Amino acid dipepetide frequency for Luteimonas granuli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.258AlaAla: 21.258 ± 0.257	1.367AlaCys: 1.367 ± 0.042	7.665AlaAsp: 7.665 ± 0.11	7.621AlaGlu: 7.621 ± 0.118	4.177AlaPhe: 4.177 ± 0.078	13.393AlaGly: 13.393 ± 0.162	2.717AlaHis: 2.717 ± 0.063	5.491AlaIle: 5.491 ± 0.082	2.704AlaLys: 2.704 ± 0.096	16.293AlaLeu: 16.293 ± 0.203	3.585AlaMet: 3.585 ± 0.064	2.448AlaAsn: 2.448 ± 0.055	7.066AlaPro: 7.066 ± 0.104	4.141AlaGln: 4.141 ± 0.068	11.972AlaArg: 11.972 ± 0.152	6.423AlaSer: 6.423 ± 0.091	6.498AlaThr: 6.498 ± 0.099	9.554AlaVal: 9.554 ± 0.135	2.462AlaTrp: 2.462 ± 0.065	2.358AlaTyr: 2.358 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.072CysAla: 1.072 ± 0.042	0.133CysCys: 0.133 ± 0.013	0.502CysAsp: 0.502 ± 0.026	0.423CysGlu: 0.423 ± 0.023	0.254CysPhe: 0.254 ± 0.019	0.933CysGly: 0.933 ± 0.036	0.264CysHis: 0.264 ± 0.019	0.315CysIle: 0.315 ± 0.023	0.134CysLys: 0.134 ± 0.013	0.715CysLeu: 0.715 ± 0.03	0.155CysMet: 0.155 ± 0.014	0.176CysAsn: 0.176 ± 0.016	0.463CysPro: 0.463 ± 0.028	0.199CysGln: 0.199 ± 0.015	0.664CysArg: 0.664 ± 0.026	0.441CysSer: 0.441 ± 0.027	0.42CysThr: 0.42 ± 0.022	0.63CysVal: 0.63 ± 0.034	0.124CysTrp: 0.124 ± 0.014	0.181CysTyr: 0.181 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.571AspAla: 9.571 ± 0.144	0.436AspCys: 0.436 ± 0.021	3.673AspAsp: 3.673 ± 0.076	3.542AspGlu: 3.542 ± 0.075	2.07AspPhe: 2.07 ± 0.05	6.409AspGly: 6.409 ± 0.109	1.233AspHis: 1.233 ± 0.04	2.339AspIle: 2.339 ± 0.046	0.997AspLys: 0.997 ± 0.042	5.566AspLeu: 5.566 ± 0.095	1.193AspMet: 1.193 ± 0.04	1.156AspAsn: 1.156 ± 0.04	4.001AspPro: 4.001 ± 0.078	1.391AspGln: 1.391 ± 0.037	4.641AspArg: 4.641 ± 0.08	2.448AspSer: 2.448 ± 0.056	2.619AspThr: 2.619 ± 0.059	4.335AspVal: 4.335 ± 0.08	1.115AspTrp: 1.115 ± 0.038	1.493AspTyr: 1.493 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.363GluAla: 8.363 ± 0.129	0.383GluCys: 0.383 ± 0.023	2.775GluAsp: 2.775 ± 0.064	2.704GluGlu: 2.704 ± 0.067	1.735GluPhe: 1.735 ± 0.045	4.887GluGly: 4.887 ± 0.082	1.355GluHis: 1.355 ± 0.042	2.368GluIle: 2.368 ± 0.054	1.288GluLys: 1.288 ± 0.043	6.159GluLeu: 6.159 ± 0.104	1.1GluMet: 1.1 ± 0.042	1.0GluAsn: 1.0 ± 0.038	2.852GluPro: 2.852 ± 0.066	1.984GluGln: 1.984 ± 0.06	5.876GluArg: 5.876 ± 0.095	2.483GluSer: 2.483 ± 0.052	2.456GluThr: 2.456 ± 0.051	4.458GluVal: 4.458 ± 0.08	0.761GluTrp: 0.761 ± 0.035	1.204GluTyr: 1.204 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	4.278PheAla: 4.278 ± 0.076	0.308PheCys: 0.308 ± 0.02	2.662PheAsp: 2.662 ± 0.057	2.037PheGlu: 2.037 ± 0.051	1.074PhePhe: 1.074 ± 0.041	3.317PheGly: 3.317 ± 0.071	0.791PheHis: 0.791 ± 0.031	1.206PheIle: 1.206 ± 0.04	0.655PheLys: 0.655 ± 0.03	2.856PheLeu: 2.856 ± 0.065	0.658PheMet: 0.658 ± 0.025	0.871PheAsn: 0.871 ± 0.034	1.455PhePro: 1.455 ± 0.044	0.874PheGln: 0.874 ± 0.029	2.259PheArg: 2.259 ± 0.057	1.749PheSer: 1.749 ± 0.057	1.694PheThr: 1.694 ± 0.047	2.448PheVal: 2.448 ± 0.052	0.485PheTrp: 0.485 ± 0.029	0.638PheTyr: 0.638 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.583GlyAla: 10.583 ± 0.133	0.85GlyCys: 0.85 ± 0.031	5.615GlyAsp: 5.615 ± 0.097	5.475GlyGlu: 5.475 ± 0.095	3.519GlyPhe: 3.519 ± 0.063	8.556GlyGly: 8.556 ± 0.123	2.393GlyHis: 2.393 ± 0.063	4.225GlyIle: 4.225 ± 0.067	2.36GlyLys: 2.36 ± 0.064	9.432GlyLeu: 9.432 ± 0.123	2.489GlyMet: 2.489 ± 0.063	2.222GlyAsn: 2.222 ± 0.061	3.651GlyPro: 3.651 ± 0.061	2.803GlyGln: 2.803 ± 0.064	8.113GlyArg: 8.113 ± 0.112	5.083GlySer: 5.083 ± 0.085	4.636GlyThr: 4.636 ± 0.085	6.874GlyVal: 6.874 ± 0.102	1.682GlyTrp: 1.682 ± 0.051	2.286GlyTyr: 2.286 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	3.374HisAla: 3.374 ± 0.071	0.269HisCys: 0.269 ± 0.019	1.386HisAsp: 1.386 ± 0.036	1.109HisGlu: 1.109 ± 0.037	0.738HisPhe: 0.738 ± 0.03	2.47HisGly: 2.47 ± 0.06	0.63HisHis: 0.63 ± 0.027	0.693HisIle: 0.693 ± 0.033	0.339HisLys: 0.339 ± 0.02	2.171HisLeu: 2.171 ± 0.057	0.402HisMet: 0.402 ± 0.024	0.455HisAsn: 0.455 ± 0.025	1.612HisPro: 1.612 ± 0.042	0.562HisGln: 0.562 ± 0.024	1.868HisArg: 1.868 ± 0.052	0.947HisSer: 0.947 ± 0.037	0.892HisThr: 0.892 ± 0.033	1.756HisVal: 1.756 ± 0.04	0.421HisTrp: 0.421 ± 0.025	0.554HisTyr: 0.554 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.017IleAla: 6.017 ± 0.089	0.287IleCys: 0.287 ± 0.02	3.357IleAsp: 3.357 ± 0.062	2.979IleGlu: 2.979 ± 0.064	0.973IlePhe: 0.973 ± 0.033	4.222IleGly: 4.222 ± 0.083	0.797IleHis: 0.797 ± 0.034	1.188IleIle: 1.188 ± 0.04	0.781IleLys: 0.781 ± 0.038	2.943IleLeu: 2.943 ± 0.071	0.516IleMet: 0.516 ± 0.024	0.972IleAsn: 0.972 ± 0.041	1.986IlePro: 1.986 ± 0.051	0.94IleGln: 0.94 ± 0.03	2.77IleArg: 2.77 ± 0.054	1.773IleSer: 1.773 ± 0.057	1.944IleThr: 1.944 ± 0.053	3.134IleVal: 3.134 ± 0.064	0.355IleTrp: 0.355 ± 0.021	0.69IleTyr: 0.69 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.783LysAla: 2.783 ± 0.084	0.106LysCys: 0.106 ± 0.013	1.136LysAsp: 1.136 ± 0.044	0.981LysGlu: 0.981 ± 0.043	0.569LysPhe: 0.569 ± 0.029	1.698LysGly: 1.698 ± 0.056	0.432LysHis: 0.432 ± 0.021	0.856LysIle: 0.856 ± 0.037	0.776LysLys: 0.776 ± 0.061	2.195LysLeu: 2.195 ± 0.054	0.472LysMet: 0.472 ± 0.026	0.425LysAsn: 0.425 ± 0.025	1.385LysPro: 1.385 ± 0.042	0.735LysGln: 0.735 ± 0.033	1.796LysArg: 1.796 ± 0.047	1.059LysSer: 1.059 ± 0.035	1.061LysThr: 1.061 ± 0.039	1.802LysVal: 1.802 ± 0.066	0.244LysTrp: 0.244 ± 0.018	0.485LysTyr: 0.485 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	16.241LeuAla: 16.241 ± 0.197	0.842LeuCys: 0.842 ± 0.033	7.014LeuAsp: 7.014 ± 0.115	6.098LeuGlu: 6.098 ± 0.092	3.264LeuPhe: 3.264 ± 0.065	9.029LeuGly: 9.029 ± 0.105	2.41LeuHis: 2.41 ± 0.059	3.043LeuIle: 3.043 ± 0.07	2.32LeuLys: 2.32 ± 0.058	12.042LeuLeu: 12.042 ± 0.191	2.104LeuMet: 2.104 ± 0.049	1.871LeuAsn: 1.871 ± 0.049	6.612LeuPro: 6.612 ± 0.103	3.312LeuGln: 3.312 ± 0.066	9.772LeuArg: 9.772 ± 0.142	5.347LeuSer: 5.347 ± 0.085	4.003LeuThr: 4.003 ± 0.072	8.736LeuVal: 8.736 ± 0.112	1.291LeuTrp: 1.291 ± 0.048	1.979LeuTyr: 1.979 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.995MetAla: 2.995 ± 0.062	0.123MetCys: 0.123 ± 0.012	1.2MetAsp: 1.2 ± 0.038	0.991MetGlu: 0.991 ± 0.042	0.657MetPhe: 0.657 ± 0.032	1.535MetGly: 1.535 ± 0.046	0.479MetHis: 0.479 ± 0.024	0.839MetIle: 0.839 ± 0.031	0.694MetLys: 0.694 ± 0.03	2.485MetLeu: 2.485 ± 0.062	0.426MetMet: 0.426 ± 0.025	0.622MetAsn: 0.622 ± 0.029	1.478MetPro: 1.478 ± 0.044	0.783MetGln: 0.783 ± 0.029	1.929MetArg: 1.929 ± 0.052	1.403MetSer: 1.403 ± 0.037	1.275MetThr: 1.275 ± 0.041	1.679MetVal: 1.679 ± 0.046	0.213MetTrp: 0.213 ± 0.017	0.357MetTyr: 0.357 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.826AsnAla: 2.826 ± 0.072	0.173AsnCys: 0.173 ± 0.014	1.088AsnAsp: 1.088 ± 0.038	0.92AsnGlu: 0.92 ± 0.032	0.731AsnPhe: 0.731 ± 0.034	1.881AsnGly: 1.881 ± 0.056	0.426AsnHis: 0.426 ± 0.022	0.967AsnIle: 0.967 ± 0.035	0.421AsnLys: 0.421 ± 0.026	2.15AsnLeu: 2.15 ± 0.056	0.405AsnMet: 0.405 ± 0.024	0.483AsnAsn: 0.483 ± 0.027	1.532AsnPro: 1.532 ± 0.043	0.578AsnGln: 0.578 ± 0.028	1.662AsnArg: 1.662 ± 0.049	0.911AsnSer: 0.911 ± 0.04	1.049AsnThr: 1.049 ± 0.037	1.631AsnVal: 1.631 ± 0.045	0.296AsnTrp: 0.296 ± 0.019	0.499AsnTyr: 0.499 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.027ProAla: 8.027 ± 0.127	0.374ProCys: 0.374 ± 0.021	3.915ProAsp: 3.915 ± 0.074	3.684ProGlu: 3.684 ± 0.072	1.578ProPhe: 1.578 ± 0.04	6.109ProGly: 6.109 ± 0.105	1.111ProHis: 1.111 ± 0.04	1.588ProIle: 1.588 ± 0.045	1.136ProLys: 1.136 ± 0.04	5.578ProLeu: 5.578 ± 0.103	1.315ProMet: 1.315 ± 0.04	0.871ProAsn: 0.871 ± 0.033	3.318ProPro: 3.318 ± 0.094	1.624ProGln: 1.624 ± 0.046	4.198ProArg: 4.198 ± 0.083	2.494ProSer: 2.494 ± 0.058	2.331ProThr: 2.331 ± 0.055	4.676ProVal: 4.676 ± 0.079	0.903ProTrp: 0.903 ± 0.034	1.078ProTyr: 1.078 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.63GlnAla: 4.63 ± 0.071	0.199GlnCys: 0.199 ± 0.016	1.33GlnAsp: 1.33 ± 0.04	1.319GlnGlu: 1.319 ± 0.04	0.854GlnPhe: 0.854 ± 0.033	2.484GlnGly: 2.484 ± 0.054	0.617GlnHis: 0.617 ± 0.029	1.006GlnIle: 1.006 ± 0.043	0.688GlnLys: 0.688 ± 0.033	3.158GlnLeu: 3.158 ± 0.064	0.619GlnMet: 0.619 ± 0.03	0.566GlnAsn: 0.566 ± 0.031	1.914GlnPro: 1.914 ± 0.052	1.202GlnGln: 1.202 ± 0.048	3.094GlnArg: 3.094 ± 0.083	1.425GlnSer: 1.425 ± 0.042	1.089GlnThr: 1.089 ± 0.042	2.705GlnVal: 2.705 ± 0.058	0.469GlnTrp: 0.469 ± 0.025	0.595GlnTyr: 0.595 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	10.552ArgAla: 10.552 ± 0.142	0.642ArgCys: 0.642 ± 0.03	5.155ArgAsp: 5.155 ± 0.087	5.421ArgGlu: 5.421 ± 0.077	3.062ArgPhe: 3.062 ± 0.066	6.769ArgGly: 6.769 ± 0.104	2.228ArgHis: 2.228 ± 0.06	4.216ArgIle: 4.216 ± 0.065	1.637ArgLys: 1.637 ± 0.049	9.626ArgLeu: 9.626 ± 0.155	2.217ArgMet: 2.217 ± 0.056	1.866ArgAsn: 1.866 ± 0.051	4.449ArgPro: 4.449 ± 0.083	2.812ArgGln: 2.812 ± 0.07	7.687ArgArg: 7.687 ± 0.131	3.821ArgSer: 3.821 ± 0.073	3.74ArgThr: 3.74 ± 0.066	6.165ArgVal: 6.165 ± 0.083	1.395ArgTrp: 1.395 ± 0.043	2.03ArgTyr: 2.03 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	6.125SerAla: 6.125 ± 0.106	0.415SerCys: 0.415 ± 0.022	2.614SerAsp: 2.614 ± 0.061	2.329SerGlu: 2.329 ± 0.05	1.648SerPhe: 1.648 ± 0.053	5.397SerGly: 5.397 ± 0.092	1.127SerHis: 1.127 ± 0.036	1.984SerIle: 1.984 ± 0.053	1.032SerLys: 1.032 ± 0.046	5.063SerLeu: 5.063 ± 0.094	1.113SerMet: 1.113 ± 0.037	1.081SerAsn: 1.081 ± 0.042	2.792SerPro: 2.792 ± 0.064	1.409SerGln: 1.409 ± 0.051	3.724SerArg: 3.724 ± 0.077	2.46SerSer: 2.46 ± 0.063	2.486SerThr: 2.486 ± 0.061	3.565SerVal: 3.565 ± 0.059	0.746SerTrp: 0.746 ± 0.033	1.082SerTyr: 1.082 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.753ThrAla: 5.753 ± 0.097	0.355ThrCys: 0.355 ± 0.021	2.284ThrAsp: 2.284 ± 0.057	1.945ThrGlu: 1.945 ± 0.046	1.4ThrPhe: 1.4 ± 0.048	4.906ThrGly: 4.906 ± 0.094	0.988ThrHis: 0.988 ± 0.035	1.951ThrIle: 1.951 ± 0.052	0.764ThrLys: 0.764 ± 0.037	5.679ThrLeu: 5.679 ± 0.089	0.927ThrMet: 0.927 ± 0.033	0.843ThrAsn: 0.843 ± 0.037	3.123ThrPro: 3.123 ± 0.063	1.116ThrGln: 1.116 ± 0.037	3.694ThrArg: 3.694 ± 0.06	2.234ThrSer: 2.234 ± 0.068	2.323ThrThr: 2.323 ± 0.059	3.972ThrVal: 3.972 ± 0.085	0.668ThrTrp: 0.668 ± 0.03	0.911ThrTyr: 0.911 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.762ValAla: 10.762 ± 0.126	0.619ValCys: 0.619 ± 0.024	4.944ValAsp: 4.944 ± 0.081	4.961ValGlu: 4.961 ± 0.09	2.652ValPhe: 2.652 ± 0.059	5.885ValGly: 5.885 ± 0.102	1.829ValHis: 1.829 ± 0.049	2.932ValIle: 2.932 ± 0.068	1.541ValLys: 1.541 ± 0.053	8.86ValLeu: 8.86 ± 0.11	1.616ValMet: 1.616 ± 0.044	1.726ValAsn: 1.726 ± 0.055	4.321ValPro: 4.321 ± 0.072	2.187ValGln: 2.187 ± 0.053	6.213ValArg: 6.213 ± 0.089	3.765ValSer: 3.765 ± 0.064	3.544ValThr: 3.544 ± 0.077	6.814ValVal: 6.814 ± 0.101	0.819ValTrp: 0.819 ± 0.032	1.439ValTyr: 1.439 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.35TrpAla: 1.35 ± 0.045	0.151TrpCys: 0.151 ± 0.013	0.658TrpAsp: 0.658 ± 0.029	0.598TrpGlu: 0.598 ± 0.027	0.593TrpPhe: 0.593 ± 0.03	0.931TrpGly: 0.931 ± 0.036	0.371TrpHis: 0.371 ± 0.023	0.706TrpIle: 0.706 ± 0.031	0.373TrpLys: 0.373 ± 0.021	2.28TrpLeu: 2.28 ± 0.066	0.437TrpMet: 0.437 ± 0.026	0.429TrpAsn: 0.429 ± 0.022	0.839TrpPro: 0.839 ± 0.038	0.648TrpGln: 0.648 ± 0.03	1.509TrpArg: 1.509 ± 0.052	0.906TrpSer: 0.906 ± 0.038	0.775TrpThr: 0.775 ± 0.036	0.929TrpVal: 0.929 ± 0.035	0.316TrpTrp: 0.316 ± 0.021	0.328TrpTyr: 0.328 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.633TyrAla: 2.633 ± 0.057	0.165TyrCys: 0.165 ± 0.012	1.255TyrAsp: 1.255 ± 0.049	1.054TyrGlu: 1.054 ± 0.037	0.768TyrPhe: 0.768 ± 0.03	2.036TyrGly: 2.036 ± 0.055	0.449TyrHis: 0.449 ± 0.024	0.709TyrIle: 0.709 ± 0.033	0.355TyrLys: 0.355 ± 0.021	2.078TyrLeu: 2.078 ± 0.047	0.413TyrMet: 0.413 ± 0.024	0.548TyrAsn: 0.548 ± 0.032	1.06TyrPro: 1.06 ± 0.038	0.662TyrGln: 0.662 ± 0.028	2.049TyrArg: 2.049 ± 0.045	1.025TyrSer: 1.025 ± 0.04	0.997TyrThr: 0.997 ± 0.036	1.567TyrVal: 1.567 ± 0.048	0.363TyrTrp: 0.363 ± 0.024	0.493TyrTyr: 0.493 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2469 proteins (828099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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