLeu: 1.437 ± 0.033
0.32MetMet: 0.32 ± 0.017
0.619MetAsn: 0.619 ± 0.021
0.773MetPro: 0.773 ± 0.03
0.476MetGln: 0.476 ± 0.02
1.146MetArg: 1.146 ± 0.027
1.539MetSer: 1.539 ± 0.033
1.57MetThr: 1.57 ± 0.038
1.308MetVal: 1.308 ± 0.042
0.161MetTrp: 0.161 ± 0.011
0.401MetTyr: 0.401 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.441AsnAla: 2.441 ± 0.037
0.199AsnCys: 0.199 ± 0.014
1.622AsnAsp: 1.622 ± 0.044
1.688AsnGlu: 1.688 ± 0.036
0.64AsnPhe: 0.64 ± 0.022
2.048AsnGly: 2.048 ± 0.049
0.475AsnHis: 0.475 ± 0.02
0.846AsnIle: 0.846 ± 0.034
0.402AsnLys: 0.402 ± 0.018
1.989AsnLeu: 1.989 ± 0.038
0.395AsnMet: 0.395 ± 0.019
0.538AsnAsn: 0.538 ± 0.024
1.595AsnPro: 1.595 ± 0.035
0.624AsnGln: 0.624 ± 0.023
1.656AsnArg: 1.656 ± 0.03
1.009AsnSer: 1.009 ± 0.028
1.328AsnThr: 1.328 ± 0.038
2.236AsnVal: 2.236 ± 0.037
0.297AsnTrp: 0.297 ± 0.014
0.631AsnTyr: 0.631 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
4.627ProAla: 4.627 ± 0.066
0.273ProCys: 0.273 ± 0.015
4.542ProAsp: 4.542 ± 0.066
4.134ProGlu: 4.134 ± 0.063
1.705ProPhe: 1.705 ± 0.036
3.855ProGly: 3.855 ± 0.057
1.009ProHis: 1.009 ± 0.03
1.645ProIle: 1.645 ± 0.035
0.819ProLys: 0.819 ± 0.03
4.09ProLeu: 4.09 ± 0.063
0.812ProMet: 0.812 ± 0.022
1.123ProAsn: 1.123 ± 0.034
2.425ProPro: 2.425 ± 0.05
1.027ProGln: 1.027 ± 0.029
2.712ProArg: 2.712 ± 0.052
3.069ProSer: 3.069 ± 0.05
3.639ProThr: 3.639 ± 0.063
4.389ProVal: 4.389 ± 0.057
0.555ProTrp: 0.555 ± 0.019
1.157ProTyr: 1.157 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
2.352GlnAla: 2.352 ± 0.041
0.177GlnCys: 0.177 ± 0.013
1.111GlnAsp: 1.111 ± 0.033
1.591GlnGlu: 1.591 ± 0.034
1.054GlnPhe: 1.054 ± 0.027
1.692GlnGly: 1.692 ± 0.038
0.511GlnHis: 0.511 ± 0.02
0.905GlnIle: 0.905 ± 0.03
0.529GlnLys: 0.529 ± 0.022
2.163GlnLeu: 2.163 ± 0.047
0.479GlnMet: 0.479 ± 0.024
0.753GlnAsn: 0.753 ± 0.026
1.108GlnPro: 1.108 ± 0.031
0.983GlnGln: 0.983 ± 0.033
1.986GlnArg: 1.986 ± 0.041
1.611GlnSer: 1.611 ± 0.039
1.629GlnThr: 1.629 ± 0.036
1.947GlnVal: 1.947 ± 0.041
0.339GlnTrp: 0.339 ± 0.018
0.765GlnTyr: 0.765 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.079ArgAla: 7.079 ± 0.084
0.547ArgCys: 0.547 ± 0.023
5.025ArgAsp: 5.025 ± 0.053
6.626ArgGlu: 6.626 ± 0.087
2.602ArgPhe: 2.602 ± 0.05
4.861ArgGly: 4.861 ± 0.068
1.381ArgHis: 1.381 ± 0.034
2.817ArgIle: 2.817 ± 0.05
1.341ArgLys: 1.341 ± 0.035
6.694ArgLeu: 6.694 ± 0.087
1.412ArgMet: 1.412 ± 0.035
1.642ArgAsn: 1.642 ± 0.037
2.904ArgPro: 2.904 ± 0.057
1.834ArgGln: 1.834 ± 0.043
5.79ArgArg: 5.79 ± 0.09
3.737ArgSer: 3.737 ± 0.059
4.39ArgThr: 4.39 ± 0.062
6.522ArgVal: 6.522 ± 0.08
0.85ArgTrp: 0.85 ± 0.027
2.035ArgTyr: 2.035 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.502SerAla: 5.502 ± 0.07
0.344SerCys: 0.344 ± 0.017
4.436SerAsp: 4.436 ± 0.066
4.396SerGlu: 4.396 ± 0.052
1.991SerPhe: 1.991 ± 0.042
5.802SerGly: 5.802 ± 0.086
1.119SerHis: 1.119 ± 0.031
2.175SerIle: 2.175 ± 0.042
1.212SerLys: 1.212 ± 0.035
5.426SerLeu: 5.426 ± 0.082
1.149SerMet: 1.149 ± 0.029
1.43SerAsn: 1.43 ± 0.039
2.93SerPro: 2.93 ± 0.051
1.338SerGln: 1.338 ± 0.036
3.804SerArg: 3.804 ± 0.064
3.497SerSer: 3.497 ± 0.063
4.077SerThr: 4.077 ± 0.072
5.668SerVal: 5.668 ± 0.086
0.647SerTrp: 0.647 ± 0.021
1.484SerTyr: 1.484 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
7.089ThrAla: 7.089 ± 0.089
0.418ThrCys: 0.418 ± 0.022
5.343ThrAsp: 5.343 ± 0.087
4.809ThrGlu: 4.809 ± 0.069
2.263ThrPhe: 2.263 ± 0.048
5.835ThrGly: 5.835 ± 0.076
1.318ThrHis: 1.318 ± 0.033
2.39ThrIle: 2.39 ± 0.054
1.053ThrLys: 1.053 ± 0.032
6.267ThrLeu: 6.267 ± 0.077
1.063ThrMet: 1.063 ± 0.03
1.545ThrAsn: 1.545 ± 0.034
3.789ThrPro: 3.789 ± 0.073
1.41ThrGln: 1.41 ± 0.037
3.962ThrArg: 3.962 ± 0.064
3.316ThrSer: 3.316 ± 0.058
4.605ThrThr: 4.605 ± 0.068
7.319ThrVal: 7.319 ± 0.087
0.729ThrTrp: 0.729 ± 0.026
1.769ThrTyr: 1.769 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
10.879ValAla: 10.879 ± 0.125
0.736ValCys: 0.736 ± 0.023
8.36ValAsp: 8.36 ± 0.092
8.11ValGlu: 8.11 ± 0.092
3.253ValPhe: 3.253 ± 0.057
8.492ValGly: 8.492 ± 0.1
1.793ValHis: 1.793 ± 0.036
2.961ValIle: 2.961 ± 0.057
1.412ValLys: 1.412 ± 0.037
8.511ValLeu: 8.511 ± 0.111
1.376ValMet: 1.376 ± 0.032
2.034ValAsn: 2.034 ± 0.041
4.515ValPro: 4.515 ± 0.072
1.943ValGln: 1.943 ± 0.036
6.319ValArg: 6.319 ± 0.08
5.801ValSer: 5.801 ± 0.074
6.641ValThr: 6.641 ± 0.089
11.113ValVal: 11.113 ± 0.13
0.956ValTrp: 0.956 ± 0.025
2.216ValTyr: 2.216 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.009TrpAla: 1.009 ± 0.028
0.112TrpCys: 0.112 ± 0.009
0.771TrpAsp: 0.771 ± 0.025
0.827TrpGlu: 0.827 ± 0.027
0.472TrpPhe: 0.472 ± 0.02
0.839TrpGly: 0.839 ± 0.025
0.249TrpHis: 0.249 ± 0.016
0.431TrpIle: 0.431 ± 0.017
0.276TrpLys: 0.276 ± 0.016
1.209TrpLeu: 1.209 ± 0.033
0.23TrpMet: 0.23 ± 0.014
0.362TrpAsn: 0.362 ± 0.02
0.443TrpPro: 0.443 ± 0.019
0.374TrpGln: 0.374 ± 0.017
0.914TrpArg: 0.914 ± 0.029
0.638TrpSer: 0.638 ± 0.022
0.842TrpThr: 0.842 ± 0.027
1.0TrpVal: 1.0 ± 0.03
0.209TrpTrp: 0.209 ± 0.012
0.403TrpTyr: 0.403 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.64TyrAla: 2.64 ± 0.045
0.243TyrCys: 0.243 ± 0.014
2.418TyrAsp: 2.418 ± 0.039
2.258TyrGlu: 2.258 ± 0.044
0.793TyrPhe: 0.793 ± 0.024
2.285TyrGly: 2.285 ± 0.04
0.666TyrHis: 0.666 ± 0.023
0.767TyrIle: 0.767 ± 0.026
0.391TyrLys: 0.391 ± 0.019
2.58TyrLeu: 2.58 ± 0.047
0.328TyrMet: 0.328 ± 0.017
0.586TyrAsn: 0.586 ± 0.022
1.262TyrPro: 1.262 ± 0.033
0.732TyrGln: 0.732 ± 0.025
2.038TyrArg: 2.038 ± 0.039
1.206TyrSer: 1.206 ± 0.03
1.535TyrThr: 1.535 ± 0.035
2.379TyrVal: 2.379 ± 0.045
0.35TyrTrp: 0.35 ± 0.018
0.792TyrTyr: 0.792 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4473 proteins (1264196 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski