Amino acid dipepetide frequency for Arenibacter aquaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.573AlaAla: 4.573 ± 0.061	0.513AlaCys: 0.513 ± 0.019	3.574AlaAsp: 3.574 ± 0.072	3.977AlaGlu: 3.977 ± 0.061	3.051AlaPhe: 3.051 ± 0.056	4.367AlaGly: 4.367 ± 0.068	1.235AlaHis: 1.235 ± 0.028	5.075AlaIle: 5.075 ± 0.07	4.624AlaLys: 4.624 ± 0.074	6.373AlaLeu: 6.373 ± 0.075	1.728AlaMet: 1.728 ± 0.037	3.566AlaAsn: 3.566 ± 0.054	2.172AlaPro: 2.172 ± 0.041	2.602AlaGln: 2.602 ± 0.069	2.099AlaArg: 2.099 ± 0.038	4.314AlaSer: 4.314 ± 0.063	3.994AlaThr: 3.994 ± 0.145	4.22AlaVal: 4.22 ± 0.063	0.72AlaTrp: 0.72 ± 0.023	2.615AlaTyr: 2.615 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.479CysAla: 0.479 ± 0.016	0.106CysCys: 0.106 ± 0.008	0.392CysAsp: 0.392 ± 0.019	0.406CysGlu: 0.406 ± 0.018	0.386CysPhe: 0.386 ± 0.018	0.572CysGly: 0.572 ± 0.024	0.206CysHis: 0.206 ± 0.014	0.534CysIle: 0.534 ± 0.021	0.482CysLys: 0.482 ± 0.019	0.634CysLeu: 0.634 ± 0.02	0.142CysMet: 0.142 ± 0.01	0.386CysAsn: 0.386 ± 0.019	0.323CysPro: 0.323 ± 0.018	0.211CysGln: 0.211 ± 0.012	0.208CysArg: 0.208 ± 0.012	0.58CysSer: 0.58 ± 0.019	0.441CysThr: 0.441 ± 0.018	0.386CysVal: 0.386 ± 0.019	0.069CysTrp: 0.069 ± 0.007	0.303CysTyr: 0.303 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.6AspAla: 3.6 ± 0.052	0.384AspCys: 0.384 ± 0.019	2.774AspAsp: 2.774 ± 0.053	3.401AspGlu: 3.401 ± 0.053	3.425AspPhe: 3.425 ± 0.055	4.494AspGly: 4.494 ± 0.092	1.134AspHis: 1.134 ± 0.029	4.413AspIle: 4.413 ± 0.064	4.02AspLys: 4.02 ± 0.063	5.427AspLeu: 5.427 ± 0.063	1.309AspMet: 1.309 ± 0.034	3.247AspAsn: 3.247 ± 0.051	2.302AspPro: 2.302 ± 0.046	1.912AspGln: 1.912 ± 0.045	2.203AspArg: 2.203 ± 0.038	3.266AspSer: 3.266 ± 0.05	2.799AspThr: 2.799 ± 0.067	3.398AspVal: 3.398 ± 0.055	0.968AspTrp: 0.968 ± 0.034	2.933AspTyr: 2.933 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.436GluAla: 4.436 ± 0.059	0.329GluCys: 0.329 ± 0.016	3.711GluAsp: 3.711 ± 0.056	5.143GluGlu: 5.143 ± 0.077	2.715GluPhe: 2.715 ± 0.043	4.205GluGly: 4.205 ± 0.063	1.221GluHis: 1.221 ± 0.031	4.901GluIle: 4.901 ± 0.067	5.43GluLys: 5.43 ± 0.102	6.194GluLeu: 6.194 ± 0.073	1.647GluMet: 1.647 ± 0.037	4.155GluAsn: 4.155 ± 0.059	1.755GluPro: 1.755 ± 0.035	2.327GluGln: 2.327 ± 0.048	2.621GluArg: 2.621 ± 0.047	3.32GluSer: 3.32 ± 0.048	3.376GluThr: 3.376 ± 0.063	4.595GluVal: 4.595 ± 0.064	0.756GluTrp: 0.756 ± 0.023	2.438GluTyr: 2.438 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.77PheAla: 2.77 ± 0.047	0.381PheCys: 0.381 ± 0.016	2.947PheAsp: 2.947 ± 0.049	2.896PheGlu: 2.896 ± 0.05	2.451PhePhe: 2.451 ± 0.046	3.654PheGly: 3.654 ± 0.056	0.826PheHis: 0.826 ± 0.026	3.318PheIle: 3.318 ± 0.054	3.377PheLys: 3.377 ± 0.057	4.505PheLeu: 4.505 ± 0.062	1.175PheMet: 1.175 ± 0.026	3.055PheAsn: 3.055 ± 0.056	1.802PhePro: 1.802 ± 0.037	1.46PheGln: 1.46 ± 0.034	1.697PheArg: 1.697 ± 0.035	3.729PheSer: 3.729 ± 0.058	2.797PheThr: 2.797 ± 0.052	2.915PheVal: 2.915 ± 0.051	0.615PheTrp: 0.615 ± 0.022	2.033PheTyr: 2.033 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.891GlyAla: 4.891 ± 0.239	0.64GlyCys: 0.64 ± 0.028	4.114GlyAsp: 4.114 ± 0.128	4.356GlyGlu: 4.356 ± 0.165	3.562GlyPhe: 3.562 ± 0.051	4.969GlyGly: 4.969 ± 0.078	1.373GlyHis: 1.373 ± 0.036	5.613GlyIle: 5.613 ± 0.094	5.299GlyLys: 5.299 ± 0.075	6.511GlyLeu: 6.511 ± 0.072	1.764GlyMet: 1.764 ± 0.034	3.973GlyAsn: 3.973 ± 0.057	1.819GlyPro: 1.819 ± 0.047	2.234GlyGln: 2.234 ± 0.046	2.525GlyArg: 2.525 ± 0.041	4.543GlySer: 4.543 ± 0.07	4.194GlyThr: 4.194 ± 0.065	4.732GlyVal: 4.732 ± 0.065	1.02GlyTrp: 1.02 ± 0.034	3.295GlyTyr: 3.295 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.056HisAla: 1.056 ± 0.027	0.189HisCys: 0.189 ± 0.011	0.878HisAsp: 0.878 ± 0.027	0.937HisGlu: 0.937 ± 0.027	1.1HisPhe: 1.1 ± 0.023	1.261HisGly: 1.261 ± 0.027	0.53HisHis: 0.53 ± 0.022	1.444HisIle: 1.444 ± 0.031	1.257HisLys: 1.257 ± 0.035	1.87HisLeu: 1.87 ± 0.037	0.438HisMet: 0.438 ± 0.017	1.059HisAsn: 1.059 ± 0.027	1.011HisPro: 1.011 ± 0.026	0.727HisGln: 0.727 ± 0.024	0.767HisArg: 0.767 ± 0.022	1.121HisSer: 1.121 ± 0.028	0.983HisThr: 0.983 ± 0.025	0.929HisVal: 0.929 ± 0.026	0.295HisTrp: 0.295 ± 0.014	0.924HisTyr: 0.924 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.207IleAla: 5.207 ± 0.07	0.589IleCys: 0.589 ± 0.022	4.269IleAsp: 4.269 ± 0.053	4.451IleGlu: 4.451 ± 0.062	3.141IlePhe: 3.141 ± 0.051	5.183IleGly: 5.183 ± 0.059	1.277IleHis: 1.277 ± 0.031	4.963IleIle: 4.963 ± 0.084	5.228IleLys: 5.228 ± 0.064	6.736IleLeu: 6.736 ± 0.088	1.437IleMet: 1.437 ± 0.031	4.226IleAsn: 4.226 ± 0.06	3.156IlePro: 3.156 ± 0.044	2.28IleGln: 2.28 ± 0.068	2.71IleArg: 2.71 ± 0.038	5.316IleSer: 5.316 ± 0.061	4.29IleThr: 4.29 ± 0.062	4.353IleVal: 4.353 ± 0.068	0.749IleTrp: 0.749 ± 0.022	2.567IleTyr: 2.567 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.752LysAla: 4.752 ± 0.064	0.331LysCys: 0.331 ± 0.014	4.447LysAsp: 4.447 ± 0.058	6.192LysGlu: 6.192 ± 0.071	2.582LysPhe: 2.582 ± 0.046	5.158LysGly: 5.158 ± 0.149	1.19LysHis: 1.19 ± 0.031	5.249LysIle: 5.249 ± 0.069	6.276LysLys: 6.276 ± 0.102	6.221LysLeu: 6.221 ± 0.076	1.876LysMet: 1.876 ± 0.036	4.563LysAsn: 4.563 ± 0.065	2.388LysPro: 2.388 ± 0.039	2.315LysGln: 2.315 ± 0.039	2.795LysArg: 2.795 ± 0.046	4.256LysSer: 4.256 ± 0.055	4.188LysThr: 4.188 ± 0.058	4.599LysVal: 4.599 ± 0.058	0.92LysTrp: 0.92 ± 0.025	2.757LysTyr: 2.757 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	6.131LeuAla: 6.131 ± 0.074	0.723LeuCys: 0.723 ± 0.024	5.572LeuAsp: 5.572 ± 0.066	6.433LeuGlu: 6.433 ± 0.08	4.529LeuPhe: 4.529 ± 0.067	6.643LeuGly: 6.643 ± 0.072	1.608LeuHis: 1.608 ± 0.034	6.061LeuIle: 6.061 ± 0.082	7.187LeuLys: 7.187 ± 0.076	8.988LeuLeu: 8.988 ± 0.101	2.172LeuMet: 2.172 ± 0.035	5.257LeuAsn: 5.257 ± 0.072	3.952LeuPro: 3.952 ± 0.06	3.337LeuGln: 3.337 ± 0.061	3.432LeuArg: 3.432 ± 0.058	6.706LeuSer: 6.706 ± 0.07	4.934LeuThr: 4.934 ± 0.057	5.633LeuVal: 5.633 ± 0.069	1.022LeuTrp: 1.022 ± 0.029	3.39LeuTyr: 3.39 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.981MetAla: 1.981 ± 0.039	0.118MetCys: 0.118 ± 0.009	1.547MetAsp: 1.547 ± 0.032	1.778MetGlu: 1.778 ± 0.036	0.868MetPhe: 0.868 ± 0.031	1.831MetGly: 1.831 ± 0.035	0.415MetHis: 0.415 ± 0.016	1.322MetIle: 1.322 ± 0.033	1.946MetLys: 1.946 ± 0.038	1.947MetLeu: 1.947 ± 0.043	0.573MetMet: 0.573 ± 0.024	1.224MetAsn: 1.224 ± 0.027	0.988MetPro: 0.988 ± 0.025	0.824MetGln: 0.824 ± 0.022	0.923MetArg: 0.923 ± 0.027	1.322MetSer: 1.322 ± 0.034	1.097MetThr: 1.097 ± 0.029	1.699MetVal: 1.699 ± 0.035	0.212MetTrp: 0.212 ± 0.012	0.708MetTyr: 0.708 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.613AsnAla: 3.613 ± 0.055	0.427AsnCys: 0.427 ± 0.02	2.993AsnAsp: 2.993 ± 0.055	3.301AsnGlu: 3.301 ± 0.052	2.944AsnPhe: 2.944 ± 0.047	4.355AsnGly: 4.355 ± 0.065	1.007AsnHis: 1.007 ± 0.025	4.518AsnIle: 4.518 ± 0.054	4.074AsnLys: 4.074 ± 0.059	5.218AsnLeu: 5.218 ± 0.065	1.337AsnMet: 1.337 ± 0.029	3.719AsnAsn: 3.719 ± 0.063	2.763AsnPro: 2.763 ± 0.041	2.0AsnGln: 2.0 ± 0.038	2.27AsnArg: 2.27 ± 0.042	3.867AsnSer: 3.867 ± 0.049	3.533AsnThr: 3.533 ± 0.054	3.286AsnVal: 3.286 ± 0.056	0.846AsnTrp: 0.846 ± 0.027	2.602AsnTyr: 2.602 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.079ProAla: 2.079 ± 0.043	0.206ProCys: 0.206 ± 0.01	2.327ProAsp: 2.327 ± 0.038	3.032ProGlu: 3.032 ± 0.049	1.903ProPhe: 1.903 ± 0.037	2.385ProGly: 2.385 ± 0.048	0.78ProHis: 0.78 ± 0.022	2.801ProIle: 2.801 ± 0.047	2.782ProLys: 2.782 ± 0.047	3.365ProLeu: 3.365 ± 0.047	0.872ProMet: 0.872 ± 0.026	2.589ProAsn: 2.589 ± 0.044	1.006ProPro: 1.006 ± 0.032	1.283ProGln: 1.283 ± 0.029	1.13ProArg: 1.13 ± 0.031	2.465ProSer: 2.465 ± 0.042	2.15ProThr: 2.15 ± 0.043	2.406ProVal: 2.406 ± 0.041	0.464ProTrp: 0.464 ± 0.019	1.57ProTyr: 1.57 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	1.994GlnAla: 1.994 ± 0.039	0.183GlnCys: 0.183 ± 0.01	1.843GlnAsp: 1.843 ± 0.041	2.512GlnGlu: 2.512 ± 0.041	1.557GlnPhe: 1.557 ± 0.035	2.43GlnGly: 2.43 ± 0.171	0.667GlnHis: 0.667 ± 0.02	2.481GlnIle: 2.481 ± 0.043	2.614GlnLys: 2.614 ± 0.045	3.725GlnLeu: 3.725 ± 0.06	0.834GlnMet: 0.834 ± 0.023	2.067GlnAsn: 2.067 ± 0.041	1.149GlnPro: 1.149 ± 0.027	1.446GlnGln: 1.446 ± 0.033	1.363GlnArg: 1.363 ± 0.031	1.896GlnSer: 1.896 ± 0.038	1.672GlnThr: 1.672 ± 0.036	1.872GlnVal: 1.872 ± 0.037	0.491GlnTrp: 0.491 ± 0.018	1.362GlnTyr: 1.362 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.31ArgAla: 2.31 ± 0.038	0.2ArgCys: 0.2 ± 0.012	1.987ArgAsp: 1.987 ± 0.043	2.416ArgGlu: 2.416 ± 0.04	1.912ArgPhe: 1.912 ± 0.036	2.235ArgGly: 2.235 ± 0.039	0.662ArgHis: 0.662 ± 0.022	2.869ArgIle: 2.869 ± 0.046	2.735ArgLys: 2.735 ± 0.05	3.431ArgLeu: 3.431 ± 0.052	0.935ArgMet: 0.935 ± 0.027	2.193ArgAsn: 2.193 ± 0.039	1.373ArgPro: 1.373 ± 0.033	1.189ArgGln: 1.189 ± 0.029	1.417ArgArg: 1.417 ± 0.034	2.244ArgSer: 2.244 ± 0.046	2.021ArgThr: 2.021 ± 0.042	2.3ArgVal: 2.3 ± 0.038	0.484ArgTrp: 0.484 ± 0.018	1.761ArgTyr: 1.761 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.902SerAla: 3.902 ± 0.055	0.696SerCys: 0.696 ± 0.026	3.522SerAsp: 3.522 ± 0.051	3.885SerGlu: 3.885 ± 0.062	3.594SerPhe: 3.594 ± 0.057	4.798SerGly: 4.798 ± 0.064	1.209SerHis: 1.209 ± 0.029	4.797SerIle: 4.797 ± 0.058	4.538SerLys: 4.538 ± 0.057	6.338SerLeu: 6.338 ± 0.071	1.399SerMet: 1.399 ± 0.03	3.658SerAsn: 3.658 ± 0.055	2.451SerPro: 2.451 ± 0.046	2.177SerGln: 2.177 ± 0.037	2.348SerArg: 2.348 ± 0.042	4.407SerSer: 4.407 ± 0.067	3.495SerThr: 3.495 ± 0.051	3.874SerVal: 3.874 ± 0.059	0.85SerTrp: 0.85 ± 0.023	2.827SerTyr: 2.827 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	3.92ThrAla: 3.92 ± 0.06	0.291ThrCys: 0.291 ± 0.014	3.404ThrAsp: 3.404 ± 0.058	3.148ThrGlu: 3.148 ± 0.043	2.722ThrPhe: 2.722 ± 0.038	4.601ThrGly: 4.601 ± 0.248	1.049ThrHis: 1.049 ± 0.028	4.23ThrIle: 4.23 ± 0.064	3.453ThrLys: 3.453 ± 0.051	5.145ThrLeu: 5.145 ± 0.065	1.061ThrMet: 1.061 ± 0.026	3.093ThrAsn: 3.093 ± 0.052	2.565ThrPro: 2.565 ± 0.042	1.897ThrGln: 1.897 ± 0.036	1.663ThrArg: 1.663 ± 0.031	3.519ThrSer: 3.519 ± 0.047	3.402ThrThr: 3.402 ± 0.064	3.735ThrVal: 3.735 ± 0.059	0.603ThrTrp: 0.603 ± 0.022	2.371ThrTyr: 2.371 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.394ValAla: 4.394 ± 0.061	0.533ValCys: 0.533 ± 0.023	3.824ValAsp: 3.824 ± 0.049	3.805ValGlu: 3.805 ± 0.058	3.112ValPhe: 3.112 ± 0.055	4.275ValGly: 4.275 ± 0.061	1.178ValHis: 1.178 ± 0.027	4.232ValIle: 4.232 ± 0.059	3.992ValLys: 3.992 ± 0.056	6.171ValLeu: 6.171 ± 0.071	1.467ValMet: 1.467 ± 0.034	3.317ValAsn: 3.317 ± 0.05	2.488ValPro: 2.488 ± 0.041	1.967ValGln: 1.967 ± 0.036	2.193ValArg: 2.193 ± 0.044	4.398ValSer: 4.398 ± 0.062	3.394ValThr: 3.394 ± 0.058	4.499ValVal: 4.499 ± 0.064	0.673ValTrp: 0.673 ± 0.022	2.424ValTyr: 2.424 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.734TrpAla: 0.734 ± 0.023	0.095TrpCys: 0.095 ± 0.007	0.828TrpAsp: 0.828 ± 0.035	0.863TrpGlu: 0.863 ± 0.025	0.583TrpPhe: 0.583 ± 0.021	0.904TrpGly: 0.904 ± 0.027	0.324TrpHis: 0.324 ± 0.015	0.769TrpIle: 0.769 ± 0.024	0.899TrpLys: 0.899 ± 0.032	1.085TrpLeu: 1.085 ± 0.029	0.353TrpMet: 0.353 ± 0.016	0.761TrpAsn: 0.761 ± 0.024	0.434TrpPro: 0.434 ± 0.018	0.479TrpGln: 0.479 ± 0.017	0.508TrpArg: 0.508 ± 0.022	0.76TrpSer: 0.76 ± 0.024	0.688TrpThr: 0.688 ± 0.024	0.745TrpVal: 0.745 ± 0.025	0.204TrpTrp: 0.204 ± 0.012	0.497TrpTyr: 0.497 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.569TyrAla: 2.569 ± 0.035	0.312TyrCys: 0.312 ± 0.014	2.455TyrAsp: 2.455 ± 0.042	2.342TyrGlu: 2.342 ± 0.039	2.266TyrPhe: 2.266 ± 0.04	3.106TyrGly: 3.106 ± 0.051	0.886TyrHis: 0.886 ± 0.027	2.536TyrIle: 2.536 ± 0.044	2.844TyrLys: 2.844 ± 0.046	3.824TyrLeu: 3.824 ± 0.057	0.803TyrMet: 0.803 ± 0.025	2.567TyrAsn: 2.567 ± 0.041	1.698TyrPro: 1.698 ± 0.037	1.493TyrGln: 1.493 ± 0.032	1.804TyrArg: 1.804 ± 0.037	2.734TyrSer: 2.734 ± 0.05	2.423TyrThr: 2.423 ± 0.048	2.162TyrVal: 2.162 ± 0.036	0.553TyrTrp: 0.553 ± 0.02	1.89TyrTyr: 1.89 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3975 proteins (1516357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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