Amino acid dipepetide frequency for Saliterribacillus persicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.525AlaAla: 4.525 ± 0.087	0.57AlaCys: 0.57 ± 0.024	3.328AlaAsp: 3.328 ± 0.062	4.509AlaGlu: 4.509 ± 0.079	3.224AlaPhe: 3.224 ± 0.062	4.624AlaGly: 4.624 ± 0.072	1.176AlaHis: 1.176 ± 0.036	6.243AlaIle: 6.243 ± 0.098	4.435AlaLys: 4.435 ± 0.065	6.809AlaLeu: 6.809 ± 0.085	1.939AlaMet: 1.939 ± 0.043	2.933AlaAsn: 2.933 ± 0.054	1.86AlaPro: 1.86 ± 0.045	1.923AlaGln: 1.923 ± 0.049	2.298AlaArg: 2.298 ± 0.05	4.157AlaSer: 4.157 ± 0.064	3.617AlaThr: 3.617 ± 0.068	4.582AlaVal: 4.582 ± 0.078	0.676AlaTrp: 0.676 ± 0.028	2.358AlaTyr: 2.358 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.37CysAla: 0.37 ± 0.019	0.068CysCys: 0.068 ± 0.008	0.356CysAsp: 0.356 ± 0.016	0.401CysGlu: 0.401 ± 0.019	0.272CysPhe: 0.272 ± 0.016	0.551CysGly: 0.551 ± 0.027	0.167CysHis: 0.167 ± 0.013	0.453CysIle: 0.453 ± 0.018	0.359CysLys: 0.359 ± 0.017	0.562CysLeu: 0.562 ± 0.024	0.155CysMet: 0.155 ± 0.013	0.319CysAsn: 0.319 ± 0.017	0.292CysPro: 0.292 ± 0.018	0.213CysGln: 0.213 ± 0.013	0.231CysArg: 0.231 ± 0.014	0.411CysSer: 0.411 ± 0.018	0.348CysThr: 0.348 ± 0.018	0.375CysVal: 0.375 ± 0.019	0.06CysTrp: 0.06 ± 0.007	0.242CysTyr: 0.242 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.412AspAla: 3.412 ± 0.068	0.31AspCys: 0.31 ± 0.017	2.804AspAsp: 2.804 ± 0.067	4.695AspGlu: 4.695 ± 0.089	2.67AspPhe: 2.67 ± 0.051	3.495AspGly: 3.495 ± 0.074	1.222AspHis: 1.222 ± 0.037	4.593AspIle: 4.593 ± 0.069	3.652AspLys: 3.652 ± 0.058	5.144AspLeu: 5.144 ± 0.071	1.408AspMet: 1.408 ± 0.04	2.452AspAsn: 2.452 ± 0.052	2.132AspPro: 2.132 ± 0.05	2.421AspGln: 2.421 ± 0.052	2.284AspArg: 2.284 ± 0.047	2.858AspSer: 2.858 ± 0.059	2.59AspThr: 2.59 ± 0.058	3.778AspVal: 3.778 ± 0.066	0.739AspTrp: 0.739 ± 0.032	2.362AspTyr: 2.362 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.791GluAla: 5.791 ± 0.075	0.295GluCys: 0.295 ± 0.016	4.444GluAsp: 4.444 ± 0.068	8.123GluGlu: 8.123 ± 0.134	2.498GluPhe: 2.498 ± 0.046	4.187GluGly: 4.187 ± 0.076	1.452GluHis: 1.452 ± 0.041	6.238GluIle: 6.238 ± 0.091	7.174GluLys: 7.174 ± 0.109	7.107GluLeu: 7.107 ± 0.092	2.375GluMet: 2.375 ± 0.058	4.641GluAsn: 4.641 ± 0.077	2.037GluPro: 2.037 ± 0.06	3.149GluGln: 3.149 ± 0.067	3.055GluArg: 3.055 ± 0.057	3.852GluSer: 3.852 ± 0.065	4.021GluThr: 4.021 ± 0.064	5.437GluVal: 5.437 ± 0.074	0.91GluTrp: 0.91 ± 0.03	2.232GluTyr: 2.232 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.766PheAla: 2.766 ± 0.061	0.316PheCys: 0.316 ± 0.018	2.676PheAsp: 2.676 ± 0.055	2.985PheGlu: 2.985 ± 0.053	2.6PhePhe: 2.6 ± 0.068	3.07PheGly: 3.07 ± 0.069	1.038PheHis: 1.038 ± 0.034	4.333PheIle: 4.333 ± 0.078	2.667PheLys: 2.667 ± 0.045	4.837PheLeu: 4.837 ± 0.098	1.214PheMet: 1.214 ± 0.041	2.043PheAsn: 2.043 ± 0.044	1.655PhePro: 1.655 ± 0.044	1.677PheGln: 1.677 ± 0.043	1.573PheArg: 1.573 ± 0.041	3.4PheSer: 3.4 ± 0.057	2.583PheThr: 2.583 ± 0.051	3.056PheVal: 3.056 ± 0.055	0.523PheTrp: 0.523 ± 0.022	1.89PheTyr: 1.89 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.388GlyAla: 4.388 ± 0.063	0.536GlyCys: 0.536 ± 0.026	3.278GlyAsp: 3.278 ± 0.069	4.513GlyGlu: 4.513 ± 0.077	3.327GlyPhe: 3.327 ± 0.058	4.231GlyGly: 4.231 ± 0.078	1.246GlyHis: 1.246 ± 0.041	5.73GlyIle: 5.73 ± 0.089	4.547GlyLys: 4.547 ± 0.069	6.172GlyLeu: 6.172 ± 0.095	2.013GlyMet: 2.013 ± 0.046	2.644GlyAsn: 2.644 ± 0.06	1.604GlyPro: 1.604 ± 0.046	1.891GlyGln: 1.891 ± 0.046	2.109GlyArg: 2.109 ± 0.053	3.741GlySer: 3.741 ± 0.062	3.57GlyThr: 3.57 ± 0.069	4.59GlyVal: 4.59 ± 0.076	0.766GlyTrp: 0.766 ± 0.023	2.774GlyTyr: 2.774 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.421HisAla: 1.421 ± 0.035	0.176HisCys: 0.176 ± 0.013	1.057HisAsp: 1.057 ± 0.034	1.411HisGlu: 1.411 ± 0.036	1.098HisPhe: 1.098 ± 0.036	1.288HisGly: 1.288 ± 0.034	0.683HisHis: 0.683 ± 0.03	1.528HisIle: 1.528 ± 0.037	1.01HisLys: 1.01 ± 0.036	2.137HisLeu: 2.137 ± 0.053	0.519HisMet: 0.519 ± 0.022	0.823HisAsn: 0.823 ± 0.028	1.086HisPro: 1.086 ± 0.036	0.899HisGln: 0.899 ± 0.028	0.867HisArg: 0.867 ± 0.028	1.105HisSer: 1.105 ± 0.036	1.029HisThr: 1.029 ± 0.03	1.394HisVal: 1.394 ± 0.037	0.202HisTrp: 0.202 ± 0.013	0.924HisTyr: 0.924 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.109IleAla: 6.109 ± 0.087	0.614IleCys: 0.614 ± 0.023	5.079IleAsp: 5.079 ± 0.06	6.314IleGlu: 6.314 ± 0.083	3.994IlePhe: 3.994 ± 0.075	6.134IleGly: 6.134 ± 0.1	1.652IleHis: 1.652 ± 0.045	6.814IleIle: 6.814 ± 0.103	5.057IleLys: 5.057 ± 0.078	7.809IleLeu: 7.809 ± 0.121	1.82IleMet: 1.82 ± 0.05	3.941IleAsn: 3.941 ± 0.066	3.344IlePro: 3.344 ± 0.055	2.885IleGln: 2.885 ± 0.055	2.972IleArg: 2.972 ± 0.058	5.435IleSer: 5.435 ± 0.085	4.719IleThr: 4.719 ± 0.068	5.447IleVal: 5.447 ± 0.077	0.734IleTrp: 0.734 ± 0.026	2.758IleTyr: 2.758 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.409LysAla: 4.409 ± 0.075	0.308LysCys: 0.308 ± 0.015	4.295LysAsp: 4.295 ± 0.063	7.431LysGlu: 7.431 ± 0.105	1.942LysPhe: 1.942 ± 0.038	4.001LysGly: 4.001 ± 0.067	1.467LysHis: 1.467 ± 0.032	5.249LysIle: 5.249 ± 0.073	6.376LysLys: 6.376 ± 0.099	5.843LysLeu: 5.843 ± 0.087	2.111LysMet: 2.111 ± 0.044	3.799LysAsn: 3.799 ± 0.063	1.986LysPro: 1.986 ± 0.043	3.072LysGln: 3.072 ± 0.061	3.17LysArg: 3.17 ± 0.057	3.719LysSer: 3.719 ± 0.059	3.408LysThr: 3.408 ± 0.067	4.469LysVal: 4.469 ± 0.075	0.85LysTrp: 0.85 ± 0.028	2.329LysTyr: 2.329 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.804LeuAla: 6.804 ± 0.082	0.543LeuCys: 0.543 ± 0.024	5.243LeuAsp: 5.243 ± 0.074	7.217LeuGlu: 7.217 ± 0.088	5.071LeuPhe: 5.071 ± 0.095	5.827LeuGly: 5.827 ± 0.088	1.935LeuHis: 1.935 ± 0.048	7.899LeuIle: 7.899 ± 0.121	6.693LeuLys: 6.693 ± 0.079	10.023LeuLeu: 10.023 ± 0.15	2.439LeuMet: 2.439 ± 0.049	4.553LeuAsn: 4.553 ± 0.072	3.674LeuPro: 3.674 ± 0.067	3.191LeuGln: 3.191 ± 0.06	3.264LeuArg: 3.264 ± 0.065	6.74LeuSer: 6.74 ± 0.098	5.584LeuThr: 5.584 ± 0.078	5.954LeuVal: 5.954 ± 0.077	0.863LeuTrp: 0.863 ± 0.028	3.304LeuTyr: 3.304 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.798MetAla: 1.798 ± 0.037	0.111MetCys: 0.111 ± 0.01	1.526MetAsp: 1.526 ± 0.04	2.179MetGlu: 2.179 ± 0.045	1.056MetPhe: 1.056 ± 0.034	1.561MetGly: 1.561 ± 0.045	0.517MetHis: 0.517 ± 0.023	2.271MetIle: 2.271 ± 0.051	2.34MetLys: 2.34 ± 0.051	2.552MetLeu: 2.552 ± 0.052	0.842MetMet: 0.842 ± 0.027	1.476MetAsn: 1.476 ± 0.036	0.914MetPro: 0.914 ± 0.036	1.043MetGln: 1.043 ± 0.035	1.075MetArg: 1.075 ± 0.033	1.525MetSer: 1.525 ± 0.038	1.555MetThr: 1.555 ± 0.031	1.805MetVal: 1.805 ± 0.038	0.213MetTrp: 0.213 ± 0.016	0.805MetTyr: 0.805 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.78AsnAla: 2.78 ± 0.056	0.287AsnCys: 0.287 ± 0.016	2.692AsnAsp: 2.692 ± 0.054	4.11AsnGlu: 4.11 ± 0.071	2.003AsnPhe: 2.003 ± 0.044	3.295AsnGly: 3.295 ± 0.065	1.187AsnHis: 1.187 ± 0.031	3.957AsnIle: 3.957 ± 0.064	3.474AsnLys: 3.474 ± 0.06	4.211AsnLeu: 4.211 ± 0.063	1.254AsnMet: 1.254 ± 0.034	2.628AsnAsn: 2.628 ± 0.056	2.072AsnPro: 2.072 ± 0.046	2.345AsnGln: 2.345 ± 0.05	2.105AsnArg: 2.105 ± 0.043	2.476AsnSer: 2.476 ± 0.056	2.486AsnThr: 2.486 ± 0.052	3.0AsnVal: 3.0 ± 0.053	0.678AsnTrp: 0.678 ± 0.026	1.94AsnTyr: 1.94 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.08ProAla: 2.08 ± 0.045	0.202ProCys: 0.202 ± 0.014	1.922ProAsp: 1.922 ± 0.049	2.809ProGlu: 2.809 ± 0.063	1.848ProPhe: 1.848 ± 0.037	1.974ProGly: 1.974 ± 0.046	0.818ProHis: 0.818 ± 0.028	2.878ProIle: 2.878 ± 0.049	2.08ProLys: 2.08 ± 0.045	3.279ProLeu: 3.279 ± 0.056	0.806ProMet: 0.806 ± 0.025	1.817ProAsn: 1.817 ± 0.042	0.863ProPro: 0.863 ± 0.031	0.975ProGln: 0.975 ± 0.031	0.969ProArg: 0.969 ± 0.03	2.189ProSer: 2.189 ± 0.056	2.047ProThr: 2.047 ± 0.044	2.568ProVal: 2.568 ± 0.043	0.393ProTrp: 0.393 ± 0.02	1.406ProTyr: 1.406 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.755GlnAla: 2.755 ± 0.058	0.146GlnCys: 0.146 ± 0.013	1.831GlnAsp: 1.831 ± 0.034	3.011GlnGlu: 3.011 ± 0.064	1.623GlnPhe: 1.623 ± 0.037	2.032GlnGly: 2.032 ± 0.041	0.689GlnHis: 0.689 ± 0.024	2.786GlnIle: 2.786 ± 0.056	2.706GlnLys: 2.706 ± 0.048	3.99GlnLeu: 3.99 ± 0.068	1.025GlnMet: 1.025 ± 0.032	1.732GlnAsn: 1.732 ± 0.038	1.133GlnPro: 1.133 ± 0.038	1.632GlnGln: 1.632 ± 0.042	1.26GlnArg: 1.26 ± 0.037	2.077GlnSer: 2.077 ± 0.047	1.998GlnThr: 1.998 ± 0.049	2.42GlnVal: 2.42 ± 0.042	0.387GlnTrp: 0.387 ± 0.021	1.301GlnTyr: 1.301 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.107ArgAla: 2.107 ± 0.047	0.208ArgCys: 0.208 ± 0.015	1.946ArgAsp: 1.946 ± 0.046	2.897ArgGlu: 2.897 ± 0.052	1.784ArgPhe: 1.784 ± 0.045	2.01ArgGly: 2.01 ± 0.047	0.658ArgHis: 0.658 ± 0.021	3.047ArgIle: 3.047 ± 0.057	3.069ArgLys: 3.069 ± 0.056	3.61ArgLeu: 3.61 ± 0.072	1.238ArgMet: 1.238 ± 0.036	1.968ArgAsn: 1.968 ± 0.048	1.145ArgPro: 1.145 ± 0.033	1.318ArgGln: 1.318 ± 0.037	1.513ArgArg: 1.513 ± 0.038	1.975ArgSer: 1.975 ± 0.047	1.835ArgThr: 1.835 ± 0.037	2.466ArgVal: 2.466 ± 0.05	0.394ArgTrp: 0.394 ± 0.019	1.566ArgTyr: 1.566 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.361SerAla: 3.361 ± 0.054	0.373SerCys: 0.373 ± 0.021	3.111SerAsp: 3.111 ± 0.057	4.206SerGlu: 4.206 ± 0.071	3.441SerPhe: 3.441 ± 0.065	4.133SerGly: 4.133 ± 0.075	1.152SerHis: 1.152 ± 0.036	5.398SerIle: 5.398 ± 0.07	3.906SerLys: 3.906 ± 0.067	5.967SerLeu: 5.967 ± 0.084	1.708SerMet: 1.708 ± 0.043	3.085SerAsn: 3.085 ± 0.057	1.879SerPro: 1.879 ± 0.044	1.883SerGln: 1.883 ± 0.041	2.038SerArg: 2.038 ± 0.046	3.962SerSer: 3.962 ± 0.073	3.262SerThr: 3.262 ± 0.062	4.003SerVal: 4.003 ± 0.064	0.648SerTrp: 0.648 ± 0.025	2.479SerTyr: 2.479 ± 0.052	0.001SerXaa: 0.001 ± 0.001
Thr	3.585ThrAla: 3.585 ± 0.062	0.346ThrCys: 0.346 ± 0.019	2.947ThrAsp: 2.947 ± 0.057	3.835ThrGlu: 3.835 ± 0.067	2.798ThrPhe: 2.798 ± 0.046	3.794ThrGly: 3.794 ± 0.064	1.082ThrHis: 1.082 ± 0.033	4.78ThrIle: 4.78 ± 0.068	3.304ThrLys: 3.304 ± 0.053	5.338ThrLeu: 5.338 ± 0.074	1.256ThrMet: 1.256 ± 0.037	2.729ThrAsn: 2.729 ± 0.051	2.18ThrPro: 2.18 ± 0.048	1.559ThrGln: 1.559 ± 0.036	1.648ThrArg: 1.648 ± 0.036	3.339ThrSer: 3.339 ± 0.061	3.061ThrThr: 3.061 ± 0.062	3.794ThrVal: 3.794 ± 0.065	0.565ThrTrp: 0.565 ± 0.025	2.1ThrTyr: 2.1 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.62ValAla: 4.62 ± 0.08	0.462ValCys: 0.462 ± 0.022	3.763ValAsp: 3.763 ± 0.052	5.098ValGlu: 5.098 ± 0.075	3.074ValPhe: 3.074 ± 0.06	4.395ValGly: 4.395 ± 0.069	1.307ValHis: 1.307 ± 0.041	5.819ValIle: 5.819 ± 0.073	4.359ValLys: 4.359 ± 0.07	6.48ValLeu: 6.48 ± 0.087	1.758ValMet: 1.758 ± 0.037	3.139ValAsn: 3.139 ± 0.058	2.271ValPro: 2.271 ± 0.046	2.048ValGln: 2.048 ± 0.044	2.281ValArg: 2.281 ± 0.058	4.31ValSer: 4.31 ± 0.062	3.92ValThr: 3.92 ± 0.057	4.721ValVal: 4.721 ± 0.08	0.625ValTrp: 0.625 ± 0.027	2.315ValTyr: 2.315 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.556TrpAla: 0.556 ± 0.025	0.063TrpCys: 0.063 ± 0.008	0.601TrpAsp: 0.601 ± 0.027	0.743TrpGlu: 0.743 ± 0.028	0.553TrpPhe: 0.553 ± 0.024	0.64TrpGly: 0.64 ± 0.026	0.216TrpHis: 0.216 ± 0.013	0.966TrpIle: 0.966 ± 0.031	0.826TrpLys: 0.826 ± 0.027	1.159TrpLeu: 1.159 ± 0.036	0.367TrpMet: 0.367 ± 0.021	0.609TrpAsn: 0.609 ± 0.025	0.269TrpPro: 0.269 ± 0.019	0.442TrpGln: 0.442 ± 0.023	0.405TrpArg: 0.405 ± 0.021	0.63TrpSer: 0.63 ± 0.029	0.544TrpThr: 0.544 ± 0.024	0.671TrpVal: 0.671 ± 0.026	0.174TrpTrp: 0.174 ± 0.014	0.401TrpTyr: 0.401 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.149TyrAla: 2.149 ± 0.045	0.269TyrCys: 0.269 ± 0.018	2.123TyrAsp: 2.123 ± 0.047	2.533TyrGlu: 2.533 ± 0.049	2.028TyrPhe: 2.028 ± 0.047	2.428TyrGly: 2.428 ± 0.05	0.993TyrHis: 0.993 ± 0.033	2.65TyrIle: 2.65 ± 0.047	2.197TyrLys: 2.197 ± 0.042	3.793TyrLeu: 3.793 ± 0.065	0.916TyrMet: 0.916 ± 0.032	1.648TyrAsn: 1.648 ± 0.044	1.527TyrPro: 1.527 ± 0.04	1.964TyrGln: 1.964 ± 0.047	1.638TyrArg: 1.638 ± 0.038	2.095TyrSer: 2.095 ± 0.053	1.863TyrThr: 1.863 ± 0.045	2.234TyrVal: 2.234 ± 0.045	0.439TyrTrp: 0.439 ± 0.021	1.582TyrTyr: 1.582 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3585 proteins (1071052 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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